Renal cell carcinoma grading - Revision history

Michael: /* General */

2018-05-14T00:08:26Z

General

← Older revision		Revision as of 00:08, 14 May 2018
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	**Newer and less complicated.		**Newer and less complicated.
	**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology		**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology
	**Developed based on ''Fuhrman grading''~~; ISUP grading validated~~ in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>		**Developed based on ''Fuhrman grading''
			**Prognostic value demonstrated in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>
	*''Fuhrman grading'':		*''Fuhrman grading'':
	**Older and more complicated.		**Older and more complicated.

Michael: /* General */

2018-05-14T00:07:00Z

General

← Older revision		Revision as of 00:07, 14 May 2018
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	**Newer and less complicated.		**Newer and less complicated.
	**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology		**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology
	**Developed based on ''Fuhrman grading''.		**Developed based on ''Fuhrman grading''; ISUP grading validated in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>
	**Validated in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>
	*''Fuhrman grading'':		*''Fuhrman grading'':
	**Older and more complicated.		**Older and more complicated.

Michael: /* General */

2018-05-14T00:06:11Z

General

← Older revision		Revision as of 00:06, 14 May 2018
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	==General==		==General==
	There are two systems:		There are two systems:
	*''Fuhrman grading'':
	**Older and more complicated.
	**Based on nuclear size and shape, chromatin pattern and [[nucleoli\|nucleolar size]].<ref name=Ref_GUP282>{{Ref GUP\|282}}</ref>
	*''[[ISUP]] grading'':<ref name=pmid24025520>{{cite journal \|author=Delahunt B, Cheville JC, Martignoni G, ''et al.'' \|title=The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters \|journal=Am. J. Surg. Pathol. \|volume=37 \|issue=10 \|pages=1490–504 \|year=2013 \|month=October \|pmid=24025520 \|doi=10.1097/PAS.0b013e318299f0fb \|url=}}</ref>		*''[[ISUP]] grading'':<ref name=pmid24025520>{{cite journal \|author=Delahunt B, Cheville JC, Martignoni G, ''et al.'' \|title=The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters \|journal=Am. J. Surg. Pathol. \|volume=37 \|issue=10 \|pages=1490–504 \|year=2013 \|month=October \|pmid=24025520 \|doi=10.1097/PAS.0b013e318299f0fb \|url=}}</ref>
	**Newer and less complicated.		**Newer and less complicated.
	**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology		**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology
	**Developed based on ''Fuhrman grading''.		**Developed based on ''Fuhrman grading''.
	**Validated in ~~other independent cohorts~~.<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>		**Validated in a larger cohort by Dagher ''et al.''<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>
			*''Fuhrman grading'':
			**Older and more complicated.
			**Based on nuclear size and shape, chromatin pattern and [[nucleoli\|nucleolar size]].<ref name=Ref_GUP282>{{Ref GUP\|282}}</ref>

	==ISUP grading==		==ISUP grading==

Michael: /* General */ bit of clean up

2018-05-14T00:02:55Z

General: bit of clean up

← Older revision		Revision as of 00:02, 14 May 2018
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	**Developed based on ''Fuhrman grading''.		**Developed based on ''Fuhrman grading''.
	**Validated in other independent cohorts.<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>		**Validated in other independent cohorts.<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>
	**

	==ISUP grading==		==ISUP grading==

Mark: reference to independent validation study

2018-05-12T16:16:50Z

reference to independent validation study

← Older revision		Revision as of 16:16, 12 May 2018
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	**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology		**Mostly based on [[nucleoli\|nucleolar size]] and to a much lesser degree on size and morphology
	**Developed based on ''Fuhrman grading''.		**Developed based on ''Fuhrman grading''.
			**Validated in other independent cohorts.<ref name=pmid28718911>{{Cite journal \| last1 = Dagher \| first1 = J. \| last2 = Delahunt \| first2 = B. \| last3 = Rioux-Leclercq \| first3 = N. \| last4 = Egevad \| first4 = L. \| last5 = Srigley \| first5 = JR. \| last6 = Coughlin \| first6 = G. \| last7 = Dunglinson \| first7 = N. \| last8 = Gianduzzo \| first8 = T. \| last9 = Kua \| first9 = B. \| title = Clear cell renal cell carcinoma: validation of World Health Organization/International Society of Urological Pathology grading. \| journal = Histopathology \| volume = 71 \| issue = 6 \| pages = 918-925 \| month = Dec \| year = 2017 \| doi = 10.1111/his.13311 \| PMID = 28718911 }}</ref>
			**

	==ISUP grading==		==ISUP grading==

Michael at 20:09, 9 November 2016

2016-11-09T20:09:37Z

← Older revision		Revision as of 20:09, 9 November 2016
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	This article deals with '''renal cell carcinoma grading'''.		This article deals with '''renal cell carcinoma grading'''.

	''Fuhrman grading'', ''ISUP grading'' ~~and~~ ''ISUP nucleolar grading'' redirect here.		''Fuhrman grading'', ''ISUP grading'', ''ISUP nucleolar grading'' and ''kidney cancer grading'' redirect here.

	==General==		==General==

Michael at 03:22, 27 May 2016

2016-05-27T03:22:58Z

← Older revision		Revision as of 03:22, 27 May 2016
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	This article deals with '''renal cell carcinoma grading'''.		This article deals with '''renal cell carcinoma grading'''.

	''Fuhrman grading'' and ''ISUP nucleolar grading'' redirect here.		''Fuhrman grading'', ''ISUP grading'' and ''ISUP nucleolar grading'' redirect here.

	==General==		==General==

Michael at 17:00, 26 May 2016

2016-05-26T17:00:47Z

← Older revision		Revision as of 17:00, 26 May 2016
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	[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg\|right\|thumb\|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]]		[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg\|right\|thumb\|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]]
	[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]		[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]
	[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|~~Sarcomatoid differentiation is~~ ISUP nucleolar grade 4. [[H&E stain]].]]		[[Image:Renal cell carcinoma with rhabdoid change -- high mag.jpg\|thumb\|right\|ISUP grade 4 is used for [[renal cell carcinoma with rhabdoid change]]. [[H&E stain]].]]
			[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|ISUP nucleolar grade 4 is used for [[renal cell carcinoma with sarcomatoid differentiation]]. [[H&E stain]].]]
	This article deals with '''renal cell carcinoma grading'''.		This article deals with '''renal cell carcinoma grading'''.

Michael: +image

2016-05-26T16:57:19Z

+image

← Older revision		Revision as of 16:57, 26 May 2016
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			[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg\|right\|thumb\|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]]
	[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]		[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]
	[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation is ISUP nucleolar grade 4. [[H&E stain]].]]		[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation is ISUP nucleolar grade 4. [[H&E stain]].]]

Michael: /* See also */

2016-05-26T16:53:25Z

← Older revision		Revision as of 17:00, 26 May 2016
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	[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg\|right\|thumb\|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]]		[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg\|right\|thumb\|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]]
	[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]		[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]
	[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|~~Sarcomatoid differentiation is~~ ISUP nucleolar grade 4. [[H&E stain]].]]		[[Image:Renal cell carcinoma with rhabdoid change -- high mag.jpg\|thumb\|right\|ISUP grade 4 is used for [[renal cell carcinoma with rhabdoid change]]. [[H&E stain]].]]
			[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|ISUP nucleolar grade 4 is used for [[renal cell carcinoma with sarcomatoid differentiation]]. [[H&E stain]].]]
	This article deals with '''renal cell carcinoma grading'''.		This article deals with '''renal cell carcinoma grading'''.

← Older revision		Revision as of 16:57, 26 May 2016
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			[[Image:Renal cell carcinoma with clear cells and fibromuscular bands -- intermed mag.jpg\|right\|thumb\|ISUP nucleolar grade 2 in a [[renal cell carcinoma]]. [[H&E stain]].]]
	[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]		[[Image:Clear cell renal cell carcinoma -- intermed mag.jpg\|thumb\|right\|ISUP nucleolar grade 3 in [[clear cell renal cell carcinoma]] with eosinophilic change. [[H&E stain]].]]
	[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation is ISUP nucleolar grade 4. [[H&E stain]].]]		[[Image:Sarcomatoid differentiation in renal cell carcinoma - alt -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation is ISUP nucleolar grade 4. [[H&E stain]].]]

← Older revision		Revision as of 16:53, 26 May 2016
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	*[[Renal cell carcinoma]].		*[[Renal cell carcinoma]].
	*[[Kidney tumours]].		*[[Kidney tumours]].
			*[[Renal cell carcinoma with rhabdoid change]].

	==References==		==References==