Progressive multifocal leukoencephalopathy - Revision history

Michael: /* IHC */

2016-06-29T17:23:59Z

IHC

← Older revision		Revision as of 17:23, 29 June 2016
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	==IHC==		==IHC==
	*SV40 +ve.<ref name=pmid15581180>{{Cite journal \| last1 = Muñoz-Mármol \| first1 = AM. \| last2 = Mola \| first2 = G. \| last3 = Fernández-Vasalo \| first3 = A. \| last4 = Vela \| first4 = E. \| last5 = Mate \| first5 = JL. \| last6 = Ariza \| first6 = A. \| title = JC virus early protein detection by immunohistochemistry in progressive multifocal leukoencephalopathy: a comparative study with in situ hybridization and polymerase chain reaction. \| journal = J Neuropathol Exp Neurol \| volume = 63 \| issue = 11 \| pages = 1124-30 \| month = Nov \| year = 2004 \| doi = \| PMID = 15581180 }}</ref>		*[[SV40]] +ve.<ref name=pmid15581180>{{Cite journal \| last1 = Muñoz-Mármol \| first1 = AM. \| last2 = Mola \| first2 = G. \| last3 = Fernández-Vasalo \| first3 = A. \| last4 = Vela \| first4 = E. \| last5 = Mate \| first5 = JL. \| last6 = Ariza \| first6 = A. \| title = JC virus early protein detection by immunohistochemistry in progressive multifocal leukoencephalopathy: a comparative study with in situ hybridization and polymerase chain reaction. \| journal = J Neuropathol Exp Neurol \| volume = 63 \| issue = 11 \| pages = 1124-30 \| month = Nov \| year = 2004 \| doi = \| PMID = 15581180 }}</ref>

	==See also==		==See also==

Jensflorian: pictures added

2015-07-15T07:58:12Z

pictures added

← Older revision		Revision as of 07:58, 15 July 2015
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	===Images===		===Images===
			<gallery>
			File:PML-HE_brain_biopsy.jpg \| Oligodendrocytes with nuclear enlargement and glassy magenta chromatin (WC/jensflorian)
			File:PML-SV40.jpg \| Same case with SV40-positive immunoreactivity (WC/jensflorian)
			</gallery>

	*[http://path.upmc.edu/cases/case120/micro.html PML - case 1 (upmc.edu)].		*[http://path.upmc.edu/cases/case120/micro.html PML - case 1 (upmc.edu)].
	*[http://path.upmc.edu/cases/case120/dx.html PML - case 1 (upmc.edu)].		*[http://path.upmc.edu/cases/case120/dx.html PML - case 1 (upmc.edu)].
	*[http://path.upmc.edu/cases/case336/images/fig03.jpg ~~Crutzfeldt~~ cell - case 2 (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case336.html http://path.upmc.edu/cases/case336.html]. Accessed on: 15 January 2012.</ref>		*[http://path.upmc.edu/cases/case336/images/fig03.jpg Creutzfeldt cell - case 2 (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case336.html http://path.upmc.edu/cases/case336.html]. Accessed on: 15 January 2012.</ref>
	*[http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Figures/PMLHandE.jpg PML oligodendrocyte (ucsf.edu)].<ref name=uscf_pml>URL: [http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm]. Accessed on: 3 January 2012.</ref>		*[http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Figures/PMLHandE.jpg PML oligodendrocyte (ucsf.edu)].<ref name=uscf_pml>URL: [http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm]. Accessed on: 3 January 2012.</ref>
	*[http://neuro.psychiatryonline.org/data/Journals/NP/3923/RA4831F2.jpeg PML oligodendrocyte (psychiatryonline.org)].<ref>{{Cite journal \| last1 = Hurley \| first1 = RA. \| last2 = Ernst \| first2 = T. \| last3 = Khalili \| first3 = K. \| last4 = Del Valle \| first4 = L. \| last5 = Simone \| first5 = IL. \| last6 = Taber \| first6 = KH. \| title = Identification of HIV-associated progressive multifocal leukoencephalopathy: magnetic resonance imaging and spectroscopy. \| journal = J Neuropsychiatry Clin Neurosci \| volume = 15 \| issue = 1 \| pages = 1-6 \| month = \| year = 2003 \| doi = \| PMID = 12556565 }}</ref>		*[http://neuro.psychiatryonline.org/data/Journals/NP/3923/RA4831F2.jpeg PML oligodendrocyte (psychiatryonline.org)].<ref>{{Cite journal \| last1 = Hurley \| first1 = RA. \| last2 = Ernst \| first2 = T. \| last3 = Khalili \| first3 = K. \| last4 = Del Valle \| first4 = L. \| last5 = Simone \| first5 = IL. \| last6 = Taber \| first6 = KH. \| title = Identification of HIV-associated progressive multifocal leukoencephalopathy: magnetic resonance imaging and spectroscopy. \| journal = J Neuropsychiatry Clin Neurosci \| volume = 15 \| issue = 1 \| pages = 1-6 \| month = \| year = 2003 \| doi = \| PMID = 12556565 }}</ref>

Michael: split out

2014-12-09T06:46:05Z

split out

← Older revision		Revision as of 06:46, 9 December 2014
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	#~~redirect~~ [[Neuropathology~~#Progressive_multifocal_leukoencephalopathy~~]]		'''Progressive multifocal leukoencephalopathy''', abbreviated '''PML''', is a rare [[neuropathology]] caused by a [[polyomavirus]].

			==General==
			*Caused by ''JC virus'' (a type of [[polyomavirus]]<ref name=pmid21499097>{{Cite journal \| last1 = Berger \| first1 = JR. \| title = The basis for modeling progressive multifocal leukoencephalopathy pathogenesis. \| journal = Curr Opin Neurol \| volume = 24 \| issue = 3 \| pages = 262-7 \| month = Jun \| year = 2011 \| doi = 10.1097/WCO.0b013e328346d2a3 \| PMID = 21499097 }}</ref>) in the context of immunodeficiency; usu. in the setting of [[HIV]] infection.<ref name=pmid12709870>{{Cite journal \| last1 = Berger \| first1 = JR. \| title = Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome: explaining the high incidence and disproportionate frequency of the illness relative to other immunosuppressive conditions. \| journal = J Neurovirol \| volume = 9 Suppl 1 \| issue = \| pages = 38-41 \| month = \| year = 2003 \| doi = 10.1080/13550280390195261 \| PMID = 12709870 }}</ref>
			**Approximately 5% of HIV patients develop PML.<ref name=pmid12709870/>
			**Virus destroys oligodendrocytes -> demyelination results.<ref name=pmid21823157>{{Cite journal \| last1 = Mateen \| first1 = FJ. \| last2 = Muralidharan \| first2 = R. \| last3 = Carone \| first3 = M. \| last4 = van de Beek \| first4 = D. \| last5 = Harrison \| first5 = DM. \| last6 = Aksamit \| first6 = AJ. \| last7 = Gould \| first7 = MS. \| last8 = Clifford \| first8 = DB. \| last9 = Nath \| first9 = A. \| title = Progressive multifocal leukoencephalopathy in transplant recipients. \| journal = Ann Neurol \| volume = 70 \| issue = 2 \| pages = 305-22 \| month = Aug \| year = 2011 \| doi = 10.1002/ana.22408 \| PMID = 21823157 }}
			</ref>
			*Suspected cases are biopsied - unlike other demyelinating diseases.<ref>URL: [http://path.upmc.edu/cases/case336/dx.html http://path.upmc.edu/cases/case336/dx.html]. Accessed on: 15 January 2012.</ref>
			==Gross==
			*Multifocal - as the name suggests.

			DDx:
			*[[Multiple sclerosis]].

			==Microscopic==
			Features:<ref>URL: [http://path.upmc.edu/cases/case120/dx.html http://path.upmc.edu/cases/case120/dx.html]. Accessed on: 3 January 2012.</ref>
			*Perivascular inflammatory cells.
			*Foamy histiocytes.
			*Abnormal appearing glial cells:<ref name=uscf_pml>URL: [http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm]. Accessed on: 3 January 2012.</ref>
			**Reactive astrocytes.
			**Oligodendrocytes with nuclear enlargement and glassy magenta chromatin - '''key feature'''.
			**Atypical mitoses - known as ''[[Creutzfeldt cell]]''.

			Note:
			*The chromatin changes remind me of [[Urine_cytopathology#Human_polyomavirus_infection\|polyomavirus]] in [[urine cytology]]... perhaps ''not'' surprising as they are related.

			===Images===
			*[http://path.upmc.edu/cases/case120/micro.html PML - case 1 (upmc.edu)].
			*[http://path.upmc.edu/cases/case120/dx.html PML - case 1 (upmc.edu)].
			*[http://path.upmc.edu/cases/case336/images/fig03.jpg Crutzfeldt cell - case 2 (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case336.html http://path.upmc.edu/cases/case336.html]. Accessed on: 15 January 2012.</ref>
			*[http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Figures/PMLHandE.jpg PML oligodendrocyte (ucsf.edu)].<ref name=uscf_pml>URL: [http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm http://missinglink.ucsf.edu/lm/ids_104_Demyelination/Didactic/Pml.htm]. Accessed on: 3 January 2012.</ref>
			*[http://neuro.psychiatryonline.org/data/Journals/NP/3923/RA4831F2.jpeg PML oligodendrocyte (psychiatryonline.org)].<ref>{{Cite journal \| last1 = Hurley \| first1 = RA. \| last2 = Ernst \| first2 = T. \| last3 = Khalili \| first3 = K. \| last4 = Del Valle \| first4 = L. \| last5 = Simone \| first5 = IL. \| last6 = Taber \| first6 = KH. \| title = Identification of HIV-associated progressive multifocal leukoencephalopathy: magnetic resonance imaging and spectroscopy. \| journal = J Neuropsychiatry Clin Neurosci \| volume = 15 \| issue = 1 \| pages = 1-6 \| month = \| year = 2003 \| doi = \| PMID = 12556565 }}</ref>

			==IHC==
			*SV40 +ve.<ref name=pmid15581180>{{Cite journal \| last1 = Muñoz-Mármol \| first1 = AM. \| last2 = Mola \| first2 = G. \| last3 = Fernández-Vasalo \| first3 = A. \| last4 = Vela \| first4 = E. \| last5 = Mate \| first5 = JL. \| last6 = Ariza \| first6 = A. \| title = JC virus early protein detection by immunohistochemistry in progressive multifocal leukoencephalopathy: a comparative study with in situ hybridization and polymerase chain reaction. \| journal = J Neuropathol Exp Neurol \| volume = 63 \| issue = 11 \| pages = 1124-30 \| month = Nov \| year = 2004 \| doi = \| PMID = 15581180 }}</ref>

			==See also==
			*[[Neuropathology]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology]]

Michael: redirect

2012-01-03T05:45:43Z

redirect

New page

#redirect [[Neuropathology#Progressive_multifocal_leukoencephalopathy]]

[[Category:Diagnosis]]