Squamous cell carcinoma of the urinary bladder - Revision history

Michael: /* Subclassification */

2018-02-14T16:50:10Z

Subclassification

← Older revision		Revision as of 16:50, 14 February 2018
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	*Typical patient 7th decade.		*Typical patient 7th decade.
	**Fifth decade for BSCC		**Fifth decade for BSCC
	*Present with ~~hemature~~ without irritative bladder symptoms.		*Present with hematuria without irritative bladder symptoms.
	*Risk factors: indwelling catheters, chronic inflammation/irritants.		*Risk factors: indwelling catheters, chronic inflammation/irritants.

Michael: /* Subclassification */

2018-02-14T16:00:43Z

Subclassification

← Older revision		Revision as of 16:00, 14 February 2018
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	*Non-bilharzial SCC (NBSCC).		*Non-bilharzial SCC (NBSCC).

	Characteristics of NBSCC:<ref name=pmid27547458>		Characteristics of NBSCC:<ref name=pmid27547458/>
	*Prevalance ~2-5% of bladder tumours (in Western countries).<ref>URL: [https://www.myvmc.com/diseases/bladder-cancer-squamous-cell-carcinoma-of-the-bladder/ https://www.myvmc.com/diseases/bladder-cancer-squamous-cell-carcinoma-of-the-bladder/]. Accessed on: 14 February 2018.</ref>		*Prevalance ~2-5% of bladder tumours (in Western countries).<ref>URL: [https://www.myvmc.com/diseases/bladder-cancer-squamous-cell-carcinoma-of-the-bladder/ https://www.myvmc.com/diseases/bladder-cancer-squamous-cell-carcinoma-of-the-bladder/]. Accessed on: 14 February 2018.</ref>
	*Usually high-grade.		*Usually high-grade.

Michael: /* General */

2018-02-14T16:00:32Z

General

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	*Five year survival of SCC of the bladder is similar to UCC of the bladder.<ref name=pmid26199176 >{{Cite journal \| last1 = Izard \| first1 = JP. \| last2 = Siemens \| first2 = DR. \| last3 = Mackillop \| first3 = WJ. \| last4 = Wei \| first4 = X. \| last5 = Leveridge \| first5 = MJ. \| last6 = Berman \| first6 = DM. \| last7 = Peng \| first7 = Y. \| last8 = Booth \| first8 = CM. \| title = Outcomes of squamous histology in bladder cancer: a population-based study. \| journal = Urol Oncol \| volume = 33 \| issue = 10 \| pages = 425.e7-13 \| month = Oct \| year = 2015 \| doi = 10.1016/j.urolonc.2015.06.011 \| PMID = 26199176 }}</ref>		*Five year survival of SCC of the bladder is similar to UCC of the bladder.<ref name=pmid26199176 >{{Cite journal \| last1 = Izard \| first1 = JP. \| last2 = Siemens \| first2 = DR. \| last3 = Mackillop \| first3 = WJ. \| last4 = Wei \| first4 = X. \| last5 = Leveridge \| first5 = MJ. \| last6 = Berman \| first6 = DM. \| last7 = Peng \| first7 = Y. \| last8 = Booth \| first8 = CM. \| title = Outcomes of squamous histology in bladder cancer: a population-based study. \| journal = Urol Oncol \| volume = 33 \| issue = 10 \| pages = 425.e7-13 \| month = Oct \| year = 2015 \| doi = 10.1016/j.urolonc.2015.06.011 \| PMID = 26199176 }}</ref>
	**Unadjusted five year survival of UCC, SCC and UCC with squamous differentiation is 34%, 33% and 28% respectively.		**Unadjusted five year survival of UCC, SCC and UCC with squamous differentiation is 34%, 33% and 28% respectively.

			===Subclassification===
			Divided into two subtypes: <ref name=pmid27547458>{{Cite journal \| last1 = Martin \| first1 = JW. \| last2 = Carballido \| first2 = EM. \| last3 = Ahmed \| first3 = A. \| last4 = Farhan \| first4 = B. \| last5 = Dutta \| first5 = R. \| last6 = Smith \| first6 = C. \| last7 = Youssef \| first7 = RF. \| title = Squamous cell carcinoma of the urinary bladder: Systematic review of clinical characteristics and therapeutic approaches. \| journal = Arab J Urol \| volume = 14 \| issue = 3 \| pages = 183-91 \| month = Sep \| year = 2016 \| doi = 10.1016/j.aju.2016.07.001 \| PMID = 27547458 }}</ref>
			*Bilharzial-associated SCC (BSCC) - not associated with bilharziasis (Schistosoma).
			*Non-bilharzial SCC (NBSCC).

			Characteristics of NBSCC:<ref name=pmid27547458>
			*Prevalance ~2-5% of bladder tumours (in Western countries).<ref>URL: [https://www.myvmc.com/diseases/bladder-cancer-squamous-cell-carcinoma-of-the-bladder/ https://www.myvmc.com/diseases/bladder-cancer-squamous-cell-carcinoma-of-the-bladder/]. Accessed on: 14 February 2018.</ref>
			*Usually high-grade.
			*Typical patient 7th decade.
			**Fifth decade for BSCC
			*Present with hemature without irritative bladder symptoms.
			*Risk factors: indwelling catheters, chronic inflammation/irritants.

	==Microscopic==		==Microscopic==

Michael at 01:49, 9 May 2016

2016-05-09T01:49:58Z

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	\| LMDDx = [[metastatic]] squamous cell carcinoma (esp. [[squamous cell carcinoma of the uterine cervix]]), [[urothelial carcinoma]] with squamous differentiation, [[condyloma acuminatum]], [[squamous dysplasia]], [[keratinising squamous metaplasia of the urinary bladder]]		\| LMDDx = [[metastatic]] squamous cell carcinoma (esp. [[squamous cell carcinoma of the uterine cervix]]), [[urothelial carcinoma]] with squamous differentiation, [[condyloma acuminatum]], [[squamous dysplasia]], [[keratinising squamous metaplasia of the urinary bladder]]
	\| Stains =		\| Stains =
	\| IHC = p16 -ve/+ve, CK20 +ve, CK7+, CK14 +ve, GATA3 -ve		\| IHC = p16 -ve/+ve, CK20 -ve, CK7 -ve, CK14 +ve, GATA3 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: /* IHC */

2016-05-09T01:49:24Z

IHC

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	**Not definite for separating from cervix - but suggestive: cervix ~86% +ve, bladder ~37% +ve.<ref name=pmid20571342>{{Cite journal \| last1 = Cioffi-Lavina \| first1 = M. \| last2 = Chapman-Fredricks \| first2 = J. \| last3 = Gomez-Fernandez \| first3 = C. \| last4 = Ganjei-Azar \| first4 = P. \| last5 = Manoharan \| first5 = M. \| last6 = Jorda \| first6 = M. \| title = P16 expression in squamous cell carcinomas of cervix and bladder. \| journal = Appl Immunohistochem Mol Morphol \| volume = 18 \| issue = 4 \| pages = 344-7 \| month = Jul \| year = 2010 \| doi = 10.1097/PAI.0b013e3181d2bbd7 \| PMID = 20571342 }}</ref>		**Not definite for separating from cervix - but suggestive: cervix ~86% +ve, bladder ~37% +ve.<ref name=pmid20571342>{{Cite journal \| last1 = Cioffi-Lavina \| first1 = M. \| last2 = Chapman-Fredricks \| first2 = J. \| last3 = Gomez-Fernandez \| first3 = C. \| last4 = Ganjei-Azar \| first4 = P. \| last5 = Manoharan \| first5 = M. \| last6 = Jorda \| first6 = M. \| title = P16 expression in squamous cell carcinomas of cervix and bladder. \| journal = Appl Immunohistochem Mol Morphol \| volume = 18 \| issue = 4 \| pages = 344-7 \| month = Jul \| year = 2010 \| doi = 10.1097/PAI.0b013e3181d2bbd7 \| PMID = 20571342 }}</ref>
	*CK14 +ve.<ref name=pmid25643514>{{Cite journal \| last1 = Hammam \| first1 = O. \| last2 = Wishahiz \| first2 = M. \| last3 = Khalil \| first3 = H. \| last4 = El Ganzouri \| first4 = H. \| last5 = Badawy \| first5 = M. \| last6 = Elkhquly \| first6 = A. \| last7 = Elesaily \| first7 = K. \| title = Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyprian urinary bladder cancer. \| journal = J Egypt Soc Parasitol \| volume = 44 \| issue = 3 \| pages = 733-40 \| month = Dec \| year = 2014 \| doi = \| PMID = 25643514 }}</ref>		*CK14 +ve.<ref name=pmid25643514>{{Cite journal \| last1 = Hammam \| first1 = O. \| last2 = Wishahiz \| first2 = M. \| last3 = Khalil \| first3 = H. \| last4 = El Ganzouri \| first4 = H. \| last5 = Badawy \| first5 = M. \| last6 = Elkhquly \| first6 = A. \| last7 = Elesaily \| first7 = K. \| title = Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyprian urinary bladder cancer. \| journal = J Egypt Soc Parasitol \| volume = 44 \| issue = 3 \| pages = 733-40 \| month = Dec \| year = 2014 \| doi = \| PMID = 25643514 }}</ref>
	*CK7 -ve.		*CK7 -ve.<ref name=pmid25643514/>
	*CK20 -ve.		*CK20 -ve.<ref name=pmid25643514/>

	===UCC versus SCC===		===UCC versus SCC===

Michael: /* IHC */

2016-05-09T01:48:20Z

IHC

← Older revision		Revision as of 01:48, 9 May 2016
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	*CK14 +ve.<ref name=pmid25643514>{{Cite journal \| last1 = Hammam \| first1 = O. \| last2 = Wishahiz \| first2 = M. \| last3 = Khalil \| first3 = H. \| last4 = El Ganzouri \| first4 = H. \| last5 = Badawy \| first5 = M. \| last6 = Elkhquly \| first6 = A. \| last7 = Elesaily \| first7 = K. \| title = Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyprian urinary bladder cancer. \| journal = J Egypt Soc Parasitol \| volume = 44 \| issue = 3 \| pages = 733-40 \| month = Dec \| year = 2014 \| doi = \| PMID = 25643514 }}</ref>		*CK14 +ve.<ref name=pmid25643514>{{Cite journal \| last1 = Hammam \| first1 = O. \| last2 = Wishahiz \| first2 = M. \| last3 = Khalil \| first3 = H. \| last4 = El Ganzouri \| first4 = H. \| last5 = Badawy \| first5 = M. \| last6 = Elkhquly \| first6 = A. \| last7 = Elesaily \| first7 = K. \| title = Expression of cytokeratin 7, 20, 14 in urothelial carcinoma and squamous cell carcinoma of the Egyprian urinary bladder cancer. \| journal = J Egypt Soc Parasitol \| volume = 44 \| issue = 3 \| pages = 733-40 \| month = Dec \| year = 2014 \| doi = \| PMID = 25643514 }}</ref>
	*CK7 -ve.		*CK7 -ve.
			*CK20 -ve.

	===UCC versus SCC===		===UCC versus SCC===

Michael at 01:46, 9 May 2016

2016-05-09T01:46:56Z

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	\| Clinicalhx = lived in areas with ''Schistosoma haematobium''		\| Clinicalhx = lived in areas with ''Schistosoma haematobium''
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms = hematuria
	\| Prevalence = very rare		\| Prevalence = very rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = similar to UCC of the bladder
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = other bladder tumours
	\| Tx =		\| Tx = cystectomy
	}}		}}
	'''Squamous cell carcinoma of the urinary bladder''', abbreviated '''SCC of the bladder''', is a rare [[cancer]] of the [[urinary bladder]].		'''Squamous cell carcinoma of the urinary bladder''', abbreviated '''SCC of the bladder''', is a rare [[cancer]] of the [[urinary bladder]].

Michael: /* General */

2016-05-09T01:45:41Z

General

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	**Uncommon in areas without ''S. haematobium''.		**Uncommon in areas without ''S. haematobium''.
	*Five year survival of SCC of the bladder is similar to UCC of the bladder.<ref name=pmid26199176 >{{Cite journal \| last1 = Izard \| first1 = JP. \| last2 = Siemens \| first2 = DR. \| last3 = Mackillop \| first3 = WJ. \| last4 = Wei \| first4 = X. \| last5 = Leveridge \| first5 = MJ. \| last6 = Berman \| first6 = DM. \| last7 = Peng \| first7 = Y. \| last8 = Booth \| first8 = CM. \| title = Outcomes of squamous histology in bladder cancer: a population-based study. \| journal = Urol Oncol \| volume = 33 \| issue = 10 \| pages = 425.e7-13 \| month = Oct \| year = 2015 \| doi = 10.1016/j.urolonc.2015.06.011 \| PMID = 26199176 }}</ref>		*Five year survival of SCC of the bladder is similar to UCC of the bladder.<ref name=pmid26199176 >{{Cite journal \| last1 = Izard \| first1 = JP. \| last2 = Siemens \| first2 = DR. \| last3 = Mackillop \| first3 = WJ. \| last4 = Wei \| first4 = X. \| last5 = Leveridge \| first5 = MJ. \| last6 = Berman \| first6 = DM. \| last7 = Peng \| first7 = Y. \| last8 = Booth \| first8 = CM. \| title = Outcomes of squamous histology in bladder cancer: a population-based study. \| journal = Urol Oncol \| volume = 33 \| issue = 10 \| pages = 425.e7-13 \| month = Oct \| year = 2015 \| doi = 10.1016/j.urolonc.2015.06.011 \| PMID = 26199176 }}</ref>
	**~~The unadjusted~~ survival of UCC, SCC and UCC with squamous differentiation is 34%, 33% and 28% respectively.		**Unadjusted five year survival of UCC, SCC and UCC with squamous differentiation is 34%, 33% and 28% respectively.

	==Microscopic==		==Microscopic==

Michael: /* General */

2016-05-09T01:44:18Z

General

← Older revision		Revision as of 01:44, 9 May 2016
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	**Common in areas with ''S. haematobium''.		**Common in areas with ''S. haematobium''.
	**Uncommon in areas without ''S. haematobium''.		**Uncommon in areas without ''S. haematobium''.
			*Five year survival of SCC of the bladder is similar to UCC of the bladder.<ref name=pmid26199176 >{{Cite journal \| last1 = Izard \| first1 = JP. \| last2 = Siemens \| first2 = DR. \| last3 = Mackillop \| first3 = WJ. \| last4 = Wei \| first4 = X. \| last5 = Leveridge \| first5 = MJ. \| last6 = Berman \| first6 = DM. \| last7 = Peng \| first7 = Y. \| last8 = Booth \| first8 = CM. \| title = Outcomes of squamous histology in bladder cancer: a population-based study. \| journal = Urol Oncol \| volume = 33 \| issue = 10 \| pages = 425.e7-13 \| month = Oct \| year = 2015 \| doi = 10.1016/j.urolonc.2015.06.011 \| PMID = 26199176 }}</ref>
			**The unadjusted survival of UCC, SCC and UCC with squamous differentiation is 34%, 33% and 28% respectively.

	==Microscopic==		==Microscopic==

Michael at 17:13, 8 May 2016

2016-05-08T17:13:34Z

← Older revision		Revision as of 17:13, 8 May 2016
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	\| LMDDx = [[metastatic]] squamous cell carcinoma (esp. [[squamous cell carcinoma of the uterine cervix]]), [[urothelial carcinoma]] with squamous differentiation, [[condyloma acuminatum]], [[squamous dysplasia]], [[keratinising squamous metaplasia of the urinary bladder]]		\| LMDDx = [[metastatic]] squamous cell carcinoma (esp. [[squamous cell carcinoma of the uterine cervix]]), [[urothelial carcinoma]] with squamous differentiation, [[condyloma acuminatum]], [[squamous dysplasia]], [[keratinising squamous metaplasia of the urinary bladder]]
	\| Stains =		\| Stains =
	\| IHC = p16 -ve/+ve		\| IHC = p16 -ve/+ve, CK20 +ve, CK7+, CK14 +ve, GATA3 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =