Teratoma - Revision history

Michael: fix ectoderm & endoderm - thanks JD

2019-06-19T20:24:15Z

fix ectoderm & endoderm - thanks JD

← Older revision		Revision as of 20:24, 19 June 2019
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	\| Width =		\| Width =
	\| Caption = Mature teratoma. [[H&E stain]].		\| Caption = Mature teratoma. [[H&E stain]].
	\| Micro = classically all three [[germ layers]]: ~~endoderm~~ (skin, (mature) CNS), mesoderm (muscle, bone, connective tissue, blood), ~~ectoderm~~ (internal organs)		\| Micro = classically all three [[germ layers]]: ectoderm (skin, (mature) CNS), mesoderm (muscle, bone, connective tissue, blood), endoderm (internal organs)
	\| Subtypes = [[mature teratoma]], [[immature teratoma]], [[strumal carcinoid]], [[struma ovarii]], [[fetus in fetu]] (subtype of ''mature teratoma'')		\| Subtypes = [[mature teratoma]], [[immature teratoma]], [[strumal carcinoid]], [[struma ovarii]], [[fetus in fetu]] (subtype of ''mature teratoma'')
	\| LMDDx = [[mixed germ cell tumour]], [[squamous cell carcinoma]], [[epidermoid cyst of the testis]] (testis only)		\| LMDDx = [[mixed germ cell tumour]], [[squamous cell carcinoma]], [[epidermoid cyst of the testis]] (testis only)

Michael: /* Molecular */

2019-03-23T13:50:32Z

Molecular

← Older revision		Revision as of 13:50, 23 March 2019
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	[[Testis]] - divided into ''prepubertal'' and ''postpubertal'':		[[Testis]] - divided into ''prepubertal'' and ''postpubertal'':
	*Postpubertal (testicular) teratoma typically have ''isochromosome 12p i(12p)''.<ref name=pmid16547466>{{Cite journal \| last1 = Poulos \| first1 = C. \| last2 = Cheng \| first2 = L. \| last3 = Zhang \| first3 = S. \| last4 = Gersell \| first4 = DJ. \| last5 = Ulbright \| first5 = TM. \| title = Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. \| journal = Mod Pathol \| volume = 19 \| issue = 6 \| pages = 766-71 \| month = Jun \| year = 2006 \| doi = 10.1038/modpathol.3800596 \| PMID = 16547466 }}</ref>		*Postpubertal (testicular) teratoma typically have ''isochromosome 12p i(12p)''.<ref name=pmid16547466>{{Cite journal \| last1 = Poulos \| first1 = C. \| last2 = Cheng \| first2 = L. \| last3 = Zhang \| first3 = S. \| last4 = Gersell \| first4 = DJ. \| last5 = Ulbright \| first5 = TM. \| title = Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. \| journal = Mod Pathol \| volume = 19 \| issue = 6 \| pages = 766-71 \| month = Jun \| year = 2006 \| doi = 10.1038/modpathol.3800596 \| PMID = 16547466 }}</ref>
	**Prepubertal tumours lack ~~these changes~~.		**Prepubertal tumours lack this molecular change.

	[[Ovary]]:		[[Ovary]]:

Michael: /* Molecular */

2019-03-23T13:50:12Z

Molecular

← Older revision		Revision as of 13:50, 23 March 2019
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	[[Testis]] - divided into ''prepubertal'' and ''postpubertal'':		[[Testis]] - divided into ''prepubertal'' and ''postpubertal'':
	*Postpubertal (testicular) teratoma typically have ''isochromosome 12p i(12p)''.<ref name=pmid16547466>{{Cite journal \| last1 = Poulos \| first1 = C. \| last2 = Cheng \| first2 = L. \| last3 = Zhang \| first3 = S. \| last4 = Gersell \| first4 = DJ. \| last5 = Ulbright \| first5 = TM. \| title = Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. \| journal = Mod Pathol \| volume = 19 \| issue = 6 \| pages = 766-71 \| month = Jun \| year = 2006 \| doi = 10.1038/modpathol.3800596 \| PMID = 16547466 }}</ref>		*Postpubertal (testicular) teratoma typically have ''isochromosome 12p i(12p)''.<ref name=pmid16547466>{{Cite journal \| last1 = Poulos \| first1 = C. \| last2 = Cheng \| first2 = L. \| last3 = Zhang \| first3 = S. \| last4 = Gersell \| first4 = DJ. \| last5 = Ulbright \| first5 = TM. \| title = Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. \| journal = Mod Pathol \| volume = 19 \| issue = 6 \| pages = 766-71 \| month = Jun \| year = 2006 \| doi = 10.1038/modpathol.3800596 \| PMID = 16547466 }}</ref>
			**Prepubertal tumours lack these changes.

	[[Ovary]]:		[[Ovary]]:
	*[[Mixed germ cell tumour]]s of the ovary also typically have i(12p).<ref name=pmid16547466/>		*[[Mixed germ cell tumour]]s of the ovary also typically have i(12p).<ref name=pmid16547466/>
			**Pure ''mature teratomas'' and pure ''immature teratomas'' do not have this changes.

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Michael: /* Monodermal teratomas */ +molecular

2019-03-23T13:48:25Z

Monodermal teratomas: +molecular

← Older revision		Revision as of 13:48, 23 March 2019
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	===Epidermoid cyst===		===Epidermoid cyst===
	Some authors consider [[epidermoid cyst]] as a monodermal teratoma.<ref>{{Cite journal \| last1 = Aneiros-Fernandez \| first1 = J. \| last2 = Arias-Santiago \| first2 = S. \| last3 = Cancela-Diez \| first3 = B. \| last4 = O'Valle \| first4 = F. \| last5 = Cachaza \| first5 = JA. \| title = Intratesticular epidermoid cyst: a rare tumor. \| journal = J Clin Med Res \| volume = 2 \| issue = 6 \| pages = 281-3 \| month = Dec \| year = 2010 \| doi = 10.4021/jocmr474w \| PMID = 22043263 }}</ref>		Some authors consider [[epidermoid cyst]] as a monodermal teratoma.<ref>{{Cite journal \| last1 = Aneiros-Fernandez \| first1 = J. \| last2 = Arias-Santiago \| first2 = S. \| last3 = Cancela-Diez \| first3 = B. \| last4 = O'Valle \| first4 = F. \| last5 = Cachaza \| first5 = JA. \| title = Intratesticular epidermoid cyst: a rare tumor. \| journal = J Clin Med Res \| volume = 2 \| issue = 6 \| pages = 281-3 \| month = Dec \| year = 2010 \| doi = 10.4021/jocmr474w \| PMID = 22043263 }}</ref>

			==Molecular==
			[[Testis]] - divided into ''prepubertal'' and ''postpubertal'':
			*Postpubertal (testicular) teratoma typically have ''isochromosome 12p i(12p)''.<ref name=pmid16547466>{{Cite journal \| last1 = Poulos \| first1 = C. \| last2 = Cheng \| first2 = L. \| last3 = Zhang \| first3 = S. \| last4 = Gersell \| first4 = DJ. \| last5 = Ulbright \| first5 = TM. \| title = Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. \| journal = Mod Pathol \| volume = 19 \| issue = 6 \| pages = 766-71 \| month = Jun \| year = 2006 \| doi = 10.1038/modpathol.3800596 \| PMID = 16547466 }}</ref>

			[[Ovary]]:
			*[[Mixed germ cell tumour]]s of the ovary also typically have i(12p).<ref name=pmid16547466/>

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Michael: /* General */

2017-02-22T05:26:09Z

General

← Older revision		Revision as of 05:26, 22 February 2017
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	*CNS teratomas are overrepresented in males.<ref>{{Cite journal \| last1 = Zygourakis \| first1 = CC. \| last2 = Davis \| first2 = JL. \| last3 = Kaur \| first3 = G. \| last4 = Ames \| first4 = CP. \| last5 = Gupta \| first5 = N. \| last6 = Auguste \| first6 = KI. \| last7 = Parsa \| first7 = AT. \| title = Management of central nervous system teratoma. \| journal = J Clin Neurosci \| volume = 22 \| issue = 1 \| pages = 98-104 \| month = Jan \| year = 2015 \| doi = 10.1016/j.jocn.2014.03.039 \| PMID = 25150764 }}</ref>		*CNS teratomas are overrepresented in males.<ref>{{Cite journal \| last1 = Zygourakis \| first1 = CC. \| last2 = Davis \| first2 = JL. \| last3 = Kaur \| first3 = G. \| last4 = Ames \| first4 = CP. \| last5 = Gupta \| first5 = N. \| last6 = Auguste \| first6 = KI. \| last7 = Parsa \| first7 = AT. \| title = Management of central nervous system teratoma. \| journal = J Clin Neurosci \| volume = 22 \| issue = 1 \| pages = 98-104 \| month = Jan \| year = 2015 \| doi = 10.1016/j.jocn.2014.03.039 \| PMID = 25150764 }}</ref>
	**Intracranial teratomas are usually located in midline locations such as the pineal region, suprasellar cistern, basal ganglia, and thalamus.<ref>{{Cite journal \| last1 = Lee \| first1 = YH. \| last2 = Park \| first2 = EK. \| last3 = Park \| first3 = YS. \| last4 = Shim \| first4 = KW. \| last5 = Choi \| first5 = JU. \| last6 = Kim \| first6 = DS. \| title = Treatment and outcomes of primary intracranial teratoma. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 12 \| pages = 1581-7 \| month = Dec \| year = 2009 \| doi = 10.1007/s00381-009-0974-8 \| PMID = 19693515 }}</ref>		**Intracranial teratomas are usually located in midline locations such as the pineal region, suprasellar cistern, basal ganglia, and thalamus.<ref>{{Cite journal \| last1 = Lee \| first1 = YH. \| last2 = Park \| first2 = EK. \| last3 = Park \| first3 = YS. \| last4 = Shim \| first4 = KW. \| last5 = Choi \| first5 = JU. \| last6 = Kim \| first6 = DS. \| title = Treatment and outcomes of primary intracranial teratoma. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 12 \| pages = 1581-7 \| month = Dec \| year = 2009 \| doi = 10.1007/s00381-009-0974-8 \| PMID = 19693515 }}</ref>



	===Classification===		===Classification===

Michael: /* Images */

2016-06-02T03:17:28Z

Images

← Older revision		Revision as of 03:17, 2 June 2016
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	====Images====		====Images====
			=====Case 1=====
	<gallery>		<gallery>
	Image:Teratoma_2_low_mag.jpg \| Mature teratoma - low mag. (WC/Nephron)		Image:Teratoma_2_low_mag.jpg \| Mature teratoma - low mag. (WC/Nephron)
	Image:Teratoma_2_high_mag.jpg \| Mature teratoma - high mag. (WC/Nephron)		Image:Teratoma_2_high_mag.jpg \| Mature teratoma - high mag. (WC/Nephron)
	</gallery>		</gallery>
			=====Case 2=====
	<gallery>		<gallery>
	Image: Mature ovarian teratoma with mature neural elements -- low mag.jpg \| MT - low mag. (WC)		Image: Mature ovarian teratoma with mature neural elements -- low mag.jpg \| MT - low mag. (WC)
	Image: Mature ovarian teratoma with mature neural elements -- intermed mag.jpg \| MT - intermed. mag. (WC)		Image: Mature ovarian teratoma with mature neural elements -- intermed mag.jpg \| MT - intermed. mag. (WC)
	Image: Mature ovarian teratoma with mature neural elements -- high mag.jpg \| MT - high mag. (WC)		Image: Mature ovarian teratoma with mature neural elements -- high mag.jpg \| MT - high mag. (WC)
			</gallery>
			=====Case 3=====
			<gallery>
			Image: Choroid plexus in teratoma -- low mag.jpg \| Neural tissue in teratoma - low mag. (WC)
			Image: Choroid plexus in teratoma -- intermed mag.jpg \| Neural tissue in teratoma - intermed. mag. (WC)
			Image: Choroid plexus in teratoma -- high mag.jpg \| Neural tissue in teratoma - high mag. (WC)
	</gallery>		</gallery>

Michael at 20:58, 26 April 2016

2016-04-26T20:58:46Z

← Older revision		Revision as of 20:58, 26 April 2016
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	\| Gross = may contain identifiable hair and/or teeth, typically cystic and solid		\| Gross = may contain identifiable hair and/or teeth, typically cystic and solid
	\| Grossing = [[orchiectomy grossing]]		\| Grossing = [[orchiectomy grossing]]
			\| Staging = [[testicular cancer staging]]
	\| Site = [[ovary]], [[testis]], other		\| Site = [[ovary]], [[testis]], other
	\| Assdx = ovarian torsion (if large)		\| Assdx = ovarian torsion (if large)

Michael: /* Images */

2016-01-14T04:18:21Z

Images

← Older revision		Revision as of 04:18, 14 January 2016
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	Image:Teratoma_2_low_mag.jpg \| Mature teratoma - low mag. (WC/Nephron)		Image:Teratoma_2_low_mag.jpg \| Mature teratoma - low mag. (WC/Nephron)
	Image:Teratoma_2_high_mag.jpg \| Mature teratoma - high mag. (WC/Nephron)		Image:Teratoma_2_high_mag.jpg \| Mature teratoma - high mag. (WC/Nephron)
			</gallery>
			<gallery>
			Image: Mature ovarian teratoma with mature neural elements -- low mag.jpg \| MT - low mag. (WC)
			Image: Mature ovarian teratoma with mature neural elements -- intermed mag.jpg \| MT - intermed. mag. (WC)
			Image: Mature ovarian teratoma with mature neural elements -- high mag.jpg \| MT - high mag. (WC)
	</gallery>		</gallery>

Jensflorian: some neuropathology facts added

2015-12-09T08:12:59Z

some neuropathology facts added

← Older revision		Revision as of 08:12, 9 December 2015
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	**Immature teratomas may have a benign or malignant behaviour.		**Immature teratomas may have a benign or malignant behaviour.
	**Mature teratomas may have a benign or malignant behaviour.		**Mature teratomas may have a benign or malignant behaviour.
			*CNS teratomas are overrepresented in males.<ref>{{Cite journal \| last1 = Zygourakis \| first1 = CC. \| last2 = Davis \| first2 = JL. \| last3 = Kaur \| first3 = G. \| last4 = Ames \| first4 = CP. \| last5 = Gupta \| first5 = N. \| last6 = Auguste \| first6 = KI. \| last7 = Parsa \| first7 = AT. \| title = Management of central nervous system teratoma. \| journal = J Clin Neurosci \| volume = 22 \| issue = 1 \| pages = 98-104 \| month = Jan \| year = 2015 \| doi = 10.1016/j.jocn.2014.03.039 \| PMID = 25150764 }}</ref>
			**Intracranial teratomas are usually located in midline locations such as the pineal region, suprasellar cistern, basal ganglia, and thalamus.<ref>{{Cite journal \| last1 = Lee \| first1 = YH. \| last2 = Park \| first2 = EK. \| last3 = Park \| first3 = YS. \| last4 = Shim \| first4 = KW. \| last5 = Choi \| first5 = JU. \| last6 = Kim \| first6 = DS. \| title = Treatment and outcomes of primary intracranial teratoma. \| journal = Childs Nerv Syst \| volume = 25 \| issue = 12 \| pages = 1581-7 \| month = Dec \| year = 2009 \| doi = 10.1007/s00381-009-0974-8 \| PMID = 19693515 }}</ref>



	===Classification===		===Classification===
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	Image:Strumal_carcinoid_-_high_mag.jpg \| Strumal carcinoid - high mag. (WC/Nephron)		Image:Strumal_carcinoid_-_high_mag.jpg \| Strumal carcinoid - high mag. (WC/Nephron)
	</gallery>		</gallery>

			===Epidermoid cyst===
			Some authors consider [[epidermoid cyst]] as a monodermal teratoma.<ref>{{Cite journal \| last1 = Aneiros-Fernandez \| first1 = J. \| last2 = Arias-Santiago \| first2 = S. \| last3 = Cancela-Diez \| first3 = B. \| last4 = O'Valle \| first4 = F. \| last5 = Cachaza \| first5 = JA. \| title = Intratesticular epidermoid cyst: a rare tumor. \| journal = J Clin Med Res \| volume = 2 \| issue = 6 \| pages = 281-3 \| month = Dec \| year = 2010 \| doi = 10.4021/jocmr474w \| PMID = 22043263 }}</ref>

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	[[Category:Gynecologic pathology]]		[[Category:Gynecologic pathology]]
	[[Category:Germ cell tumours]]		[[Category:Germ cell tumours]]
			[[Category:Neuropathology]]

Michael: /* Mature teratoma */

2015-12-08T15:23:37Z

Mature teratoma

← Older revision		Revision as of 15:23, 8 December 2015
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	<pre>		<pre>
	Mass, Right Ovary, Excision:		Mass, Right Ovary, Excision:
	- Mature teratoma with mature neural tissue ~~and dermal elements~~.		- Mature teratoma with dermal elements and mature neural tissue.
	- NEGATIVE for evidence of malignancy.		- NEGATIVE for evidence of malignancy.
	</pre>		</pre>