Typical carcinoid lung tumour - Revision history

Michael: /* General */

2019-03-17T23:40:57Z

General

← Older revision		Revision as of 23:40, 17 March 2019
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	**Often re-occur - but long term survival good.		**Often re-occur - but long term survival good.
	*Can be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH).<ref name=pmid26104490>{{Cite journal \| last1 = Wirtschafter \| first1 = E. \| last2 = Walts \| first2 = AE. \| last3 = Liu \| first3 = ST. \| last4 = Marchevsky \| first4 = AM. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9755-1 \| PMID = 26104490 }}</ref><ref name=pmid26112453>{{Cite journal \| last1 = Chauhan \| first1 = A. \| last2 = Ramirez \| first2 = RA. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9754-2 \| PMID = 26112453 }}</ref>		*Can be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH).<ref name=pmid26104490>{{Cite journal \| last1 = Wirtschafter \| first1 = E. \| last2 = Walts \| first2 = AE. \| last3 = Liu \| first3 = ST. \| last4 = Marchevsky \| first4 = AM. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9755-1 \| PMID = 26104490 }}</ref><ref name=pmid26112453>{{Cite journal \| last1 = Chauhan \| first1 = A. \| last2 = Ramirez \| first2 = RA. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9754-2 \| PMID = 26112453 }}</ref>
	*~~Most~~ common primary lung tumour in children ~~(~50% of primary~~ lung ~~tumours~~ in children).		*A common primary lung tumour in children.<ref name=pmid26971789>{{Cite journal \| last1 = Giuseppucci \| first1 = C. \| last2 = Reusmann \| first2 = A. \| last3 = Giubergia \| first3 = V. \| last4 = Barrias \| first4 = C. \| last5 = Krüger \| first5 = A. \| last6 = Siminovich \| first6 = M. \| last7 = Botto \| first7 = H. \| last8 = Cadario \| first8 = M. \| last9 = Boglione \| first9 = M. \| title = Primary lung tumors in children: 24 years of experience at a referral center. \| journal = Pediatr Surg Int \| volume = 32 \| issue = 5 \| pages = 451-7 \| month = May \| year = 2016 \| doi = 10.1007/s00383-016-3884-3 \| PMID = 26971789 }}
			</ref>
	**Most common lung tumour in children: metastasis (80-85% of lung tumours in children<ref name=pmid>{{Cite journal \| last1 = Dishop \| first1 = MK. \| last2 = Kuruvilla \| first2 = S. \| title = Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 7 \| pages = 1079-103 \| month = Jul \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[1079:PAMLTI]2.0.CO;2 \| PMID = 18605764 }}</ref>).		**Most common lung tumour in children: metastasis (80-85% of lung tumours in children<ref name=pmid>{{Cite journal \| last1 = Dishop \| first1 = MK. \| last2 = Kuruvilla \| first2 = S. \| title = Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 7 \| pages = 1079-103 \| month = Jul \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[1079:PAMLTI]2.0.CO;2 \| PMID = 18605764 }}</ref>).

Michael: /* General */

2019-03-17T23:37:34Z

General

← Older revision		Revision as of 23:37, 17 March 2019
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	*Can be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH).<ref name=pmid26104490>{{Cite journal \| last1 = Wirtschafter \| first1 = E. \| last2 = Walts \| first2 = AE. \| last3 = Liu \| first3 = ST. \| last4 = Marchevsky \| first4 = AM. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9755-1 \| PMID = 26104490 }}</ref><ref name=pmid26112453>{{Cite journal \| last1 = Chauhan \| first1 = A. \| last2 = Ramirez \| first2 = RA. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9754-2 \| PMID = 26112453 }}</ref>		*Can be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH).<ref name=pmid26104490>{{Cite journal \| last1 = Wirtschafter \| first1 = E. \| last2 = Walts \| first2 = AE. \| last3 = Liu \| first3 = ST. \| last4 = Marchevsky \| first4 = AM. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9755-1 \| PMID = 26104490 }}</ref><ref name=pmid26112453>{{Cite journal \| last1 = Chauhan \| first1 = A. \| last2 = Ramirez \| first2 = RA. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9754-2 \| PMID = 26112453 }}</ref>
	*Most common primary lung tumour in children (~50% of primary lung tumours in children).		*Most common primary lung tumour in children (~50% of primary lung tumours in children).
	**Most common lung tumour in children: metastasis (~85% of lung tumours in children).		**Most common lung tumour in children: metastasis (80-85% of lung tumours in children<ref name=pmid>{{Cite journal \| last1 = Dishop \| first1 = MK. \| last2 = Kuruvilla \| first2 = S. \| title = Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. \| journal = Arch Pathol Lab Med \| volume = 132 \| issue = 7 \| pages = 1079-103 \| month = Jul \| year = 2008 \| doi = 10.1043/1543-2165(2008)132[1079:PAMLTI]2.0.CO;2 \| PMID = 18605764 }}</ref>).

	Presentation:<ref name=pmid16810137>{{Cite journal \| last1 = Gungor \| first1 = S. \| last2 = Damadoglu \| first2 = E. \| last3 = Aybatli \| first3 = A. \| last4 = Yilmaz \| first4 = A. \| last5 = Kir \| first5 = A. \| last6 = Akkaya \| first6 = E. \| title = Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases. \| journal = Med Sci Monit \| volume = 12 \| issue = 7 \| pages = CR315-8 \| month = Jul \| year = 2006 \| doi = \| PMID = 16810137 }}</ref>		Presentation:<ref name=pmid16810137>{{Cite journal \| last1 = Gungor \| first1 = S. \| last2 = Damadoglu \| first2 = E. \| last3 = Aybatli \| first3 = A. \| last4 = Yilmaz \| first4 = A. \| last5 = Kir \| first5 = A. \| last6 = Akkaya \| first6 = E. \| title = Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases. \| journal = Med Sci Monit \| volume = 12 \| issue = 7 \| pages = CR315-8 \| month = Jul \| year = 2006 \| doi = \| PMID = 16810137 }}</ref>

Michael: /* General */ tweak

2019-03-17T12:54:48Z

General: tweak

← Older revision		Revision as of 12:54, 17 March 2019
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	**Often re-occur - but long term survival good.		**Often re-occur - but long term survival good.
	*Can be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH).<ref name=pmid26104490>{{Cite journal \| last1 = Wirtschafter \| first1 = E. \| last2 = Walts \| first2 = AE. \| last3 = Liu \| first3 = ST. \| last4 = Marchevsky \| first4 = AM. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9755-1 \| PMID = 26104490 }}</ref><ref name=pmid26112453>{{Cite journal \| last1 = Chauhan \| first1 = A. \| last2 = Ramirez \| first2 = RA. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9754-2 \| PMID = 26112453 }}</ref>		*Can be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH).<ref name=pmid26104490>{{Cite journal \| last1 = Wirtschafter \| first1 = E. \| last2 = Walts \| first2 = AE. \| last3 = Liu \| first3 = ST. \| last4 = Marchevsky \| first4 = AM. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9755-1 \| PMID = 26104490 }}</ref><ref name=pmid26112453>{{Cite journal \| last1 = Chauhan \| first1 = A. \| last2 = Ramirez \| first2 = RA. \| title = Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series. \| journal = Lung \| volume = \| issue = \| pages = \| month = Jun \| year = 2015 \| doi = 10.1007/s00408-015-9754-2 \| PMID = 26112453 }}</ref>
			*Most common primary lung tumour in children (~50% of primary lung tumours in children).
			**Most common lung tumour in children: metastasis (~85% of lung tumours in children).

	Presentation:<ref name=pmid16810137>{{Cite journal \| last1 = Gungor \| first1 = S. \| last2 = Damadoglu \| first2 = E. \| last3 = Aybatli \| first3 = A. \| last4 = Yilmaz \| first4 = A. \| last5 = Kir \| first5 = A. \| last6 = Akkaya \| first6 = E. \| title = Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases. \| journal = Med Sci Monit \| volume = 12 \| issue = 7 \| pages = CR315-8 \| month = Jul \| year = 2006 \| doi = \| PMID = 16810137 }}</ref>		Presentation:<ref name=pmid16810137>{{Cite journal \| last1 = Gungor \| first1 = S. \| last2 = Damadoglu \| first2 = E. \| last3 = Aybatli \| first3 = A. \| last4 = Yilmaz \| first4 = A. \| last5 = Kir \| first5 = A. \| last6 = Akkaya \| first6 = E. \| title = Typical pulmonary carcinoid tumors: presentation and outcome of 24 cases. \| journal = Med Sci Monit \| volume = 12 \| issue = 7 \| pages = CR315-8 \| month = Jul \| year = 2006 \| doi = \| PMID = 16810137 }}</ref>

Michael: /* Microscopic */

2016-04-21T12:38:48Z

Microscopic

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	**Stippled chromatin.		**Stippled chromatin.
	**Scant-to-moderate cytoplasm.		**Scant-to-moderate cytoplasm.
	*No necrosis.		*Nuclei round or ellipsoid.
			*No necrosis - '''important'''.
	*Low mitotic rate.		*Low mitotic rate.
	*[[diagnostic size cutoff\|Size criterion]]: >= 5 mm.<ref name=pct_ucsf>URL: [http://pathhsw5m54.ucsf.edu/case7/image75.html http://pathhsw5m54.ucsf.edu/case7/image75.html]. Accessed on: 23 January 2012.</ref><ref name=pmid23205296>{{Cite journal \| last1 = He \| first1 = P. \| last2 = Gu \| first2 = X. \| last3 = Wu \| first3 = Q. \| last4 = Lin \| first4 = Y. \| last5 = Gu \| first5 = Y. \| last6 = He \| first6 = J. \| title = Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis. \| journal = J Thorac Dis \| volume = 4 \| issue = 6 \| pages = 655-8 \| month = Dec \| year = 2012 \| doi = 10.3978/j.issn.2072-1439.2012.06.11 \| PMID = 23205296 }}</ref>		*[[diagnostic size cutoff\|Size criterion]]: >= 5 mm.<ref name=pct_ucsf>URL: [http://pathhsw5m54.ucsf.edu/case7/image75.html http://pathhsw5m54.ucsf.edu/case7/image75.html]. Accessed on: 23 January 2012.</ref><ref name=pmid23205296>{{Cite journal \| last1 = He \| first1 = P. \| last2 = Gu \| first2 = X. \| last3 = Wu \| first3 = Q. \| last4 = Lin \| first4 = Y. \| last5 = Gu \| first5 = Y. \| last6 = He \| first6 = J. \| title = Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis. \| journal = J Thorac Dis \| volume = 4 \| issue = 6 \| pages = 655-8 \| month = Dec \| year = 2012 \| doi = 10.3978/j.issn.2072-1439.2012.06.11 \| PMID = 23205296 }}</ref>

Michael: /* Microscopic */

2016-04-19T15:16:47Z

Microscopic

← Older revision		Revision as of 15:16, 19 April 2016
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	*[[Atypical carcinoid lung tumour]].		*[[Atypical carcinoid lung tumour]].
	*[[Lung adenocarcinoma]].<ref name=pmid22269186>{{Cite journal \| last1 = Demirci \| first1 = I. \| last2 = Herold \| first2 = S. \| last3 = Kopp \| first3 = A. \| last4 = Flaßhove \| first4 = M. \| last5 = Klosterhalfen \| first5 = B. \| last6 = Janßen \| first6 = H. \| title = Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature. \| journal = World J Surg Oncol \| volume = 10 \| issue = \| pages = 19 \| month = \| year = 2012 \| doi = 10.1186/1477-7819-10-19 \| PMID = 22269186 }}</ref>		*[[Lung adenocarcinoma]].<ref name=pmid22269186>{{Cite journal \| last1 = Demirci \| first1 = I. \| last2 = Herold \| first2 = S. \| last3 = Kopp \| first3 = A. \| last4 = Flaßhove \| first4 = M. \| last5 = Klosterhalfen \| first5 = B. \| last6 = Janßen \| first6 = H. \| title = Overdiagnosis of a typical carcinoid tumor as an adenocarcinoma of the lung: a case report and review of the literature. \| journal = World J Surg Oncol \| volume = 10 \| issue = \| pages = 19 \| month = \| year = 2012 \| doi = 10.1186/1477-7819-10-19 \| PMID = 22269186 }}</ref>
			*[[Pulmonary meningothelial-like nodule]] - usually 1-3 mm, not associated with airway.

	===Images===		===Images===

Michael: /* IHC */

2016-04-19T15:14:44Z

IHC

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	*Synaptophysin +ve.		*Synaptophysin +ve.
	*[[CD56]] +ve.		*[[CD56]] +ve.
			**Also +ve in [[pulmonary meningothelial-like nodule]].

	Others:		Others:

Michael: /* Sign out */

2015-11-02T20:16:20Z

Sign out

← Older revision		Revision as of 20:16, 2 November 2015
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	==Sign out==		==Sign out==
			===Biopsy===
			<pre>
			Lung, Left Upper Lobe, Core Biopsy:
			- Consistent with typical lung carcinoid.

			Comment:
			The tumour stains as follow:
			POSITIVE: CK7, TTF-1 (very weak, focal), CD56, chromogranin A, synaptophysin.
			NEGATIVE: p63.
			PROLIFERATION (Ki-67): ~3% of tumour cells.
			</pre>

			===Excision===
	<pre>		<pre>
	A. Lymph Node, Station 2L, Lymphadenectomy:		A. Lymph Node, Station 2L, Lymphadenectomy:

Michael: /* Microscopic */

2015-10-30T02:00:37Z

Microscopic

← Older revision		Revision as of 02:00, 30 October 2015
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	*Nests of cells.		*Nests of cells.
	**Stippled chromatin.		**Stippled chromatin.
	**~~Moderate~~ cytoplasm.		**Scant-to-moderate cytoplasm.
	*No necrosis.		*No necrosis.
	*Low mitotic rate.		*Low mitotic rate.

Michael: /* See also */

2015-10-30T01:59:51Z

Michael: /* IHC */

2015-10-30T01:58:55Z

IHC

← Older revision		Revision as of 01:58, 30 October 2015
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	*Chromogranin A +ve.		*Chromogranin A +ve.
	*Synaptophysin +ve.		*Synaptophysin +ve.
	*CD56 +ve.		*[[CD56]] +ve.

	Others:		Others:
	*TTF-1 +ve/-ve (11 +ve of 16 cases<ref name=pmid11679943/>).		*[[TTF-1]] +ve/-ve (11 +ve of 16 cases<ref name=pmid11679943/>).
	*CK7 +ve/-ve (10 +ve of 16 cases<ref name=pmid11679943>{{Cite journal \| last1 = Cai \| first1 = YC. \| last2 = Banner \| first2 = B. \| last3 = Glickman \| first3 = J. \| last4 = Odze \| first4 = RD. \| title = Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. \| journal = Hum Pathol \| volume = 32 \| issue = 10 \| pages = 1087-93 \| month = Oct \| year = 2001 \| doi = 10.1053/hupa.2001.28245 \| PMID = 11679943 }}</ref>).		*[[CK7]] +ve/-ve (10 +ve of 16 cases<ref name=pmid11679943>{{Cite journal \| last1 = Cai \| first1 = YC. \| last2 = Banner \| first2 = B. \| last3 = Glickman \| first3 = J. \| last4 = Odze \| first4 = RD. \| title = Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. \| journal = Hum Pathol \| volume = 32 \| issue = 10 \| pages = 1087-93 \| month = Oct \| year = 2001 \| doi = 10.1053/hupa.2001.28245 \| PMID = 11679943 }}</ref>).
	*CK20 -ve (0 +ve of 16 cases<ref name=pmid11679943/>).		*[[CK20]] -ve (0 +ve of 16 cases<ref name=pmid11679943/>).

	==Sign out==		==Sign out==

← Older revision		Revision as of 01:59, 30 October 2015
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	==See also==		==See also==
	*[[Lung tumours]].		*[[Lung tumours]].
			*[[Pancreatic neuroendocrine tumour]].
			*[[Gastric neuroendocrine tumour]].
			*[[Neuroendocrine tumours]].

	==References==		==References==