Pyoderma gangrenosum - Revision history

Michael at 14:53, 5 November 2015

2015-11-05T14:53:49Z

← Older revision		Revision as of 14:53, 5 November 2015
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	'''Pyoderma gangrenosum''', abbreviated '''PG''', is a benign [[inflammatory skin disorder]] associated with [[inflammatory		'''Pyoderma gangrenosum''', abbreviated '''PG''', is a benign [[inflammatory skin disorder]] associated with [[inflammatory bowel disease]].

	==General==		==General==

Michael at 14:53, 5 November 2015

2015-11-05T14:53:10Z

← Older revision		Revision as of 14:53, 5 November 2015
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	'''Pyoderma gangrenosum''' is a benign [[inflammatory skin disorder]] associated with [[inflammatory		'''Pyoderma gangrenosum''', abbreviated '''PG''', is a benign [[inflammatory skin disorder]] associated with [[inflammatory

	==General==		==General==

Michael: /* Sign out */

2015-11-05T14:44:35Z

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← Older revision		Revision as of 14:44, 5 November 2015
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	The vasculitis is seen superficially and is likely secondary to the ulceration.		The vasculitis is seen superficially and is likely secondary to the ulceration.
			</pre>

			===Alternate===
			<pre>
			Skin, Left Lower Leg, Punch Biopsy:
			- Skin with ulceration, necrotic debris, superficial vasculitis,
			subepidermal fibrosis and maturing granulation tissue, see comment.
			- NEGATIVE for evidence of malignancy.

			Comment:
			The findings are in keeping with pyoderma gangrenosum; however, vasculitis and
			atherosclerosis should be considered clinically.

			The vasculitis is seen superficially and is favoured to be secondary to
			the ulceration.
	</pre>		</pre>

Michael at 20:14, 19 October 2015

2015-10-19T20:14:07Z

← Older revision		Revision as of 20:14, 19 October 2015
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	==General==		==General==
	*May be seen in [[IBD]] (UC and CD) - approximately 30% of cases.<ref name=pmid16858047/>		*May be seen in [[IBD]] ([[ulcerative colitis]] and [[Crohn's disease]]) - approximately 30% of cases.<ref name=pmid16858047/>

	Clinical		Clinical
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:~~Inflammatory skin disorders~~]]		[[Category:Dermatopathology]]

Michael: split out

2015-10-19T20:12:50Z

split out

← Older revision		Revision as of 20:12, 19 October 2015
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	~~#redirect~~ [[~~Inflammatory_skin_disorders#Pyoderma_gangrenosum~~]]		'''Pyoderma gangrenosum''' is a benign [[inflammatory skin disorder]] associated with [[inflammatory

			==General==
			*May be seen in [[IBD]] (UC and CD) - approximately 30% of cases.<ref name=pmid16858047/>

			Clinical
			*''[[Pathergy]]'' = minor trauma (to the skin) results in a non-healing lesion.<ref name=pmid22202507>{{Cite journal \| last1 = Wong \| first1 = WW. \| last2 = Machado \| first2 = GR. \| last3 = Hill \| first3 = ME. \| title = Pyoderma gangrenosum: the great pretender and a challenging diagnosis. \| journal = J Cutan Med Surg \| volume = 15 \| issue = 6 \| pages = 322-8 \| month = \| year = \| doi = \| PMID = 22202507 }}</ref>

			==Gross==
			*Skin ulceration - classically on the legs.<ref name=pmid16858047>{{Cite journal \| last1 = Brooklyn \| first1 = T. \| last2 = Dunnill \| first2 = G. \| last3 = Probert \| first3 = C. \| title = Diagnosis and treatment of pyoderma gangrenosum. \| journal = BMJ \| volume = 333 \| issue = 7560 \| pages = 181-4 \| month = Jul \| year = 2006 \| doi = 10.1136/bmj.333.7560.181 \| PMID = 16858047 \| PMC = 1513476 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/?tool=pubmed }}</ref>

			==Microscopic==
			Features:<ref name=pmid16858047/>
			*Early: lymphocytes cells only in the dermis - often perivascular & vascular.
			**+/-Fibrinoid necrosis of vessels at edge of lesion.
			*Late: abscess formation ([[neutrophil]]s).

			DDx:
			*[[Vasculitis]].
			*[[Sweet syndrome]].

			===Image===
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)].

			==Sign out==
			<pre>
			A. Skin, Left Leg from Central Wound, Punch Biopsy:
			- Necrotic debris with underlying granulation tissue and benign connective tissue
			with superficial vasculitis, see comment.
			- NEGATIVE for skin surface.

			B. Skin, Left Leg from Wound and Normal Skin Junction, Punch Biopsy:
			- Skin with ulceration, necrotic debris, and superficial vasculitis, see comment.
			- Fat necrosis and severe atherosclerosis.

			Comment:
			The findings are in keeping with pyoderma gangrenosum; however, atherosclerotic disease
			and vasculitis should be considered clinically.

			The vasculitis is seen superficially and is likely secondary to the ulceration.
			</pre>

			==See also==
			*[[Inflammatory skin disorders]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Inflammatory skin disorders]]

Michael: redirect

2012-05-03T22:54:11Z

redirect

New page

#redirect [[Inflammatory_skin_disorders#Pyoderma_gangrenosum]]

[[Category:Diagnosis]]