Squamous cell carcinoma - Revision history

Michael: split out

2024-03-19T14:25:49Z

split out

← Older revision		Revision as of 14:25, 19 March 2024
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	==Verrucous squamous cell carcinoma==		==Verrucous squamous cell carcinoma==
	*[[AKA]] ''verrucous carcinoma''.		*[[AKA]] ''verrucous carcinoma''.
			{{Main\|Verrucous carcinoma}}
	~~===General===~~
	*Good prognosis.
	*Histomorphologically deceptively bland, i.e. non-malignant appearing.
	*Wart-like (verruca = [[wart]]).
	*The clinical history, e.g. ''huge verrucous cancer'', is often important for making the diagnosis.

	~~===Microscopic===~~
	~~Features:~~
	*Exophytic growth.
	*Well-differentiated.
	*"Glassy" appearance.
	*Pushing border - described "elephant feet".

	~~DDx:~~
	*[[Papilloma]].
	*[[Wart]].

	~~====Images====~~
	*[http://www.juniordentist.com/wp-content/uploads/2011/06/Verrucous-carcinoma-histology.jpg Verrucous carcinoma (juniordentist.com)].<ref>URL: [http://www.juniordentist.com/verrucous-carcinoma.html http://www.juniordentist.com/verrucous-carcinoma.html]. Accessed on: 3 April 2012.</ref>
	*[http://www.pathologyoutlines.com/images/prostate/psverrucous_scc_01.jpg Verrucous SCC (pathologyoutlines.com)].

	==Spindle cell squamous carcinoma==		==Spindle cell squamous carcinoma==

Michael: /* Microscopic */

2021-03-01T17:27:50Z

Microscopic

← Older revision		Revision as of 17:27, 1 March 2021
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	*Acanthosis.		*Acanthosis.

			<!--
	Image:		Image:
	*[http://www.cmaj.ca/content/177/3/249.2/F2.expansion.html Carcinoma cuniculatum (cmaj.ca)].		*[http://www.cmaj.ca/content/177/3/249.2/F2.expansion.html Carcinoma cuniculatum (cmaj.ca)]. -->

	==Verrucous squamous cell carcinoma==		==Verrucous squamous cell carcinoma==

Michael: /* See also */

2020-09-21T18:21:57Z

Michael: /* IHC */

2020-03-04T19:28:12Z

IHC

← Older revision		Revision as of 19:28, 4 March 2020
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	Note:		Note:
	*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung SCC.<ref name=pmid20823766>{{cite journal \|vauthors=Pereira TC, Share SM, Magalhães AV, Silverman JF \|title=Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=19 \|issue=1 \|pages=10–4 \|date=January 2011 \|pmid=20823766 \|doi=10.1097/~~PAI.0b013e3181ecaf1c \|url=}}</ref~~>		*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung SCC.<ref name=pmid20823766/>

	=See also=		=See also=

Michael: /* IHC */

2020-03-04T19:26:39Z

IHC

← Older revision		Revision as of 19:26, 4 March 2020
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	*[[p63]] +ve.		*[[p63]] +ve.
	*K903 +ve.		*K903 +ve.
	*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>		*[[p16]] +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>
			*[[p40]] +ve.

	Note:		Note:
	*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung.<ref name=pmid20823766>{{cite journal \|vauthors=Pereira TC, Share SM, Magalhães AV, Silverman JF \|title=Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=19 \|issue=1 \|pages=10–4 \|date=January 2011 \|pmid=20823766 \|doi=10.1097/PAI.0b013e3181ecaf1c \|url=}}</ref>		*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung SCC.<ref name=pmid20823766>{{cite journal \|vauthors=Pereira TC, Share SM, Magalhães AV, Silverman JF \|title=Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=19 \|issue=1 \|pages=10–4 \|date=January 2011 \|pmid=20823766 \|doi=10.1097/PAI.0b013e3181ecaf1c \|url=}}</ref>

	=See also=		=See also=

Michael: /* IHC */

2020-03-04T19:25:53Z

IHC

← Older revision		Revision as of 19:25, 4 March 2020
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	*K903 +ve.		*K903 +ve.
	*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>		*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>

			Note:
			*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung.<ref name=pmid20823766>{{cite journal \|vauthors=Pereira TC, Share SM, Magalhães AV, Silverman JF \|title=Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases \|journal=Appl. Immunohistochem. Mol. Morphol. \|volume=19 \|issue=1 \|pages=10–4 \|date=January 2011 \|pmid=20823766 \|doi=10.1097/PAI.0b013e3181ecaf1c \|url=}}</ref>

	=See also=		=See also=

Michael: /* Spindle cell squamous carcinoma */

2019-03-23T14:06:56Z

Spindle cell squamous carcinoma

← Older revision		Revision as of 14:06, 23 March 2019
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	==Spindle cell squamous carcinoma==		==Spindle cell squamous carcinoma==
			*[[AKA]] ''sarcomatoid squamous cell carcinoma''.<ref name=pmid18787630 >{{Cite journal \| last1 = Hall \| first1 = JM. \| last2 = Saenger \| first2 = JS. \| last3 = Fadare \| first3 = O. \| title = Diagnostic utility of P63 and CD10 in distinguishing cutaneous spindle cell/sarcomatoid squamous cell carcinomas and atypical fibroxanthomas. \| journal = Int J Clin Exp Pathol \| volume = 1 \| issue = 6 \| pages = 524-30 \| month = Mar \| year = 2008 \| doi = \| PMID = 18787630 }}</ref>
	===General===		===General===
	*Common spindle cell lesion of the head and neck.		*Common spindle cell lesion of the head and neck.

Michael: /* Head and neck */

2017-07-18T16:26:50Z

Head and neck

← Older revision		Revision as of 16:26, 18 July 2017
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	{{Main\|Squamous cell carcinoma of the head and neck}}		{{Main\|Squamous cell carcinoma of the head and neck}}
	*Most common tumour of the [[head and neck pathology\|head & neck]].		*Most common tumour of the [[head and neck pathology\|head & neck]].
			**[[Tongue squamous cell carcinoma]] is dealt with separately.
	*''[[Nasopharyngeal carcinoma]]'' can be considered a variant SCC.		*''[[Nasopharyngeal carcinoma]]'' can be considered a variant SCC.
	*HPV-associated SCC is dealt with in ''[[HPV-associated head and neck squamous cell carcinoma]]''.		*HPV-associated SCC is dealt with in ''[[HPV-associated head and neck squamous cell carcinoma]]''.

Michael at 20:44, 5 May 2016

2016-05-05T20:44:33Z

← Older revision		Revision as of 20:44, 5 May 2016
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	=IHC=		=IHC=
	Features:<ref name=pmid20823766>{{Cite journal \| last1 = Pereira \| first1 = TC. \| last2 = Share \| first2 = SM. \| last3 = Magalhães \| first3 = AV. \| last4 = Silverman \| first4 = JF. \| title = Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases. \| journal = Appl Immunohistochem Mol Morphol \| volume = 19 \| issue = 1 \| pages = 10-4 \| month = Jan \| year = 2011 \| doi = 10.1097/PAI.0b013e3181ecaf1c \| PMID = 20823766 }}</ref>		Features:<ref name=pmid20823766>{{Cite journal \| last1 = Pereira \| first1 = TC. \| last2 = Share \| first2 = SM. \| last3 = Magalhães \| first3 = AV. \| last4 = Silverman \| first4 = JF. \| title = Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases. \| journal = Appl Immunohistochem Mol Morphol \| volume = 19 \| issue = 1 \| pages = 10-4 \| month = Jan \| year = 2011 \| doi = 10.1097/PAI.0b013e3181ecaf1c \| PMID = 20823766 }}</ref>
	*CK5/6 +ve.		*[[CK5/6]] +ve.
	*p63 +ve.		*[[p63]] +ve.
	*K903 +ve.		*K903 +ve.
	*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>		*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/>

Michael: /* Images */

2015-08-17T18:38:31Z

Images

← Older revision		Revision as of 18:38, 17 August 2015
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	*[http://www.juniordentist.com/wp-content/uploads/2011/06/Verrucous-carcinoma-histology.jpg Verrucous carcinoma (juniordentist.com)].<ref>URL: [http://www.juniordentist.com/verrucous-carcinoma.html http://www.juniordentist.com/verrucous-carcinoma.html]. Accessed on: 3 April 2012.</ref>		*[http://www.juniordentist.com/wp-content/uploads/2011/06/Verrucous-carcinoma-histology.jpg Verrucous carcinoma (juniordentist.com)].<ref>URL: [http://www.juniordentist.com/verrucous-carcinoma.html http://www.juniordentist.com/verrucous-carcinoma.html]. Accessed on: 3 April 2012.</ref>
	*[http://www.pathologyoutlines.com/images/prostate/psverrucous_scc_01.jpg Verrucous SCC (pathologyoutlines.com)].		*[http://www.pathologyoutlines.com/images/prostate/psverrucous_scc_01.jpg Verrucous SCC (pathologyoutlines.com)].
	*[http://www.jle.com/e-docs/00/04/1D/79/article.phtml?fichier=images.htm Verrucous carcinoma (jle.com)].

	==Spindle cell squamous carcinoma==		==Spindle cell squamous carcinoma==

← Older revision		Revision as of 18:21, 21 September 2020
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	=See also=		=See also=
	*[[Adenocarcinoma]].		*[[Adenocarcinoma]].
			*[[Pseudoepitheliomatous hyperplasia]] - can mimic squamous cell carcinoma.
	*[[Basics]].		*[[Basics]].