Serous carcinoma of the endometrium - Revision history

Michael: /* IHC */

2016-06-06T14:13:41Z

IHC

← Older revision		Revision as of 14:13, 6 June 2016
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	Notes:		Notes:
	*p16 +ve in tubal metaplasia.<ref name=pmid17429140>{{Cite journal \| last1 = Horree \| first1 = N. \| last2 = Heintz \| first2 = AP. \| last3 = Sie-Go \| first3 = DM. \| last4 = van Diest \| first4 = PJ. \| title = p16 is consistently expressed in endometrial tubal metaplasia. \| journal = Cell Oncol \| volume = 29 \| issue = 1 \| pages = 37-45 \| month = \| year = 2007 \| doi = \| PMID = 17429140 }}</ref>		*[[p16]] +ve in tubal metaplasia.<ref name=pmid17429140>{{Cite journal \| last1 = Horree \| first1 = N. \| last2 = Heintz \| first2 = AP. \| last3 = Sie-Go \| first3 = DM. \| last4 = van Diest \| first4 = PJ. \| title = p16 is consistently expressed in endometrial tubal metaplasia. \| journal = Cell Oncol \| volume = 29 \| issue = 1 \| pages = 37-45 \| month = \| year = 2007 \| doi = \| PMID = 17429140 }}</ref>
	*WT1 usu. -ve -- useful to differentiate from [[ovarian serous carcinoma]].<ref name=pmid21993272>{{Cite journal \| last1 = Bárcena \| first1 = C. \| last2 = Oliva \| first2 = E. \| title = WT1 expression in the female genital tract. \| journal = Adv Anat Pathol \| volume = 18 \| issue = 6 \| pages = 454-65 \| month = Nov \| year = 2011 \| doi = 10.1097/PAP.0b013e318234aaed \| PMID = 21993272 }}</ref>		*WT1 usu. -ve -- useful to differentiate from [[ovarian serous carcinoma]].<ref name=pmid21993272>{{Cite journal \| last1 = Bárcena \| first1 = C. \| last2 = Oliva \| first2 = E. \| title = WT1 expression in the female genital tract. \| journal = Adv Anat Pathol \| volume = 18 \| issue = 6 \| pages = 454-65 \| month = Nov \| year = 2011 \| doi = 10.1097/PAP.0b013e318234aaed \| PMID = 21993272 }}</ref>

Michael: /* IHC */

2016-06-05T05:26:32Z

IHC

← Older revision		Revision as of 05:26, 5 June 2016
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	==IHC==		==IHC==
	*p16 +ve<ref name=pmid17581420>{{Cite journal \| last1 = Chiesa-Vottero \| first1 = AG. \| last2 = Malpica \| first2 = A. \| last3 = Deavers \| first3 = MT. \| last4 = Broaddus \| first4 = R. \| last5 = Nuovo \| first5 = GJ. \| last6 = Silva \| first6 = EG. \| title = Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. \| journal = Int J Gynecol Pathol \| volume = 26 \| issue = 3 \| pages = 328-33 \| month = Jul \| year = 2007 \| doi = 10.1097/01.pgp.0000235065.31301.3e \| PMID = 17581420 }}</ref> - should be strong.		*[[p16]] +ve<ref name=pmid17581420>{{Cite journal \| last1 = Chiesa-Vottero \| first1 = AG. \| last2 = Malpica \| first2 = A. \| last3 = Deavers \| first3 = MT. \| last4 = Broaddus \| first4 = R. \| last5 = Nuovo \| first5 = GJ. \| last6 = Silva \| first6 = EG. \| title = Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. \| journal = Int J Gynecol Pathol \| volume = 26 \| issue = 3 \| pages = 328-33 \| month = Jul \| year = 2007 \| doi = 10.1097/01.pgp.0000235065.31301.3e \| PMID = 17581420 }}</ref> - should be strong.
	*p53 +ve<ref name=pmid19623034>{{Cite journal \| last1 = Yemelyanova \| first1 = A. \| last2 = Ji \| first2 = H. \| last3 = Shih \| first3 = IeM. \| last4 = Wang \| first4 = TL. \| last5 = Wu \| first5 = LS. \| last6 = Ronnett \| first6 = BM. \| title = Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 10 \| pages = 1504-14 \| month = Oct \| year = 2009 \| doi = 10.1097/PAS.0b013e3181ac35f5 \| PMID = 19623034 }}</ref> diffuse & strong > 50% ''or'' 75% of the tumour - depending on the paper one reads.		*p53 +ve<ref name=pmid19623034>{{Cite journal \| last1 = Yemelyanova \| first1 = A. \| last2 = Ji \| first2 = H. \| last3 = Shih \| first3 = IeM. \| last4 = Wang \| first4 = TL. \| last5 = Wu \| first5 = LS. \| last6 = Ronnett \| first6 = BM. \| title = Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 10 \| pages = 1504-14 \| month = Oct \| year = 2009 \| doi = 10.1097/PAS.0b013e3181ac35f5 \| PMID = 19623034 }}</ref> diffuse & strong > 50% ''or'' 75% of the tumour - depending on the paper one reads.
	**Subset is p53 -ve.		**Subset is p53 -ve.

Michael: /* Microscopic */

2014-06-18T12:32:49Z

Microscopic

← Older revision		Revision as of 12:32, 18 June 2014
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	*[[Arias-Stella reaction]].		*[[Arias-Stella reaction]].
	*Metastatic [[serous carcinoma]].		*Metastatic [[serous carcinoma]].
			*[[Endometrium with psammoma bodies]] - no atypical cells.

	===Images===		===Images===

Michael: +SO

2014-05-21T15:39:56Z

+SO

← Older revision		Revision as of 15:39, 21 May 2014
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	*p16 +ve in tubal metaplasia.<ref name=pmid17429140>{{Cite journal \| last1 = Horree \| first1 = N. \| last2 = Heintz \| first2 = AP. \| last3 = Sie-Go \| first3 = DM. \| last4 = van Diest \| first4 = PJ. \| title = p16 is consistently expressed in endometrial tubal metaplasia. \| journal = Cell Oncol \| volume = 29 \| issue = 1 \| pages = 37-45 \| month = \| year = 2007 \| doi = \| PMID = 17429140 }}</ref>		*p16 +ve in tubal metaplasia.<ref name=pmid17429140>{{Cite journal \| last1 = Horree \| first1 = N. \| last2 = Heintz \| first2 = AP. \| last3 = Sie-Go \| first3 = DM. \| last4 = van Diest \| first4 = PJ. \| title = p16 is consistently expressed in endometrial tubal metaplasia. \| journal = Cell Oncol \| volume = 29 \| issue = 1 \| pages = 37-45 \| month = \| year = 2007 \| doi = \| PMID = 17429140 }}</ref>
	*WT1 usu. -ve -- useful to differentiate from [[ovarian serous carcinoma]].<ref name=pmid21993272>{{Cite journal \| last1 = Bárcena \| first1 = C. \| last2 = Oliva \| first2 = E. \| title = WT1 expression in the female genital tract. \| journal = Adv Anat Pathol \| volume = 18 \| issue = 6 \| pages = 454-65 \| month = Nov \| year = 2011 \| doi = 10.1097/PAP.0b013e318234aaed \| PMID = 21993272 }}</ref>		*WT1 usu. -ve -- useful to differentiate from [[ovarian serous carcinoma]].<ref name=pmid21993272>{{Cite journal \| last1 = Bárcena \| first1 = C. \| last2 = Oliva \| first2 = E. \| title = WT1 expression in the female genital tract. \| journal = Adv Anat Pathol \| volume = 18 \| issue = 6 \| pages = 454-65 \| month = Nov \| year = 2011 \| doi = 10.1097/PAP.0b013e318234aaed \| PMID = 21993272 }}</ref>

			==Sign out==
			<pre>
			ENDOMETRIUM, BIOPSY:
			- SEROUS CARCINOMA, HIGH-GRADE.

			COMMENT:
			The tumour stains as follows:
			POSITIVE: p16 (strong, diffuse), p53 (strong >85% of tumour).
			NEGATIVE: ER, PR.
			PROLIFERATION (Ki-67): 80% of the tumour.
			</pre>

	==See also==		==See also==

Michael at 01:04, 23 January 2014

2014-01-23T01:04:02Z

← Older revision		Revision as of 01:04, 23 January 2014
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = high-grade [[endometrioid endometrial carcinoma]], [[clear cell carcinoma of the endometrium]],[[Arias-Stella reaction]]		\| LMDDx = high-grade [[endometrioid endometrial carcinoma]], [[clear cell carcinoma of the endometrium]],[[Arias-Stella reaction]], [[serous carcinoma]] from elsewhere
	\| Stains =		\| Stains =
	\| IHC = p16 +ve (strong), p53 +ve usu. (diffuse & strong > 50% ''or'' 75% of the tumour), Ki-67 "high", ER -ve, PR -ve		\| IHC = p16 +ve (strong), p53 +ve usu. (diffuse & strong > 50% ''or'' 75% of the tumour), Ki-67 "high", ER -ve, PR -ve
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	*[[Clear cell carcinoma of the endometrium]] - usually have less nuclear pleomorphism and less mitoses.		*[[Clear cell carcinoma of the endometrium]] - usually have less nuclear pleomorphism and less mitoses.
	*[[Arias-Stella reaction]].		*[[Arias-Stella reaction]].
			*Metastatic [[serous carcinoma]].

	===Images===		===Images===

Michael at 01:00, 23 January 2014

2014-01-23T01:00:15Z

← Older revision		Revision as of 01:00, 23 January 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Uterine serous carcinoma high mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Serous carcinoma of the endometrium. [[H&E stain]].
	\| Synonyms = serous endometrial carcinoma, serous carcinoma of the uterus, uterine serous carcinoma, uterine papillary serous carcinoma		\| Synonyms = serous endometrial carcinoma, serous carcinoma of the uterus, uterine serous carcinoma, uterine papillary serous carcinoma
	\| Micro =		\| Micro =

Michael: split-out, infobox

2014-01-23T00:59:35Z

split-out, infobox

← Older revision		Revision as of 00:59, 23 January 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms = serous endometrial carcinoma, serous carcinoma of the uterus, uterine serous carcinoma, uterine papillary serous carcinoma
			\| Micro =
			\| Subtypes =
			\| LMDDx = high-grade [[endometrioid endometrial carcinoma]], [[clear cell carcinoma of the endometrium]],[[Arias-Stella reaction]]
			\| Stains =
			\| IHC = p16 +ve (strong), p53 +ve usu. (diffuse & strong > 50% ''or'' 75% of the tumour), Ki-67 "high", ER -ve, PR -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[endometrium]] - see ''[[endometrial carcinoma]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = usu. post-menopausal women
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = moderate-to-poor - dependent on stage
			\| Other =
			\| ClinDDx =
			\| Tx = total hysterectomy + lymph node dissection
			}}
	'''Serous carcinoma of the endometrium''' is an aggressive type of [[endometrial carcinoma]] that typically afflicts post-menopausal women.		'''Serous carcinoma of the endometrium''' is an aggressive type of [[endometrial carcinoma]] that typically afflicts post-menopausal women.

Michael: split -out

2014-01-23T00:53:44Z

split -out

← Older revision		Revision as of 00:53, 23 January 2014
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	~~#redirect~~ [[~~Endometrial_carcinoma#Serous_carcinoma_of_the_endometrium~~]]		'''Serous carcinoma of the endometrium''' is an aggressive type of [[endometrial carcinoma]] that typically afflicts post-menopausal women.

			It is also known as '''serous endometrial carcinoma''', '''serous carcinoma of the uterus''', '''uterine serous carcinoma''' and '''uterine papillary serous carcinoma'''.

			==General==
			*Arising in the setting of atrophy.
			*Usually post-menopausal.
			*Precursor lesion: ''endometrial intraepithelial carcinoma''.<ref name=pmid22249577>{{Cite journal \| last1 = Roelofsen \| first1 = T. \| last2 = van Kempen \| first2 = LC. \| last3 = van der Laak \| first3 = JA. \| last4 = van Ham \| first4 = MA. \| last5 = Bulten \| first5 = J. \| last6 = Massuger \| first6 = LF. \| title = Concurrent endometrial intraepithelial carcinoma (EIC) and serous ovarian cancer: can EIC be seen as the precursor lesion? \| journal = Int J Gynecol Cancer \| volume = 22 \| issue = 3 \| pages = 457-64 \| month = Mar \| year = 2012 \| doi = 10.1097/IGC.0b013e3182434a81 \| PMID = 22249577 }}</ref>
			*Aggressive behaviour - high probability of disseminated disease.

			==Gross==
			*Thin endometrium.
			*+/-Polypoid mass.

			==Microscopic==
			Features - serous:
			*Architecture - classically papillary.
			**May be glomeruloid, tubulocystic, solid (uncommon).
			*Cytology:
			**Columnar or cuboidal cells.
			**#Moderate to marked nuclear pleomorphism - variation of size, shape and staining.
			*#Large nuclear size variation between cells often esp. prominent.
			**#Singular prominent, classically red, [[red nucleolus\|nucleolus]].
			*+/-[[Psammoma bodies]].

			DDx:
			*High-grade [[endometrioid endometrial carcinoma]] - uncommon, typically younger age.
			*[[Clear cell carcinoma of the endometrium]] - usually have less nuclear pleomorphism and less mitoses.
			*[[Arias-Stella reaction]].

			===Images===
			<gallery>
			Image:Uterine_papillary_serous_carcinoma_low_mag.jpg \| Uterine serous carcinoma - low mag. (WC)
			Image:Uterine_serous_carcinoma_high_mag.jpg \| Uterine serous carcinoma - high mag. (WC)
			</gallery>

			==IHC==
			*p16 +ve<ref name=pmid17581420>{{Cite journal \| last1 = Chiesa-Vottero \| first1 = AG. \| last2 = Malpica \| first2 = A. \| last3 = Deavers \| first3 = MT. \| last4 = Broaddus \| first4 = R. \| last5 = Nuovo \| first5 = GJ. \| last6 = Silva \| first6 = EG. \| title = Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. \| journal = Int J Gynecol Pathol \| volume = 26 \| issue = 3 \| pages = 328-33 \| month = Jul \| year = 2007 \| doi = 10.1097/01.pgp.0000235065.31301.3e \| PMID = 17581420 }}</ref> - should be strong.
			*p53 +ve<ref name=pmid19623034>{{Cite journal \| last1 = Yemelyanova \| first1 = A. \| last2 = Ji \| first2 = H. \| last3 = Shih \| first3 = IeM. \| last4 = Wang \| first4 = TL. \| last5 = Wu \| first5 = LS. \| last6 = Ronnett \| first6 = BM. \| title = Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 10 \| pages = 1504-14 \| month = Oct \| year = 2009 \| doi = 10.1097/PAS.0b013e3181ac35f5 \| PMID = 19623034 }}</ref> diffuse & strong > 50% ''or'' 75% of the tumour - depending on the paper one reads.
			**Subset is p53 -ve.
			*Ki-67 "high" - no cut-point defined.
			*ER often -ve.<ref name=pmid10786803>{{Cite journal \| last1 = Kounelis \| first1 = S. \| last2 = Kapranos \| first2 = N. \| last3 = Kouri \| first3 = E. \| last4 = Coppola \| first4 = D. \| last5 = Papadaki \| first5 = H. \| last6 = Jones \| first6 = MW. \| title = Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. \| journal = Mod Pathol \| volume = 13 \| issue = 4 \| pages = 379-88 \| month = Apr \| year = 2000 \| doi = 10.1038/modpathol.3880062 \| PMID = 10786803 }}</ref>
			*PR often -ve.<ref name=pmid10786803/>

			High-grade endometrioid carcinoma versus serous carcinoma:<ref name=pmid15577675>{{Cite journal \| last1 = Darvishian \| first1 = F. \| last2 = Hummer \| first2 = AJ. \| last3 = Thaler \| first3 = HT. \| last4 = Bhargava \| first4 = R. \| last5 = Linkov \| first5 = I. \| last6 = Asher \| first6 = M. \| last7 = Soslow \| first7 = RA. \| title = Serous endometrial cancers that mimic endometrioid adenocarcinomas: a clinicopathologic and immunohistochemical study of a group of problematic cases. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 12 \| pages = 1568-78 \| month = Dec \| year = 2004 \| doi = \| PMID = 15577675 }}</ref>
			*p53 -ve, PR +ve, PTEN loss -- suggest endometrioid.
			*p16 and PTEN superior to ER, PR, and p53.<ref name=pmid20567148>{{Cite journal \| last1 = Alkushi \| first1 = A. \| last2 = Köbel \| first2 = M. \| last3 = Kalloger \| first3 = SE. \| last4 = Gilks \| first4 = CB. \| title = High-grade endometrial carcinoma: serous and grade 3 endometrioid carcinomas have different immunophenotypes and outcomes. \| journal = Int J Gynecol Pathol \| volume = 29 \| issue = 4 \| pages = 343-50 \| month = Jul \| year = 2010 \| doi = 10.1097/PGP.0b013e3181cd6552 \| PMID = 20567148 }}</ref>

			Notes:
			*p16 +ve in tubal metaplasia.<ref name=pmid17429140>{{Cite journal \| last1 = Horree \| first1 = N. \| last2 = Heintz \| first2 = AP. \| last3 = Sie-Go \| first3 = DM. \| last4 = van Diest \| first4 = PJ. \| title = p16 is consistently expressed in endometrial tubal metaplasia. \| journal = Cell Oncol \| volume = 29 \| issue = 1 \| pages = 37-45 \| month = \| year = 2007 \| doi = \| PMID = 17429140 }}</ref>
			*WT1 usu. -ve -- useful to differentiate from [[ovarian serous carcinoma]].<ref name=pmid21993272>{{Cite journal \| last1 = Bárcena \| first1 = C. \| last2 = Oliva \| first2 = E. \| title = WT1 expression in the female genital tract. \| journal = Adv Anat Pathol \| volume = 18 \| issue = 6 \| pages = 454-65 \| month = Nov \| year = 2011 \| doi = 10.1097/PAP.0b013e318234aaed \| PMID = 21993272 }}</ref>

			==See also==
			*[[Endometrial carcinoma]].
			*[[Serous carcinoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Endometrial carcinoma]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: create

2012-02-11T02:40:58Z

create

New page

#redirect [[Endometrial_carcinoma#Serous_carcinoma_of_the_endometrium]]

[[Category:Diagnosis]]