Simple endometrial hyperplasia - Revision history

Michael: /* Microscopic */

2015-06-01T15:47:51Z

Microscopic

← Older revision		Revision as of 15:47, 1 June 2015
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	***Nuclei lacking atypical = uniform columnar nuclei.		***Nuclei lacking atypical = uniform columnar nuclei.
	**Nucleoli.		**Nucleoli.
	**Hyperchromasia or vesicular nuclei.		**Hyperchromasia or [[vesicular nuclei]].

	Notes:		Notes:

Michael: +infobox

2014-09-24T04:25:42Z

+infobox

← Older revision		Revision as of 04:25, 24 September 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Simple_endometrial_hyperplasia_-_low_mag.jpg
			\| Width =
			\| Caption = Simple endometrial hyperplasia. [[H&E stain]].
			\| Synonyms =
			\| Micro = irregular dilated glands (described as "animal shapes"), variation of gland size, normal gland density (gland area in plane of section/total area ~= 1/3), +/-nuclear atypia (see below)
			\| Subtypes = with atypia, without atypia
			\| LMDDx = [[disordered proliferative endometrium]], [[complex endometrial hyperplasia]], [[Atrophic endometrium\|cystic atrophy of the endometrium]], [[benign endometrial polyp]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[endometrium]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = [[abnormal uterine bleeding]]
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good, may progress to [[endometrial carcinoma]] - esp. with atypia
			\| Other =
			\| ClinDDx = other cause of [[abnormal uterine bleeding]]
			\| Tx =
			}}
	'''Simple endometrial hyperplasia''', abbreviated '''SEH''', is an uncommon pre-malignant change of the [[endometrium]]. Like [[complex endometrial hyperplasia]], it is subdivided into ''with atypia'' and ''without atypia''.		'''Simple endometrial hyperplasia''', abbreviated '''SEH''', is an uncommon pre-malignant change of the [[endometrium]]. Like [[complex endometrial hyperplasia]], it is subdivided into ''with atypia'' and ''without atypia''.

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	**Glands described as "animal shapes".		**Glands described as "animal shapes".
	*Variation of gland size.		*Variation of gland size.
	*No nuclear atypia.
	**Uniform columnar nuclei.
	*Normal gland density (gland area in plane of section/total area ~= 1/3).		*Normal gland density (gland area in plane of section/total area ~= 1/3).
	*+/-Nuclear atypia:<ref>{{Cite journal \| last1 = Silverberg \| first1 = SG. \| title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. \| journal = Mod Pathol \| volume = 13 \| issue = 3 \| pages = 309-27 \| month = Mar \| year = 2000 \| doi = 10.1038/modpathol.3880053 \| PMID = 10757341 }}</ref>		*+/-Nuclear atypia:<ref>{{Cite journal \| last1 = Silverberg \| first1 = SG. \| title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. \| journal = Mod Pathol \| volume = 13 \| issue = 3 \| pages = 309-27 \| month = Mar \| year = 2000 \| doi = 10.1038/modpathol.3880053 \| PMID = 10757341 }}</ref>

Michael: split out

2014-05-15T14:52:48Z

split out

← Older revision		Revision as of 14:52, 15 May 2014
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	~~#redirect~~ [[~~Endometrial_hyperplasia#Simple_endometrial_hyperplasia~~]]		'''Simple endometrial hyperplasia''', abbreviated '''SEH''', is an uncommon pre-malignant change of the [[endometrium]]. Like [[complex endometrial hyperplasia]], it is subdivided into ''with atypia'' and ''without atypia''.

			==General==
			*More common than simple endometrial hyperplasia with atypia.
			*Very low risk for progressing to [[endometrioid endometrial carcinoma]].

			==Microscopic==
			Features:<ref name=Ref_GP236>{{Ref GP\|236}}</ref>
			*Irregular dilated glands (with large lumens) - '''key feature'''.
			**Glands described as "animal shapes".
			*Variation of gland size.
			*No nuclear atypia.
			**Uniform columnar nuclei.
			*Normal gland density (gland area in plane of section/total area ~= 1/3).
			*+/-Nuclear atypia:<ref>{{Cite journal \| last1 = Silverberg \| first1 = SG. \| title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. \| journal = Mod Pathol \| volume = 13 \| issue = 3 \| pages = 309-27 \| month = Mar \| year = 2000 \| doi = 10.1038/modpathol.3880053 \| PMID = 10757341 }}</ref>
			**Loss of basal nuclear stratification.
			**Nuclear size variation.
			**Nuclear rounding.
			***Nuclei lacking atypical = uniform columnar nuclei.
			**Nucleoli.
			**Hyperchromasia or vesicular nuclei.

			Notes:
			*There are no universally accepted criteria for atypia. Different sources list different features.
			*A proposal for atypia (all should be present):
			*#Increased NC ratio.
			#Atypical: ~ 1:2
			#Not atypical: ~1:3.
			*#Oval nuclei with small major axis to minor axis ratio.
			#Atypical: major axis:minor axis = <=2:1.
			#Not atypical: major axis:minor axis = >=3:1
			#*NB: round nuclei: major axis:minor axis = 1:1.
			*#Small nucleoli (~1/5 the size of the nucleus).

			DDx:
			*[[Disordered proliferative phase]].
			*[[Complex endometrial hyperplasia]] - has increased gland-to-stroma ratio.
			*[[Atrophic endometrium\|Cystic atrophy of the endometrium]] - does not have proliferative activity.<ref name=pmid16873562>{{Cite journal \| last1 = McCluggage \| first1 = WG. \| title = My approach to the interpretation of endometrial biopsies and curettings. \| journal = J Clin Pathol \| volume = 59 \| issue = 8 \| pages = 801-12 \| month = Aug \| year = 2006 \| doi = 10.1136/jcp.2005.029702 \| PMID = 16873562 \| PMC = 1860448 }}</ref>
			*[[Benign endometrial polyp]] - has thick-walled blood vessels; simple endometrial hyperplasia should not be diagnosed in a polyp.<ref name=pmid16873562/>

			===Images===
			<gallery>
			Image:Simple_endometrial_hyperplasia_-_low_mag.jpg \| Simple endometrial hyperplasia - low mag. (WC)
			Image:Simple_endometrial_hyperplasia_-_high_mag.jpg \| Simple endometrial hyperplasia - high mag. (WC)
			</gallery>
			www:
			*[http://www.webpathology.com/image.asp?n=1&Case=568 Simple endometrial hyperplasia without atypia (webpathology.com)].

			==See also==
			*[[Endometrium]].
			*[[Endometrial hyperplasia]].

			==References==
			{{Reflist\|2}}

			[[Category:Endometrium]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect w/ cat.

2011-11-06T12:42:35Z

redirect w/ cat.

New page

#redirect [[Endometrial_hyperplasia#Simple_endometrial_hyperplasia]]

[[Category:Diagnosis]]