Renal transplant pathology - Revision history

Michael: /* Polyomavirus nephropathy */ split out

2016-06-29T17:17:13Z

Polyomavirus nephropathy: split out

← Older revision		Revision as of 17:17, 29 June 2016
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	==Polyomavirus nephropathy==		==Polyomavirus nephropathy==
	:See also: ''[[Urine_cytopathology#Human_polyomavirus_infection]]'' and ''[[Polyomavirus]]''.		:See also: ''[[Urine_cytopathology#Human_polyomavirus_infection]]'' and ''[[Polyomavirus]]''.
	~~===General===~~		{{Main\|Polyomavirus nephropathy}}
	*This bad-boy is associated with failure of transplanted kidneys.<ref name=pmid216990>{{~~cite journal~~ \|author=Mackenzie EF, Poulding JM, Harrison PR, Amer B \|title=Human polyoma virus (HPV)--a significant pathogen in renal transplantation \|journal=Proc Eur Dial Transplant Assoc \|volume=15 \|issue= \|pages=352–60 \|year=1978 \|pmid=216990 \|doi= \|url=}}</ref>
	*Treatment: reduce immunosuppression.<ref name=Nickeleit>Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539]. Accessed on: 8 November 2010.</ref>
	*Implicated in [[urothelial carcinoma]] - esp. in renal transplant recipients.<ref name=pmid18971934>{{Cite journal \| last1 = Roberts \| first1 = IS. \| last2 = Besarani \| first2 = D. \| last3 = Mason \| first3 = P. \| last4 = Turner \| first4 = G. \| last5 = Friend \| first5 = PJ. \| last6 = Newton \| first6 = R. \| title = Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation. \| journal = Br J Cancer \| volume = 99 \| issue = 9 \| pages = 1383-6 \| month = Nov \| year = 2008 \| doi = 10.1038/sj.bjc.6604711 \| PMID = 18971934 }}</ref>
	~~===Microscopic===~~
	~~Features:<ref name=Nickeleit/>~~
	*Ground glass-like nuclear inclusions.
	*Nuclear enlargement.

	~~====Images====~~
	~~<gallery>~~
	~~Image:Polyomavirus_nephropathy_-_high_mag.jpg \| PN - high mag. (WC)~~
	~~Image:Polyomavirus_nephropathy_-_very_high_mag.jpg \| PN - very high mag. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref>
	*[http://path.upmc.edu/cases/case582.html Polyomavirus nephropathy - several images (upmc.edu)].

	~~===IHC===~~
	~~Features:~~
	*SV40 +ve<ref name=pmid25359127>{{Cite journal \| last1 = Lautenschlager \| first1 = I. \| last2 = Jahnukainen \| first2 = T. \| last3 = Kardas \| first3 = P. \| last4 = Lohi \| first4 = J. \| last5 = Auvinen \| first5 = E. \| last6 = Mannonen \| first6 = L. \| last7 = Dumoulin \| first7 = A. \| last8 = Hirsch \| first8 = HH. \| last9 = Jalanko \| first9 = H. \| title = A case of primary JC polyomavirus infection-associated nephropathy~~. \| journal = Am J Transplant \| volume = 14 \| issue = 12 \| pages = 2887-92 \| month = Dec \| year = 2014 \| doi = 10.1111/ajt.12945 \| PMID = 25359127~~ }}~~</ref> (nuclear staining).~~

	~~====Images====~~
	~~<gallery>~~
	~~Image:Polyomavirus_nephropathy_-_sv40_-_high_mag.jpg \| PN - high mag. (WC/Nephron)~~
	~~Image:Polyomavirus_nephropathy_-_sv40_-_very_high_mag.jpg \| PN - very high mag. (WC/Nephron)~~
	~~</gallery>~~
	~~www:~~
	*[http://tpis1.upmc.com:81/tpis/GU/G00011b.html Polyomavirus (upmc.com)].

	=Transplant-related pathology=		=Transplant-related pathology=

Michael: /* IHC */

2016-06-29T16:30:58Z

IHC

← Older revision		Revision as of 16:30, 29 June 2016
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	===IHC===		===IHC===
	Features:		Features:
	*SV40 +ve (nuclear staining).		*SV40 +ve<ref name=pmid25359127>{{Cite journal \| last1 = Lautenschlager \| first1 = I. \| last2 = Jahnukainen \| first2 = T. \| last3 = Kardas \| first3 = P. \| last4 = Lohi \| first4 = J. \| last5 = Auvinen \| first5 = E. \| last6 = Mannonen \| first6 = L. \| last7 = Dumoulin \| first7 = A. \| last8 = Hirsch \| first8 = HH. \| last9 = Jalanko \| first9 = H. \| title = A case of primary JC polyomavirus infection-associated nephropathy. \| journal = Am J Transplant \| volume = 14 \| issue = 12 \| pages = 2887-92 \| month = Dec \| year = 2014 \| doi = 10.1111/ajt.12945 \| PMID = 25359127 }}</ref> (nuclear staining).

	====Images====		====Images====

Michael: /* Images */

2014-12-03T02:52:13Z

Images

← Older revision		Revision as of 02:52, 3 December 2014
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	<gallery>		<gallery>
	Image:Transplant_glomerulopathy_-_intermed_mag.jpg \| Transplant glomerulopathy - intermed. mag. (WC/Nephron)		Image:Transplant_glomerulopathy_-_intermed_mag.jpg \| Transplant glomerulopathy - intermed. mag. (WC/Nephron)
			Image:Transplant_glomerulopathy_-_high_mag.jpg \| Transplant glomerulopathy - high mag. (WC/Nephron)
	Image:Transplant_glomerulopathy_-_very_high_mag.jpg \| Transplant glomerulopathy - very high mag. (WC/Nephron)		Image:Transplant_glomerulopathy_-_very_high_mag.jpg \| Transplant glomerulopathy - very high mag. (WC/Nephron)
	</gallery>		</gallery>

Michael: /* Images */ fix

2014-12-03T02:51:24Z

Images: fix

← Older revision		Revision as of 02:51, 3 December 2014
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	Image:Polyomavirus_nephropathy_-_high_mag.jpg \| PN - high mag. (WC)		Image:Polyomavirus_nephropathy_-_high_mag.jpg \| PN - high mag. (WC)
	Image:Polyomavirus_nephropathy_-_very_high_mag.jpg \| PN - very high mag. (WC)		Image:Polyomavirus_nephropathy_-_very_high_mag.jpg \| PN - very high mag. (WC)
	</gallery		</gallery>
	www:		www:
	*[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref>		*[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref>

Michael: /* Microscopic */ +images

2014-12-03T02:51:09Z

Microscopic: +images

← Older revision		Revision as of 02:51, 3 December 2014
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	*Nuclear enlargement.		*Nuclear enlargement.

	Images:		====Images====
	*www:		<gallery>
	**[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref>		Image:Polyomavirus_nephropathy_-_high_mag.jpg \| PN - high mag. (WC)
	**[http://path.upmc.edu/cases/case582.html Polyomavirus nephropathy - several images (upmc.edu~~)].~~		Image:Polyomavirus_nephropathy_-_very_high_mag.jpg \| PN - very high mag. (WC)
	*[[WC]]:		</gallery
	**[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_high_mag.jpg PN - high mag. (WC)].		www:
	**[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_very_high_mag.jpg PN - very high mag. (WC)].		*[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref>
			*[http://path.upmc.edu/cases/case582.html Polyomavirus nephropathy - several images (upmc.edu)].

	===IHC===		===IHC===

Michael: /* Microscopic */

2013-05-16T00:19:04Z

Microscopic

← Older revision		Revision as of 00:19, 16 May 2013
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	*Interstitial fibrosis and renal tubular atrophy.		*Interstitial fibrosis and renal tubular atrophy.

	Image:		===Images===
	*[http://commons.wikimedia.org/wiki/File:Chronic_allograft_nephropathy_-_intermed_mag.jpg CAN - intermed. mag. (WC)].		<gallery>
			Image:Chronic_allograft_nephropathy_-_intermed_mag.jpg \| CAN - intermed. mag. (WC/Nephron)
			</gallery>

	==Calcineurin-inhibitor toxicity==		==Calcineurin-inhibitor toxicity==

Michael: /* Transplant glomerulopathy */

2013-05-16T00:18:03Z

Transplant glomerulopathy

← Older revision		Revision as of 00:18, 16 May 2013
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	*[[Thrombotic microangiopathy]] (TMA).		*[[Thrombotic microangiopathy]] (TMA).

	Images:		====Images====
	*[http://commons.wikimedia.org/wiki/File:Transplant_glomerulopathy_-_intermed_mag.jpg Transplant glomerulopathy - intermed. mag. (WC)].		<gallery>
	*[http://commons.wikimedia.org/wiki/File:Transplant_glomerulopathy_-_very_high_mag.jpg Transplant glomerulopathy - very high mag. (WC)].		Image:Transplant_glomerulopathy_-_intermed_mag.jpg \| Transplant glomerulopathy - intermed. mag. (WC/Nephron)
			Image:Transplant_glomerulopathy_-_very_high_mag.jpg \| Transplant glomerulopathy - very high mag. (WC/Nephron)
			</gallery>

	==Chronic allograft nephropathy==		==Chronic allograft nephropathy==

Michael: /* Polyomavirus nephropathy */

2013-05-16T00:16:59Z

Polyomavirus nephropathy

← Older revision		Revision as of 00:16, 16 May 2013
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	*SV40 +ve (nuclear staining).		*SV40 +ve (nuclear staining).

	Images:		====Images====
	*www:		<gallery>
	**[http:~~//tpis1~~.~~upmc~~.~~com:81/tpis/GU~~/~~G00011b.html Polyomavirus (upmc.com~~)].		Image:Polyomavirus_nephropathy_-_sv40_-_high_mag.jpg \| PN - high mag. (WC/Nephron)
	*[[WC]]:		Image:Polyomavirus_nephropathy_-_sv40_-_very_high_mag.jpg \| PN - very high mag. (WC/Nephron)
	**[http://commons.wikimedia.org/wiki/File:Polyomavirus_nephropathy_-_sv40_-~~_high_mag~~.jpg PN - high mag. (WC)].		</gallery>
	**[http://~~commons~~.~~wikimedia~~.~~org~~/~~wiki~~/~~File:Polyomavirus_nephropathy_-_sv40_-_very_high_mag~~.~~jpg PN - very high mag~~. ~~(WC~~)].		www:
			*[http://tpis1.upmc.com:81/tpis/GU/G00011b.html Polyomavirus (upmc.com)].

	=Transplant-related pathology=		=Transplant-related pathology=

Michael: /* Polyomavirus nephropathy */

2012-11-23T11:39:18Z

Polyomavirus nephropathy

← Older revision		Revision as of 11:39, 23 November 2012
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	*This bad-boy is associated with failure of transplanted kidneys.<ref name=pmid216990>{{cite journal \|author=Mackenzie EF, Poulding JM, Harrison PR, Amer B \|title=Human polyoma virus (HPV)--a significant pathogen in renal transplantation \|journal=Proc Eur Dial Transplant Assoc \|volume=15 \|issue= \|pages=352–60 \|year=1978 \|pmid=216990 \|doi= \|url=}}</ref>		*This bad-boy is associated with failure of transplanted kidneys.<ref name=pmid216990>{{cite journal \|author=Mackenzie EF, Poulding JM, Harrison PR, Amer B \|title=Human polyoma virus (HPV)--a significant pathogen in renal transplantation \|journal=Proc Eur Dial Transplant Assoc \|volume=15 \|issue= \|pages=352–60 \|year=1978 \|pmid=216990 \|doi= \|url=}}</ref>
	*Treatment: reduce immunosuppression.<ref name=Nickeleit>Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539]. Accessed on: 8 November 2010.</ref>		*Treatment: reduce immunosuppression.<ref name=Nickeleit>Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539]. Accessed on: 8 November 2010.</ref>
			*Implicated in [[urothelial carcinoma]] - esp. in renal transplant recipients.<ref name=pmid18971934>{{Cite journal \| last1 = Roberts \| first1 = IS. \| last2 = Besarani \| first2 = D. \| last3 = Mason \| first3 = P. \| last4 = Turner \| first4 = G. \| last5 = Friend \| first5 = PJ. \| last6 = Newton \| first6 = R. \| title = Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation. \| journal = Br J Cancer \| volume = 99 \| issue = 9 \| pages = 1383-6 \| month = Nov \| year = 2008 \| doi = 10.1038/sj.bjc.6604711 \| PMID = 18971934 }}</ref>
	===Microscopic===		===Microscopic===
	Features:<ref name=Nickeleit/>		Features:<ref name=Nickeleit/>

Michael: tweak lead-in

2012-07-08T04:52:15Z

tweak lead-in

← Older revision		Revision as of 04:52, 8 July 2012
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	'''Renal transplant pathology''' is grouped with the ''[[medical kidney diseases]]'', as this ~~one leads to~~ the ~~other~~, ~~and~~ many renal transplants have recurrence of the pathology that lead to renal failure.		'''Renal transplant pathology''', also '''kidney tranplant pathology''', is grouped with the ''[[medical kidney diseases]]'', as this usually precedes the transplant. Also, many renal transplants have recurrence of the pathology that lead to renal failure.

	=Rejection=		=Rejection=