Spitz nevus - Revision history

Michael: /* Microscopic */

2018-02-23T20:44:12Z

Microscopic

← Older revision		Revision as of 20:44, 23 February 2018
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	*Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal \| last1 = Kirkwood \| first1 = John M. \| last2 = Jukic \| first2 = Drazen \| last3 = Averbook \| first3 = Bruce J. \| last4 = Sender \| first4 = Leonard S. \| title = Melanoma in Pediatric, Adolescent, and Young Adult Patients \| journal = Semin Oncol. \| volume = 36 \| issue = 5 \| pages = 419-31 \| month = October \| year = 2009 \| doi = \| PMID = \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez \|PMC = 2797485 }}</ref>		*Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal \| last1 = Kirkwood \| first1 = John M. \| last2 = Jukic \| first2 = Drazen \| last3 = Averbook \| first3 = Bruce J. \| last4 = Sender \| first4 = Leonard S. \| title = Melanoma in Pediatric, Adolescent, and Young Adult Patients \| journal = Semin Oncol. \| volume = 36 \| issue = 5 \| pages = 419-31 \| month = October \| year = 2009 \| doi = \| PMID = \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez \|PMC = 2797485 }}</ref>
	**Kamino bodies are rare in melanoma.		**Kamino bodies are rare in melanoma.
	**Pathogenesis uncertain - ~~the~~ classic teachng is Kamino bodies are apoptotic cells; however, this is disputed.<ref name=pmid9855350>{{Cite journal \| last1 = Wesselmann \| first1 = U. \| last2 = Becker \| first2 = LR. \| last3 = Bröcker \| first3 = EB. \| last4 = LeBoit \| first4 = PE. \| last5 = Bastian \| first5 = BC. \| title = Eosinophilic globules in spitz nevi: no evidence for apoptosis. \| journal = Am J Dermatopathol \| volume = 20 \| issue = 6 \| pages = 551-4 \| month = Dec \| year = 1998 \| doi = \| PMID = 9855350 }}</ref>		**Pathogenesis uncertain - probably represent aggregates of basement membrane material.<ref name=pmid9855349>{{Cite journal \| last1 = Skelton \| first1 = HG. \| last2 = Miller \| first2 = ML. \| last3 = Lupton \| first3 = GP. \| last4 = Smith \| first4 = KJ. \| title = Eosinophilic globules in spindle cell and epithelioid cell nevi: composition and possible origin. \| journal = Am J Dermatopathol \| volume = 20 \| issue = 6 \| pages = 547-50 \| month = Dec \| year = 1998 \| doi = \| PMID = 9855349 }}</ref>
			***The classic teachng is Kamino bodies are apoptotic cells; however, this is disputed by evidence.<ref name=pmid9855350>{{Cite journal \| last1 = Wesselmann \| first1 = U. \| last2 = Becker \| first2 = LR. \| last3 = Bröcker \| first3 = EB. \| last4 = LeBoit \| first4 = PE. \| last5 = Bastian \| first5 = BC. \| title = Eosinophilic globules in spitz nevi: no evidence for apoptosis. \| journal = Am J Dermatopathol \| volume = 20 \| issue = 6 \| pages = 551-4 \| month = Dec \| year = 1998 \| doi = \| PMID = 9855350 }}</ref>
	Notes:		Notes:
	*'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref>		*'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref>

Michael: /* Microscopic */ tweak

2018-02-23T20:40:11Z

Microscopic: tweak

← Older revision		Revision as of 20:40, 23 February 2018
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	*+/-[[Acanthosis]] (thick stratum spinosum).		*+/-[[Acanthosis]] (thick stratum spinosum).
	*Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal \| last1 = Kirkwood \| first1 = John M. \| last2 = Jukic \| first2 = Drazen \| last3 = Averbook \| first3 = Bruce J. \| last4 = Sender \| first4 = Leonard S. \| title = Melanoma in Pediatric, Adolescent, and Young Adult Patients \| journal = Semin Oncol. \| volume = 36 \| issue = 5 \| pages = 419-31 \| month = October \| year = 2009 \| doi = \| PMID = \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez \|PMC = 2797485 }}</ref>		*Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal \| last1 = Kirkwood \| first1 = John M. \| last2 = Jukic \| first2 = Drazen \| last3 = Averbook \| first3 = Bruce J. \| last4 = Sender \| first4 = Leonard S. \| title = Melanoma in Pediatric, Adolescent, and Young Adult Patients \| journal = Semin Oncol. \| volume = 36 \| issue = 5 \| pages = 419-31 \| month = October \| year = 2009 \| doi = \| PMID = \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez \|PMC = 2797485 }}</ref>
	**Apoptotic cells.
	**Kamino bodies are rare in melanoma.		**Kamino bodies are rare in melanoma.
			**Pathogenesis uncertain - the classic teachng is Kamino bodies are apoptotic cells; however, this is disputed.<ref name=pmid9855350>{{Cite journal \| last1 = Wesselmann \| first1 = U. \| last2 = Becker \| first2 = LR. \| last3 = Bröcker \| first3 = EB. \| last4 = LeBoit \| first4 = PE. \| last5 = Bastian \| first5 = BC. \| title = Eosinophilic globules in spitz nevi: no evidence for apoptosis. \| journal = Am J Dermatopathol \| volume = 20 \| issue = 6 \| pages = 551-4 \| month = Dec \| year = 1998 \| doi = \| PMID = 9855350 }}</ref>
	Notes:		Notes:
	*'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref>		*'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref>

Michael at 01:32, 6 December 2013

2013-12-06T01:32:36Z

← Older revision		Revision as of 01:32, 6 December 2013
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	\| ClinDDx = [[melanoma]], other [[melanocytic lesions]]		\| ClinDDx = [[melanoma]], other [[melanocytic lesions]]
	}}		}}
	'''Spitz nevus''', also known as '''epithelioid and spindle-cell nevus''', is an uncommon [[melanocytic lesion]] that can be difficult to differentiate from [[malignant melanoma]].		'''Spitz nevus''', also known as '''epithelioid and spindle cell nevus''', is an uncommon [[melanocytic lesion]] that can be difficult to differentiate from [[malignant melanoma]].

	==General==		==General==

Michael at 01:23, 6 December 2013

2013-12-06T01:23:39Z

← Older revision		Revision as of 01:23, 6 December 2013
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	'''Spitz nevus''', also known as ''epithelioid and spindle-cell nevus''', is an uncommon [[melanocytic lesion]] that can be difficult to differentiate from [[malignant melanoma]].		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Spitz_nevus_-_high_mag.jpg
			\| Width =
			\| Caption = Spitz nevus. [[H&E stain]].
			\| Micro = nests of cells (spindle, epithelioid or spindle/epithelioid) - in both dermis and epidermis - nests are vertically arranged ("hanging bananas"), +/-hyperkeratosis, +/-hypergranulosis, +/-[[acanthosis]] (thick stratum spinosum), Kamino bodies - dense eosinophilic bodies (rare in melanoma)
			\| Subtypes =
			\| LMDDx = [[malignant melanoma]], [[pigmented spindle cell nevus of Reed]]
			\| Stains = HMB-45 -ve deep aspect, Ki-67 usu. low
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin]] - typically face or extremity
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = children and adolescents
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = [[melanoma]], other [[melanocytic lesions]]
			}}
			'''Spitz nevus''', also known as '''epithelioid and spindle-cell nevus''', is an uncommon [[melanocytic lesion]] that can be difficult to differentiate from [[malignant melanoma]].

	==General==		==General==

Michael: split-out

2013-12-06T01:18:13Z

split-out

← Older revision		Revision as of 01:18, 6 December 2013
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	~~#redirect~~ [[~~Melanocytic_lesions#Spitz_nevus~~]]		'''Spitz nevus''', also known as ''epithelioid and spindle-cell nevus''', is an uncommon [[melanocytic lesion]] that can be difficult to differentiate from [[malignant melanoma]].

			==General==
			*May be very difficult to differentiate from [[melanoma]].

			Epidemiology:
			*Children & adolescents.

			Treatment:
			*Complete excision.<ref name=pmid12140468>{{Cite journal \| last1 = Gelbard \| first1 = SN. \| last2 = Tripp \| first2 = JM. \| last3 = Marghoob \| first3 = AA. \| last4 = Kopf \| first4 = AW. \| last5 = Koenig \| first5 = KL. \| last6 = Kim \| first6 = JY. \| last7 = Bart \| first7 = RS. \| title = Management of Spitz nevi: a survey of dermatologists in the United States. \| journal = J Am Acad Dermatol \| volume = 47 \| issue = 2 \| pages = 224-30 \| month = Aug \| year = 2002 \| doi = \| PMID = 12140468 }}</ref>

			==Gross==
			*Usually face ''or'' extremity.<ref name=Ref_Derm449>{{Ref Derm\|449}}</ref>

			==Microscopic==
			Features:<ref name=Ref_WMSP499>{{Ref WMSP\|499}}</ref>
			*Architecture:
			**Nests of cells (spindle, epithelioid or spindle/epithelioid) - in both dermis and epidermis.
			***Nests are vertically arranged, i.e. the long axis of the nests are perpendicular to the skin surface.
			****Nest arrangement/orientation described as "cluster of bananas".
			*+/-Hyperkeratosis (more keratin, i.e. thick stratum corneum).
			*+/-Hypergranulosis (thick stratum granulosum).
			*+/-[[Acanthosis]] (thick stratum spinosum).
			*Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal \| last1 = Kirkwood \| first1 = John M. \| last2 = Jukic \| first2 = Drazen \| last3 = Averbook \| first3 = Bruce J. \| last4 = Sender \| first4 = Leonard S. \| title = Melanoma in Pediatric, Adolescent, and Young Adult Patients \| journal = Semin Oncol. \| volume = 36 \| issue = 5 \| pages = 419-31 \| month = October \| year = 2009 \| doi = \| PMID = \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez \|PMC = 2797485 }}</ref>
			**Apoptotic cells.
			**Kamino bodies are rare in melanoma.

			Notes:
			*'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref>
			**If there is solar elastosis -- it's melanoma.

			DDx:
			*[[Malignant melanoma]] - so-called ''Spitzoid melanoma''.
			*[[Pigmented spindle cell nevus of Reed]].

			===Images===
			<gallery>
			Image:Spitz_nevus_-_low_mag.jpg \| Spitz nevus - low mag. (WC)
			Image:Spitz_nevus_-_intermed_mag.jpg \| Spitz nevus - intermed. mag. (WC)
			Image:Spitz_nevus_-_high_mag.jpg \| Spitz nevus - high mag. (WC)
			</gallery>
			www:
			*[http://www.drmihm.com/cases/case.cfm?CaseID=51 Spitz nevus - collection of images (drmihm.com)].
			*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=006734 Spitz nevus with arrow to camino body (unibas.ch)].

			==IHC==
			*HMB-45 -ve at deep aspect.
			*Ki-67 low.

			==See also==
			*[[Melanocytic lesions]].
			*[[Malignant melanoma]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Melanocytic lesions]]

Michael: redirect

2011-10-18T03:14:17Z

redirect

← Older revision		Revision as of 03:14, 18 October 2011
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	#redirect [[Melanocytic_lesions#Spitz_nevus]]		#redirect [[Melanocytic_lesions#Spitz_nevus]]

			[[Category:Diagnosis]]

Michael: redirect to melanocytic lesions article

2011-05-18T15:30:00Z

redirect to melanocytic lesions article

New page

#redirect [[Melanocytic_lesions#Spitz_nevus]]