Spermatocytic tumour - Revision history

Michael at 16:15, 4 November 2024

2024-11-04T16:15:06Z

← Older revision		Revision as of 16:15, 4 November 2024
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	\| Width =		\| Width =
	\| Caption = Spermatocytic tumour		\| Caption = Spermatocytic tumour
	\| Synonyms = spermatocytic seminoma (old term)		\| Synonyms = spermatocytic seminoma (old term, not recommended by World Health Organization)
	\| Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread		\| Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread
	\| Subtypes =		\| Subtypes =

Michael: tweak

2024-10-31T21:00:55Z

tweak

← Older revision		Revision as of 21:00, 31 October 2024
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	The tumour stains as follows:		The tumour stains as follows:
	POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse~~), CAM5.2 (dot-like staining~~), BCL2 (scattered cells, moderate membranous).		POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), BCL2 (scattered cells, moderate membranous).
	NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4.		NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4, CAM5.2, D2-40.

	This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the World Health Organization, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS).		This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the World Health Organization, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS).

Michael at 15:09, 25 October 2024

2024-10-25T15:09:42Z

← Older revision		Revision as of 15:09, 25 October 2024
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	NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4.		NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4.

	This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the ~~WHO~~, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS).		This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the World Health Organization, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS).
	</pre>		</pre>

Michael at 15:09, 25 October 2024

2024-10-25T15:09:00Z

← Older revision		Revision as of 15:09, 25 October 2024
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	\| LMDDx = [[DLBCL]], [[seminoma]]		\| LMDDx = [[DLBCL]], [[seminoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = SALL4 +ve, OCT3/4 -ve, CD117 +ve/-ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
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	*CD117 -ve (7 positive/17).		*CD117 -ve (7 positive/17).
	*CAM5.2 -ve (1 positive/17).		*CAM5.2 -ve (1 positive/17).

			Others:<ref>{{Ref WHOGU2022\|289}}</ref>
			*SALL4 +ve.
			*OCT3/4 -ve.
			*AFP -ve.
			*CD30 -ve.
			*Beta-hCG -ve.

	==Sign out==		==Sign out==

Michael at 15:05, 25 October 2024

2024-10-25T15:05:28Z

← Older revision		Revision as of 15:05, 25 October 2024
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	The tumour stains as follows:		The tumour stains as follows:
	POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), CAM5.2 (dot-like staining), BCL2 (scattered cells, moderate membranous)		POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), CAM5.2 (dot-like staining), BCL2 (scattered cells, moderate membranous).
	NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4.		NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4.

Michael at 15:05, 25 October 2024

2024-10-25T15:05:03Z

← Older revision		Revision as of 15:05, 25 October 2024
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	*CD117 -ve (7 positive/17).		*CD117 -ve (7 positive/17).
	*CAM5.2 -ve (1 positive/17).		*CAM5.2 -ve (1 positive/17).

			==Sign out==
			<pre>
			Left Testis, Radical Orchiectomy:
			- Spermatocytic tumour, see comment.
			- NEGATIVE for germ cell neoplasia in situ.
			- Background testis with spermatogenesis and atrophy.

			Comment:
			Spermatocytic tumours are rare. They are not associated with germ cell neoplasia in situ (GCNIS) and typically not seen together with other germ cell types.

			The tumour stains as follows:
			POSITIVE: CD117 (moderate, patchy), SALL4 (moderate, diffuse), CAM5.2 (dot-like staining), BCL2 (scattered cells, moderate membranous)
			NEGATIVE: AE1/AE3, AFP, CD31, CD34, calretinin, hCG, CD3, CD10, CD20, CD30, CD45, GATA3, PLAP, PSA, OCT3/4.

			This tumour (spermatoctyic tumour) was previously known as "spermatocytic seminoma". The term "spermatocytic seminoma" is no longer recommended by the WHO, presumably as the name may: (1) create confusion with "seminoma" and (2) falsely raise the possibility of a mixed tumour (that develops in the context of GCNIS).
			</pre>

			===Micro===
			This tumour has three cell types with spireme chromatin in the larger and intermediate cell type. Infiltrating lymphocytes are absent.

			The background testis has some spermatogenesis and atrophic change. Germ cell neoplasia in situ (GCNIS) is ABSENT. The seminiferous tubules adjacent to the tumour, where visualized, are atrophic.

	==See also==		==See also==

Mark: correct missing .jpg extension

2018-09-30T16:18:55Z

correct missing .jpg extension

← Older revision		Revision as of 16:18, 30 September 2018
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	Image:Spermatocytic_seminoma_high_mag.jpg \| Spermatocytic tumour - high mag. (WC)		Image:Spermatocytic_seminoma_high_mag.jpg \| Spermatocytic tumour - high mag. (WC)
	Image:Spermatocytic_seminoma_intermed_mag.jpg \| Spermatocytic tumour - intermed. mag. (WC)		Image:Spermatocytic_seminoma_intermed_mag.jpg \| Spermatocytic tumour - intermed. mag. (WC)
	Image:testicular spermatocytic tumour high mag \| Spermatocytic tumour - high mag. (WC)		Image:testicular spermatocytic tumour high mag.jpg \| Spermatocytic tumour - high mag. (WC)
	</gallery>		</gallery>

Mark: add image

2018-09-30T16:18:25Z

add image

← Older revision		Revision as of 16:18, 30 September 2018
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	Image:Spermatocytic_seminoma_high_mag.jpg \| Spermatocytic tumour - high mag. (WC)		Image:Spermatocytic_seminoma_high_mag.jpg \| Spermatocytic tumour - high mag. (WC)
	Image:Spermatocytic_seminoma_intermed_mag.jpg \| Spermatocytic tumour - intermed. mag. (WC)		Image:Spermatocytic_seminoma_intermed_mag.jpg \| Spermatocytic tumour - intermed. mag. (WC)
			Image:testicular spermatocytic tumour high mag \| Spermatocytic tumour - high mag. (WC)
	</gallery>		</gallery>

Michael at 04:40, 22 March 2016

2016-03-22T04:40:54Z

← Older revision		Revision as of 04:40, 22 March 2016
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	\| Width =		\| Width =
	\| Caption = Spermatocytic tumour		\| Caption = Spermatocytic tumour
			\| Synonyms = spermatocytic seminoma (old term)
	\| Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread		\| Micro = three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread
	\| Subtypes =		\| Subtypes =
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	\| Other =		\| Other =
	\| ClinDDx = other [[germ cell tumours]], [[lymphoma]]		\| ClinDDx = other [[germ cell tumours]], [[lymphoma]]
			\| Tx = excision to exclude malignancy
	}}		}}
	'''Spermatocytic tumour''' is a rare benign testicular tumour.		'''Spermatocytic tumour''' is a rare benign testicular tumour.

Michael: /* General */

2016-03-15T23:30:43Z

General

← Older revision		Revision as of 23:30, 15 March 2016
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	===Epidemiology===		===Epidemiology===
	*Does ''not'' arise from ''[[germ cell neoplasia in situ]]'' (previously known as ''intratubular germ cell neoplasia'').<ref name=pmid3583416>{{cite journal \|author=Müller J, Skakkebaek NE, Parkinson MC \|title=The spermatocytic seminoma: views on pathogenesis \|journal=Int. J. Androl. \|volume=10 \|issue=1 \|pages=147–56 \|year=1987 \|month=February \|pmid=3583416 \|doi= 10.1111/j.1365-2605.1987.tb00176.x\|url=}}</ref> - '''not''' considered a subtype of [[seminoma]].		*Does ''not'' arise from ''[[germ cell neoplasia in situ]]'' (previously known as ''intratubular germ cell neoplasia'')<ref name=pmid3583416>{{cite journal \|author=Müller J, Skakkebaek NE, Parkinson MC \|title=The spermatocytic seminoma: views on pathogenesis \|journal=Int. J. Androl. \|volume=10 \|issue=1 \|pages=147–56 \|year=1987 \|month=February \|pmid=3583416 \|doi= 10.1111/j.1365-2605.1987.tb00176.x\|url=}}</ref> - '''not''' considered a subtype of [[seminoma]].

	==Microscopic==		==Microscopic==