Sinonasal undifferentiated carcinoma - Revision history

Michael: SMARC4

2023-12-20T18:07:14Z

SMARC4

← Older revision		Revision as of 18:07, 20 December 2023
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	\| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition		\| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition
	\| Subtypes =		\| Subtypes =
	\| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], [[nasopharyngeal carcinoma]], others		\| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], [[SMARCA4-deficient sinonasal carcinoma]], [[nasopharyngeal carcinoma]], others
	\| Stains =		\| Stains =
	\| IHC = pankeratin +ve, [[EMA]] +ve, [[CK7]] +ve, [[CK5/6]] -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, [[p63]] +ve/-ve		\| IHC = pankeratin +ve, [[EMA]] +ve, [[CK7]] +ve, [[CK5/6]] -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, [[p63]] +ve/-ve
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	*[[Small cell carcinoma]].		*[[Small cell carcinoma]].
	*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>		*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>
			*[[SMARCA4-deficient sinonasal carcinoma]].<ref name=pmid34871352>{{cite journal \|authors=Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D \|title=SMARCA4/BRG1-Deficient Sinonasal Carcinoma \|journal=Arch Pathol Lab Med \|volume=146 \|issue=9 \|pages=1122–1130 \|date=September 2022 \|pmid=34871352 \|doi=10.5858/arpa.2021-0001-OA \|url=}}</ref>
	*[[Nasopharyngeal carcinoma]].		*[[Nasopharyngeal carcinoma]].
	*Other tumours, especially [[small round blue cell tumours]] and [[lymphoma]].		*Other tumours, especially [[small round blue cell tumours]] and [[lymphoma]].

Michael at 22:30, 9 October 2021

2021-10-09T22:30:42Z

← Older revision		Revision as of 22:30, 9 October 2021
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	===Comparison between different sinonasal carcinomas===		===Comparison between different sinonasal carcinomas===
	Based on a modest size study, keratins can useful for subclassifying sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|~~vauthors~~=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>		Based on a modest size study, keratins can useful for subclassifying sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|authors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	! Diagnosis		! Diagnosis
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	==Molecular==		==Molecular==
	*EBER -ve.<ref name=pmid11176064>{{cite journal \|~~vauthors~~=Cerilli LA, Holst VA, Brandwein MS, Stoler MH, Mills SE \|title=Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association \|journal=Am J Surg Pathol \|volume=25 \|issue=2 \|pages=156–63 \|date=February 2001 \|pmid=11176064 \|doi=10.1097/00000478-200102000-00003 \|url=}}</ref>		*EBER -ve.<ref name=pmid11176064>{{cite journal \|authors=Cerilli LA, Holst VA, Brandwein MS, Stoler MH, Mills SE \|title=Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association \|journal=Am J Surg Pathol \|volume=25 \|issue=2 \|pages=156–63 \|date=February 2001 \|pmid=11176064 \|doi=10.1097/00000478-200102000-00003 \|url=}}</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2021-10-04T15:04:41Z

Microscopic

← Older revision		Revision as of 15:04, 4 October 2021
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	*[[Small cell carcinoma]].		*[[Small cell carcinoma]].
	*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>		*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>
			*[[Nasopharyngeal carcinoma]].
	*Other tumours, especially [[small round blue cell tumours]] and [[lymphoma]].		*Other tumours, especially [[small round blue cell tumours]] and [[lymphoma]].

Michael at 15:04, 4 October 2021

2021-10-04T15:04:21Z

← Older revision		Revision as of 15:04, 4 October 2021
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	\| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition		\| Micro = tumour with variable architecture (nested, trabecular or lobular), small-to-moderate cytoplasm, +/-distinct nucleoli, cell size variable (small to large); glandular and squamous differentiation are absent by definition
	\| Subtypes =		\| Subtypes =
	\| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], others		\| LMDDx = poorly differentiated [[squamous cell carcinoma of the head and neck]], [[small cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], [[nasopharyngeal carcinoma]], others
	\| Stains =		\| Stains =
	\| IHC = pankeratin +ve, [[EMA]] +ve, [[CK7]] +ve, [[CK5/6]] -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, [[p63]] +ve/-ve		\| IHC = pankeratin +ve, [[EMA]] +ve, [[CK7]] +ve, [[CK5/6]] -ve, NSE +ve/-ve, chromogranin A -ve, synaptophysin -ve, [[p63]] +ve/-ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = [[EBER]] -ve
	\| IF =		\| IF =
	\| Gross =		\| Gross =

Michael: /* Comparison between different sinonasal carcinomas */

2021-10-04T15:03:44Z

Comparison between different sinonasal carcinomas

← Older revision		Revision as of 15:03, 4 October 2021
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	\|-		\|-
	\|}		\|}

			==Molecular==
			*EBER -ve.<ref name=pmid11176064>{{cite journal \|vauthors=Cerilli LA, Holst VA, Brandwein MS, Stoler MH, Mills SE \|title=Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association \|journal=Am J Surg Pathol \|volume=25 \|issue=2 \|pages=156–63 \|date=February 2001 \|pmid=11176064 \|doi=10.1097/00000478-200102000-00003 \|url=}}</ref>

	==See also==		==See also==

Michael: /* Comparison between different sinonasal carcinomas */

2021-10-04T14:32:32Z

Comparison between different sinonasal carcinomas

← Older revision		Revision as of 14:32, 4 October 2021
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	\|-		\|-
	\| Sinonasal undifferentiated carcinoma (SNUC)		\| Sinonasal undifferentiated carcinoma (SNUC)
	\| 0%		\| +0%
	\| 0%		\| +0%
	\| 50%		\| +50%
	\| 0%		\| +0%
	\| 0%		\| +0%
	\| 50%		\| +50%
	\|-		\|-
	\| Nasopharyngeal-type undifferentiated carcinoma (NPTC)		\| Nasopharyngeal-type undifferentiated carcinoma (NPTC)
	\| 0%		\| +0%
	\| 80%		\| +80%
	\| 0%		\| +0%
	\| 80%		\| +80%
	\| 0%		\| +0%
	\| 100%		\| +100%
	\|-		\|-
	\| Nonkeratinizing squamous cell carcinoma (NKSCC)		\| Nonkeratinizing squamous cell carcinoma (NKSCC)
	\| 0%		\| +0%
	\| 90%		\| +90%
	\| 0%		\| +0%
	\| 80%		\| +80%
	\| 80%		\| +80%
	\| 90%		\| +90%
	\|-		\|-
	\|Squamous cell carcinoma (keratainizing)		\|Squamous cell carcinoma (keratainizing)
	\| 30%		\| +30%
	\| 90%		\| +90%
	\| 60%		\| +60%
	\| 90%		\| +90%
	\| 80%		\| +80%
	\| 90%		\| +90%
	\|-		\|-
	\|}		\|}

Michael: /* Comparison between different sinonasal carcinomas */

2021-10-04T14:31:30Z

Comparison between different sinonasal carcinomas

← Older revision		Revision as of 14:31, 4 October 2021
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	===Comparison between different sinonasal carcinomas===		===Comparison between different sinonasal carcinomas===
	Based on a modest size study, keratins can ~~subclassify~~ sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>		Based on a modest size study, keratins can useful for subclassifying sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	! Diagnosis		! Diagnosis

Michael: /* Comparison between different sinonasal carcinomas */

2021-10-04T14:24:56Z

Comparison between different sinonasal carcinomas

← Older revision		Revision as of 14:24, 4 October 2021
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	===Comparison between different sinonasal carcinomas===		===Comparison between different sinonasal carcinomas===
	~~Keratins~~ can subclassify sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>		Based on a modest size study, keratins can subclassify sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	! Diagnosis		! Diagnosis
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	\| 90%		\| 90%
	\|-		\|-
	\|Squamous cell carcinoma, keratainizing ~~(KSCC~~)		\|Squamous cell carcinoma (keratainizing)
	\| 30%		\| 30%
	\| 90%		\| 90%

Michael: /* Comparison between different H&N carcinomas */

2021-10-04T14:23:24Z

Comparison between different H&N carcinomas

← Older revision		Revision as of 14:23, 4 October 2021
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	**Nuclear staining lost in [[SMARCB1-deficient sinonasal carcinoma]].		**Nuclear staining lost in [[SMARCB1-deficient sinonasal carcinoma]].

	===Comparison between different ~~H&N~~ carcinomas===		===Comparison between different sinonasal carcinomas===
	Keratins can subclassify ~~the H&N~~ carcinomas:<~~reF~~>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>		Keratins can subclassify sinonasal carcinomas:<ref name=pmid12459626>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	! Diagnosis		! Diagnosis

Michael: /* IHC */

2021-10-04T14:22:12Z

IHC

← Older revision		Revision as of 14:22, 4 October 2021
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	*SMARCB1 ([[INI1]]) +ve (nuclear staining present).		*SMARCB1 ([[INI1]]) +ve (nuclear staining present).
	**Nuclear staining lost in [[SMARCB1-deficient sinonasal carcinoma]].		**Nuclear staining lost in [[SMARCB1-deficient sinonasal carcinoma]].

			===Comparison between different H&N carcinomas===
			Keratins can subclassify the H&N carcinomas:<reF>{{cite journal \|vauthors=Franchi A, Moroni M, Massi D, Paglierani M, Santucci M \|title=Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns \|journal=Am J Surg Pathol \|volume=26 \|issue=12 \|pages=1597–604 \|date=December 2002 \|pmid=12459626 \|doi=10.1097/00000478-200212000-00007 \|url=}}</ref>
			{\| class="wikitable sortable"
			! Diagnosis
			! CK4
			! CK5/6
			! CK7
			! CK13
			! CK14
			! CK19
			\|-
			\| Sinonasal undifferentiated carcinoma (SNUC)
			\| 0%
			\| 0%
			\| 50%
			\| 0%
			\| 0%
			\| 50%
			\|-
			\| Nasopharyngeal-type undifferentiated carcinoma (NPTC)
			\| 0%
			\| 80%
			\| 0%
			\| 80%
			\| 0%
			\| 100%
			\|-
			\| Nonkeratinizing squamous cell carcinoma (NKSCC)
			\| 0%
			\| 90%
			\| 0%
			\| 80%
			\| 80%
			\| 90%
			\|-
			\|Squamous cell carcinoma, keratainizing (KSCC)
			\| 30%
			\| 90%
			\| 60%
			\| 90%
			\| 80%
			\| 90%
			\|-
			\|}

	==See also==		==See also==