Serous borderline tumour - Revision history

Michael at 11:25, 29 March 2016

2016-03-29T11:25:58Z

← Older revision		Revision as of 11:25, 29 March 2016
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	\| Micro = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)		\| Micro = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
	\| Subtypes = serous borderline tumour (SBT) with micropapillary pattern, typical SBT ''or'' SBT not otherwise specified		\| Subtypes = serous borderline tumour (SBT) with micropapillary pattern, typical SBT ''or'' SBT not otherwise specified
	\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]		\| LMDDx = [[serous cystadenoma of the ovary\|serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael: /* Microscopic */

2016-03-29T11:25:05Z

Microscopic

← Older revision		Revision as of 11:25, 29 March 2016
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	**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).		**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
	*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.		*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.
	*[[Serous cystadenoma]].		*[[Serous cystadenoma of the ovary]].

	===Images===		===Images===

Michael at 02:22, 29 March 2016

2016-03-29T02:22:59Z

← Older revision		Revision as of 02:22, 29 March 2016
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	\| Synonyms =		\| Synonyms =
	\| Micro = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)		\| Micro = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
	\| Subtypes = serous borderline tumour (SBT) with micropapillary pattern, SBT ~~conventional pattern~~ ''or'' SBT not otherwise specified		\| Subtypes = serous borderline tumour (SBT) with micropapillary pattern, typical SBT ''or'' SBT not otherwise specified
	\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]		\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]
	\| Stains =		\| Stains =

Michael at 02:22, 29 March 2016

2016-03-29T02:22:20Z

← Older revision		Revision as of 02:22, 29 March 2016
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	\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].		\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = ~~suboidal~~ to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)		\| Micro = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
	\| Subtypes =		\| Subtypes = serous borderline tumour (SBT) with micropapillary pattern, SBT conventional pattern ''or'' SBT not otherwise specified
	\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]		\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]
	\| Stains =		\| Stains =

Michael: /* Microscopic */

2016-03-29T02:20:03Z

Microscopic

← Older revision		Revision as of 02:20, 29 March 2016
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	Features:<ref name=Ref_GP399>{{Ref GP\|399}}</ref>		Features:<ref name=Ref_GP399>{{Ref GP\|399}}</ref>
	*Cuboidal to columnar epithelium with mild to moderate atypia.		*Cuboidal to columnar epithelium with mild to moderate atypia.
	*No invasive.		*Non-invasive.
	*"Sparse" mitoses.		*"Sparse" mitoses.
	*+/-[[Psammoma bodies]].		*+/-[[Psammoma bodies]].

Michael at 02:19, 29 March 2016

2016-03-29T02:19:42Z

← Older revision		Revision as of 02:19, 29 March 2016
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	\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].		\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = suboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[~~ssammoma~~ bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)		\| Micro = suboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]		\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]

Michael at 02:19, 29 March 2016

2016-03-29T02:19:32Z

← Older revision		Revision as of 02:19, 29 March 2016
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	\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].		\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = suboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[ssammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]		\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]
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	<pre>		<pre>
	Cyst and Right Fallopian Tube, Excision:		Cyst and Right Fallopian Tube, Excision:
	- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.		- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
	- Fallopian tube within normal limits.		- Fallopian tube within normal limits.
	- NEGATIVE for evidence of invasion.		- NEGATIVE for evidence of invasion.

	Comment:		Comment:

Michael: tweak

2016-03-29T02:16:51Z

tweak

← Older revision		Revision as of 02:16, 29 March 2016
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Serous borderline tumour with micropapillary pattern -- intermed mag.jpg
			\| Width =
			\| Caption = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[ovary]], [[uterine tube]] - see ''[[ovarian tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usually benign, need follow-up
			\| Other =
			\| ClinDDx = other [[ovarian tumours]] (benign and malignant)
			\| Tx = excision, follow-up
			}}
	'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].		'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].

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	**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).		**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
	*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.		*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.
			*[[Serous cystadenoma]].

	Images:		===Images===
			<gallery>
			Image: Serous borderline tumour with micropapillary pattern -- intermed mag.jpg -- very very low mag.jpg \| SBTMP - very very low mag.
			Image: Serous borderline tumour with micropapillary pattern -- very low mag.jpg \| SBTMP - very low mag.
			Image: Serous borderline tumour with micropapillary pattern -- low mag.jpg \| SBTMP - low mag.
			Image: Serous borderline tumour with micropapillary pattern -- intermed mag.jpg \| SBTMP - intermed. mag.
			Image: Serous borderline tumour with micropapillary pattern -- high mag.jpg \| SBTMP - high mag.

			Image: Serous borderline tumour with micropapillary pattern - a -- very low mag.jpg \| SBTMP - very low mag.
			Image: Serous borderline tumour with micropapillary pattern - a -- low mag.jpg \| SBTMP - low mag.
			Image: Serous borderline tumour with micropapillary pattern - a -- intermed mag.jpg \| SBTMP - intermed. mag.
			Image: Serous borderline tumour with micropapillary pattern - a -- high mag.jpg \| SBTMP - high mag.
			Image: Serous borderline tumour with micropapillary pattern - a2 -- high mag.jpg \| SBTMP - high mag.
			Image: Serous borderline tumour with micropapillary pattern - a3 -- high mag.jpg \| SBTMP - high mag.
			Image: Serous borderline tumour with micropapillary pattern - a -- very high mag.jpg \| SBTMP - very high mag.
			</gallery>
			====www====
	*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal \| last1 = Burkholz \| first1 = KJ. \| last2 = Wood \| first2 = BP. \| last3 = Zuppan \| first3 = C. \| title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. \| journal = Radiographics \| volume = 25 \| issue = 6 \| pages = 1689-92 \| month = \| year = \| doi = 10.1148/rg.256055015 \| PMID = 16284143 }}</ref>		*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal \| last1 = Burkholz \| first1 = KJ. \| last2 = Wood \| first2 = BP. \| last3 = Zuppan \| first3 = C. \| title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. \| journal = Radiographics \| volume = 25 \| issue = 6 \| pages = 1689-92 \| month = \| year = \| doi = 10.1148/rg.256055015 \| PMID = 16284143 }}</ref>

Michael at 02:10, 29 March 2016

2016-03-29T02:10:47Z

← Older revision		Revision as of 02:10, 29 March 2016
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	'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].		'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].

	It is also known as '''serous ovarian tumour of low malignant potential'''.<ref name=pmid10881733/>		It is also known as '''serous tumour of low malignant potential''', abbreviated ''SLMP''.<ref name=pmid10836293>{{Cite journal \| last1 = Seidman \| first1 = JD. \| last2 = Kurman \| first2 = RJ. \| title = Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. \| journal = Hum Pathol \| volume = 31 \| issue = 5 \| pages = 539-57 \| month = May \| year = 2000 \| doi = \| PMID = 10836293 }}</ref><ref name=pmid10881733>{{Cite journal \| last1 = Dietel \| first1 = M. \| last2 = Hauptmann \| first2 = S. \| title = Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology. \| journal = Virchows Arch \| volume = 436 \| issue = 5 \| pages = 403-12 \| month = May \| year = 2000 \| doi = \| PMID = 10881733 }}</ref>

			''Serous ovarian tumour of low malignant potential'' redirects here.<ref name=pmid10881733/>

	==General==		==General==

Michael: split out from ovarian tumours

2016-03-29T02:07:22Z

split out from ovarian tumours

← Older revision		Revision as of 02:07, 29 March 2016
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	~~#redirect~~ [[Ovarian tumours#Ovarian ~~serous borderline tumour~~]]		'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].

			It is also known as '''serous ovarian tumour of low malignant potential'''.<ref name=pmid10881733/>

			==General==
			*Usually benign.
			*Require long term follow-up.

			==Microscopic==
			Features:<ref name=Ref_GP399>{{Ref GP\|399}}</ref>
			*Cuboidal to columnar epithelium with mild to moderate atypia.
			*No invasive.
			*"Sparse" mitoses.
			*+/-[[Psammoma bodies]].
			*+/-Micropapillary architecture - often described as a ''medusa head'' pattern.

			DDx:
			*[[Serous carcinoma of the ovary]] - focus a with stromal invasion >5mm (linear measurement) ''or'' > 10 mm<sup>2</sup> (area).<ref name=Ref_GP399>{{Ref GP\|399}}</ref>
			**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
			*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.

			Images:
			*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal \| last1 = Burkholz \| first1 = KJ. \| last2 = Wood \| first2 = BP. \| last3 = Zuppan \| first3 = C. \| title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. \| journal = Radiographics \| volume = 25 \| issue = 6 \| pages = 1689-92 \| month = \| year = \| doi = 10.1148/rg.256055015 \| PMID = 16284143 }}</ref>

			===Subclassification===
			Typical subdivided into:<ref name=pmid21917305>{{Cite journal \| last1 = Park \| first1 = JY. \| last2 = Kim \| first2 = DY. \| last3 = Kim \| first3 = JH. \| last4 = Kim \| first4 = YM. \| last5 = Kim \| first5 = KR. \| last6 = Kim \| first6 = YT. \| last7 = Nam \| first7 = JH. \| title = Micropapillary pattern in serous borderline ovarian tumors: does it matter? \| journal = Gynecol Oncol \| volume = 123 \| issue = 3 \| pages = 511-6 \| month = Dec \| year = 2011 \| doi = 10.1016/j.ygyno.2011.08.008 \| PMID = 21917305 }}</ref>
			*Micropapillary serous borderline tumour.
			*Typical serous borderline tumour (SBOT).

			==Sign out==
			<pre>
			Cyst and Right Fallopian Tube, Excision:
			- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
			- Fallopian tube within normal limits.
			- NEGATIVE for evidence of invasion.

			Comment:
			The lesion appears to be confined to a cystic structure.
			</pre>

			==See also==
			*[[Ovarian tumours]].

			==References==
			{{Reflist\|1}}

			[[Category:Diagnosis]]
			[[Category:Ovarian tumours]]