Small vessel leukocytoclastic vasculitis - Revision history

Michael: /* Sign out */

2019-01-03T16:56:38Z

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← Older revision		Revision as of 16:56, 3 January 2019
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	==Sign out==		==Sign out==
			<pre>
			Skin, Left Outer Thigh, Punch Biopsy:
			- Hypersensitivity vasculitis (leukocytoclastic vasculitis).
			</pre>

			===Alternate===
	<pre>		<pre>
	Skin, Right Leg, Punch Biopsy:		Skin, Right Leg, Punch Biopsy:

Michael: +alt term

2019-01-03T16:53:31Z

+alt term

← Older revision		Revision as of 16:53, 3 January 2019
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	\| Width =		\| Width =
	\| Caption = Leukocytoclastic vasculitis. [[H&E stain]].		\| Caption = Leukocytoclastic vasculitis. [[H&E stain]].
	\| Synonyms = leukocytoclastic vasculitis		\| Synonyms = leukocytoclastic vasculitis, hypersensitivity vasculitis
	\| Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)		\| Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)
	\| Subtypes =		\| Subtypes =
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	\| Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression		\| Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression
	}}		}}
	'''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]].		'''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV''') and '''hypersensitivity vasculitis''',<ref name=pmid26176572>{{Cite journal \| last1 = Einhorn \| first1 = J. \| last2 = Levis \| first2 = JT. \| title = Dermatologic Diagnosis: Leukocytoclastic Vasculitis. \| journal = Perm J \| volume = 19 \| issue = 3 \| pages = 77-8 \| month = \| year = 2015 \| doi = 10.7812/TPP/15-001 \| PMID = 26176572 }}</ref> is an inflammatory process of the small [[blood vessel]].

	==General==		==General==

Michael: /* Microscopic */

2018-01-11T23:12:42Z

Microscopic

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	*#Neutrophils.		*#Neutrophils.
	#Fragmentation of [[neutrophil]]s (leukocytoclasia).		#Fragmentation of [[neutrophil]]s (leukocytoclasia).
	*#Vessel damage: fibrin deposition (bright pink acellular stuff).		*#Vessel damage: fibrin deposition (bright pink acellular stuff) or "nuclear dust" (punctate hyperchromatic material).

	DDx:		DDx:

Michael: /* Sign out */

2018-01-11T23:10:54Z

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	- Leukocytoclastic vasculitis.		- Leukocytoclastic vasculitis.
	</pre>		</pre>

			===Micro===
			The sections show red blood cells extravasation and nuclear dust. Scattered neutrophils are within the wall of small blood vessels.

	==See also==		==See also==

Michael: /* See also */ more

2018-01-11T23:04:51Z

Michael at 21:42, 28 November 2016

2016-11-28T21:42:01Z

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	#Vasculitic disorders:		#Vasculitic disorders:
	#*ANCA mediated vasculitides:		#*ANCA mediated vasculitides:
	#**[[Wegener granulomatosis]].		#**[[Granulomatosis with polyangiitis]] (Wegener granulomatosis).
	#**[[Churg-Strauss syndrome]].		#**[[Eosinophilic granulomatosis with polyangiitis]] (Churg-Strauss syndrome).
	#*[[Henoch–Schönlein purpura]].<ref name=pmid9713395>{{Cite journal \| last1 = Kraft \| first1 = DM. \| last2 = Mckee \| first2 = D. \| last3 = Scott \| first3 = C. \| title = Henoch-Schönlein purpura: a review. \| journal = Am Fam Physician \| volume = 58 \| issue = 2 \| pages = 405-8, 411 \| month = Aug \| year = 1998 \| doi = \| PMID = 9713395 }}</ref>		#*[[Henoch–Schönlein purpura]].<ref name=pmid9713395>{{Cite journal \| last1 = Kraft \| first1 = DM. \| last2 = Mckee \| first2 = D. \| last3 = Scott \| first3 = C. \| title = Henoch-Schönlein purpura: a review. \| journal = Am Fam Physician \| volume = 58 \| issue = 2 \| pages = 405-8, 411 \| month = Aug \| year = 1998 \| doi = \| PMID = 9713395 }}</ref>
	#*Urticarial vasculitis.		#*Urticarial vasculitis.

Michael at 04:04, 14 August 2015

2015-08-14T04:04:09Z

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	\| Prognosis = dependent on underlying cause		\| Prognosis = dependent on underlying cause
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = see ''etiology'' section
	\| Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression		\| Tx = remove underlying cause; colchicine and/or dapsone; immunosuppression
	}}		}}

Michael at 04:03, 14 August 2015

2015-08-14T04:03:18Z

← Older revision		Revision as of 04:03, 14 August 2015
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	*Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal \| last1 = Brinster \| first1 = NK. \| title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). \| journal = Adv Anat Pathol \| volume = 15 \| issue = 6 \| pages = 350-69 \| month = Nov \| year = 2008 \| doi = 10.1097/PAP.0b013e31818b1ac6 \| PMID = 18948765 }}</ref>		*Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal \| last1 = Brinster \| first1 = NK. \| title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). \| journal = Adv Anat Pathol \| volume = 15 \| issue = 6 \| pages = 350-69 \| month = Nov \| year = 2008 \| doi = 10.1097/PAP.0b013e31818b1ac6 \| PMID = 18948765 }}</ref>

			Clinical:
			*Palpable purpura, usu. lower extremity.

			Treatment - dependent on cause - may include:<ref name=pmid24756249>{{Cite journal \| last1 = Goeser \| first1 = MR. \| last2 = Laniosz \| first2 = V. \| last3 = Wetter \| first3 = DA. \| title = A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. \| journal = Am J Clin Dermatol \| volume = 15 \| issue = 4 \| pages = 299-306 \| month = Aug \| year = 2014 \| doi = 10.1007/s40257-014-0076-6 \| PMID = 24756249 }}</ref>
			*Remove underlying cause if it can be determined.
			*Colchicine and/or dapsone.
			*Immunosuppression.

			===Etiology===
	Has a very broad DDx:<ref name=pmid18948765/>		Has a very broad DDx:<ref name=pmid18948765/>
	#Infectious:		#Infectious:
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	#*Drugs.		#*Drugs.

	~~Clinical:~~		==Gross==
	*Palpable purpura, usu. lower extremity.		*Palpable purpura - raised lesions that can appreciated with touch, red/purple in colour.

	Treatment - dependent on cause - may include:<ref name=pmid24756249>{{Cite journal \| last1 = Goeser \| first1 = MR. \| last2 = Laniosz \| first2 = V. \| last3 = Wetter \| first3 = DA. \| title = A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. \| journal = Am J Clin Dermatol \| volume = 15 \| issue = 4 \| pages = 299-306 \| month = ~~Aug \| year~~ = ~~2014 \| doi~~ = ~~10.1007/s40257-014-0076-6 \| PMID~~ = ~~24756249 }}</ref>~~
	*~~Remove underlying cause if it~~ can ~~be determined.~~
	*Colchicine and/~~or dapsone.~~
	*Immunosuppression.

	==Microscopic==		==Microscopic==

Michael at 04:00, 14 August 2015

2015-08-14T04:00:46Z

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	\| Width =		\| Width =
	\| Caption = Leukocytoclastic vasculitis. [[H&E stain]].		\| Caption = Leukocytoclastic vasculitis. [[H&E stain]].
	\| Synonyms =		\| Synonyms = leukocytoclastic vasculitis
	\| Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)		\| Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)
	\| Subtypes =		\| Subtypes =

Michael at 04:00, 14 August 2015

2015-08-14T04:00:18Z

← Older revision		Revision as of 04:00, 14 August 2015
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	==See also==		==See also==
	*[[Vasculitides]].		*[[Vasculitides]].
			*[[Inflammatory skin disorders]].

	==References==		==References==

← Older revision		Revision as of 23:04, 11 January 2018
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	==Stains==		==Stains==
	*[[PAS stain\|PAS]] - look for fungus.		*[[PAS stain\|PAS]] - look for fungus.

			==Sign out==
			<pre>
			Skin, Right Leg, Punch Biopsy:
			- Leukocytoclastic vasculitis.
			</pre>

	==See also==		==See also==