Peutz-Jeghers syndrome - Revision history

Michael at 21:35, 13 March 2016

2016-03-13T21:35:08Z

← Older revision		Revision as of 21:35, 13 March 2016
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			[[Image:Peutz-Jeghers_syndrome_polyp.jpg\|thumb\|300px \| Peutz-Jeghers polyp, as may be seen in Peutz-Jeghers syndrome. (WC)]]
	'''Peutz-Jeghers syndrome''', abbreviated '''PJS''', is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene.<ref name=omim602216>{{OMIM\|602216}}</ref>		'''Peutz-Jeghers syndrome''', abbreviated '''PJS''', is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene.<ref name=omim602216>{{OMIM\|602216}}</ref>

Michael: /* Microscopic */

2016-03-13T21:33:57Z

Microscopic

← Older revision		Revision as of 21:33, 13 March 2016
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	*# M. mucosae.		*# M. mucosae.

	Image:		===Images===
	*[http://commons.wikimedia.org/wiki/File:Peutz-Jeghers_syndrome_polyp.jpg Peutz-Jeghers syndrome polyp (WC)].		<gallery>
			Image:Peutz-Jeghers_syndrome_polyp.jpg \| Peutz-Jeghers syndrome polyp. (WC)
			</gallery>
			www:
	*[http://www.nature.com/modpathol/journal/v16/n4/fig_tab/3880773f3.html Peutz-Jeghers polyp (nature.com)].		*[http://www.nature.com/modpathol/journal/v16/n4/fig_tab/3880773f3.html Peutz-Jeghers polyp (nature.com)].
	*[http://path.upmc.edu/cases/case190.html PJS - several images (upmc.edu).]		*[http://path.upmc.edu/cases/case190.html PJS - several images (upmc.edu).]

Michael: /* Clinical */

2014-07-15T20:31:40Z

Clinical

← Older revision		Revision as of 20:31, 15 July 2014
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	Increased risk of various neoplasms - primarily:		Increased risk of various neoplasms - primarily:
	*Breast and gastrointestinal cancer.<ref name=pmid20581245>{{cite journal \|author=Beggs AD, Latchford AR, Vasen HF, ''et al.'' \|title=Peutz-Jeghers syndrome: a systematic review and recommendations for management \|journal=Gut \|volume=59 \|issue=7 \|pages=975–86 \|year=2010 \|month=July \|pmid=20581245 \|doi=10.1136/gut.2009.198499 \|url=}}</ref>		*Breast and gastrointestinal cancer.<ref name=pmid20581245>{{cite journal \|author=Beggs AD, Latchford AR, Vasen HF, ''et al.'' \|title=Peutz-Jeghers syndrome: a systematic review and recommendations for management \|journal=Gut \|volume=59 \|issue=7 \|pages=975–86 \|year=2010 \|month=July \|pmid=20581245 \|doi=10.1136/gut.2009.198499 \|url=}}</ref>
	*~~Others~~ tumours:<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/175200 http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 22 December 2010.</ref>		*Other tumours:<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/175200 http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 22 December 2010.</ref>
	**[[Granulosa cell tumour]].		**[[Granulosa cell tumour]].
	**[[Sertoli cell tumour]] - especially with calcification.		**[[Sertoli cell tumour]] - especially with calcification.

Michael: /* Clinical */ +MDA

2012-08-26T02:08:32Z

Clinical: +MDA

← Older revision		Revision as of 02:08, 26 August 2012
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	*Others tumours:<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/175200 http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 22 December 2010.</ref>		*Others tumours:<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/175200 http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 22 December 2010.</ref>
	**[[Granulosa cell tumour]].		**[[Granulosa cell tumour]].
	**[[Sertoli cell tumour]] - ~~esp.~~ with calcification.		**[[Sertoli cell tumour]] - especially with calcification.
			**[[Minimal deviation adenocarcinoma of the uterine cervix]].<ref name=pmid2764221>{{cite journal \|author=Gilks CB, Young RH, Aguirre P, DeLellis RA, Scully RE \|title=Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases \|journal=Am. J. Surg. Pathol. \|volume=13 \|issue=9 \|pages=717–29 \|year=1989 \|month=September \|pmid=2764221 \|doi= \|url=}}</ref>

	Reported associations:		Reported associations:

Michael: /* Clinical */ w

2012-01-14T17:48:52Z

Clinical: w

← Older revision		Revision as of 17:48, 14 January 2012
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	Reported associations:		Reported associations:
	*Associated with (ovarian) ~~SCTAT (~~sex cord tumour with annular tubules).<ref name=pmid7358344>{{cite journal \|author=Purohit RC, Alam SZ \|title=Sex cord tumour of the ovary with annular tubules (SCTAT) \|journal=Histopathology \|volume=4 \|issue=2 \|pages=147–54 \|year=1980 \|month=March \|pmid=7358344 \|doi= \|url=}}</ref>		*Associated with (ovarian) [[sex cord tumour with annular tubules]] (SCTAT).<ref name=pmid7358344>{{cite journal \|author=Purohit RC, Alam SZ \|title=Sex cord tumour of the ovary with annular tubules (SCTAT) \|journal=Histopathology \|volume=4 \|issue=2 \|pages=147–54 \|year=1980 \|month=March \|pmid=7358344 \|doi= \|url=}}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */ +images

2012-01-09T01:07:44Z

Microscopic: +images

← Older revision		Revision as of 01:07, 9 January 2012
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	*[http://commons.wikimedia.org/wiki/File:Peutz-Jeghers_syndrome_polyp.jpg Peutz-Jeghers syndrome polyp (WC)].		*[http://commons.wikimedia.org/wiki/File:Peutz-Jeghers_syndrome_polyp.jpg Peutz-Jeghers syndrome polyp (WC)].
	*[http://www.nature.com/modpathol/journal/v16/n4/fig_tab/3880773f3.html Peutz-Jeghers polyp (nature.com)].		*[http://www.nature.com/modpathol/journal/v16/n4/fig_tab/3880773f3.html Peutz-Jeghers polyp (nature.com)].
			*[http://path.upmc.edu/cases/case190.html PJS - several images (upmc.edu).]

	==See also==		==See also==

Michael: +omim ref

2011-09-27T02:05:57Z

+omim ref

← Older revision		Revision as of 02:05, 27 September 2011
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	'''Peutz-Jeghers syndrome''', abbreviated '''PJS''', is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene.		'''Peutz-Jeghers syndrome''', abbreviated '''PJS''', is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene.<ref name=omim602216>{{OMIM\|602216}}</ref>

	==Clinical==		==Clinical==
	Features:<ref>~~URL: [http://www.ncbi.nlm.nih.gov/omim/~~175200 ~~http://www.ncbi.nlm.nih.gov/omim/175200]. Accessed on: 13 July 2010.~~</ref>		Features:<ref name=omim175200>{{OMIM\|175200}}</ref>
	*Melanocytic macules.		*Melanocytic macules.
	**Lips, buccal mucosa, and digits.		**Lips, buccal mucosa, and digits.

Michael: +abbrev.

2011-09-27T02:02:43Z

+abbrev.

← Older revision		Revision as of 02:02, 27 September 2011
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	'''Peutz-Jeghers syndrome''' is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene.		'''Peutz-Jeghers syndrome''', abbreviated '''PJS''', is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene.

	==Clinical==		==Clinical==

Michael: /* Clinical */ +SCTAT

2011-04-26T12:51:38Z

Clinical: +SCTAT

← Older revision		Revision as of 12:51, 26 April 2011
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	*Melanocytic macules.		*Melanocytic macules.
	**Lips, buccal mucosa, and digits.		**Lips, buccal mucosa, and digits.
	**Multiple [[Peutz-Jeghers polyps]].		*Multiple [[Peutz-Jeghers polyps]].

	Increased risk of various neoplasms - primarily:		Increased risk of various neoplasms - primarily:
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	**[[Granulosa cell tumour]].		**[[Granulosa cell tumour]].
	**[[Sertoli cell tumour]] - esp. with calcification.		**[[Sertoli cell tumour]] - esp. with calcification.

			Reported associations:
			*Associated with (ovarian) SCTAT (sex cord tumour with annular tubules).<ref name=pmid7358344>{{cite journal \|author=Purohit RC, Alam SZ \|title=Sex cord tumour of the ovary with annular tubules (SCTAT) \|journal=Histopathology \|volume=4 \|issue=2 \|pages=147–54 \|year=1980 \|month=March \|pmid=7358344 \|doi= \|url=}}</ref>

	==Microscopic==		==Microscopic==

Michael: fix ref

2011-03-04T19:17:10Z

fix ref

← Older revision		Revision as of 19:17, 4 March 2011
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	==Microscopic==		==Microscopic==
	Features:<ref name=Ref_PBoD859/><ref name=pmid12692201>{{Cite journal \| last1 = Bronner \| first1 = MP. \| title = Gastrointestinal inherited polyposis syndromes. \| journal = Mod Pathol \| volume = 16 \| issue = 4 \| pages = 359-65 \| month = Apr \| year = 2003 \| doi = 10.1097/01.MP.0000062992.54036.E4 \| PMID = 12692201 \| url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>		Features:<ref name=Ref_PBoD859>{{Ref PBoD\|859}}</ref><ref name=pmid12692201>{{Cite journal \| last1 = Bronner \| first1 = MP. \| title = Gastrointestinal inherited polyposis syndromes. \| journal = Mod Pathol \| volume = 16 \| issue = 4 \| pages = 359-65 \| month = Apr \| year = 2003 \| doi = 10.1097/01.MP.0000062992.54036.E4 \| PMID = 12692201 \| url = http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html }}</ref>
	*Frond-like polyp with all three components of mucosa:		*Frond-like polyp with all three components of mucosa:
	*# Muscosal epithelium (melanotic mucosa, goblet cells).		*# Muscosal epithelium (melanotic mucosa, goblet cells).