Salivary glands - Revision history

Michael at 20:36, 2 June 2024

2024-06-02T20:36:47Z

← Older revision		Revision as of 20:36, 2 June 2024
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	\| [[Image:Salivary_duct_carcinoma_-a-_low_mag.jpg \| thumb\| center\|150px \| SDC. (WC/Nephron)]]		\| [[Image:Salivary_duct_carcinoma_-a-_low_mag.jpg \| thumb\| center\|150px \| SDC. (WC/Nephron)]]
	\|-		\|-
	\|[[Polymorphous low-grade adenocarcinoma]]		\|[[Polymorphous adenocarcinoma]] (previously polymorphous low-grade adenocarcinoma)
	\| variable, often small<br>nests, may be targetoid		\| variable, often small<br>nests, may be targetoid
	\| epithelioid		\| epithelioid
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	==DDx==		==DDx==
	===Palate===		===Palate===
	*[[Polymorphous ~~low-grade~~ adenocarcinoma]].		*[[Polymorphous adenocarcinoma]].
	*[[Adenoid cystic carcinoma]].		*[[Adenoid cystic carcinoma]].
	*[[Pleomorphic adenoma]].		*[[Pleomorphic adenoma]].
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	Specifics:		Specifics:
	*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal \| last1 = Nagao \| first1 = T. \| last2 = Sato \| first2 = E. \| last3 = Inoue \| first3 = R. \| last4 = Oshiro \| first4 = H. \| last5 = H Takahashi \| first5 = R. \| last6 = Nagai \| first6 = T. \| last7 = Yoshida \| first7 = M. \| last8 = Suzuki \| first8 = F. \| last9 = Obikane \| first9 = H. \| title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. \| journal = Acta Histochem Cytochem \| volume = 45 \| issue = 5 \| pages = 269-82 \| month = Oct \| year = 2012 \| doi = 10.1267/ahc.12019 \| PMID = 23209336 }}</ref>		*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal \| last1 = Nagao \| first1 = T. \| last2 = Sato \| first2 = E. \| last3 = Inoue \| first3 = R. \| last4 = Oshiro \| first4 = H. \| last5 = H Takahashi \| first5 = R. \| last6 = Nagai \| first6 = T. \| last7 = Yoshida \| first7 = M. \| last8 = Suzuki \| first8 = F. \| last9 = Obikane \| first9 = H. \| title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. \| journal = Acta Histochem Cytochem \| volume = 45 \| issue = 5 \| pages = 269-82 \| month = Oct \| year = 2012 \| doi = 10.1267/ahc.12019 \| PMID = 23209336 }}</ref>
	*Most salivary gland tumours are p40 positive and p63 positive; polymorphous adenocarcinoma is p63 positive and p40 negative.<ref name=pmid34518135>{{cite journal \|authors=Sivakumar N, Narwal A, Pandiar D, Devi A, Anand R, Bansal D, Kamboj M \|title=Diagnostic utility of p63/p40 in the histologic differentiation of salivary gland tumors: A systematic review \|journal=Oral Surg Oral Med Oral Pathol Oral Radiol \|volume=133 \|issue=2 \|pages=189–198 \|date=February 2022 \|pmid=34518135 \|doi=10.1016/j.oooo.2021.07.010 \|url=}}</ref>		*Most salivary gland tumours are p40 positive and p63 positive; [[polymorphous adenocarcinoma]] is p63 positive and p40 negative.<ref name=pmid34518135>{{cite journal \|authors=Sivakumar N, Narwal A, Pandiar D, Devi A, Anand R, Bansal D, Kamboj M \|title=Diagnostic utility of p63/p40 in the histologic differentiation of salivary gland tumors: A systematic review \|journal=Oral Surg Oral Med Oral Pathol Oral Radiol \|volume=133 \|issue=2 \|pages=189–198 \|date=February 2022 \|pmid=34518135 \|doi=10.1016/j.oooo.2021.07.010 \|url=}}</ref>

	=Benign=		=Benign=

Michael at 20:35, 2 June 2024

2024-06-02T20:35:41Z

← Older revision		Revision as of 20:35, 2 June 2024
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	Specifics:		Specifics:
	*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal \| last1 = Nagao \| first1 = T. \| last2 = Sato \| first2 = E. \| last3 = Inoue \| first3 = R. \| last4 = Oshiro \| first4 = H. \| last5 = H Takahashi \| first5 = R. \| last6 = Nagai \| first6 = T. \| last7 = Yoshida \| first7 = M. \| last8 = Suzuki \| first8 = F. \| last9 = Obikane \| first9 = H. \| title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. \| journal = Acta Histochem Cytochem \| volume = 45 \| issue = 5 \| pages = 269-82 \| month = Oct \| year = 2012 \| doi = 10.1267/ahc.12019 \| PMID = 23209336 }}</ref>		*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal \| last1 = Nagao \| first1 = T. \| last2 = Sato \| first2 = E. \| last3 = Inoue \| first3 = R. \| last4 = Oshiro \| first4 = H. \| last5 = H Takahashi \| first5 = R. \| last6 = Nagai \| first6 = T. \| last7 = Yoshida \| first7 = M. \| last8 = Suzuki \| first8 = F. \| last9 = Obikane \| first9 = H. \| title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. \| journal = Acta Histochem Cytochem \| volume = 45 \| issue = 5 \| pages = 269-82 \| month = Oct \| year = 2012 \| doi = 10.1267/ahc.12019 \| PMID = 23209336 }}</ref>
			*Most salivary gland tumours are p40 positive and p63 positive; polymorphous adenocarcinoma is p63 positive and p40 negative.<ref name=pmid34518135>{{cite journal \|authors=Sivakumar N, Narwal A, Pandiar D, Devi A, Anand R, Bansal D, Kamboj M \|title=Diagnostic utility of p63/p40 in the histologic differentiation of salivary gland tumors: A systematic review \|journal=Oral Surg Oral Med Oral Pathol Oral Radiol \|volume=133 \|issue=2 \|pages=189–198 \|date=February 2022 \|pmid=34518135 \|doi=10.1016/j.oooo.2021.07.010 \|url=}}</ref>

	=Benign=		=Benign=

Michael: /* Polymorphous low-grade adenocarcinoma */

2021-02-25T20:16:55Z

Polymorphous low-grade adenocarcinoma

← Older revision		Revision as of 20:16, 25 February 2021
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	{{Main\|Intraductal carcinoma of the salivary gland}}		{{Main\|Intraductal carcinoma of the salivary gland}}

	==Polymorphous ~~low-grade~~ adenocarcinoma==		==Polymorphous adenocarcinoma==
	*Abbreviated ''PLGA''.		*Abbreviated ''PAC''.
	{{Main\|Polymorphous ~~low-grade~~ adenocarcinoma}}		*Previously known as ''polymorphous low-grade adenocarcinoma'', abbreviated ''PLGA''.
			{{Main\|Polymorphous adenocarcinoma}}

	==Carcinoma ex pleomorphic adenoma==		==Carcinoma ex pleomorphic adenoma==

Michael: /* Salivary gland mucocele */ split out

2020-06-23T19:15:47Z

Salivary gland mucocele: split out

← Older revision		Revision as of 19:15, 23 June 2020
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	==Salivary gland mucocele==		==Salivary gland mucocele==
	*[[AKA]] ''salivary mucocele''.		{{Main\|Salivary gland mucocele}}
	*May be referred to as ''[[mucocele]]''.
	~~===General===~~
	*Benign.
	*Infected [[mucocele]] = mucopyocele.

	~~===Microscopic===~~
	~~Features:<ref>URL: [http://emedicine.medscape.com/article/1076717-workup http://emedicine.medscape.com/article/1076717-workup]. Accessed on: 6 March 2012.</ref>~~
	*Granulation tissue-like and pseudocyst-like.
	**Granulation tissue-like:
	***Fibroblasts.
	***Small caliber blood vessels.
	***Histocytes.
	***Neutrophils.
	**Pseudocyst:
	***No epithelial lining.
	***Poorly circumscribed.
	*Pale pink extracellular material (mucous) - '''key feature'''.
	*+/-[[Granuloma]]s.<ref name=pmid7251405>{{~~Cite journal~~ \| last1 = Seifert \| first1 = G. \| last2 = Donath \| first2 = K. \| last3 = von Gumberz \| first3 = C. \| title = [Mucoceles of the minor salivary glands. Extravasation mucoceles (mucus granulomas) and retention mucoceles (mucus retention cysts) (author's transl)]. \| journal = HNO \| volume = 29 \| issue = 6 \| pages = 179-91 \| month = Jun \| year = 1981 \| doi = \| PMID = 7251405 }}~~</ref>~~

	~~DDx:~~
	*[[Granulation tissue]].
	*[[Signet ring cell carcinoma]] - muciphages may mimic signet ring cells.

	~~====Images====~~
	~~<gallery>~~
	~~Image:Mucocele_of_lower_lip_%281%29.JPG \| Mucocele - low mag. (WC/KGH)~~
	~~Image:Mucocele_of_lower_lip_%282%29.JPG \| Mucocele - high mag. (WC/KGH)~~
	~~Image:Mucocele_-_low_mag.jpg \| Mucocele - low mag. (WC/Nephron)~~
	~~Image:Mucocele_-_high_mag.jpg \| Mucocele - high mag. (WC/Nephron)~~
	~~</gallery>~~
	~~www:~~
	*[http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=292590975 Mucocele (dermatlas.med.jhmi.edu)].

	~~===Sign out===~~
	~~<pre>~~
	~~LESION, LEFT LOWER LIP, EXCISION:~~
	~~- BENIGN MUCOCELE.~~
	~~</pre>~~

	~~====Micro====~~
	~~The sections show a stratified squamous epithelium with a thin layer of parakeratosis,~~
	~~minor salivary glands, and a well-circumscribed cystic lesion.~~

	The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. No significant nuclear atypia is identified. Mitotic activity is not readily apparent.

	==Pleomorphic adenoma==		==Pleomorphic adenoma==

Michael: /* IHC overview */

2019-04-24T13:03:48Z

IHC overview

← Older revision		Revision as of 13:03, 24 April 2019
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	==IHC overview==		==IHC overview==
	General:		General:
	*Usually has limited value.		*Usually has limited value. <!--as per Ilan Weinreb-->

	~~Specifics~~:		Overview:
	*Luminal markers: [[CK7]], [[CK19]], CAM5.2 (LMWK).		*Luminal markers: [[CK7]], [[CK19]], CAM5.2 (LMWK).
	*Basal markers: p63, HMWK, CK14.		*Basal markers: p63, HMWK, CK14.
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	Notes:		Notes:
	*p63 and S-100 are sometimes call myoepithelial.		*p63 and S-100 are sometimes call myoepithelial.

			Specifics:
			*Calponin, S-100, Ki-67 may be useful as per Nagao ''et al.''<ref>{{Cite journal \| last1 = Nagao \| first1 = T. \| last2 = Sato \| first2 = E. \| last3 = Inoue \| first3 = R. \| last4 = Oshiro \| first4 = H. \| last5 = H Takahashi \| first5 = R. \| last6 = Nagai \| first6 = T. \| last7 = Yoshida \| first7 = M. \| last8 = Suzuki \| first8 = F. \| last9 = Obikane \| first9 = H. \| title = Immunohistochemical analysis of salivary gland tumors: application for surgical pathology practice. \| journal = Acta Histochem Cytochem \| volume = 45 \| issue = 5 \| pages = 269-82 \| month = Oct \| year = 2012 \| doi = 10.1267/ahc.12019 \| PMID = 23209336 }}</ref>

	=Benign=		=Benign=

Michael: /* Benign tumours */ +CA

2018-06-04T20:58:23Z

Benign tumours: +CA

← Older revision		Revision as of 20:58, 4 June 2018
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	\| [[basal cell adenoma]]		\| [[basal cell adenoma]]
	\| exclusively oral cavity, 80% in upper lip; IHC: p63-		\| exclusively oral cavity, 80% in upper lip; IHC: p63-
	\| -		\| [[Image:Canalicular_adenoma_--_high_mag.jpg \| thumb \| center \|150px\| CA. (WC)]]
	\|-		\|-
	\|[[Sialoblastoma]]		\|[[Sialoblastoma]]

Michael: /* Adenoid cystic carcinoma */

2018-05-08T20:04:41Z

Adenoid cystic carcinoma

← Older revision		Revision as of 20:04, 8 May 2018
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	==Adenoid cystic carcinoma==		==Adenoid cystic carcinoma==
	{{Main\|Adenoid cystic carcinoma}}		{{Main\|Adenoid cystic carcinoma}}
	Note:		Note: The [[breast]] tumour is dealt with in ''[[adenoid cystic carcinoma of the breast]]''.
	*The [[breast]] tumour is dealt with in ''[[adenoid cystic carcinoma of the breast]]''.

	==Salivary duct carcinoma==		==Salivary duct carcinoma==

Michael: /* Adenoid cystic carcinoma */

2018-05-08T20:04:19Z

Adenoid cystic carcinoma

← Older revision		Revision as of 20:04, 8 May 2018
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	==Adenoid cystic carcinoma==		==Adenoid cystic carcinoma==
	~~:See: ''[[Adenoid cystic carcinoma of the breast]]'' for the [[breast]] tumour.~~
	{{Main\|Adenoid cystic carcinoma}}		{{Main\|Adenoid cystic carcinoma}}
			Note:
			*The [[breast]] tumour is dealt with in ''[[adenoid cystic carcinoma of the breast]]''.

	==Salivary duct carcinoma==		==Salivary duct carcinoma==

Michael: /* Salivary duct carcinoma */

2018-05-08T20:03:08Z

Salivary duct carcinoma

← Older revision		Revision as of 20:03, 8 May 2018
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	==Salivary duct carcinoma==		==Salivary duct carcinoma==
	{{Main\|Salivary duct carcinoma}}		{{Main\|Salivary duct carcinoma}}


	==Intraductal carcinoma of the salivary gland==		==Intraductal carcinoma of the salivary gland==

Michael: /* Salivary duct carcinoma */

2018-05-08T20:03:01Z

Salivary duct carcinoma

← Older revision		Revision as of 20:03, 8 May 2018
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	==Salivary duct carcinoma==		==Salivary duct carcinoma==
	{{Main\|Salivary duct carcinoma}}		{{Main\|Salivary duct carcinoma}}


			==Intraductal carcinoma of the salivary gland==
			{{Main\|Intraductal carcinoma of the salivary gland}}

	==Polymorphous low-grade adenocarcinoma==		==Polymorphous low-grade adenocarcinoma==