Sarcomatoid urothelial carcinoma - Revision history

Michael: /* Microscopic */ tweak

2019-04-18T13:47:00Z

Microscopic: tweak

← Older revision		Revision as of 13:47, 18 April 2019
Line 49:		Line 49:
	*[[Carcinosarcoma]] - esp. in women.		*[[Carcinosarcoma]] - esp. in women.
	*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]].		*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]].
	*[[Collision tumour]] (rare) - ~~component~~ should ''not'' intermingle.		*[[Collision tumour]] (rare) - components should ''not'' intermingle.

	===Images===		===Images===

Michael: /* Microscopic */

2015-06-19T06:53:02Z

Microscopic

← Older revision		Revision as of 06:53, 19 June 2015
Line 48:		Line 48:
	*[[Sarcoma]] - esp. those arising from the retroperitoneum.		*[[Sarcoma]] - esp. those arising from the retroperitoneum.
	*[[Carcinosarcoma]] - esp. in women.		*[[Carcinosarcoma]] - esp. in women.
	*Other sarcomatoid ~~carcinomas~~, e.g. [[sarcomatoid prostate carcinoma]].		*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]].
	*[[Collision tumour]] (rare) - component should ''not'' intermingle.		*[[Collision tumour]] (rare) - component should ''not'' intermingle.

Michael: /* Microscopic */

2015-06-19T06:52:23Z

Microscopic

← Older revision		Revision as of 06:52, 19 June 2015
Line 48:		Line 48:
	*[[Sarcoma]] - esp. those arising from the retroperitoneum.		*[[Sarcoma]] - esp. those arising from the retroperitoneum.
	*[[Carcinosarcoma]] - esp. in women.		*[[Carcinosarcoma]] - esp. in women.
	*Other [[sarcomatoid ~~carcinoma]]s~~, e.g. [[sarcomatoid prostate carcinoma]].		*Other sarcomatoid carcinomas, e.g. [[sarcomatoid prostate carcinoma]].
	*[[Collision tumour]] (rare) - component should ''not'' intermingle.		*[[Collision tumour]] (rare) - component should ''not'' intermingle.

Michael: /* Microscopic */

2015-06-19T06:51:58Z

Microscopic

← Older revision		Revision as of 06:51, 19 June 2015
Line 48:		Line 48:
	*[[Sarcoma]] - esp. those arising from the retroperitoneum.		*[[Sarcoma]] - esp. those arising from the retroperitoneum.
	*[[Carcinosarcoma]] - esp. in women.		*[[Carcinosarcoma]] - esp. in women.
			*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]].
	*[[Collision tumour]] (rare) - component should ''not'' intermingle.		*[[Collision tumour]] (rare) - component should ''not'' intermingle.

Michael at 06:40, 19 June 2015

2015-06-19T06:40:15Z

← Older revision		Revision as of 06:40, 19 June 2015
Line 47:		Line 47:
	DDx:		DDx:
	*[[Sarcoma]] - esp. those arising from the retroperitoneum.		*[[Sarcoma]] - esp. those arising from the retroperitoneum.
			*[[Carcinosarcoma]] - esp. in women.
	~~==IHC==~~		*[[Collision tumour]] (rare) - component should ''not'' intermingle.
	*~~GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal \| last1 = Fatima \| first1 = N. \| last2 = Osunkoya \| first2 = AO~~. ~~\| title = GATA3 expression~~ in ~~sarcomatoid urothelial carcinoma of the bladder~~. ~~\| journal = Hum Pathol \| volume = 45 \| issue = 8 \| pages = 1625~~-~~9 \| month = Aug \| year = 2014 \| doi = 10.1016/j.humpath.2014.03.015 \| PMID = 24824028 }}</ref>)~~.

	===Images===		===Images===
Line 57:		Line 56:
	Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg \| Sarcomatoid UCC - high mag.		Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg \| Sarcomatoid UCC - high mag.
	</gallery>		</gallery>

			==IHC==
			*GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal \| last1 = Fatima \| first1 = N. \| last2 = Osunkoya \| first2 = AO. \| title = GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. \| journal = Hum Pathol \| volume = 45 \| issue = 8 \| pages = 1625-9 \| month = Aug \| year = 2014 \| doi = 10.1016/j.humpath.2014.03.015 \| PMID = 24824028 }}</ref>).

	==See also==		==See also==

Michael: fix

2015-06-19T06:38:52Z

fix

← Older revision		Revision as of 06:38, 19 June 2015
Line 9:		Line 9:
	\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas, [[collision tumour]]		\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas, [[collision tumour]]
	\| Stains =		\| Stains =
	\| IHC = ~~GATA~~ +ve		\| IHC = GATA3 +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 06:38, 19 June 2015

2015-06-19T06:38:35Z

← Older revision		Revision as of 06:38, 19 June 2015
Line 7:		Line 7:
	\| Micro =		\| Micro =
	\| Subtypes = (subtype of [[urothelial carcinoma]])		\| Subtypes = (subtype of [[urothelial carcinoma]])
	\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas		\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas, [[collision tumour]]
	\| Stains =		\| Stains =
	\| IHC = GATA +ve		\| IHC = GATA +ve
Line 33:		Line 33:

	==General==		==General==
	*Rare.<ref name=~~pmid26068625~~/>		*Rare<ref name=pmid26068625/> approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.<ref name=pmid20706685>{{Cite journal \| last1 = Wang \| first1 = J. \| last2 = Wang \| first2 = FW. \| last3 = Lagrange \| first3 = CA. \| last4 = Hemstreet Iii \| first4 = GP. \| last5 = Kessinger \| first5 = A. \| title = Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases. \| journal = Sarcoma \| volume = 2010 \| issue = \| pages = \| month = \| year = 2010 \| doi = 10.1155/2010/454792 \| PMID = 20706685 }}</ref>
	*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/>		*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/>

Michael at 06:26, 19 June 2015

2015-06-19T06:26:58Z

← Older revision		Revision as of 06:26, 19 June 2015
Line 9:		Line 9:
	\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas		\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = GATA +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
Line 47:		Line 47:
	DDx:		DDx:
	*[[Sarcoma]] - esp. those arising from the retroperitoneum.		*[[Sarcoma]] - esp. those arising from the retroperitoneum.

			==IHC==
			*GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal \| last1 = Fatima \| first1 = N. \| last2 = Osunkoya \| first2 = AO. \| title = GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. \| journal = Hum Pathol \| volume = 45 \| issue = 8 \| pages = 1625-9 \| month = Aug \| year = 2014 \| doi = 10.1016/j.humpath.2014.03.015 \| PMID = 24824028 }}</ref>).

	===Images===		===Images===

Michael at 06:22, 19 June 2015

2015-06-19T06:22:41Z

← Older revision		Revision as of 06:22, 19 June 2015
Line 1:		Line 1:
			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Urothelial carcinoma with sarcomatoid differentiation -- intermed mag.jpg
			\| Width =
			\| Caption = Sarcomatoid urothelial carcinoma. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes = (subtype of [[urothelial carcinoma]])
			\| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[urothelium]] - [[urinary bladder]], [[ureter]], renal pelvis
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx =
			\| Tx = resection if feasible
			}}
	'''Sarcomatoid urothelial carcinoma''' (abbreviated '''sarcomatoid UC'''), also '''sarcomatoid urothelial cell carcinoma''' (abbreviated '''sarcomatoid UCC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid26068625>{{Cite journal \| last1 = Fatima \| first1 = N. \| last2 = Canter \| first2 = DJ. \| last3 = Carthon \| first3 = BC. \| last4 = Kucuk \| first4 = O. \| last5 = Master \| first5 = VA. \| last6 = Nieh \| first6 = PT. \| last7 = Ogan \| first7 = K. \| last8 = Osunkoya \| first8 = AO. \| title = Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases. \| journal = Can J Urol \| volume = 22 \| issue = 3 \| pages = 7783-7 \| month = Jun \| year = 2015 \| doi = \| PMID = 26068625 }}</ref>		'''Sarcomatoid urothelial carcinoma''' (abbreviated '''sarcomatoid UC'''), also '''sarcomatoid urothelial cell carcinoma''' (abbreviated '''sarcomatoid UCC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid26068625>{{Cite journal \| last1 = Fatima \| first1 = N. \| last2 = Canter \| first2 = DJ. \| last3 = Carthon \| first3 = BC. \| last4 = Kucuk \| first4 = O. \| last5 = Master \| first5 = VA. \| last6 = Nieh \| first6 = PT. \| last7 = Ogan \| first7 = K. \| last8 = Osunkoya \| first8 = AO. \| title = Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases. \| journal = Can J Urol \| volume = 22 \| issue = 3 \| pages = 7783-7 \| month = Jun \| year = 2015 \| doi = \| PMID = 26068625 }}</ref>

Michael: /* General */

2015-06-19T06:18:16Z

General

← Older revision		Revision as of 06:18, 19 June 2015
Line 3:		Line 3:
	==General==		==General==
	*Rare.<ref name=pmid26068625/>		*Rare.<ref name=pmid26068625/>
	*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/>		*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/>

			==Gross==
			*Tumour of bladder, [[ureter]]<ref name=pmid24902363>{{Cite journal \| last1 = Nicolas \| first1 = MM. \| last2 = Nazarullah \| first2 = A. \| last3 = Guo \| first3 = CC. \| title = Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report. \| journal = Anal Quant Cytopathol Histpathol \| volume = 36 \| issue = 2 \| pages = 111-6 \| month = Apr \| year = 2014 \| doi = \| PMID = 24902363 }}</ref> or renal pelvis.<ref name=pmid25120689>{{Cite journal \| last1 = Tian \| first1 = X. \| last2 = Zhao \| first2 = J. \| last3 = Wang \| first3 = Y. \| last4 = Xing \| first4 = N. \| title = Sarcomatoid carcinoma of the renal pelvis: A case report. \| journal = Oncol Lett \| volume = 8 \| issue = 3 \| pages = 1208-1210 \| month = Sep \| year = 2014 \| doi = 10.3892/ol.2014.2240 \| PMID = 25120689 }}</ref>

	==Microscopic==		==Microscopic==