Traditional serrated adenoma - Revision history

Michael at 15:49, 5 June 2017

2017-06-05T15:49:03Z

← Older revision		Revision as of 15:49, 5 June 2017
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	**Nuclear hyperchromasia, enlargement and pseudostratification.		**Nuclear hyperchromasia, enlargement and pseudostratification.
	*Villous-like architecture.		*Villous-like architecture.
	*Ectopic crypt foci (ECF) - short crypts oriented perpendicular to the main crypt, do not reach muscularis mucosae.‡		*Ectopic crypt foci (ECF) - short crypts oriented perpendicular to the main crypt, do not reach muscularis mucosae.<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/printable.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/printable.html]. Accessed on: 5 June 2017.</ref>‡

	Note:		Note:

Michael: /* Microscopic */

2017-06-05T15:48:13Z

Microscopic

← Older revision		Revision as of 15:48, 5 June 2017
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	**Nuclear hyperchromasia, enlargement and pseudostratification.		**Nuclear hyperchromasia, enlargement and pseudostratification.
	*Villous-like architecture.		*Villous-like architecture.
	*Ectopic crypt foci (ECF) - short crypts oriented perpendicular ~~normal crypts~~, do not reach muscularis mucosae.‡		*Ectopic crypt foci (ECF) - short crypts oriented perpendicular to the main crypt, do not reach muscularis mucosae.‡

	Note:		Note:

Michael: /* Microscopic */

2017-06-05T15:41:17Z

Microscopic

← Older revision		Revision as of 15:41, 5 June 2017
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	**Nuclear hyperchromasia, enlargement and pseudostratification.		**Nuclear hyperchromasia, enlargement and pseudostratification.
	*Villous-like architecture.		*Villous-like architecture.
	*Ectopic crypt foci (ECF) - short crypts oriented perpendicular normal crypts, do not reach muscularis mucosae.		*Ectopic crypt foci (ECF) - short crypts oriented perpendicular normal crypts, do not reach muscularis mucosae.‡
	**ECF considered pathognomonic for TSA but seen in other entities.<ref name=pmid27281826>{{Cite journal \| last1 = Väyrynen \| first1 = SA. \| last2 = Väyrynen \| first2 = JP. \| last3 = Klintrup \| first3 = K. \| last4 = Mäkelä \| first4 = J. \| last5 = Tuomisto \| first5 = A. \| last6 = Mäkinen \| first6 = MJ. \| title = Ectopic crypt foci in conventional and serrated colorectal polyps. \| journal = J Clin Pathol \| volume = 69 \| issue = 12 \| pages = 1063-1069 \| month = Dec \| year = 2016 \| doi = 10.1136/jclinpath-2015-203593 \| PMID = 27281826 }}</ref>
			Note:
			*‡ECF considered pathognomonic for TSA - but seen in other entities.<ref name=pmid27281826>{{Cite journal \| last1 = Väyrynen \| first1 = SA. \| last2 = Väyrynen \| first2 = JP. \| last3 = Klintrup \| first3 = K. \| last4 = Mäkelä \| first4 = J. \| last5 = Tuomisto \| first5 = A. \| last6 = Mäkinen \| first6 = MJ. \| title = Ectopic crypt foci in conventional and serrated colorectal polyps. \| journal = J Clin Pathol \| volume = 69 \| issue = 12 \| pages = 1063-1069 \| month = Dec \| year = 2016 \| doi = 10.1136/jclinpath-2015-203593 \| PMID = 27281826 }}</ref>

	DDx:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html]. Accessed on: 28 May 2015.</ref>		DDx:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html]. Accessed on: 28 May 2015.</ref>

Michael: /* Microscopic */

2017-06-05T15:39:18Z

Microscopic

← Older revision		Revision as of 15:39, 5 June 2017
Line 48:		Line 48:
	**Nuclear hyperchromasia, enlargement and pseudostratification.		**Nuclear hyperchromasia, enlargement and pseudostratification.
	*Villous-like architecture.		*Villous-like architecture.
			*Ectopic crypt foci (ECF) - short crypts oriented perpendicular normal crypts, do not reach muscularis mucosae.
			**ECF considered pathognomonic for TSA but seen in other entities.<ref name=pmid27281826>{{Cite journal \| last1 = Väyrynen \| first1 = SA. \| last2 = Väyrynen \| first2 = JP. \| last3 = Klintrup \| first3 = K. \| last4 = Mäkelä \| first4 = J. \| last5 = Tuomisto \| first5 = A. \| last6 = Mäkinen \| first6 = MJ. \| title = Ectopic crypt foci in conventional and serrated colorectal polyps. \| journal = J Clin Pathol \| volume = 69 \| issue = 12 \| pages = 1063-1069 \| month = Dec \| year = 2016 \| doi = 10.1136/jclinpath-2015-203593 \| PMID = 27281826 }}</ref>

	DDx:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html]. Accessed on: 28 May 2015.</ref>		DDx:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html]. Accessed on: 28 May 2015.</ref>

Michael: wiki

2016-02-13T15:50:51Z

wiki

← Older revision		Revision as of 15:50, 13 February 2016
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	\| Other =		\| Other =
	\| ClinDDx = other [[GI polyps]]		\| ClinDDx = other [[GI polyps]]
	\| Tx = polypectomy, q3years surveillance colonoscopy		\| Tx = [[polypectomy]], q3years surveillance colonoscopy
	}}		}}
	'''Traditional serrated adenoma''', abbreviated '''TSA''', are a rare type of [[gastrointestinal polyp]].		'''Traditional serrated adenoma''', abbreviated '''TSA''', are a rare type of [[gastrointestinal polyp]].

Michael: /* Sign out */

2015-10-02T12:32:41Z

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← Older revision		Revision as of 12:32, 2 October 2015
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	==Sign out==		==Sign out==
	<~~pref~~>		<pre>
	Polyp, Sigmoid Colon, Polypectomy:		Polyp, Sigmoid Colon, Polypectomy:
	- Traditional serrated adenoma.		- Traditional serrated adenoma.

Michael: /* Sign out */

2015-10-02T12:32:32Z

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← Older revision		Revision as of 12:32, 2 October 2015
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	==Sign out==		==Sign out==
			<pref>
			Polyp, Sigmoid Colon, Polypectomy:
			- Traditional serrated adenoma.
			-- NEGATIVE for high-grade dysplasia.
			</pre>

			===Block letters===
	<pre>		<pre>
	POLYP, SIGMOID COLON, POLYPECTOMY:		POLYP, SIGMOID COLON, POLYPECTOMY:
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	-- NEGATIVE FOR HIGH-GRADE DYSPLASIA.		-- NEGATIVE FOR HIGH-GRADE DYSPLASIA.
	</pre>		</pre>

			===Micro===
			====Nonvilliform TSA====
			This polyp has cytologic dysplasia and serrations at the surface; however, it does not have a villiform architecture. The surface epithelium has eosinophilic cytoplasm. Overall, the morphology is most in keeping with a traditional serrated adenoma.

	==See also==		==See also==

Michael at 17:52, 28 May 2015

2015-05-28T17:52:07Z

← Older revision		Revision as of 17:52, 28 May 2015
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	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy = ~~q3year surveillance colonoscopy~~		\| Endoscopy =
	\| Prognosis = benign (pre-malignant)		\| Prognosis = benign (pre-malignant)
	\| Other =		\| Other =
	\| ClinDDx = other [[GI polyps]]		\| ClinDDx = other [[GI polyps]]
	\| Tx = polypectomy		\| Tx = polypectomy, q3years surveillance colonoscopy
	}}		}}
	'''Traditional serrated adenoma''', abbreviated '''TSA''', are a rare type of [[gastrointestinal polyp]].		'''Traditional serrated adenoma''', abbreviated '''TSA''', are a rare type of [[gastrointestinal polyp]].
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	==Gross==		==Gross==
	*Polypoid mass.		*Polypoid mass.
	*Usually in the left colon.		*Usually in the [[left colon]].

	==Microscopic==		==Microscopic==

Michael: small fixes, +ref

2015-05-28T17:44:06Z

small fixes, +ref

← Older revision		Revision as of 17:44, 28 May 2015
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	\| Micro = ectopic crypt foci (ECF), serrated, eosinophilic cytoplasm, villous-like architecture, "pine cone, fernlike, stellate pit pattern"		\| Micro = ectopic crypt foci (ECF), serrated, eosinophilic cytoplasm, villous-like architecture, "pine cone, fernlike, stellate pit pattern"
	\| Subtypes = With and without high grade dysplasia, mixed with other types of polyps		\| Subtypes = With and without high grade dysplasia, mixed with other types of polyps
	\| LMDDx = [[villous adenoma]], [[~~hyperplasic~~ polyp]], [[~~sessiles~~ serrated adenoma]]		\| LMDDx = [[villous adenoma]], [[hyperplastic polyp]], [[sessile serrated adenoma]]
	\| Stains =		\| Stains =
	\| IHC = CK20 in the eosinophilic cells, absent in ECF; Ki67 (MIB1) stains ECF and absent in eosinophilic cells, MUC2+, MUC5CA+, MUC6-; In areas of dysplasia TP53+, nuclear B-catenin+; p16+ in late dysplasia		\| IHC = CK20 in the eosinophilic cells, absent in ECF; Ki67 (MIB1) stains ECF and absent in eosinophilic cells, MUC2+, MUC5CA+, MUC6-; In areas of dysplasia TP53+, nuclear B-catenin+; p16+ in late dysplasia
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	*Villous-like architecture.		*Villous-like architecture.

	DDx:		DDx:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html http://surgpathcriteria.stanford.edu/gitumors/traditional-serrated-adenoma/differential-diagnosis.html]. Accessed on: 28 May 2015.</ref>
	*[[Villous adenoma]].		*[[Villous adenoma]].
			*[[Hyperplastic polyp]].
			*[[Sessile serrated adenoma]].

	===Images===		===Images===

Tate at 01:31, 20 May 2015

2015-05-20T01:31:04Z

← Older revision		Revision as of 01:31, 20 May 2015
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	\| Width = Traditional serrated adenoma. [[H&E stain]].		\| Width = Traditional serrated adenoma. [[H&E stain]].
	\| Caption =		\| Caption =
	\| Micro = serrated, eosinophilic cytoplasm, villous-like architecture		\| Micro = ectopic crypt foci (ECF), serrated, eosinophilic cytoplasm, villous-like architecture, "pine cone, fernlike, stellate pit pattern"
	\| Subtypes =		\| Subtypes = With and without high grade dysplasia, mixed with other types of polyps
	\| LMDDx = [[villous adenoma]]		\| LMDDx = [[villous adenoma]], [[hyperplasic polyp]], [[sessiles serrated adenoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CK20 in the eosinophilic cells, absent in ECF; Ki67 (MIB1) stains ECF and absent in eosinophilic cells, MUC2+, MUC5CA+, MUC6-; In areas of dysplasia TP53+, nuclear B-catenin+; p16+ in late dysplasia
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = [[BRAF]] & [[KRAS]]
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy = q3year surveillance colonoscopy
	\| Prognosis = benign (pre-malignant)		\| Prognosis = benign (pre-malignant)
	\| Other =		\| Other =