Thyroid gland nodular hyperplasia - Revision history

Michael: /* See also */

2015-08-11T18:16:08Z

Michael at 06:02, 4 March 2015

2015-03-04T06:02:08Z

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	\| Tx = surgical resection		\| Tx = surgical resection
	}}		}}
	'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for [[thyroidectomy]].		'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for thyroidectomy.

	==General==		==General==

Michael at 05:58, 4 March 2015

2015-03-04T05:58:16Z

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	\| Micro = typically follicles of variable size - may be microfollicular or solid; no nuclear changes of [[papillary thyroid carcinoma\|PTC]]; no fibrous capsule		\| Micro = typically follicles of variable size - may be microfollicular or solid; no nuclear changes of [[papillary thyroid carcinoma\|PTC]]; no fibrous capsule
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[papillary thyroid carcinoma]], [[follicular thyroid adenoma]]		\| LMDDx = [[papillary thyroid carcinoma]], [[follicular thyroid adenoma]], [[follicular thyroid carcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael: /* Molecular */

2015-03-04T05:57:47Z

Molecular

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	==Molecular==		==Molecular==
	*~~Large lesions~~ may be clonal;<ref name=pmid1973172>{{Cite journal \| last1 = Namba \| first1 = H. \| last2 = Matsuo \| first2 = K. \| last3 = Fagin \| first3 = JA. \| title = Clonal composition of benign and malignant human thyroid tumors. \| journal = J Clin Invest \| volume = 86 \| issue = 1 \| pages = 120-5 \| month = Jul \| year = 1990 \| doi = 10.1172/JCI114673 \| PMID = 1973172 }}</ref> however, this is not used for diagnosis and considered clinically irrelevant.		*Nodular hyperplasias may be clonal;<ref name=pmid1973172>{{Cite journal \| last1 = Namba \| first1 = H. \| last2 = Matsuo \| first2 = K. \| last3 = Fagin \| first3 = JA. \| title = Clonal composition of benign and malignant human thyroid tumors. \| journal = J Clin Invest \| volume = 86 \| issue = 1 \| pages = 120-5 \| month = Jul \| year = 1990 \| doi = 10.1172/JCI114673 \| PMID = 1973172 }}</ref> however, this is not used for diagnosis and considered clinically irrelevant.

	==Sign out==		==Sign out==

Michael at 05:57, 4 March 2015

2015-03-04T05:57:18Z

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	**If you've seen a handful of thyroids you've seen this.		**If you've seen a handful of thyroids you've seen this.
	*Considered to be a combination of environmental factors (e.g. lack of iodine in the diet) and genetic factors (often with autosomal dominant inheritance).<ref name=pmid21487943>{{Cite journal \| last1 = Paschke \| first1 = R. \| title = Molecular pathogenesis of nodular goiter. \| journal = Langenbecks Arch Surg \| volume = 396 \| issue = 8 \| pages = 1127-36 \| month = Dec \| year = 2011 \| doi = 10.1007/s00423-011-0788-5 \| PMID = 21487943 }}</ref>		*Considered to be a combination of environmental factors (e.g. lack of iodine in the diet) and genetic factors (often with autosomal dominant inheritance).<ref name=pmid21487943>{{Cite journal \| last1 = Paschke \| first1 = R. \| title = Molecular pathogenesis of nodular goiter. \| journal = Langenbecks Arch Surg \| volume = 396 \| issue = 8 \| pages = 1127-36 \| month = Dec \| year = 2011 \| doi = 10.1007/s00423-011-0788-5 \| PMID = 21487943 }}</ref>

	~~Notes:~~
	*Large lesions may be clonal; however, this is clinically irrelevant.

	==Gross==		==Gross==
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	Image: Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg \| FNA c/w AN. (WC/Euthman)		Image: Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg \| FNA c/w AN. (WC/Euthman)
	</gallery>		</gallery>

			==Molecular==
			*Large lesions may be clonal;<ref name=pmid1973172>{{Cite journal \| last1 = Namba \| first1 = H. \| last2 = Matsuo \| first2 = K. \| last3 = Fagin \| first3 = JA. \| title = Clonal composition of benign and malignant human thyroid tumors. \| journal = J Clin Invest \| volume = 86 \| issue = 1 \| pages = 120-5 \| month = Jul \| year = 1990 \| doi = 10.1172/JCI114673 \| PMID = 1973172 }}</ref> however, this is not used for diagnosis and considered clinically irrelevant.

	==Sign out==		==Sign out==

Michael: tweak

2015-03-04T05:53:40Z

tweak

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	*Most common diagnosis in the thyroid.		*Most common diagnosis in the thyroid.
	**If you've seen a handful of thyroids you've seen this.		**If you've seen a handful of thyroids you've seen this.
			*Considered to be a combination of environmental factors (e.g. lack of iodine in the diet) and genetic factors (often with autosomal dominant inheritance).<ref name=pmid21487943>{{Cite journal \| last1 = Paschke \| first1 = R. \| title = Molecular pathogenesis of nodular goiter. \| journal = Langenbecks Arch Surg \| volume = 396 \| issue = 8 \| pages = 1127-36 \| month = Dec \| year = 2011 \| doi = 10.1007/s00423-011-0788-5 \| PMID = 21487943 }}</ref>

	Notes:		Notes:

Michael: /* Microscopic */

2015-03-04T05:43:31Z

Microscopic

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	*[[Follicular thyroid adenoma]] - contained in a fibrous capsule.		*[[Follicular thyroid adenoma]] - contained in a fibrous capsule.
	*[[Follicular thyroid carcinoma]] - has fibrous capsule and invasion through it.		*[[Follicular thyroid carcinoma]] - has fibrous capsule and invasion through it.

			===Images===
			<gallery>
			Image: Thyroid Benign Adenomatoid Nodule, FNA (5690954863).jpg \| FNA c/w with AN. (WC/Euthman)
			Image: Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg \| FNA c/w AN. (WC/Euthman)
			</gallery>

	==Sign out==		==Sign out==

Michael: tweak

2015-03-04T05:42:10Z

tweak

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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Thyroid FNA, Benign, Consistent with Adenomatoid Nodule (8116075837).jpg
			\| Width =
			\| Caption = Thyroid FNA compatible with adenomatoid nodule.
			\| Synonyms = nodular hyperplasia, adenomatoid nodule
			\| Micro = typically follicles of variable size - may be microfollicular or solid; no nuclear changes of [[papillary thyroid carcinoma\|PTC]]; no fibrous capsule
			\| Subtypes =
			\| LMDDx = [[papillary thyroid carcinoma]], [[follicular thyroid adenoma]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = enlarged thyroid gland +/- distinct nodules
			\| Grossing =
			\| Site = [[thyroid gland]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = thyroid gland enlargement
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = malignancy of thyroid gland
			\| Tx = surgical resection
			}}
	'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for [[thyroidectomy]].		'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for [[thyroidectomy]].

Michael: split out

2015-03-04T05:33:55Z

split out

← Older revision		Revision as of 05:33, 4 March 2015
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	~~#redirect~~ [[~~Thyroid_gland#~~Thyroid gland ~~nodular hyperplasia~~]]		'''Thyroid gland nodular hyperplasia''' is a common [[thyroid gland]] pathology and may be an indication for [[thyroidectomy]].

			==General==
			*Clinical diagnosis: ''goitre'', [[AKA]] ''sporadic goitre'', AKA ''multinodular goitre'' (MNG).
			*Most common diagnosis in the thyroid.
			**If you've seen a handful of thyroids you've seen this.

			Notes:
			*Large lesions may be clonal; however, this is clinically irrelevant.

			==Gross==
			Features:
			*Enlarge thyroid gland.
			*+/-Distinct (well-circumscribed) nodules.

			==Microscopic==
			Features:
			*Follicles of variable size - '''key feature'''.
			**Should be obvious at low power, i.e. with the 2.5x objective.
			*+/-Nodules.
			**Do not have a thick fibrous capsule.
			**May have a high cellularity.
			**Architecture: solid or microfollicular.<ref name=Ref_EP36>{{Ref EP\|36}}</ref>

			Negatives:
			*No nuclear features suggestive of malignancy (at lower power).
			**One should not look at high power.
			*Not cellular.

			DDx:
			*[[Papillary thyroid carcinoma]] - esp. [[papillary thyroid carcinoma follicular variant]].
			*[[Follicular thyroid adenoma]] - contained in a fibrous capsule.
			*[[Follicular thyroid carcinoma]] - has fibrous capsule and invasion through it.

			==Sign out==
			<pre>
			HEMITHYROID, RIGHT, HEMITHYROIDECTOMY:
			- NODULAR HYPERPLASIA.
			- NEGATIVE FOR MALIGNANCY.
			</pre>

			<pre>
			HEMITHYROID, RIGHT, HEMITHYROIDECTOMY:
			- CELLULAR ADENOMATOID NODULE ON A BACKGROUND OF NODULAR HYPERPLASIA.
			- NEGATIVE FOR MALIGNANCY.
			</pre>

			<pre>
			RIGHT THYROID, RIGHT HEMITHYROIDECTOMY:
			- BENIGN NODULE WITH MICROFOLLICLES IN A BACKGROUND OF NODULAR HYPERPLASIA.
			- NEGATIVE FOR MALIGNANCY.
			</pre>

			===Micro===
			The sections show thyroid gland with follicles of variable size and marked enlargement.
			A lymphocytic infiltrate is present. Focal germinal centre formation is present. Oncocytic changes and reactive changes are seen focally. No significant nuclear atypia is identified.

			====Alternate====
			The sections show thyroid gland with follicles of variable size and marked enlargement. A large nodule is present with microfollicles that are densely packed around the edge and few in the centre. The nuclei of the microfollicles are round. No significant nuclear membrane irregularities there are apparent. Very rare enlarged nuclei are present. Occasional nucleoli are seen. No nuclear overlap is readily apparent.

			==See also==
			*[[Thyroid gland]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Thyroid gland]]

Michael: Redirected page to Thyroid gland#Thyroid gland nodular hyperplasia

2012-02-15T13:25:42Z

Redirected page to Thyroid gland#Thyroid gland nodular hyperplasia

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	#redirect [[Thyroid_gland#~~Nodular_hyperplasia~~]]		#redirect [[Thyroid_gland#Thyroid gland nodular hyperplasia]]

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

← Older revision		Revision as of 18:16, 11 August 2015
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	==See also==		==See also==
	*[[Thyroid gland]].		*[[Thyroid gland]].
			*[[Thyroid cytopathology]].

	==References==		==References==