Papillary urothelial hyperplasia - Revision history

Michael: /* Microscopic */

2014-01-27T19:56:07Z

Microscopic

← Older revision		Revision as of 19:56, 27 January 2014
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	Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>		Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
	*Inflammation.		*Inflammation.
	*~~Rare papillary~~ structures.		*Papillary structures without well-developed fibrovascular cores.
	**Do not have a well-developed fibrovascular ~~core~~.		**Tent-like appearance ''or'' spike-like appearance - short/stubby papillae not longer than the urothelium is thick.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>
	**Tent-like appearance - short/stubby.
	*No urothelial cell atypia.		*No urothelial cell atypia.

Michael: /* Microscopic */

2014-01-27T19:37:04Z

Microscopic

← Older revision		Revision as of 19:37, 27 January 2014
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	DDx:		DDx:
	*[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core.		*[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core.
			<!--
	*[[PUNLMP]].		*[[PUNLMP]].
	*[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness.		*[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness.
			-->
	===Image===		===Image===
	*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].		*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].

Michael: abbrev

2014-01-27T19:34:22Z

abbrev

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	'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.		'''Papillary urothelial hyperplasia''', abbreviated '''PUH''', is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.

	==General==		==General==

Michael: /* Microscopic */

2014-01-27T19:33:25Z

Microscopic

← Older revision		Revision as of 19:33, 27 January 2014
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	*Rare papillary structures.		*Rare papillary structures.
	**Do not have a well-developed fibrovascular core.		**Do not have a well-developed fibrovascular core.
			**Tent-like appearance - short/stubby.
	*No urothelial cell atypia.		*No urothelial cell atypia.

Michael at 19:32, 27 January 2014

2014-01-27T19:32:00Z

← Older revision		Revision as of 19:32, 27 January 2014
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	*Benign.		*Benign.
	*Strong association with papillary neoplasms.		*Strong association with papillary neoplasms.
	**On follow-up, in one study, >1/3 have ~~a neoplasm~~; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal \| last1 = Readal \| first1 = N. \| last2 = Epstein \| first2 = JI. \| title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. \| journal = Pathology \| volume = 42 \| issue = 4 \| pages = 360-3 \| month = Jun \| year = 2010 \| doi = 10.3109/00313021003767322 \| PMID = 20438409 }}</ref>		**On follow-up (in one study) >1/4, without prior history of urothelial neoplasia, have urothelial carcinoma; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal \| last1 = Readal \| first1 = N. \| last2 = Epstein \| first2 = JI. \| title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. \| journal = Pathology \| volume = 42 \| issue = 4 \| pages = 360-3 \| month = Jun \| year = 2010 \| doi = 10.3109/00313021003767322 \| PMID = 20438409 }}</ref>

	==Microscopic==		==Microscopic==
	Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>		Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
	*Inflammation.		*Inflammation.
	*Rare ~~papillae~~		*Rare papillary structures.
	**Do not have a well-developed fibrovascular core.		**Do not have a well-developed fibrovascular core.
	*No urothelial cell atypia.		*No urothelial cell atypia.

	DDx:		DDx:
	*[[Low-grade papillary urothelial carcinoma]].		*[[Low-grade papillary urothelial carcinoma]] - have well-developed fibrovascular core.
	*[[PUNLMP]].		*[[PUNLMP]].
	*[[Urothelial papilloma]].		*[[Urothelial papilloma]] - well-developed fibrovascular cores, uniform urothelial thickness.

	===Image===		===Image===
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	The urothelium stains as follow:		The urothelium stains as follow:
	CK7: positive (~~patchy~~).		CK7: positive, patchy (normal).
	CK20: ~~very~~ rare superficial cells (normal).		CK20: only rare superficial cells (normal).
	Ki-67: rare, focally increased, negative in papillary structures (<10%).		Ki-67: rare, focally increased, negative in papillary structures (<10%).
	p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%).		p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%).

Michael at 19:27, 27 January 2014

2014-01-27T19:27:32Z

← Older revision		Revision as of 19:27, 27 January 2014
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	'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.		'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.

	===General===		==General==
	*Benign.		*Benign.
	*Strong association with papillary neoplasms.		*Strong association with papillary neoplasms.
	**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal \| last1 = Readal \| first1 = N. \| last2 = Epstein \| first2 = JI. \| title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. \| journal = Pathology \| volume = 42 \| issue = 4 \| pages = 360-3 \| month = Jun \| year = 2010 \| doi = 10.3109/00313021003767322 \| PMID = 20438409 }}</ref>		**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal \| last1 = Readal \| first1 = N. \| last2 = Epstein \| first2 = JI. \| title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. \| journal = Pathology \| volume = 42 \| issue = 4 \| pages = 360-3 \| month = Jun \| year = 2010 \| doi = 10.3109/00313021003767322 \| PMID = 20438409 }}</ref>

	===Microscopic===		==Microscopic==
	Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>		Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
	*Inflammation.		*Inflammation.
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	*No urothelial cell atypia.		*No urothelial cell atypia.

	Image:		DDx:
			*[[Low-grade papillary urothelial carcinoma]].
			*[[PUNLMP]].
			*[[Urothelial papilloma]].

			===Image===
	*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].		*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].

	===Sign out===		==Sign out==
	<pre>		<pre>
	URINARY BLADDER, BIOPSY:		URINARY BLADDER, BIOPSY:

Michael: create

2014-01-27T19:26:09Z

create

New page

'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.

===General===
*Benign.
*Strong association with papillary neoplasms.
**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref>

===Microscopic===
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
*Inflammation.
*Rare papillae
**Do not have a well-developed fibrovascular core.
*No urothelial cell atypia.

Image:
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].

===Sign out===
<pre>
URINARY BLADDER, BIOPSY:
- REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT.
- NO MUSCULARIS PROPRIA IDENTIFIED.
- CYSTITIS CYSTICA ET GLANDULARIS.
- NO EVIDENCE OF MALIGNANCY.

COMMENT:
The urothelial forms rare papillary structures; these are interpreted as reactive.

The urothelium stains as follow:
CK7: positive (patchy).
CK20: very rare superficial cells (normal).
Ki-67: rare, focally increased, negative in papillary structures (<10%).
p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%).

Follow-up is recommended.
</pre>

==See also==
*[[Urothelium]].

==References==
{{Reflist|1}}

[[Category:Urothelium]]
[[Category:Diagnosis]]