Serrated polyposis syndrome - Revision history

Michael at 06:05, 19 October 2014

2014-10-19T06:05:21Z

← Older revision		Revision as of 06:05, 19 October 2014
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			[[Image:Hyperplastic polyp -- high mag.jpg\|thumb\|right\|150px\|Micrograph showing the serrations of a [[hyperplastic polyp]] as may be seen in serrated polyposis syndrome.]]
	'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>		'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

Michael: +cat

2013-08-21T22:54:44Z

+cat

← Older revision		Revision as of 22:54, 21 August 2013
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	[[Category:Syndromes]]		[[Category:Syndromes]]
			[[Category:Gastrointestinal pathology]]

Michael: tweak

2013-04-16T11:32:09Z

tweak

← Older revision		Revision as of 11:32, 16 April 2013
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	'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>		'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

			No specific gene mutation for the syndrome is identified as of 2012.<ref name=pmid22710576>{{Cite journal \| last1 = Rex \| first1 = DK. \| last2 = Ahnen \| first2 = DJ. \| last3 = Baron \| first3 = JA. \| last4 = Batts \| first4 = KP. \| last5 = Burke \| first5 = CA. \| last6 = Burt \| first6 = RW. \| last7 = Goldblum \| first7 = JR. \| last8 = Guillem \| first8 = JG. \| last9 = Kahi \| first9 = CJ. \| title = Serrated lesions of the colorectum: review and recommendations from an expert panel. \| journal = Am J Gastroenterol \| volume = 107 \| issue = 9 \| pages = 1315-29; quiz 1314, 1330 \| month = Sep \| year = 2012 \| doi = 10.1038/ajg.2012.161 \| PMID = 22710576 }}</ref>

	==WHO definition==		==WHO definition==
	One of the following three:<ref name=pmid21660283>{{Cite journal \| last1 = Rosty \| first1 = C. \| last2 = Parry \| first2 = S. \| last3 = Young \| first3 = JP. \| title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. \| journal = Patholog Res Int \| volume = 2011 \| issue = \| pages = 157073 \| month = \| year = 2011 \| doi = 10.4061/2011/157073 \| PMID = 21660283 \| URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref>		One of the following three:<ref name=pmid22710576/><ref name=pmid21660283>{{Cite journal \| last1 = Rosty \| first1 = C. \| last2 = Parry \| first2 = S. \| last3 = Young \| first3 = JP. \| title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. \| journal = Patholog Res Int \| volume = 2011 \| issue = \| pages = 157073 \| month = \| year = 2011 \| doi = 10.4061/2011/157073 \| PMID = 21660283 \| URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref>
	#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.		#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.
	#One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.		#One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
	#>20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.		#>20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
	#*One source suggests it ought to be >=30 HPs.<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

	==See also==		==See also==

Michael: tweak -- based on comments by ALS

2012-01-25T14:01:23Z

tweak -- based on comments by ALS

← Older revision		Revision as of 14:01, 25 January 2012
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	'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, ~~may represent~~ several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>		'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

	==WHO definition==		==WHO definition==

Michael: moved Hyperplastic polyposis syndrome to Serrated polyposis syndrome: move to SPS

2012-01-19T22:23:46Z

moved Hyperplastic polyposis syndrome to Serrated polyposis syndrome: move to SPS

← Older revision	Revision as of 22:23, 19 January 2012
(No difference)

Michael: tweak refs

2012-01-19T22:23:18Z

tweak refs

← Older revision		Revision as of 22:23, 19 January 2012
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	'''~~Hyperplastic~~ polyposis syndrome''' is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, may represent several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>		'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, may represent several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

	==WHO definition==		==WHO definition==
	One of the following three:<ref name=~~pmid21045813~~>{{Cite journal \| last1 = ~~Huang~~ \| first1 = CS. \| last2 = ~~Farraye~~ \| first2 = FA. \| last3 = ~~Yang~~ \| first3 = ~~S. \| last4 = O'Brien \| first4 = MJ~~. \| title = ~~The clinical significance~~ of ~~serrated polyps~~. \| journal = ~~Am J Gastroenterol~~ \| volume = ~~106~~ \| issue = 2 \| pages = ~~229-40; quiz 241~~ \| month = ~~Feb~~ \| year = 2011 \| doi = 10.~~1038~~/~~ajg.2010.429~~ \| PMID = ~~21045813~~ \| URL = http://www.~~nature~~.com/~~ajg~~/~~journal~~/~~v106/n2~~/~~full~~/~~ajg2010429a.html~~ }}</ref>		One of the following three:<ref name=pmid21660283>{{Cite journal \| last1 = Rosty \| first1 = C. \| last2 = Parry \| first2 = S. \| last3 = Young \| first3 = JP. \| title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. \| journal = Patholog Res Int \| volume = 2011 \| issue = \| pages = 157073 \| month = \| year = 2011 \| doi = 10.4061/2011/157073 \| PMID = 21660283 \| URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref>
	#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.		#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.
	#One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.		#One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
	#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.		#>20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
	#*One source<ref name=~~pmid21660283~~>{{Cite journal \| last1 = ~~Rosty~~ \| first1 = C. \| last2 = ~~Parry~~ \| first2 = S. \| last3 = ~~Young~~ \| first3 = JP. \| title = ~~Serrated polyposis: an enigmatic model~~ of ~~colorectal cancer predisposition~~. \| journal = ~~Patholog Res Int~~ \| volume = ~~2011~~ \| issue = \| pages = ~~157073~~ \| month = \| year = 2011 \| doi = 10.~~4061~~/~~2011/157073~~ \| PMID = ~~21660283~~ \| URL =http://www.~~hindawi~~.com/~~journals~~/~~pri~~/~~2011~~/~~157073~~/ }}</ref> ~~suggests it ought to be >=20 HPs.~~		#*One source suggests it ought to be >=30 HPs.<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

	==See also==		==See also==

Michael: /* WHO definition */

2012-01-13T20:38:07Z

WHO definition

← Older revision		Revision as of 20:38, 13 January 2012
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	One of the following three:<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>		One of the following three:<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>
	#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.		#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.
	#One [[hyperplastic polyp]]s proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.		#One [[hyperplastic polyp]] proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
	#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.		#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
	#*One source<ref name=pmid21660283>{{Cite journal \| last1 = Rosty \| first1 = C. \| last2 = Parry \| first2 = S. \| last3 = Young \| first3 = JP. \| title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. \| journal = Patholog Res Int \| volume = 2011 \| issue = \| pages = 157073 \| month = \| year = 2011 \| doi = 10.4061/2011/157073 \| PMID = 21660283 \| URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref> suggests it ought to be >=20 HPs.		#*One source<ref name=pmid21660283>{{Cite journal \| last1 = Rosty \| first1 = C. \| last2 = Parry \| first2 = S. \| last3 = Young \| first3 = JP. \| title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. \| journal = Patholog Res Int \| volume = 2011 \| issue = \| pages = 157073 \| month = \| year = 2011 \| doi = 10.4061/2011/157073 \| PMID = 21660283 \| URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref> suggests it ought to be >=20 HPs.

Michael: /* WHO definition */ replace ref.

2011-12-14T00:33:16Z

WHO definition: replace ref.

← Older revision		Revision as of 00:33, 14 December 2011
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	#One [[hyperplastic polyp]]s proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.		#One [[hyperplastic polyp]]s proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
	#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.		#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
	#*One source<ref>~~URL: [http~~:~~//www~~.~~hindawi~~.~~com/journals/pri~~/2011/157073/ http://www.hindawi.com/journals/pri/2011/157073/~~]. Accessed on: 13 December 2011.~~</ref> suggests it ought to be >=20 HPs.		#*One source<ref name=pmid21660283>{{Cite journal \| last1 = Rosty \| first1 = C. \| last2 = Parry \| first2 = S. \| last3 = Young \| first3 = JP. \| title = Serrated polyposis: an enigmatic model of colorectal cancer predisposition. \| journal = Patholog Res Int \| volume = 2011 \| issue = \| pages = 157073 \| month = \| year = 2011 \| doi = 10.4061/2011/157073 \| PMID = 21660283 \| URL =http://www.hindawi.com/journals/pri/2011/157073/ }}</ref> suggests it ought to be >=20 HPs.

	==See also==		==See also==

Michael: +see also

2011-12-14T00:14:38Z

+see also

← Older revision		Revision as of 00:14, 14 December 2011
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	#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.		#>30 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
	#*One source<ref>URL: [http://www.hindawi.com/journals/pri/2011/157073/ http://www.hindawi.com/journals/pri/2011/157073/]. Accessed on: 13 December 2011.</ref> suggests it ought to be >=20 HPs.		#*One source<ref>URL: [http://www.hindawi.com/journals/pri/2011/157073/ http://www.hindawi.com/journals/pri/2011/157073/]. Accessed on: 13 December 2011.</ref> suggests it ought to be >=20 HPs.

			==See also==
			*[[MUTYH polyposis syndrome]].

	==References==		==References==

Michael: more

2011-12-14T00:13:30Z

← Older revision		Revision as of 00:13, 14 December 2011
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	'''Hyperplastic polyposis syndrome''' is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, may represent several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 }}</ref>		'''Hyperplastic polyposis syndrome''' is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, may represent several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>

	==WHO definition==		==WHO definition==
	One of the following three:<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 }}</ref>		One of the following three:<ref name=pmid21045813>{{Cite journal \| last1 = Huang \| first1 = CS. \| last2 = Farraye \| first2 = FA. \| last3 = Yang \| first3 = S. \| last4 = O'Brien \| first4 = MJ. \| title = The clinical significance of serrated polyps. \| journal = Am J Gastroenterol \| volume = 106 \| issue = 2 \| pages = 229-40; quiz 241 \| month = Feb \| year = 2011 \| doi = 10.1038/ajg.2010.429 \| PMID = 21045813 \| URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref>
	#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.		#>=Five [[hyperplastic polyp]]s proximal to the sigmoid colon with two of the five >=10 mm.
	#One [[hyperplastic polyp]]s proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.		#One [[hyperplastic polyp]]s proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.