Sebaceous carcinoma - Revision history

Michael: /* Sebaceous carcinoma versus squamous cell carcinoma */

2021-11-09T21:49:30Z

Sebaceous carcinoma versus squamous cell carcinoma

← Older revision		Revision as of 21:49, 9 November 2021
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	===Sebaceous carcinoma versus squamous cell carcinoma===		===Sebaceous carcinoma versus squamous cell carcinoma===
	*CK7 +ve.		*CK7 +ve.
	**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas ~~positive~~.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>		**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas +ve.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>
	*Ber-EP4 -ve/+ve.		*Ber-EP4 -ve/+ve.
	**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas +ve.<ref name=pmid26485238/>		**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas +ve.<ref name=pmid26485238/>

Michael: /* Sebaceous carcinoma versus squamous cell carcinoma */

2021-11-09T21:49:17Z

Sebaceous carcinoma versus squamous cell carcinoma

← Older revision		Revision as of 21:49, 9 November 2021
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	**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>		**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>
	*Ber-EP4 -ve/+ve.		*Ber-EP4 -ve/+ve.
	**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas ~~positive~~.<ref name=pmid26485238/>		**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas +ve.<ref name=pmid26485238/>
	*EMA +ve.		*EMA +ve.
	**Useful if negative: 27 of 27 sebaceous carcinoma ~~positive~~; 16 of 22 squamous cell carcinoma ~~positive~~.<ref name=pmid26485238/>		**Useful if negative: 27 of 27 sebaceous carcinoma +ve; 16 of 22 squamous cell carcinoma +ve.<ref name=pmid26485238/>

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Michael: /* IHC */

2021-11-09T19:00:16Z

IHC

← Older revision		Revision as of 19:00, 9 November 2021
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	*CEA -ve.		*CEA -ve.
	**Positive in [[extramammary Paget disease]], sweat duct tumours.		**Positive in [[extramammary Paget disease]], sweat duct tumours.

			Images:
			*[http://archopht.jamanetwork.com/data/journals/ophth/9858/m_ecs8482f1.png Sebaceous carcinoma - EMA, AE1/AE3, CAM5.2 (jamanetwork.com)].<ref name=pmid10369589>{{Cite journal \| last1 = Sinard \| first1 = JH. \| title = Immunohistochemical distinction of ocular sebaceous carcinoma from basal cell and squamous cell carcinoma. \| journal = Arch Ophthalmol \| volume = 117 \| issue = 6 \| pages = 776-83 \| month = Jun \| year = 1999 \| doi = \| PMID = 10369589 }}</ref>

	===Sebaceous carcinoma versus squamous cell carcinoma===		===Sebaceous carcinoma versus squamous cell carcinoma===
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	*EMA +ve.		*EMA +ve.
	**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.<ref name=pmid26485238/>		**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.<ref name=pmid26485238/>

	~~Images:~~
	*[http://archopht.jamanetwork.com/data/journals/ophth/9858/m_ecs8482f1.png Sebaceous carcinoma - EMA, AE1/AE3, CAM5.2 (jamanetwork.com)].<ref name=pmid10369589>{{Cite journal \| last1 = Sinard \| first1 = JH. \| title = Immunohistochemical distinction of ocular sebaceous carcinoma from basal cell and squamous cell carcinoma. \| journal = Arch Ophthalmol \| volume = 117 \| issue = 6 \| pages = 776-83 \| month = Jun \| year = 1999 \| doi = \| PMID = 10369589 }}</ref>

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Michael: /* Sebaceous carcinoma versus squamous cell carcinoma */

2021-11-09T18:59:57Z

Sebaceous carcinoma versus squamous cell carcinoma

← Older revision		Revision as of 18:59, 9 November 2021
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	**Positive in [[extramammary Paget disease]], sweat duct tumours.		**Positive in [[extramammary Paget disease]], sweat duct tumours.

	==Sebaceous carcinoma versus squamous cell carcinoma==		===Sebaceous carcinoma versus squamous cell carcinoma===
	*CK7 +ve.		*CK7 +ve.
	**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>		**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>

Michael: /* IHC */

2021-11-09T18:59:47Z

IHC

← Older revision		Revision as of 18:59, 9 November 2021
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	**Positive in [[extramammary Paget disease]], sweat duct tumours.		**Positive in [[extramammary Paget disease]], sweat duct tumours.

	Sebaceous carcinoma versus squamous cell carcinoma:<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=~~10.1097/DAD.0000000000000255 \|url~~=~~}}</ref>~~		==Sebaceous carcinoma versus squamous cell carcinoma==
	*CK7 +ve.		*CK7 +ve.
	**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.		**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>
	*Ber-EP4 -ve/+ve.		*Ber-EP4 -ve/+ve.
	**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas positive.		**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas positive.<ref name=pmid26485238/>
	*EMA +ve.		*EMA +ve.
	**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.		**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.<ref name=pmid26485238/>

	Images:		Images:

Michael: /* IHC */

2021-11-09T18:59:05Z

IHC

← Older revision		Revision as of 18:59, 9 November 2021
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	**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.		**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.
	*Ber-EP4 -ve/+ve.		*Ber-EP4 -ve/+ve.
	**~~Iseful~~ if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas positive.		**Useful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas positive.
	*EMA +ve.		*EMA +ve.
	**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.		**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.

Michael: /* IHC */

2021-11-09T18:58:34Z

IHC

← Older revision		Revision as of 18:58, 9 November 2021
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	Sebaceous carcinoma versus squamous cell carcinoma:<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>		Sebaceous carcinoma versus squamous cell carcinoma:<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>
	*CK7, Ber-EP4, EMA.		*CK7 +ve.
			**Useful if positive: 24 of 27 sebaceous carcinomas +ve; only 2 of 22 squamous cell carcinomas positive.
			*Ber-EP4 -ve/+ve.
			**Iseful if positive: 7 of 27 sebaceous carcinomas +ve; 0 of 22 squamous cell carcinomas positive.
			*EMA +ve.
			**Useful if negative: 27 of 27 sebaceous carcinoma positive; 16 of 22 squamous cell carcinoma positive.

	Images:		Images:

Michael: /* IHC */

2021-11-09T18:55:01Z

IHC

← Older revision		Revision as of 18:55, 9 November 2021
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	*CEA -ve.		*CEA -ve.
	**Positive in [[extramammary Paget disease]], sweat duct tumours.		**Positive in [[extramammary Paget disease]], sweat duct tumours.

			Sebaceous carcinoma versus squamous cell carcinoma:<ref name=pmid26485238>{{cite journal \|authors=Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S \|title=Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study \|journal=Am J Dermatopathol \|volume=37 \|issue=11 \|pages=809–21 \|date=November 2015 \|pmid=26485238 \|doi=10.1097/DAD.0000000000000255 \|url=}}</ref>
			*CK7, Ber-EP4, EMA.


	Images:		Images:

Michael at 02:25, 16 October 2013

2013-10-16T02:25:39Z

← Older revision		Revision as of 02:25, 16 October 2013
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	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''~~Sebaceous_carcinoma~~''', also known as '''sebaceous cell carcinoma''', is an uncommon skin tumour.		'''Sebaceous carcinoma''', also known as '''sebaceous cell carcinoma''', is an uncommon [[dermatologic neoplasms\|skin tumour]].
	==General==		==General==
	*Malignant.		*Malignant.

Michael: split-out, +infobox

2013-10-16T02:24:46Z

split-out, +infobox

← Older revision		Revision as of 02:24, 16 October 2013
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	~~#redirect~~ [[~~Dermatologic_neoplasms#~~Sebaceous_carcinoma]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Sebaceous_carcinoma_-_high_mag.jpg
			\| Width =
			\| Caption = Sebaceous carcinoma. [[H&E stain]].
			\| Micro = sebaceous differentiation (may be a minor component): sebocytes (abundant pale fluffy cytoplasm with vacuolization); basaloid cells (often dominant);
			nodular or diffuse growth pattern surrounded by a dense fibrous stroma; infiltrative border; +/-nuclear atypia, +/-squamous differentiation, +/-foreign body-type [[giant cells]]
			\| Subtypes =
			\| LMDDx = [[sebaceous adenoma]], [[squamous cell carcinoma]] (clear cell variant), [[malignant melanoma]], [[extramammary Paget disease]], [[trichoblastoma]],[[basal cell carcinoma]], [[sweat gland carcinoma]]
			\| Stains =
			\| IHC = EMA +ve (only sebaceous component), CEA -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = yellow or red (ulcerated) nodule
			\| Grossing =
			\| Site = [[skin]] - usu. [[head and neck pathology\|head and neck]], [[salivary gland]]
			\| Assdx =
			\| Syndromes = [[Muir-Torre syndrome]]
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			}}
			'''Sebaceous_carcinoma''', also known as '''sebaceous cell carcinoma''', is an uncommon skin tumour.
			==General==
			*Malignant.
			*May arise in a [[salivary gland]].<ref name=Warman/>
			*Can be part of [[Muir-Torre syndrome]].

			Notes:
			*Sebaceous lesions (from benign to malignant): [[sebaceous hyperplasia]], [[sebaceous adenoma]], sebaceoma, sebaceous carcinoma.

			==Gross==
			Features:<ref name=Ref_Derm431>{{Ref Derm\|431}}</ref>
			*Classically [[head and neck pathology\|head and neck]] tumour.
			*Yellow or red (ulcerated) nodule.

			==Microscopic==
			Features:<ref name=Ref_Derm431-2>{{Ref Derm\|431-2}}</ref>
			*Sebaceous differentiation - may be a minor component - '''key feature'''.
			**Sebocytes = abundant pale fluffy cytoplasm with vacuolization.
			*Basaloid cells - often dominant.
			**May lead to confusion with basaloid tumours.
			*Nodular or diffuse growth pattern surrounded by a dense fibrous stroma.
			*Infiltrative border - '''important'''.
			**The key difference with [[sebaceous adenoma]] in cases where there isn't significant nuclear atypia.
			*+/-Nuclear atypia.
			*+/-Squamous differentiation.
			*+/-Foreign body-type [[giant cells]].

			DDx:
			*[[Sebaceous adenoma]] - non-infiltrative border.
			*[[Squamous cell carcinoma]], clear cell variant.
			*[[Malignant melanoma]].
			*[[Extramammary Paget disease]].
			*[[Trichoblastoma]].
			*[[Basal cell carcinoma]].
			*[[Sweat gland carcinoma]].

			===Images===
			<gallery>
			Image:Sebaceous_carcinoma_-_intermed_mag.jpg \| Sebaceous carcinoma - intermed. mag. (WC/Nephron)
			Image:Sebaceous_carcinoma_-_high_mag.jpg \| Sebaceous carcinoma - high mag. (WC/Nephron)
			Image:Sebaceous_carcinoma_-_very_high_mag.jpg \| Sebaceous carcinoma - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://www.ispub.com/journal/the-internet-journal-of-otorhinolaryngology/volume-9-number-2/sebaceous-adenocarcinoma-of-the-parotid-gland-a-case-report-and-literature-review.article-g01.fs.jpg Sebaceous carcinoma (ispub.com)].<ref name=Warman>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/sebaceous_adenocarcinoma_of_the_parotid_gland_a_case_report_and_literature_review.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/sebaceous_adenocarcinoma_of_the_parotid_gland_a_case_report_and_literature_review.html]. Accessed on: 8 September 2011.</ref>

			===Grading===
			Three tier system:<ref name=Ref_Derm431-2>{{Ref Derm\|431-2}}</ref>
			*Well-differentiated - sebocytes predominant.
			*Moderately differentiated - sebocytes are easily recognized but a minor component.
			*Poorly differentiated - sebocytes are rare.

			==IHC==
			Features:<ref name=Ref_Derm431-2>{{Ref Derm\|431-2}}</ref>
			*CK7 +ve<ref name=pmid21592202>{{Cite journal \| last1 = Ansai \| first1 = S. \| last2 = Arase \| first2 = S. \| last3 = Kawana \| first3 = S. \| last4 = Kimura \| first4 = T. \| title = Immunohistochemical findings of sebaceous carcinoma and sebaceoma: retrieval of cytokeratin expression by a panel of anti-cytokeratin monoclonal antibodies. \| journal = J Dermatol \| volume = 38 \| issue = 10 \| pages = 951-8 \| month = Oct \| year = 2011 \| doi = 10.1111/j.1346-8138.2011.01274.x \| PMID = 21592202 }}</ref> - often weak.
			*EMA +ve -- only sebaceous component.<ref name=pmid10369589/>
			*CEA -ve.
			**Positive in [[extramammary Paget disease]], sweat duct tumours.

			Images:
			*[http://archopht.jamanetwork.com/data/journals/ophth/9858/m_ecs8482f1.png Sebaceous carcinoma - EMA, AE1/AE3, CAM5.2 (jamanetwork.com)].<ref name=pmid10369589>{{Cite journal \| last1 = Sinard \| first1 = JH. \| title = Immunohistochemical distinction of ocular sebaceous carcinoma from basal cell and squamous cell carcinoma. \| journal = Arch Ophthalmol \| volume = 117 \| issue = 6 \| pages = 776-83 \| month = Jun \| year = 1999 \| doi = \| PMID = 10369589 }}</ref>

			==Sign out==
			<pre>
			SKIN LESION, NOSE, BIOPSY:
			- SEBACEOUS CARCINOMA, WELL-DIFFERENTIATED, COMPLETELY EXCISED IN THE PLANE OF SECTION.

			COMMENT:
			EMA staining marks the sebocytes. The lesion is negative for Ber-EP4.

			Sebaceous carcinoma may be seen in the context of Muir-Torre syndrome.
			</pre>

			===Micro===
			====Well differentiated====
			The sections show well-circumscribed dermal nests of basaloid cells with peripheral palisading,
			surrounded by a dense fibrous stroma. The basaloid cells have distinct nucleoli. Focally, the
			basaloid nests contain small clusters of cells with abundant pale, vacuolated, fluffy-appearing
			cytoplasm (sebocytes). Mitotic activity is minimal.

			There is no artefactual clefting between the stroma and basaloid cell nests. The epidermis
			matures to the surface and does not have basal atypia.

			The lesion is completely excised in the plane of section.

			====Poor differentiated====
			The sections show well-circumscribed dermal nests of basaloid cells with peripheral
			palisading, surrounded by a dense fibrous stroma, that extend from the skin surface almost
			to the adipose tissue. The basaloid cells have moderate nuclear atypia with occasional monstrous cells. Mitotic activity is abundant and atypical mitoses are present. The nests contain rare cells with pale, fluffy-appearing cytoplasm, suggestive of sebocytes.

			==See also==
			*[[Dermatologic neoplasms]].

			==References==
			{{Reflist\|2}}

			[[Category:Dermatologic neoplasms]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]