Solitary fibrous tumour of the pleura - Revision history

Michael at 20:51, 20 February 2014

2014-02-20T20:51:42Z

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	*Uncommon overall<ref name=pmid24326857/> ~ 800 cases reported.<ref name=pmid17075563>{{Cite journal \| last1 = Robinson \| first1 = LA. \| title = Solitary fibrous tumor of the pleura. \| journal = Cancer Control \| volume = 13 \| issue = 4 \| pages = 264-9 \| month = Oct \| year = 2006 \| doi = \| PMID = 17075563 }}</ref>		*Uncommon overall<ref name=pmid24326857/> ~ 800 cases reported.<ref name=pmid17075563>{{Cite journal \| last1 = Robinson \| first1 = LA. \| title = Solitary fibrous tumor of the pleura. \| journal = Cancer Control \| volume = 13 \| issue = 4 \| pages = 264-9 \| month = Oct \| year = 2006 \| doi = \| PMID = 17075563 }}</ref>
	**Common for the anatomical site.		**Common for the anatomical site.
	*Usually benign.		*Usually benign ~ 80% of the time.<ref name=pmid17075563/>
	*Slow growing.<ref name=pmid24326857>{{Cite journal \| last1 = Mordenti \| first1 = P. \| last2 = Di Cicilia \| first2 = R. \| last3 = Delfanti \| first3 = R. \| last4 = Capelli \| first4 = P. \| last5 = Paties \| first5 = C. \| last6 = Cavanna \| first6 = L. \| title = Solitary fibrous tumors of the pleura: a case report and review of the literature. \| journal = Tumori \| volume = 99 \| issue = 4 \| pages = e177-83 \| month = \| year = \| doi = 10.1700/1361.15120 \| PMID = 24326857 }}</ref>		*Slow growing.<ref name=pmid24326857>{{Cite journal \| last1 = Mordenti \| first1 = P. \| last2 = Di Cicilia \| first2 = R. \| last3 = Delfanti \| first3 = R. \| last4 = Capelli \| first4 = P. \| last5 = Paties \| first5 = C. \| last6 = Cavanna \| first6 = L. \| title = Solitary fibrous tumors of the pleura: a case report and review of the literature. \| journal = Tumori \| volume = 99 \| issue = 4 \| pages = e177-83 \| month = \| year = \| doi = 10.1700/1361.15120 \| PMID = 24326857 }}</ref>
	*Elderly.		*Elderly.
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	==Gross/radiology==		==Gross/radiology==
	*Chest wall mass.		*Chest wall mass.
			**May be "large".<ref name=pmid17075563/>

	==Microscopic==		==Microscopic==

Michael at 20:49, 20 February 2014

2014-02-20T20:49:52Z

← Older revision		Revision as of 20:49, 20 February 2014
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	==General==		==General==
	*Uncommon overall.<ref name=~~pmid24326857~~/>		*Uncommon overall<ref name=pmid24326857/> ~ 800 cases reported.<ref name=pmid17075563>{{Cite journal \| last1 = Robinson \| first1 = LA. \| title = Solitary fibrous tumor of the pleura. \| journal = Cancer Control \| volume = 13 \| issue = 4 \| pages = 264-9 \| month = Oct \| year = 2006 \| doi = \| PMID = 17075563 }}</ref>
	**Common for the anatomical site.		**Common for the anatomical site.
	*Usually benign.		*Usually benign.

Michael: /* Images */

2014-02-20T20:45:19Z

Images

← Older revision		Revision as of 20:45, 20 February 2014
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	www:		www:
	*[http://path.upmc.edu/cases/case216/dx.html SFT (upmc.edu)].		*[http://path.upmc.edu/cases/case216/dx.html SFT (upmc.edu)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698259/figure/f2/ Pleural SFT (nih.gov)].<ref name=pmid23825765/>

	==IHC==		==IHC==

Michael: /* IHC */

2014-02-20T20:44:01Z

IHC

← Older revision		Revision as of 20:44, 20 February 2014
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	*WT1 -ve (+ve in 1 of 10 cases<ref name=pmid18528287>{{Cite journal \| last1 = Bing \| first1 = Z. \| last2 = Pasha \| first2 = TL. \| last3 = Acs \| first3 = G. \| last4 = Zhang \| first4 = PJ. \| title = Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors. \| journal = Appl Immunohistochem Mol Morphol \| volume = 16 \| issue = 4 \| pages = 316-21 \| month = Jul \| year = 2008 \| doi = 10.1097/PAI.0b013e31815c2e02 \| PMID = 18528287 }}</ref>).		*WT1 -ve (+ve in 1 of 10 cases<ref name=pmid18528287>{{Cite journal \| last1 = Bing \| first1 = Z. \| last2 = Pasha \| first2 = TL. \| last3 = Acs \| first3 = G. \| last4 = Zhang \| first4 = PJ. \| title = Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors. \| journal = Appl Immunohistochem Mol Morphol \| volume = 16 \| issue = 4 \| pages = 316-21 \| month = Jul \| year = 2008 \| doi = 10.1097/PAI.0b013e31815c2e02 \| PMID = 18528287 }}</ref>).
	*Desmin -ve.<ref name=pmid23825765>{{Cite journal \| last1 = Zhu \| first1 = Y. \| last2 = Du \| first2 = K. \| last3 = Ye \| first3 = X. \| last4 = Song \| first4 = D. \| last5 = Long \| first5 = D. \| title = Solitary fibrous tumors of pleura and lung: report of twelve cases. \| journal = J Thorac Dis \| volume = 5 \| issue = 3 \| pages = 310-3 \| month = Jun \| year = 2013 \| doi = 10.3978/j.issn.2072-1439.2013.05.19 \| PMID = 23825765 }}</ref>		*Desmin -ve.<ref name=pmid23825765>{{Cite journal \| last1 = Zhu \| first1 = Y. \| last2 = Du \| first2 = K. \| last3 = Ye \| first3 = X. \| last4 = Song \| first4 = D. \| last5 = Long \| first5 = D. \| title = Solitary fibrous tumors of pleura and lung: report of twelve cases. \| journal = J Thorac Dis \| volume = 5 \| issue = 3 \| pages = 310-3 \| month = Jun \| year = 2013 \| doi = 10.3978/j.issn.2072-1439.2013.05.19 \| PMID = 23825765 }}</ref>
			*CD117 -ve.<ref name=pmid23825765/>

	Suggested stains:{{fact}}		Suggested stains:{{fact}}

Michael: /* IHC */

2014-02-20T20:43:11Z

IHC

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	Others:		Others:
	*WT1 -ve (+ve in 1 of 10 cases<ref name=pmid18528287>{{Cite journal \| last1 = Bing \| first1 = Z. \| last2 = Pasha \| first2 = TL. \| last3 = Acs \| first3 = G. \| last4 = Zhang \| first4 = PJ. \| title = Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors. \| journal = Appl Immunohistochem Mol Morphol \| volume = 16 \| issue = 4 \| pages = 316-21 \| month = Jul \| year = 2008 \| doi = 10.1097/PAI.0b013e31815c2e02 \| PMID = 18528287 }}</ref>).		*WT1 -ve (+ve in 1 of 10 cases<ref name=pmid18528287>{{Cite journal \| last1 = Bing \| first1 = Z. \| last2 = Pasha \| first2 = TL. \| last3 = Acs \| first3 = G. \| last4 = Zhang \| first4 = PJ. \| title = Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors. \| journal = Appl Immunohistochem Mol Morphol \| volume = 16 \| issue = 4 \| pages = 316-21 \| month = Jul \| year = 2008 \| doi = 10.1097/PAI.0b013e31815c2e02 \| PMID = 18528287 }}</ref>).
			*Desmin -ve.<ref name=pmid23825765>{{Cite journal \| last1 = Zhu \| first1 = Y. \| last2 = Du \| first2 = K. \| last3 = Ye \| first3 = X. \| last4 = Song \| first4 = D. \| last5 = Long \| first5 = D. \| title = Solitary fibrous tumors of pleura and lung: report of twelve cases. \| journal = J Thorac Dis \| volume = 5 \| issue = 3 \| pages = 310-3 \| month = Jun \| year = 2013 \| doi = 10.3978/j.issn.2072-1439.2013.05.19 \| PMID = 23825765 }}</ref>

	Suggested stains:{{fact}}		Suggested stains:{{fact}}

Michael: /* IHC */

2014-02-20T20:41:17Z

IHC

← Older revision		Revision as of 20:41, 20 February 2014
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	*CD99 +ve (23/23 cases<ref name=pmid15460417/>).		*CD99 +ve (23/23 cases<ref name=pmid15460417/>).
	*SMA -ve/+ve (7 +ve/23 cases<ref name=pmid15460417/>).		*SMA -ve/+ve (7 +ve/23 cases<ref name=pmid15460417/>).

			Others:
			*WT1 -ve (+ve in 1 of 10 cases<ref name=pmid18528287>{{Cite journal \| last1 = Bing \| first1 = Z. \| last2 = Pasha \| first2 = TL. \| last3 = Acs \| first3 = G. \| last4 = Zhang \| first4 = PJ. \| title = Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors. \| journal = Appl Immunohistochem Mol Morphol \| volume = 16 \| issue = 4 \| pages = 316-21 \| month = Jul \| year = 2008 \| doi = 10.1097/PAI.0b013e31815c2e02 \| PMID = 18528287 }}</ref>).

	Suggested stains:{{fact}}		Suggested stains:{{fact}}

Michael: /* Micro */

2014-02-18T15:38:24Z

Micro

← Older revision		Revision as of 15:38, 18 February 2014
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	===Micro===		===Micro===
	The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.		The sections show cellular fibrous tissue with a patternless pattern. Rare staghorn vessels are present. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent.

	==See also==		==See also==

Michael: /* Microscopic */

2014-02-18T03:42:19Z

Microscopic

← Older revision		Revision as of 03:42, 18 February 2014
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	*Patternless pattern.		*Patternless pattern.
	*+/-Ropy collagen.		*+/-Ropy collagen.
			*[[Staghorn vessels]].

	Suggestive of malignant:<ref name=pmid24088920/>		Suggestive of malignant:<ref name=pmid24088920/>

Michael at 03:39, 18 February 2014

2014-02-18T03:39:38Z

← Older revision		Revision as of 03:39, 18 February 2014
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	\| Site = pleura of [[lung]]		\| Site = pleura of [[lung]]
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes = Doege-Potter syndrome
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs = +/-impaired respiratory function (due to mass effect)		\| Signs = +/-impaired respiratory function (due to mass effect)
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	*Elderly.		*Elderly.
	*May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal \| last1 = Abe \| first1 = M. \| last2 = Nomori \| first2 = H. \| last3 = Fukazawa \| first3 = M. \| last4 = Sugimura \| first4 = H. \| last5 = Narita \| first5 = M. \| last6 = Takeshi \| first6 = A. \| title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. \| journal = Ann Thorac Cardiovasc Surg \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = \| PMID = 24088920 }}</ref>		*May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal \| last1 = Abe \| first1 = M. \| last2 = Nomori \| first2 = H. \| last3 = Fukazawa \| first3 = M. \| last4 = Sugimura \| first4 = H. \| last5 = Narita \| first5 = M. \| last6 = Takeshi \| first6 = A. \| title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. \| journal = Ann Thorac Cardiovasc Surg \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = \| PMID = 24088920 }}</ref>
			*May be associated with hypoglycemia.
			**Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal \| last1 = Roy \| first1 = TM. \| last2 = Burns \| first2 = MV. \| last3 = Overly \| first3 = DJ. \| last4 = Curd \| first4 = BT. \| title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. \| journal = J Ky Med Assoc \| volume = 90 \| issue = 11 \| pages = 557-60 \| month = Nov \| year = 1992 \| doi = \| PMID = 1474302 }}</ref>

	==Gross/radiology==		==Gross/radiology==
	*Chest wall.		*Chest wall mass.

	==Microscopic==		==Microscopic==

Michael: +infobox

2014-02-18T03:37:24Z

+infobox

← Older revision		Revision as of 03:37, 18 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Pleural solitary fibrous tumor (2).jpg
			\| Width =
			\| Caption = Pleural solitary fibrous tumour. [[H&E stain]].
			\| Synonyms =
			\| Micro = spindle cells usually with a bland cytology, patternless pattern, +/-ropy collagen
			\| Subtypes =
			\| LMDDx = CD34 +ve, CD99 +ve, BCL2 +ve, S-100 -ve
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = pleura of [[lung]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = +/-impaired respiratory function (due to mass effect)
			\| Symptoms =
			\| Prevalence = common for site, uncommon overall
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usu. benign
			\| Other =
			\| ClinDDx =
			\| Tx = surgery
			}}
	'''Solitary fibrous tumour of the pleura''', also '''pleural solitary fibrous tumour''', is a relatively common chest wall tumour.		'''Solitary fibrous tumour of the pleura''', also '''pleural solitary fibrous tumour''', is a relatively common chest wall tumour.