Placental meconium - Revision history

Michael: touch

2015-01-10T22:24:44Z

touch

← Older revision		Revision as of 22:24, 10 January 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Meconium-laden_macrophages_high_mag.jpg		\| Image = Meconium-laden_macrophages_high_mag.jpg
	\| Width =		\| Width =

Michael: /* Sign out */

2014-06-25T12:12:24Z

Sign out

← Older revision		Revision as of 12:12, 25 June 2014
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	COMMENT:		COMMENT:
	A PAS-D stain and Prussian blue stain were used to confirm the presence of meconium.		A PAS-D stain and Prussian blue stain were used to confirm the presence of meconium.
			</pre>

			===Degenerative changes present===
			<pre>
			PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
			- FETAL MEMBRANES WITH MECONIUM-LADEN MACROPHAGES AND DEGENERATIVE CHANGES,
			NEGATIVE FOR CHORIOAMNIONITIS.
			- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
			- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.
	</pre>		</pre>

Michael at 12:10, 25 June 2014

2014-06-25T12:10:19Z

← Older revision		Revision as of 12:10, 25 June 2014
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	*Hemosiderin-laden macrophages.		*Hemosiderin-laden macrophages.
	**This is sorted-out with an iron stain -- see below.		**This is sorted-out with an iron stain -- see below.
			*[[Chorioamnionitis]] - apoptotic cells may be mistaken for [[neutrophils]].

	Notes:		Notes:

Michael: /* Images */

2013-11-18T04:31:51Z

Images

← Older revision		Revision as of 04:31, 18 November 2013
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	Image:Meconium-laden_macrophages_intermed_mag.jpg \| Meconium-laden macrophages - intermed. mag. (WC)		Image:Meconium-laden_macrophages_intermed_mag.jpg \| Meconium-laden macrophages - intermed. mag. (WC)
	</gallery>		</gallery>

	==Special stains==		==Special stains==
	*Hemosiderin +ve in hemosiderin-laden macrophages.		*Hemosiderin +ve in hemosiderin-laden macrophages.

Michael: /* Not definite */

2013-10-11T17:40:24Z

Not definite

← Older revision		Revision as of 17:40, 11 October 2013
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	===Not definite===		===Not definite===
	<pre>		<pre>
	PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, ~~CESAERIAN SECTION~~:		PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
	- EARLY CHORIOAMNIONITIS.		- EARLY CHORIOAMNIONITIS.
	- FETAL MEMBRANES WITH FOCAL AMNION CELL DROP-OUT AND RARE PIGMENTED		- FETAL MEMBRANES WITH FOCAL AMNION CELL DROP-OUT AND RARE PIGMENTED

Michael at 13:02, 27 September 2013

2013-09-27T13:02:44Z

← Older revision		Revision as of 13:02, 27 September 2013
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	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Placental meconium''', also known as '''[[meconium]] staining''', is associated with fetal distress.		'''Placental meconium''', also known as '''meconium staining''', is associated with fetal distress.

	==General==		==General==
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	*[[Placenta]].		*[[Placenta]].
	*[[Chorioamnionitis]].		*[[Chorioamnionitis]].
			*[[Meconium peritonitis]].
			*[[Meconium ileus]].

	==References==		==References==

Michael: split-out

2013-09-27T12:54:47Z

split-out

← Older revision		Revision as of 12:54, 27 September 2013
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	~~#redirect~~ [[~~Placenta#~~Placental meconium]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Meconium-laden_macrophages_high_mag.jpg
			\| Width =
			\| Caption = Meconium-laden macrophages. [[H&E stain]].
			\| Micro = macrophages with brown fine granular pigment in the amnion +/- chorion
			\| Subtypes =
			\| LMDDx = hemorrhage
			\| Stains = PASD +ve, Prussian blue -ve
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = green discolourization of fetal membranes
			\| Grossing =
			\| Site = [[placenta\|placental membranes]]
			\| Assdx = +/-[[chorioamnionitis]]
			\| Syndromes =
			\| Clinicalhx = +/-non-reassuring fetal heart rate
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			}}
			'''Placental meconium''', also known as '''[[meconium]] staining''', is associated with fetal distress.

			==General==
			*Associated with fetal distress.
			*Small amount - at term - is considered to be normal.

			Other meconium-related pathology:
			*[[Meconium peritonitis]].
			*[[Meconium ileus]].

			==Gross==
			*Fetal membranes with a green discolourization.

			==Microscopic==
			Features:<ref>ALS. 6 Febraury 2009.</ref>
			*Meconium histiocytes - '''key feature'''.
			**Macrophages with brown fine granular pigment.
			*Pseudostratified epithelium (amnion) - low power.
			*Amnion - columnar morphology (normally cuboidal).
			*"Drop-out" of individual amnion cells / loss of individual cells.

			Time of meconium passage:<ref name=pmid2413412>{{cite journal \|author=Miller PW, Coen RW, Benirschke K \|title=Dating the time interval from meconium passage to birth \|journal=Obstet Gynecol \|volume=66 \|issue=4 \|pages=459–62 \|year=1985 \|month=October \|pmid=2413412 \|doi= \|url=}}</ref>
			*<1 h - no staining of membranes.
			*1-3 h - amnion is stained.
			*>3 h - chorion is stained.

			DDx:
			*Hemosiderin-laden macrophages.
			**This is sorted-out with an iron stain -- see below.

			Notes:
			*The above time course is disputed - in vitro experiments suggest it is considerably longer.<ref name=pmid19031358>{{cite journal \|author=Funai EF, Labowsky AT, Drewes CE, Kliman HJ \|title=Timing of fetal meconium absorption by amnionic macrophages \|journal=Am J Perinatol \|volume=26 \|issue=1 \|pages=93–7 \|year=2009 \|month=January \|pmid=19031358 \|doi=10.1055/s-0028-1103028 \|url=}}</ref>

			===Images===
			<gallery>
			Image:Meconium-laden_macrophages_high_mag.jpg \| Meconium-laden macrophages - high mag. (WC)
			Image:Meconium-laden_macrophages_intermed_mag.jpg \| Meconium-laden macrophages - intermed. mag. (WC)
			</gallery>
			==Special stains==
			*Hemosiderin +ve in hemosiderin-laden macrophages.
			*PAS +ve in meconium-laden macrophages.<ref name=pmid11268705>{{cite journal \|author=Povýsil C, Bennett R, Povýsilová V \|title=CD 68 positivity of the so-called meconium corpuscles in human foetal intestine \|journal=Cesk Patol \|volume=37 \|issue=1 \|pages=7–9 \|year=2001 \|month=January \|pmid=11268705 \|doi= \|url=}}</ref>

			Useful to differentiate hemosiderin-laden macrophages and meconium laden macrophages:
			*Hemosiderin stain -- +ve for old blood.
			**Prussian-blue stain = hemosiderin stain.<ref>{{cite journal \|author=Sienko A, Altshuler G \|title=Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines \|journal=Obstet Gynecol \|volume=94 \|issue=3 \|pages=415?0 \|year=1999 \|month=September \|pmid=10472870 \|doi= \|url=}}</ref>

			Notes:
			*PAS-D -- +ve in meconium... though may rarely stain hemosiderin.
			*Meconium contains bile.<ref>{{cite journal \|author=Sienko A, Altshuler G \|title=Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines \|journal=Obstet Gynecol \|volume=94 \|issue=3 \|pages=415?0 \|year=1999 \|month=September \|pmid=10472870 \|doi= \|url=}}</ref>

			==Sign out==
			<pre>
			PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
			- FETAL MEMBRANES WITH MECONIUM-LADEN MACROPHAGES, NEGATIVE FOR CHORIOAMNIONITIS.
			- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
			- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.
			</pre>

			<pre>
			COMMENT:
			A PAS-D stain and Prussian blue stain were used to confirm the presence of meconium.
			</pre>

			===Not definite===
			<pre>
			PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CESAERIAN SECTION:
			- EARLY CHORIOAMNIONITIS.
			- FETAL MEMBRANES WITH FOCAL AMNION CELL DROP-OUT AND RARE PIGMENTED
			CELLS SUGGESTIVE OF MECONIUM.
			- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
			- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.
			</pre>

			==See also==
			*[[Placenta]].
			*[[Chorioamnionitis]].

			==References==
			{{Reflist\|2}}

			[[Category:Placenta]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2012-01-06T22:45:20Z

redirect

← Older revision		Revision as of 22:45, 6 January 2012
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	#redirect [[Placenta#Placental meconium]]		#redirect [[Placenta#Placental meconium]]

			[[Category:Diagnosis]]

Michael: redirect

2012-01-06T22:42:22Z

redirect

New page

#redirect [[Placenta#Placental meconium]]