Pleomorphic undifferentiated sarcoma - Revision history

Mitchell: /* Images */ added a case

2017-01-02T18:04:49Z

Images: added a case

← Older revision		Revision as of 18:04, 2 January 2017
Line 74:		Line 74:
	Image:Pleomorphic_undifferentiated_sarcoma_-_intermed_mag.jpg \| PUS - intermed. mag. (WC/Nephron)		Image:Pleomorphic_undifferentiated_sarcoma_-_intermed_mag.jpg \| PUS - intermed. mag. (WC/Nephron)
	</gallery>		</gallery>
			[[File:3 13646052598462 sl 1.png\|Pleomorphic sarcoma]]
			[[File:3 13646052598462 sl 2.png\|Pleomorphic sarcoma]]
			[[File:3 13646052598462 sl 3.png\|Pleomorphic sarcoma]]
			[[File:3 13646052598462 sl 4.png\|Pleomorphic sarcoma]]<br>
			Pleomorphic sarcoma in thigh of late middle aged man. A. Tumor haphazardly spreads and invades and surrounds degenerated skeletal muscle fibers. B. Bizarre, sometimes multinucleated cells are seen. C. In other areas, spindle cells predominate. D. Invasion of adipose tissue by tumor should not be interpreted as proof of dedifferentiated liposarcoma; lipoblasts should be seen. Vital is remembering this is a diagnosis of exclusion, with negative keratin, CD34, CD30, S100, and CD31 stains being suggested.

	===Subclassification===		===Subclassification===

Michael at 12:27, 24 June 2016

2016-06-24T12:27:35Z

← Older revision		Revision as of 12:27, 24 June 2016
Line 7:		Line 7:
	\| Micro = storiform pattern ([[AKA]] ''patternless pattern''), marked [[nuclear pleomorphism]], mitoses, necrosis (common), mix of spindle cells and epithelioid cells, deep to skin		\| Micro = storiform pattern ([[AKA]] ''patternless pattern''), marked [[nuclear pleomorphism]], mitoses, necrosis (common), mix of spindle cells and epithelioid cells, deep to skin
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[atypical fibroxanthoma]] (superficial), [[dedifferentiated liposarcoma]], [[leiomyosarcoma]],[[metaplastic carcinoma]], [[malignant melanoma]], [[rhabdomyosarcoma]], [[synovial sarcoma]],[[~~Undifferentiated~~ endometrial sarcoma]], others		\| LMDDx = [[atypical fibroxanthoma]] (superficial), [[dedifferentiated liposarcoma]], [[leiomyosarcoma]],[[metaplastic carcinoma]], [[malignant melanoma]], [[rhabdomyosarcoma]], [[synovial sarcoma]],[[undifferentiated endometrial sarcoma]], others
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 22:31, 16 February 2014

2014-02-16T22:31:08Z

← Older revision		Revision as of 22:31, 16 February 2014
Line 4:		Line 4:
	\| Width =		\| Width =
	\| Caption = Pleomorphic undifferentiated sarcoma. [[H&E stain]].		\| Caption = Pleomorphic undifferentiated sarcoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms = undifferentiated pleomorphic sarcoma (UPS), malignant fibrous histiocytoma (MFH)
	\| Micro = storiform pattern ([[AKA]] ''patternless pattern''), marked [[nuclear pleomorphism]], mitoses, necrosis (common), mix of spindle cells and epithelioid cells, deep to skin		\| Micro = storiform pattern ([[AKA]] ''patternless pattern''), marked [[nuclear pleomorphism]], mitoses, necrosis (common), mix of spindle cells and epithelioid cells, deep to skin
	\| Subtypes =		\| Subtypes =

Michael: create

2014-02-16T22:30:08Z

create

← Older revision		Revision as of 22:30, 16 February 2014
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Pleomorphic_undifferentiated_sarcoma_-_very_high_mag.jpg
			\| Width =
			\| Caption = Pleomorphic undifferentiated sarcoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = storiform pattern ([[AKA]] ''patternless pattern''), marked [[nuclear pleomorphism]], mitoses, necrosis (common), mix of spindle cells and epithelioid cells, deep to skin
			\| Subtypes =
			\| LMDDx = [[atypical fibroxanthoma]] (superficial), [[dedifferentiated liposarcoma]], [[leiomyosarcoma]],[[metaplastic carcinoma]], [[malignant melanoma]], [[rhabdomyosarcoma]], [[synovial sarcoma]],[[Undifferentiated endometrial sarcoma]], others
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = deep [[soft tissue lesion\|soft tissue]] - trunk and extremities
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon overall
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx =
			\| Tx = surgery if feasible
			}}
	'''Pleomorphic undifferentiated sarcoma''', abbreviated '''PUS''', is an undifferentiated malignant [[soft tissue lesion]].		'''Pleomorphic undifferentiated sarcoma''', abbreviated '''PUS''', is an undifferentiated malignant [[soft tissue lesion]].

Michael: split out

2014-02-16T21:33:02Z

split out

← Older revision		Revision as of 21:33, 16 February 2014
Line 1:		Line 1:
	~~#redirect~~ [[~~Soft_tissue_lesions#Pleomorphic_undifferentiated_sarcoma~~]]		'''Pleomorphic undifferentiated sarcoma''', abbreviated '''PUS''', is an undifferentiated malignant [[soft tissue lesion]].

			It is also known as '''undifferentiated pleomorphic sarcoma''' (abbreviated '''UPS'''). Previously, it was known as '''malignant fibrous histiocytoma''', commonly abbreviated '''MFH'''.<ref>URL: [http://sarcomahelp.org/learning_center/mfh.html http://sarcomahelp.org/learning_center/mfh.html]. Accessed on: 8 April 2011.</ref>

			==General==
			*Common sarcoma.
			*Usually deep tissue of the trunk and extremities.
			*A diagnosis of exclusion<ref name=pmid19671033>{{cite journal \|author=Matushansky I, Charytonowicz E, Mills J, Siddiqi S, Hricik T, Cordon-Cardo C \|title=MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st Century \|journal=Expert Rev Anticancer Ther \|volume=9 \|issue=8 \|pages=1135–44 \|year=2009 \|month=August \|pmid=19671033 \|pmc=3000413 \|doi=10.1586/era.09.76 \|url=}}</ref> / wastebasket for unclassifiable high grade sarcomas.

			==Microscopic==
			Features:<ref name=Ref_WMSP_613>{{Ref WMSP\|613}}</ref>
			*Storiform pattern ([[AKA]] ''patternless pattern'') - '''key feature'''.
			*Marked [[nuclear pleomorphism]] '''key feature'''.
			**Variation is nuclear size, nuclear shape and nuclear staining (esp. hyperchromasia).
			*Mitoses - abundant; atypical mitoses common.
			*Necrosis (common).
			*Mix of spindle cells and epithelioid cells.
			*Deep to skin - '''important'''.

			Other findings:
			*+/-Giant cells (see subclassification).
			*+/-Inflammation (see subclassification).
			**Neutrophils.
			**Eosinophils.

			Notes:
			*Superficial lesions with the morphology of ''PUS'' are called by some ''[[atypical fibroxanthoma]]s'' (AFXs).

			DDx:
			*[[Atypical fibroxanthoma]] (AFX) - superficial skin.
			*[[Dedifferentiated liposarcoma]].
			*[[Leiomyosarcoma]].
			*[[Metaplastic carcinoma]].
			*[[Malignant melanoma]].
			*[[Rhabdomyosarcoma]].
			*[[Synovial sarcoma]].
			*[[Undifferentiated endometrial sarcoma]] - uterus.
			*Others.

			===Images===
			<gallery>
			Image:Pleomorphic_undifferentiated_sarcoma_-_very_high_mag.jpg \| PUS - high mag. (WC/Nephron)
			Image:Pleomorphic_undifferentiated_sarcoma_-_intermed_mag.jpg \| PUS - intermed. mag. (WC/Nephron)
			</gallery>

			===Subclassification===
			Pleomorphic sarcoma (PS) is subclassified the following way:<ref name=Ref_WMSP_613-4>{{Ref WMSP\|613-4}}</ref>
			*PS with giant cells.
			*PS with inflammation.
			*PUS (not otherwise specified) - wastebasket diagnosis; if neither of the above two apply.

			==IHC==
			Exclusionary stains - should be negative:
			*AE1/AE3.
			*p63.
			*Myogenin.
			*S-100.
			*HMB-45.

			Usually negative, may be positive:<ref name=Ref_WMSP613>{{Ref WMSP\|613}}</ref>
			*Desmin.
			*SMA.

			Commonly positive:
			*CD68.<ref name=Ref_WMSP613>{{Ref WMSP\|613}}</ref>
			*Vimentin.

			==See also==
			*[[Sarcoma]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Soft tissue lesions]]

Michael: +cat.

2011-10-20T05:10:37Z

+cat.

← Older revision		Revision as of 05:10, 20 October 2011
Line 1:		Line 1:
	#redirect [[Soft_tissue_lesions#Pleomorphic_undifferentiated_sarcoma]]		#redirect [[Soft_tissue_lesions#Pleomorphic_undifferentiated_sarcoma]]

			[[Category:Diagnosis]]

Michael: tweak

2011-04-12T14:37:06Z

tweak

← Older revision		Revision as of 14:37, 12 April 2011
Line 1:		Line 1:
	#redirect [[/Soft_tissue_lesions#Pleomorphic_undifferentiated_sarcoma]]		#redirect [[Soft_tissue_lesions#Pleomorphic_undifferentiated_sarcoma]]

Michael: redirect for now

2011-04-12T14:36:54Z

redirect for now

New page

#redirect [[/Soft_tissue_lesions#Pleomorphic_undifferentiated_sarcoma]]