Solid pseudopapillary tumour - Revision history

Mitchell: /* Images */ added a case

2016-12-08T16:49:34Z

Images: added a case

← Older revision		Revision as of 16:49, 8 December 2016
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	www:		www:
	*[http://jcp.bmj.com/content/61/11/1153/F1.large.jpg Solid pseudopapillary tumour (bmj.com)].		*[http://jcp.bmj.com/content/61/11/1153/F1.large.jpg Solid pseudopapillary tumour (bmj.com)].
			[[File: PANC solid pseudo 1 sl 1.png\| Solid-pseudopapillary neoplasm of pancreas]]
			[[File: PANC solid pseudo 1 sl 2.png\| Solid-pseudopapillary neoplasm of pancreas]]
			[[File: PANC solid pseudo 1 sl 3.png\| Solid-pseudopapillary neoplasm of pancreas]]
			[[File: PANC solid pseudo 1 sl 4.png\| Solid-pseudopapillary neoplasm of pancreas]]
			[[File: PANC solid pseudo 1 sl 5.png\| Solid-pseudopapillary neoplasm of pancreas]]
			[[File: PANC solid pseudo 1 sl 6.png\| Solid-pseudopapillary neoplasm of pancreas]]

			Solid-pseudopapillary neoplasm of pancreas. A. Tumor with prominent blood vessels and small cyst like spaces contrasts with normal pancreatic acini at right. B. Cohesive cell population. C. More dishesive cell population. D. Vascular pseudopapillae with hyalinized stroma. E. Aggregates of variably sized hyaline globules. Arrow points to longitudinal nuclear groove. F. Sometimes, as here, the cells show varied nuclear sizes and shapes. The cytoplasm, lightly eosinophilic to cleared, can have vacuoles (arrows).

	==IHC==		==IHC==

Michael at 04:57, 21 October 2014

2014-10-21T04:57:18Z

← Older revision		Revision as of 04:57, 21 October 2014
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	\| Tx =		\| Tx =
	}}		}}
	'''Solid pseudopapillary tumour''' is a pancreatic tumour that is usually found in the tail.		'''Solid pseudopapillary tumour''' is a [[pancreas\|pancreatic]] tumour that is usually found in the tail.

	It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref>		It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref>

Michael: /* IHC */

2014-09-13T08:03:31Z

IHC

← Older revision		Revision as of 08:03, 13 September 2014
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	Others:		Others:
	*CD56 +ve.		*[[CD56]] +ve.
	*Chromogranin -ve.		*Chromogranin -ve.

Michael: +infobox

2014-03-05T10:37:14Z

+infobox

← Older revision		Revision as of 10:37, 5 March 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Solid_pseudopapillary_tumour_-_high_mag.jpg
			\| Width =
			\| Caption = Solid pseudopapillary tumour. [[H&E stain]].
			\| Synonyms = solid pseudopapillary neoplasm, solid and papillary epithelial neoplasm
			\| Micro = solid sheets of cells - focally dyscohesive, eosinophilic cytoplasm (occasionally clear), focal eosinophilic (intracytoplasmic) globules, uniform nuclei with occasional nuclear grooves, +/-necrosis (creating spaces/cavities), +/-cholesterol clefts
			\| Subtypes =
			\| LMDDx = [[pancreatic pseudocyst]], cystadenoma, cystadenocarcinoma (see [[invasive ductal carcinoma of the pancreas]]), [[pancreatic neuroendocrine tumour]]
			\| Stains =
			\| IHC = PR +ve, CD10 +ve, beta-catenin +ve, chromogranin -ve, synaptophysin +ve (weak)
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[pancreas]] - usually tail
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = typical young (20s or 30s), women (M:F = 1:9)
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usu. benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Solid pseudopapillary tumour''' is a pancreatic tumour that is usually found in the tail.		'''Solid pseudopapillary tumour''' is a pancreatic tumour that is usually found in the tail.

	It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref>		It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref>

Michael: /* Microscopic */

2014-03-05T10:25:00Z

Microscopic

← Older revision		Revision as of 10:25, 5 March 2014
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	*[[Pancreatic pseudocyst]].		*[[Pancreatic pseudocyst]].
	*Cystadenoma.		*Cystadenoma.
	*Cystadenocarcinoma.		*Cystadenocarcinoma - see [[invasive ductal carcinoma of the pancreas]].
	*[[Pancreatic neuroendocrine tumour]] - may have cytoplasmic vacuolation, [[hyaline globules]].<ref name=pmid18708424/>		*[[Pancreatic neuroendocrine tumour]] - may have cytoplasmic vacuolation, [[hyaline globules]].<ref name=pmid18708424/>

Michael: split out

2014-03-05T10:20:10Z

split out

← Older revision		Revision as of 10:20, 5 March 2014
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	~~#redirect~~ [[~~Pancreas#~~Solid pseudopapillary tumour]]		'''Solid pseudopapillary tumour''' is a pancreatic tumour that is usually found in the tail.
			It is also known as '''solid pseudopapillary neoplasm''' (abbreviation '''SPN''') and '''solid and papillary epithelial neoplasm''' (abbreviated '''SPEN''').<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/360/full.html]. Accessed on: 31 October 2011.</ref>

			==General==
			*Obscure cell of origin.
			*Considered low grade, i.e. prognosis is usually good.

			===Epidemiology===
			Features:<ref name=Ref_GLP493>{{Ref GLP\|493}}</ref>
			*Usually females (M:F=1:9).
			*Mean age of presentation third decade (20s).

			===Management===
			May be followed radiologically.

			==Microscopic==
			Features:<ref>{{Ref GLP\|493-5}}</ref>
			*Solid sheets of cells, focally dyscohesive.
			*Eosinophilic cytoplasm.
			**Occasionally clear cytoplasm.<ref name=pmid18708424>{{cite journal \|author=Serra S, Chetty R \|title=Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas \|journal=J. Clin. Pathol. \|volume=61 \|issue=11 \|pages=1153–9 \|year=2008 \|month=November \|pmid=18708424 \|doi=10.1136/jcp.2008.057828 \|url=http://jcp.bmj.com/content/61/11/1153}}</ref>
			**Focal eosinophilic (intracytoplasmic) globules - '''key feature'''.
			*Uniform nuclei with occasional nuclear grooves.
			*+/-Necrosis - creating spaces/cavities.
			*+/-Cholesterol clefts.<ref name=pmid19156179>{{Cite journal \| last1 = Abad Licham \| first1 = M. \| last2 = Sanchez Lihon \| first2 = J. \| last3 = Celis Zapata \| first3 = J. \| title = [Pseudopapillary solid tumor of pancreas in the INEN]. \| journal = Rev Gastroenterol Peru \| volume = 28 \| issue = 4 \| pages = 356-61 \| month = \| year = \| doi = \| PMID = 19156179 }}</ref>

			DDx:
			*[[Pancreatic pseudocyst]].
			*Cystadenoma.
			*Cystadenocarcinoma.
			*[[Pancreatic neuroendocrine tumour]] - may have cytoplasmic vacuolation, [[hyaline globules]].<ref name=pmid18708424/>

			===Images===
			<gallery>
			Image:Solid_pseudopapillary_tumour_-_very_low_mag.jpg \| SPT - very low mag. (WC)
			Image:Solid_pseudopapillary_tumour_-_low_mag.jpg \| SPT - low mag. (WC)
			Image:Solid_pseudopapillary_tumour_-_intermed_mag.jpg \| SPT - intermed. mag. (WC)
			Image:Solid_pseudopapillary_tumour_-_high_mag.jpg \| SPT - high mag. (WC)
			Image:Solid_pseudopapillary_tumour_-_very_high_mag.jpg \| SPT - very high mag. (WC)
			</gallery>
			www:
			*[http://jcp.bmj.com/content/61/11/1153/F1.large.jpg Solid pseudopapillary tumour (bmj.com)].

			==IHC==
			Features:<ref name=pmid18708424>{{cite journal \|author=Serra S, Chetty R \|title=Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas \|journal=J. Clin. Pathol. \|volume=61 \|issue=11 \|pages=1153–9 \|year=2008 \|month=November \|pmid=18708424 \|doi=10.1136/jcp.2008.057828 \|url=http://jcp.bmj.com/content/61/11/1153}}</ref>
			*Beta-catenin +ve ~100% (cytoplasmic & nuclear).
			*E-cadherin +ve ~100% (cytoplasmic), -ve (membrane); antibody dependent.
			*CD10 +ve ~ 80% (cytoplasmic + dot-like) '''key'''.
			*Synaptophysin +ve (weak cytoplasmic) ~70%.
			*Progesterone receptor +ve (nuclear) '''key'''.

			Others:
			*CD56 +ve.
			*Chromogranin -ve.

			Memory device ''PCB'': '''P'''R (nuclear), '''C'''D10 (cytoplasmic), '''b'''eta-catenin (cytoplasmic & nuclear).

			==See also==
			*[[Pancreas]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Pancreas]]

Michael: +cat.

2011-10-18T03:45:11Z

+cat.

← Older revision		Revision as of 03:45, 18 October 2011
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	#redirect [[Pancreas#Solid pseudopapillary tumour]]		#redirect [[Pancreas#Solid pseudopapillary tumour]]

			[[Category:Diagnosis]]

Michael: redirect for now

2011-08-06T20:40:37Z

redirect for now

New page

#redirect [[Pancreas#Solid pseudopapillary tumour]]