Pulmonary alveolar proteinosis - Revision history

Michael: tweak

2025-04-23T15:09:03Z

tweak

← Older revision		Revision as of 15:09, 23 April 2025
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	===Cytology===		===Cytology===
	In conjunction with history and imaging, PAP be suggested on cytology.<ref name=pmid29607238>{{cite journal \|authors=Li M, Alowami S, Schell M, Davis C, Naqvi A \|title=Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse \|journal=Case Rep Pulmonol \|volume=2018 \|issue= \|pages=5202173 \|date=2018 \|pmid=29607238 \|pmc=5828087 \|doi=10.1155/2018/5202173 \|url=}}</ref>		In conjunction with history and imaging, PAP may be suggested on cytology.<ref name=pmid29607238>{{cite journal \|authors=Li M, Alowami S, Schell M, Davis C, Naqvi A \|title=Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse \|journal=Case Rep Pulmonol \|volume=2018 \|issue= \|pages=5202173 \|date=2018 \|pmid=29607238 \|pmc=5828087 \|doi=10.1155/2018/5202173 \|url=}}</ref>

	<pre>		<pre>
	Right Lung, BAL: ~~Negative~~ for Malignancy. Macrophages and amorphous material present in a dirty background, see comment.		Right Lung, BAL: NEGATIVE for Malignancy. Macrophages and amorphous material present in a dirty background, see comment.

	Comment:		Comment:
	Satisfactory for evaluation.		Satisfactory for evaluation.

	PAS ~~positive~~ and PSAD ~~positive~~ staining globules are present. GMS stain for pneumocystis is ~~negative~~.		PAS POSITIVE and PSAD POSITIVE staining globules are present. GMS stain for pneumocystis is NEGATIVE.
	In the proper clinical context, the findings may be in keeping with pulmonary alveolar proteinosis (PAP).		In the proper clinical context, the findings may be in keeping with pulmonary alveolar proteinosis (PAP).

Michael: /* Cytology */

2025-04-17T15:56:30Z

Cytology

← Older revision		Revision as of 15:56, 17 April 2025
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	PAS positive and PSAD positive staining globules are present. GMS stain for pneumocystis is negative.		PAS positive and PSAD positive staining globules are present. GMS stain for pneumocystis is negative.
	In the proper clinical context, the findings may be in keeping with pulmonary alveolar proteinosis.		In the proper clinical context, the findings may be in keeping with pulmonary alveolar proteinosis (PAP).

	In the context of possible PAP, GM-CSF testing is suggested, if not already done. Please correlate with clinical and radiologic findings.		In the context of possible PAP, GM-CSF testing is suggested, if not already done. Please correlate with clinical and radiologic findings.

Michael: /* Cytology */

2025-04-17T15:55:17Z

Cytology

← Older revision		Revision as of 15:55, 17 April 2025
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	===Cytology===		===Cytology===
	In conjunction with history and imaging, PAP be ~~diagnosed~~ on cytology.<ref name=pmid29607238>{{cite journal \|authors=Li M, Alowami S, Schell M, Davis C, Naqvi A \|title=Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse \|journal=Case Rep Pulmonol \|volume=2018 \|issue= \|pages=5202173 \|date=2018 \|pmid=29607238 \|pmc=5828087 \|doi=10.1155/2018/5202173 \|url=}}</ref>		In conjunction with history and imaging, PAP be suggested on cytology.<ref name=pmid29607238>{{cite journal \|authors=Li M, Alowami S, Schell M, Davis C, Naqvi A \|title=Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse \|journal=Case Rep Pulmonol \|volume=2018 \|issue= \|pages=5202173 \|date=2018 \|pmid=29607238 \|pmc=5828087 \|doi=10.1155/2018/5202173 \|url=}}</ref>

	<pre>		<pre>

Michael: +SO cytol

2025-04-17T15:54:06Z

+SO cytol

← Older revision		Revision as of 15:54, 17 April 2025
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	</pre>		</pre>

	===Micro===		====Micro====
	Sections show lung with eosinophilic material in the airspaces. Focally, small (~20 micrometres), more dense appearing, bodies are also in the airspace. The alveolar walls are within normal limits. No significant inflammation is identified. No microorganisms are seen with routine stains. There is no pulmonary hemorrhage.		Sections show lung with eosinophilic material in the airspaces. Focally, small (~20 micrometres), more dense appearing, bodies are also in the airspace. The alveolar walls are within normal limits. No significant inflammation is identified. No microorganisms are seen with routine stains. There is no pulmonary hemorrhage.

			===Cytology===
			In conjunction with history and imaging, PAP be diagnosed on cytology.<ref name=pmid29607238>{{cite journal \|authors=Li M, Alowami S, Schell M, Davis C, Naqvi A \|title=Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse \|journal=Case Rep Pulmonol \|volume=2018 \|issue= \|pages=5202173 \|date=2018 \|pmid=29607238 \|pmc=5828087 \|doi=10.1155/2018/5202173 \|url=}}</ref>

			<pre>
			Right Lung, BAL: Negative for Malignancy. Macrophages and amorphous material present in a dirty background, see comment.

			Comment:
			Satisfactory for evaluation.

			PAS positive and PSAD positive staining globules are present. GMS stain for pneumocystis is negative.
			In the proper clinical context, the findings may be in keeping with pulmonary alveolar proteinosis.

			In the context of possible PAP, GM-CSF testing is suggested, if not already done. Please correlate with clinical and radiologic findings.

			The case was partially reviewed internally.
			</pre>

	==See also==		==See also==

Michael at 17:22, 4 November 2021

2021-11-04T17:22:19Z

← Older revision		Revision as of 17:22, 4 November 2021
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	\| Prevalence = uncommon		\| Prevalence = uncommon
	\| Bloodwork = anti-GM-CSF antibodies, LDH elevated		\| Bloodwork = anti-GM-CSF antibodies, LDH elevated
	\| Rads = airspace disease, "crazy paving"		\| Rads = airspace disease, "[[crazy paving]]"
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = benign		\| Prognosis = benign

Michael: /* Gross */

2021-11-04T17:17:37Z

Gross

← Older revision		Revision as of 17:17, 4 November 2021
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	==Gross==		==Gross==
			[[File:Crazy paving pattern on chest CT scan.jpg\|thumb\|Chest CT showing [[crazy paving]] pattern. (WC/Verma)]]
	*Consolidation.		*Consolidation.

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	===Radiology===		===Radiology===
	~~[[File:Crazy paving pattern on chest CT scan.jpg\|thumb\|Chest CT showing [[crazy paving]] pattern. (WC/Verma)]]~~
	*CXR: airspace disease.		*CXR: airspace disease.
	*HRCT: "[[crazy paving]]".		*HRCT: "[[crazy paving]]".

Michael: /* Gross */

2021-11-04T17:17:23Z

Gross

← Older revision		Revision as of 17:17, 4 November 2021
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	===Radiology===		===Radiology===
			[[File:Crazy paving pattern on chest CT scan.jpg\|thumb\|Chest CT showing [[crazy paving]] pattern. (WC/Verma)]]
	*CXR: airspace disease.		*CXR: airspace disease.
	*HRCT: "[[crazy paving]]" ~~- see: [http://radiographics.rsnajnls.org/cgi/content/figsonly/23/6/1509 http://radiographics.rsnajnls.org/cgi/content/figsonly/23/6/1509]~~.		*HRCT: "[[crazy paving]]".

	==Microscopic==		==Microscopic==

Michael: /* Gross */

2016-05-02T12:59:05Z

Gross

← Older revision		Revision as of 12:59, 2 May 2016
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	===Radiology===		===Radiology===
	*CXR: airspace disease.		*CXR: airspace disease.
	*HRCT: "crazy paving" - see: [http://radiographics.rsnajnls.org/cgi/content/figsonly/23/6/1509 http://radiographics.rsnajnls.org/cgi/content/figsonly/23/6/1509].		*HRCT: "[[crazy paving]]" - see: [http://radiographics.rsnajnls.org/cgi/content/figsonly/23/6/1509 http://radiographics.rsnajnls.org/cgi/content/figsonly/23/6/1509].

	==Microscopic==		==Microscopic==

Michael at 06:25, 17 November 2014

2014-11-17T06:25:30Z

← Older revision		Revision as of 06:25, 17 November 2014
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	*Serum LDH elevated.<ref name=pmid16517574/><ref name=pmid24532945>{{Cite journal \| last1 = Bhattacharyya \| first1 = D. \| last2 = Barthwal \| first2 = MS. \| last3 = Katoch \| first3 = CD. \| last4 = Rohatgi \| first4 = MG. \| last5 = Hasnain \| first5 = S. \| last6 = Rai \| first6 = SP. \| last7 = Arora \| first7 = A. \| title = Primary alveolar proteinosis - A report of two cases. \| journal = Med J Armed Forces India \| volume = 69 \| issue = 1 \| pages = 90-3 \| month = Jan \| year = 2013 \| doi = 10.1016/j.mjafi.2012.02.016 \| PMID = 24532945 }}</ref>		*Serum LDH elevated.<ref name=pmid16517574/><ref name=pmid24532945>{{Cite journal \| last1 = Bhattacharyya \| first1 = D. \| last2 = Barthwal \| first2 = MS. \| last3 = Katoch \| first3 = CD. \| last4 = Rohatgi \| first4 = MG. \| last5 = Hasnain \| first5 = S. \| last6 = Rai \| first6 = SP. \| last7 = Arora \| first7 = A. \| title = Primary alveolar proteinosis - A report of two cases. \| journal = Med J Armed Forces India \| volume = 69 \| issue = 1 \| pages = 90-3 \| month = Jan \| year = 2013 \| doi = 10.1016/j.mjafi.2012.02.016 \| PMID = 24532945 }}</ref>
	*Decreased oxygen saturation.		*Decreased oxygen saturation.

			==Gross==
			*Consolidation.

			<gallery>
			Image:Alveolar proteinosis (5397198260).jpg \| PAP. (WC/Rosen)
			</gallery>

	===Radiology===		===Radiology===

Michael: /* Images */

2014-11-17T05:51:34Z

Images

← Older revision		Revision as of 05:51, 17 November 2014
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	===Images===		===Images===
	~~www:~~
	*[http://jcp.bmjjournals.com/content/62/5/387/F23.large.jpg PAP (bmjjournals.com)].<ref name=pmid19398592>{{cite journal \|author=Leslie KO \|title=My approach to interstitial lung disease using clinical, radiological and histopathological patterns \|journal=J. Clin. Pathol. \|volume=62 \|issue=5 \|pages=387–401 \|year=2009 \|month=May \|pmid=19398592 \|pmc=2668105 \|doi=10.1136/jcp.2008.059782 \|url=}}</ref>
	<gallery>		<gallery>
	Image:Pulmonary_alveolar_proteinosis_-3-_low_mag.jpg \| PAP - low mag. (WC)		Image:Pulmonary_alveolar_proteinosis_-3-_low_mag.jpg \| PAP - low mag. (WC)
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	Image:Pulmonary_alveolar_proteinosis_-_very_high_mag.jpg \| PAP - very high mag. (WC)		Image:Pulmonary_alveolar_proteinosis_-_very_high_mag.jpg \| PAP - very high mag. (WC)
	</gallery>		</gallery>
	Images of DDx:		<gallery>
			Image:Alveolar proteinosis (5396599841).jpg \| PAP (WC/Rosen)
			Image:Alveolar proteinosis (5397198452).jpg \| PAP (WC/Rosen)
			</gallery>
			www:
			*[http://jcp.bmjjournals.com/content/62/5/387/F23.large.jpg PAP (bmjjournals.com)].<ref name=pmid19398592>{{cite journal \|author=Leslie KO \|title=My approach to interstitial lung disease using clinical, radiological and histopathological patterns \|journal=J. Clin. Pathol. \|volume=62 \|issue=5 \|pages=387–401 \|year=2009 \|month=May \|pmid=19398592 \|pmc=2668105 \|doi=10.1136/jcp.2008.059782 \|url=}}</ref>

			Images of DDx (pulmonary edema):
	*[http://www.sciencephoto.com/media/98443/enlarge Pulmonary edema (sciencephoto.com)].		*[http://www.sciencephoto.com/media/98443/enlarge Pulmonary edema (sciencephoto.com)].