Squamous dysplasia of the head and neck - Revision history

Michael: /* References */

2015-08-19T14:57:55Z

References

← Older revision		Revision as of 14:57, 19 August 2015
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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Head and neck pathology]]		[[Category:Head and neck pathology]]

			==External links==
			*[https://wiki.uiowa.edu/display/protocols/Moderate+squamous+dysplasia+causing+laryngeal+leukoplakia Squamous dysplasia (wiki.uiowa.edu)].

Michael: /* Ljubljana system */

2014-12-05T04:49:25Z

Ljubljana system

← Older revision		Revision as of 04:49, 5 December 2014
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	*High-grade SIL.		*High-grade SIL.
	*Carcinoma in situ.		*Carcinoma in situ.

			Low-grade squamous intraepithelial lesion:<ref name=pmid24689850/>
			*Increased prickle cell layer.
			*+/-Thickening of basal and/or parabasal cell layers.
			*No significant [[nuclear atypia]].
			*Rare mitotic figures.
			*Dyskeratotic cells - rare.
			*Must show maturation to surface.

			High-grade squamous intraepithelial lesion:<ref name=pmid24689850/>
			*Long axis perpendicular to basement membrane.
			*Lower half or more abnormal.
			*[[Nuclear pleomorphism]] present.
			**Irregular nuclear contours.
			**Hyperchromasia.
			**Nucleoli increased in size and number.
			*Increased [[NC ratio]].
			*Mitotic activity in predominantly in the lower 2/3 of the epithelium.
			*Dyskeratotic cell common.

			Carcinoma in situ:<ref name=pmid24689850/>
			*"Full thickness" loss of stratification.
			**May have thin layer of compressed-appearing cells (3-5 cells thick) with their long axes parallel to the basement membrane.
			*[[Nuclear pleomorphism]] present.
			**Irregular nuclear contours.
			**Hyperchromasia.
			**Nucleoli increased in size and number.
			*Increase mitotic activity.
			**Atypical mitoses common.
			*Dyskeratotic/apoptotic cells typically very common.

			Negatives:
			*Basement membrane intact.
			**Smooth contour between epithelial layer and underlying stroma.
			*No [[stromal desmoplastic response]].

			Subtypes:
			*Basal cell type.
			**Non-eosinophilic cytoplasm.
			**No apparent intercellular bridges (prickles).
			**Long axis of cells perpendicular to the basement membrane.
			**Typically non-keratinizing.
			*Spinous cell type.
			**Intercellular bridges (prickles) present.
			**Eosinophilic cytoplasm.
			**Typically keratinizing.

	===Images===		===Images===

Michael: /* Grading */

2014-12-05T01:01:15Z

Grading

← Older revision		Revision as of 01:01, 5 December 2014
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	*Moderate dysplasia.		*Moderate dysplasia.
	*Severe dysplasia.		*Severe dysplasia.
			*Carcinoma in situ.

			====Ljubljana system====
			As per ''Gale et al.'':<ref name=pmid24689850>{{Cite journal \| last1 = Gale \| first1 = N. \| last2 = Blagus \| first2 = R. \| last3 = El-Mofty \| first3 = SK. \| last4 = Helliwell \| first4 = T. \| last5 = Prasad \| first5 = ML. \| last6 = Sandison \| first6 = A. \| last7 = Volavšek \| first7 = M. \| last8 = Wenig \| first8 = BM. \| last9 = Zidar \| first9 = N. \| title = Evaluation of a new grading system for laryngeal squamous intraepithelial lesions-a proposed unified classification. \| journal = Histopathology \| volume = 65 \| issue = 4 \| pages = 456-64 \| month = Oct \| year = 2014 \| doi = 10.1111/his.12427 \| PMID = 24689850 }}</ref>
			*Low-grade SIL.
			*High-grade SIL.
	*Carcinoma in situ.		*Carcinoma in situ.

Michael: /* Microscopic */

2014-12-05T00:55:56Z

Microscopic

← Older revision		Revision as of 00:55, 5 December 2014
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	*[[Benign leukoplakia]].		*[[Benign leukoplakia]].
	*[[Head and neck squamous cell carcinoma]].		*[[Head and neck squamous cell carcinoma]].

			===Grading===
			*Numerous grading systems exist.<ref name=pmid24595419>{{Cite journal \| last1 = Gale \| first1 = N. \| last2 = Zidar \| first2 = N. \| last3 = Poljak \| first3 = M. \| last4 = Cardesa \| first4 = A. \| title = Current views and perspectives on classification of squamous intraepithelial lesions of the head and neck. \| journal = Head Neck Pathol \| volume = 8 \| issue = 1 \| pages = 16-23 \| month = Mar \| year = 2014 \| doi = 10.1007/s12105-014-0530-z \| PMID = 24595419 }}</ref>

			====WHO system====
			The 2005 "blue book" system - as summarized by Gale ''et al.'':<ref name=pmid24595419/>
			*Mild dysplasia.
			*Moderate dysplasia.
			*Severe dysplasia.
			*Carcinoma in situ.

	===Images===		===Images===

Michael at 03:19, 26 February 2014

2014-02-26T03:19:44Z

← Older revision		Revision as of 03:19, 26 February 2014
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	'''Squamous dysplasia of the head and neck''', often '''squamous dysplasia''', is a precursor to [[head and neck squamous cell carcinoma]].		'''Squamous dysplasia of the head and neck''', often '''[[squamous dysplasia]]''', is a precursor to [[head and neck squamous cell carcinoma]].

	==General==		==General==

Michael: /* Microscopic */

2014-02-26T03:13:27Z

Microscopic

← Older revision		Revision as of 03:13, 26 February 2014
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	DDx:		DDx:
			*Squamous hyperplasia.
	*[[Benign leukoplakia]].		*[[Benign leukoplakia]].
	*[[Head and neck squamous cell carcinoma]].		*[[Head and neck squamous cell carcinoma]].

Michael: /* Images */

2014-02-26T03:13:04Z

Images

← Older revision		Revision as of 03:13, 26 February 2014
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	===Images===		===Images===
	www:		www:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807542/figure/Fig1/ Squamous dysplasia - WHO grading system (nih.gov)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807542/figure/Fig2/ Squamous dysplasia (nih.gov)].<Ref name=pmid20596993/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807542/figure/Fig2/ Squamous dysplasia (nih.gov)].<Ref name=pmid20596993/>

Michael: more

2014-02-26T03:11:59Z

← Older revision		Revision as of 03:11, 26 February 2014
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	'''Squamous dysplasia of the head and neck''', often '''squamous dysplasia''', is a ~~precusor~~ to [[head and neck squamous cell carcinoma]].		'''Squamous dysplasia of the head and neck''', often '''squamous dysplasia''', is a precursor to [[head and neck squamous cell carcinoma]].

	==General==		==General==
	*Similar to squamous dysplasia elsewhere.		*Similar to squamous dysplasia elsewhere.
			*Precursor to [[head and neck squamous cell carcinoma]].

	==Gross==		==Gross==
			Features:<Ref name=pmid20596993>{{Cite journal \| last1 = Eversole \| first1 = LR. \| title = Dysplasia of the upper aerodigestive tract squamous epithelium. \| journal = Head Neck Pathol \| volume = 3 \| issue = 1 \| pages = 63-8 \| month = Mar \| year = 2009 \| doi = 10.1007/s12105-009-0103-8 \| PMID = 20596993 }}</ref>
	*[[Erythroplakia]].		*[[Erythroplakia]].
	*[[Leukoplakia]].		*[[Leukoplakia]].
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	*[[Benign leukoplakia]].		*[[Benign leukoplakia]].
	*[[Head and neck squamous cell carcinoma]].		*[[Head and neck squamous cell carcinoma]].

			===Images===
			www:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807542/figure/Fig2/ Squamous dysplasia (nih.gov)].<Ref name=pmid20596993/>

	==Sign out==		==Sign out==
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	==See also==		==See also==
	*[[Head and neck pathology]].		*[[Head and neck pathology]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Head and neck pathology]]		[[Category:Head and neck pathology]]

Michael: split out

2014-02-26T03:07:55Z

split out

New page

'''Squamous dysplasia of the head and neck''', often '''squamous dysplasia''', is a precusor to [[head and neck squamous cell carcinoma]].

==General==
*Similar to squamous dysplasia elsewhere.

==Gross==
*[[Erythroplakia]].
*[[Leukoplakia]].

==Microscopic==
Features:
*Basal nuclear atypia - may be mild.
*Lack of maturation to the surface.
*+/-Parakeratosis.

DDx:
*[[Benign leukoplakia]].
*[[Head and neck squamous cell carcinoma]].

==Sign out==
<pre>
PHARYNGEAL WALL, POSTERIOR, BIOPSY:
- SQUAMOUS MUCOSA WITH MILD SQUAMOUS DYSPLASIA.
- NEGATIVE FOR MALIGNANCY.
</pre>

==See also==
*[[Head and neck pathology]].

[[Category:Diagnosis]]
[[Category:Head and neck pathology]]