Pulmonary meningothelial-like nodule - Revision history

Michael: /* IHC */

2016-05-12T03:57:37Z

IHC

← Older revision		Revision as of 03:57, 12 May 2016
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	*EMA +ve (11 of 11 cases<ref name=pmid19047895/>).		*EMA +ve (11 of 11 cases<ref name=pmid19047895/>).
	*Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>).		*Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>).
	*PR (18 of 18 cases<ref name=pmid19047895/>.		*PR (18 of 18 cases<ref name=pmid19047895/>).

	Others:<ref name=pmid2830799/>		Others:<ref name=pmid2830799/>

Michael: /* Images */

2016-05-09T03:42:21Z

Images

← Older revision		Revision as of 03:42, 9 May 2016
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image: Pulmonary meningothelial-like nodule -- very low mag.jpg \| PMLN - very low mag. (WC)		Image: Pulmonary meningothelial-like nodule -- very low mag.jpg \| PMLN - very low mag. (WC)
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	Image: Pulmonary meningothelial-like nodule -- very high mag.jpg \| PMLN - very high mag. (WC)		Image: Pulmonary meningothelial-like nodule -- very high mag.jpg \| PMLN - very high mag. (WC)
	</gallery>		</gallery>
	www:		====Case 2====
			<gallery>
			Image: Meningothelial-like nodule of lung -- very low mag.jpg \| MLN - very low mag. (WC/Nephron)
			Image: Meningothelial-like nodule of lung -- low mag.jpg \| MLN - low mag. (WC/Nephron)
			Image: Meningothelial-like nodule of lung -- intermed mag.jpg \| MLN - intermed. mag. (WC/Nephron)
			Image: Meningothelial-like nodule of lung -- high mag.jpg \| MLN - high mag. (WC/Nephron)
			Image: Meningothelial-like nodule of lung -- very high mag.jpg \| MLN - very high mag. (WC/Nephron)
			</gallery>
			====www====
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479696/figure/F2/ MLN (nih.gov)].<ref name=pmid23109985/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479696/figure/F2/ MLN (nih.gov)].<ref name=pmid23109985/>

Michael: /* IHC */

2015-11-06T02:09:15Z

IHC

← Older revision		Revision as of 02:09, 6 November 2015
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	*Cytokeratin -ve.		*Cytokeratin -ve.
	*Actin -ve.		*Actin -ve.

			===Images===
			<gallery>
			Image: Pulmonary meningothelial-like nodule - PR -- intermed mag.jpg \| PMLN - PR - intermed. mag. (WC)
			Image: Pulmonary meningothelial-like nodule - PR -- high mag.jpg \| PMLN - PR - high mag. (WC)
			</gallery>

	==See also==		==See also==

Michael: /* Images */

2015-11-06T02:08:32Z

Images

← Older revision		Revision as of 02:08, 6 November 2015
Line 63:		Line 63:

	===Images===		===Images===
			<gallery>
			Image: Pulmonary meningothelial-like nodule -- very low mag.jpg \| PMLN - very low mag. (WC)
			Image: Pulmonary meningothelial-like nodule -- low mag.jpg \| PMLN - low mag. (WC)
			Image: Pulmonary meningothelial-like nodule -- intermed mag.jpg \| PMLN - intermed. mag. (WC)
			Image: Pulmonary meningothelial-like nodule - alt -- intermed mag.jpg \| PMLN - intermed. mag. (WC)
			Image: Pulmonary meningothelial-like nodule -- high mag.jpg \| PMLN - high mag. (WC)
			Image: Pulmonary meningothelial-like nodule - alt -- high mag.jpg \| PMLN - high mag. (WC)
			Image: Pulmonary meningothelial-like nodule -- very high mag.jpg \| PMLN - very high mag. (WC)
			</gallery>
			www:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479696/figure/F2/ MLN (nih.gov)].<ref name=pmid23109985/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479696/figure/F2/ MLN (nih.gov)].<ref name=pmid23109985/>

Michael at 02:07, 6 November 2015

2015-11-06T02:07:30Z

← Older revision		Revision as of 02:07, 6 November 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Pulmonary meningothelial-like nodule -- very low mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Pulmonary meningothelial-like nodule. [[H&E stain]].
	\| Synonyms = pulmonary chemodectoma		\| Synonyms = pulmonary chemodectoma
	\| Micro = small cell nests (expanding alveolar septa) with whorled appearance/streaming; composed of bland cells with round/ovoid nuclei without appreciable nucleoli		\| Micro = small cell nests (expanding alveolar septa) with whorled appearance/streaming; composed of bland cells with round/ovoid nuclei without appreciable nucleoli

Michael: +infobox

2015-10-06T19:27:35Z

+infobox

← Older revision		Revision as of 19:27, 6 October 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms = pulmonary chemodectoma
			\| Micro = small cell nests (expanding alveolar septa) with whorled appearance/streaming; composed of bland cells with round/ovoid nuclei without appreciable nucleoli
			\| Subtypes =
			\| LMDDx = [[lung tumourlet]], poorly differentiated carcinoma, [[lobular breast carcinoma]]
			\| Stains =
			\| IHC = PR +ve, vimentin +ve, EMA +ve, CD56 +ve, chromogranin A -ve, synaptophysin -ve, S-100 -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = tan or yellow nodules - pleural or parenchymal, typically 1-3 mm
			\| Grossing =
			\| Site = [[lung]]
			\| Assdx = poorly understood association with [[lung tumours]] - esp. [[lung adenocarcinoma]]
			\| Syndromes =
			\| Clinicalhx = typically an incidential finding
			\| Signs =
			\| Symptoms =
			\| Prevalence = very common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx = none
			}}
	'''Pulmonary meningothelial-like nodule''', abbreviated '''MLN''', is a common benign finding in the [[lung]].		'''Pulmonary meningothelial-like nodule''', abbreviated '''MLN''', is a common benign finding in the [[lung]].

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	*May be grouped with ''pulmonary meningioma'' in the larger category ''primary pleuropulmonary meningothelial proliferations''.<ref name=pmid26291511>{{Cite journal \| last1 = Weissferdt \| first1 = A. \| last2 = Tang \| first2 = X. \| last3 = Suster \| first3 = S. \| last4 = Wistuba \| first4 = II. \| last5 = Moran \| first5 = CA. \| title = Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis. \| journal = Am J Surg Pathol \| volume = \| issue = \| pages = \| month = Aug \| year = 2015 \| doi = 10.1097/PAS.0000000000000489 \| PMID = 26291511 }}</ref>		*May be grouped with ''pulmonary meningioma'' in the larger category ''primary pleuropulmonary meningothelial proliferations''.<ref name=pmid26291511>{{Cite journal \| last1 = Weissferdt \| first1 = A. \| last2 = Tang \| first2 = X. \| last3 = Suster \| first3 = S. \| last4 = Wistuba \| first4 = II. \| last5 = Moran \| first5 = CA. \| title = Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis. \| journal = Am J Surg Pathol \| volume = \| issue = \| pages = \| month = Aug \| year = 2015 \| doi = 10.1097/PAS.0000000000000489 \| PMID = 26291511 }}</ref>
	*Can mimic [[metastasis\|metastatic deposits]].<ref name=pmid24023559/><ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>		*Can mimic [[metastasis\|metastatic deposits]].<ref name=pmid24023559/><ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>


	Associations:		Associations:

Michael: /* IHC */

2015-10-02T14:27:05Z

IHC

← Older revision		Revision as of 14:27, 2 October 2015
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	*EMA +ve (11 of 11 cases<ref name=pmid19047895/>).		*EMA +ve (11 of 11 cases<ref name=pmid19047895/>).
	*Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>).		*Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>).
			*PR (18 of 18 cases<ref name=pmid19047895/>.

	Others:<ref name=pmid2830799/>		Others:<ref name=pmid2830799/>

Michael: /* Microscopic */

2015-09-28T15:39:55Z

Microscopic

← Older revision		Revision as of 15:39, 28 September 2015
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid2830799/>		Features:<ref name=pmid2830799/>
	*~~Cell~~ nests - expanding alveolar septa.		*Small cell nests - expanding alveolar septa.
			**Whorled appearance/streaming.
			**Composed of bland cells with round/ovoid nuclei without appreciable nucleoli.

	DDx:		DDx:
	*[[Lung tumourlet]].		*[[Lung tumourlet]] - associated with airway.{{fact}}
	*Poorly differentiated carcinoma.		*Poorly differentiated carcinoma.
	*[[Lobular carcinoma]].<ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>		*[[Lobular carcinoma]].<ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>

Michael: /* IHC */

2015-09-28T15:33:54Z

IHC

← Older revision		Revision as of 15:33, 28 September 2015
Line 38:		Line 38:
	*EMA +ve (11 of 11 cases<ref name=pmid19047895/>).		*EMA +ve (11 of 11 cases<ref name=pmid19047895/>).
	*Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>).		*Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>).

			Others:<ref name=pmid2830799/>
			*S-100 -ve.
			*NSE -ve.
			*Cytokeratin -ve.
			*Actin -ve.

	==See also==		==See also==

Michael: /* General */

2015-09-28T15:26:10Z

General

← Older revision		Revision as of 15:26, 28 September 2015
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	*Very common - seen in almost half of well sampled lobectomies.<ref name=pmid19047895/>		*Very common - seen in almost half of well sampled lobectomies.<ref name=pmid19047895/>
	*May be grouped with ''pulmonary meningioma'' in the larger category ''primary pleuropulmonary meningothelial proliferations''.<ref name=pmid26291511>{{Cite journal \| last1 = Weissferdt \| first1 = A. \| last2 = Tang \| first2 = X. \| last3 = Suster \| first3 = S. \| last4 = Wistuba \| first4 = II. \| last5 = Moran \| first5 = CA. \| title = Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis. \| journal = Am J Surg Pathol \| volume = \| issue = \| pages = \| month = Aug \| year = 2015 \| doi = 10.1097/PAS.0000000000000489 \| PMID = 26291511 }}</ref>		*May be grouped with ''pulmonary meningioma'' in the larger category ''primary pleuropulmonary meningothelial proliferations''.<ref name=pmid26291511>{{Cite journal \| last1 = Weissferdt \| first1 = A. \| last2 = Tang \| first2 = X. \| last3 = Suster \| first3 = S. \| last4 = Wistuba \| first4 = II. \| last5 = Moran \| first5 = CA. \| title = Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis. \| journal = Am J Surg Pathol \| volume = \| issue = \| pages = \| month = Aug \| year = 2015 \| doi = 10.1097/PAS.0000000000000489 \| PMID = 26291511 }}</ref>
	*Can mimic [[metastasis\|metastatic deposits]].<ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref~~><ref name=pmid24023559/~~>		*Can mimic [[metastasis\|metastatic deposits]].<ref name=pmid24023559/><ref name=pmid23109985>{{Cite journal \| last1 = Kfoury \| first1 = H. \| last2 = Arafah \| first2 = MA. \| last3 = Arafah \| first3 = MM. \| last4 = Alnassar \| first4 = S. \| last5 = Hajjar \| first5 = W. \| title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. \| journal = Korean J Pathol \| volume = 46 \| issue = 1 \| pages = 87-91 \| month = Feb \| year = 2012 \| doi = 10.4132/KoreanJPathol.2012.46.1.87 \| PMID = 23109985 }}</ref>