Postradiation prostatic carcinoma - Revision history

Michael: /* www */

2015-07-24T17:56:10Z

www

← Older revision		Revision as of 17:56, 24 July 2015
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	====www====		====www====
	*[http://webpathology.com/image.asp?case=97&n=6 Prostate with radiation changes (webpathology.com)].		*[http://webpathology.com/image.asp?case=97&n=6 Prostate cancer with radiation changes (webpathology.com)].
	*[http://webpathology.com/image.asp?case=97&n=7 Prostate with radiation changes (webpathology.com)].		*[http://webpathology.com/image.asp?case=97&n=7 Prostate cancer with radiation changes (webpathology.com)].

	==IHC==		==IHC==

Michael: /* Images */

2015-07-24T17:55:52Z

Images

← Older revision		Revision as of 17:55, 24 July 2015
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	===Images===		===Images===
			====Case====
	<gallery>		<gallery>
	Image: Prostatic carcinoma and radiation changes -- intermed mag.jpg \| PC and RC - intermed. mag.		Image: Prostatic carcinoma and radiation changes -- intermed mag.jpg \| PC and RC - intermed. mag.
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	Image: Radiation changes in the prostate - alt -- very high mag.jpg \| RC - very high mag.		Image: Radiation changes in the prostate - alt -- very high mag.jpg \| RC - very high mag.
	</gallery>		</gallery>

			====www====
			*[http://webpathology.com/image.asp?case=97&n=6 Prostate with radiation changes (webpathology.com)].
			*[http://webpathology.com/image.asp?case=97&n=7 Prostate with radiation changes (webpathology.com)].

	==IHC==		==IHC==

Michael: /* General */

2015-07-23T05:21:56Z

General

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	==General==		==General==
	*Overcall and undercall are both seen.<ref name=pmid10524518/>		*Overcall and undercall are both seen.<ref name=pmid10524518/>
	*Commonly missed on core biopsies.		*Commonly missed on core biopsies.<ref name=pmid10524518/>
	*History of radiation.		*History of radiation.

Michael at 05:20, 23 July 2015

2015-07-23T05:20:26Z

← Older revision		Revision as of 05:20, 23 July 2015
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	\| Symptoms =		\| Symptoms =
	\| Prevalence = uncommon		\| Prevalence = uncommon
	\| Bloodwork = elevated PSA or increasing PSA		\| Bloodwork = elevated [[PSA]] or increasing PSA
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
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	\| Tx = salvage prostatectomy		\| Tx = salvage prostatectomy
	}}		}}
	'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Cheville \| first2 = JC. \| last3 = Bostwick \| first3 = DG. \| title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. \| journal = Am J Surg Pathol \| volume = 23 \| issue = 10 \| pages = 1173-83 \| month = Oct \| year = 1999 \| doi = \| PMID = 10524518 }}</ref>		'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is a type of [[postradiation prostate cancer]]. It is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Cheville \| first2 = JC. \| last3 = Bostwick \| first3 = DG. \| title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. \| journal = Am J Surg Pathol \| volume = 23 \| issue = 10 \| pages = 1173-83 \| month = Oct \| year = 1999 \| doi = \| PMID = 10524518 }}</ref>

	==General==		==General==

Michael: /* Images */

2015-07-23T05:16:07Z

Images

← Older revision		Revision as of 05:16, 23 July 2015
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Prostatic carcinoma and radiation changes - IHC -- low mag.jpg \| PC and RC - low mag.		Image: Prostatic carcinoma and radiation changes - IHC -- low mag.jpg \| PC and RC (AMACR-CK5/6) - low mag.
	Image: Prostatic carcinoma and radiation changes - IHC -- intermed mag.jpg \| PC and RC - intermed. mag.		Image: Prostatic carcinoma and radiation changes - IHC -- intermed mag.jpg \| PC and RC (AMACR-CK5/6) - intermed. mag.
	Image: Prostatic carcinoma and radiation changes - IHC -- high mag.jpg \| PC and RC - high mag.		Image: Prostatic carcinoma and radiation changes - IHC -- high mag.jpg \| PC and RC (AMACR-CK5/6) - high mag.
	</gallery>		</gallery>

Michael: +infobox and image

2015-07-23T05:12:43Z

+infobox and image

← Older revision		Revision as of 05:12, 23 July 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Prostatic carcinoma and radiation changes -- high mag.jpg
			\| Width =
			\| Caption = Prostatic carcinoma (pale glands - left/bottom of image) and radiation changes (hyperchromatic glands with nuclear atypia (upper right of image). [[H&E stain]].
			\| Synonyms =
			\| Micro = infiltrative growth, perineural invasion, blue mucin secretions, intraluminal crystalloids
			\| Subtypes =
			\| LMDDx = [[radiation changes]], [[pleomorphic tumours]], postradiation prostatic sarcoma, [[sarcomatoid prostatic carcinoma]]
			\| Stains =
			\| IHC = AMACR +ve, CK5/6 -ve, p63 -ve, PSA +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[prostate gland]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = radiation treatment, prostate carcinoma (previously diagnosed)
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork = elevated PSA or increasing PSA
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor (?)
			\| Other =
			\| ClinDDx = radiation changes, infection
			\| Tx = salvage prostatectomy
			}}
	'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Cheville \| first2 = JC. \| last3 = Bostwick \| first3 = DG. \| title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. \| journal = Am J Surg Pathol \| volume = 23 \| issue = 10 \| pages = 1173-83 \| month = Oct \| year = 1999 \| doi = \| PMID = 10524518 }}</ref>		'''Postradiation prostatic carcinoma''', also '''prostate carcinoma after radiation therapy''', is uncommon but may be challenging to diagnose.<ref name=pmid10524518>{{Cite journal \| last1 = Cheng \| first1 = L. \| last2 = Cheville \| first2 = JC. \| last3 = Bostwick \| first3 = DG. \| title = Diagnosis of prostate cancer in needle biopsies after radiation therapy. \| journal = Am J Surg Pathol \| volume = 23 \| issue = 10 \| pages = 1173-83 \| month = Oct \| year = 1999 \| doi = \| PMID = 10524518 }}</ref>

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	Features:<ref name=pmid10524518/>		Features:<ref name=pmid10524518/>
	*Infiltrative growth (diagnostic).		*Infiltrative growth (diagnostic).
	*Perineural invasion (diagnostic).		*[[Perineural invasion]] (diagnostic).
	*Intraluminal crystalloids.		*Intraluminal crystalloids.
	*Blue mucin secretions.		*Blue mucin secretions.

Michael: /* IHC */

2015-07-23T05:04:16Z

IHC

← Older revision		Revision as of 05:04, 23 July 2015
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	*CK5/6 -ve.		*CK5/6 -ve.
	*p63 -ve.		*p63 -ve.

			===Images===
			<gallery>
			Image: Prostatic carcinoma and radiation changes - IHC -- low mag.jpg \| PC and RC - low mag.
			Image: Prostatic carcinoma and radiation changes - IHC -- intermed mag.jpg \| PC and RC - intermed. mag.
			Image: Prostatic carcinoma and radiation changes - IHC -- high mag.jpg \| PC and RC - high mag.
			</gallery>

	==See also==		==See also==

Michael: /* Microscopic */

2015-07-23T05:04:01Z

Microscopic

← Older revision		Revision as of 05:04, 23 July 2015
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	Note:		Note:
	*Nuclear enlargement and nucleoli are prevalent in [[radiation changes]] of the prostate. These features are not useful in this context.<ref name=pmid10524518/>		*Nuclear enlargement and prominent [[nucleoli]] are prevalent in [[radiation changes]] of the prostate. These features are not useful in this context.<ref name=pmid10524518/>

	DDx:		DDx:
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	*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal \| last1 = Canfield \| first1 = SE. \| last2 = Gans \| first2 = TH. \| last3 = Unger \| first3 = P. \| last4 = Hall \| first4 = SJ. \| title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? \| journal = Tech Urol \| volume = 7 \| issue = 4 \| pages = 294-5 \| month = Dec \| year = 2001 \| doi = \| PMID = 11763492 }}</ref>		*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal \| last1 = Canfield \| first1 = SE. \| last2 = Gans \| first2 = TH. \| last3 = Unger \| first3 = P. \| last4 = Hall \| first4 = SJ. \| title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? \| journal = Tech Urol \| volume = 7 \| issue = 4 \| pages = 294-5 \| month = Dec \| year = 2001 \| doi = \| PMID = 11763492 }}</ref>
	*[[Sarcomatoid prostatic carcinoma]] - may arise following radiation.		*[[Sarcomatoid prostatic carcinoma]] - may arise following radiation.

			===Images===
			<gallery>
			Image: Prostatic carcinoma and radiation changes -- intermed mag.jpg \| PC and RC - intermed. mag.
			Image: Prostatic carcinoma and radiation changes - alt -- intermed mag.jpg \| PC and RC - intermed. mag.
			Image: Prostatic carcinoma and radiation changes -- high mag.jpg \| PC and RC - high mag.
			Image: Prostatic carcinoma and radiation changes -- very high mag.jpg \| PC and RC - very high mag.

			Image: Radiation changes in the prostate - alt -- high mag.jpg \| RC - high mag.
			Image: Radiation changes in the prostate - alt -- very high mag.jpg \| RC - very high mag.
			</gallery>

	==IHC==		==IHC==

Michael: /* References */

2015-07-23T05:00:57Z

References

← Older revision		Revision as of 05:00, 23 July 2015
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	{{Reflist\|2}}		{{Reflist\|2}}

	[[Category:Prostate ~~cancer~~]]		[[Category:Prostate carcinoma]]

Michael: /* Microscopic */

2015-07-23T05:00:34Z

Microscopic

← Older revision		Revision as of 05:00, 23 July 2015
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	*[[Pleomorphic tumours]].		*[[Pleomorphic tumours]].
	*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal \| last1 = Canfield \| first1 = SE. \| last2 = Gans \| first2 = TH. \| last3 = Unger \| first3 = P. \| last4 = Hall \| first4 = SJ. \| title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? \| journal = Tech Urol \| volume = 7 \| issue = 4 \| pages = 294-5 \| month = Dec \| year = 2001 \| doi = \| PMID = 11763492 }}</ref>		*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal \| last1 = Canfield \| first1 = SE. \| last2 = Gans \| first2 = TH. \| last3 = Unger \| first3 = P. \| last4 = Hall \| first4 = SJ. \| title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? \| journal = Tech Urol \| volume = 7 \| issue = 4 \| pages = 294-5 \| month = Dec \| year = 2001 \| doi = \| PMID = 11763492 }}</ref>
	*[[Sarcomatoid prostatic carcinoma]].		*[[Sarcomatoid prostatic carcinoma]] - may arise following radiation.

	==IHC==		==IHC==