Urothelial dysplasia - Revision history

Michael: /* IHC */

2020-12-31T19:38:31Z

IHC

← Older revision		Revision as of 19:38, 31 December 2020
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	Note:		Note:
	*‡ Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{~~fact~~}} however, there is a small literature on [[p63]] for dysplasia versus UCIS that is published in lesser known journals.		*‡ Morphology is considered the gold standard for UCIS versus urothelial dysplasia;<ref name=pmid25029121>{{cite journal \|authors=Amin MB, Trpkov K, Lopez-Beltran A, Grignon D \|title=Best practices recommendations in the application of immunohistochemistry in the bladder lesions: report from the International Society of Urologic Pathology consensus conference \|journal=Am J Surg Pathol \|volume=38 \|issue=8 \|pages=e20–34 \|date=August 2014 \|pmid=25029121 \|doi=10.1097/PAS.0000000000000240 \|url=}}</ref> however, there is a small literature on [[p63]] for dysplasia versus UCIS that is published in lesser known journals.

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2016-12-26T16:18:44Z

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← Older revision		Revision as of 16:18, 26 December 2016
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	Comment:		Comment:
	The urothelium has ~~weak-to-~~moderate CK20 staining that extends to the basement membrane. A p53 stain is ~~NEGATIVE~~ (<10% staining). A Ki-67 stain shows increased staining (marks 20% of urothelium). A p63 stain shows weak/negative surface staining.		The urothelium has moderate CK20 staining that extends to the basement membrane. A p53 stain is negative (<10% staining). A Ki-67 stain shows increased staining (marks 20% of urothelium). A p63 stain shows weak/negative surface staining.
	</pre>		</pre>
	===Block letters===		===Block letters===

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2016-12-26T16:17:59Z

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← Older revision		Revision as of 16:17, 26 December 2016
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	<pre>		<pre>
	RIGHT URETER (MARGIN), EXCISION:		RIGHT URETER (MARGIN), EXCISION:
	- UROTHELIAL DYSPLASIA, SEE COMMENT.		- UROTHELIAL DYSPLASIA, SEE COMMENT.
	- NEGATIVE FOR UROTHELIAL CARCINOMA.		- NEGATIVE FOR UROTHELIAL CARCINOMA.

	COMMENT:		COMMENT:

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2016-12-26T16:17:21Z

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← Older revision		Revision as of 16:17, 26 December 2016
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	<pre>		<pre>
	A. RIGHT URETER (MARGIN), EXCISION:		Urinary Bladder, Biopsy:
			- Urothelial dysplasia, see comment.
			- Giant cell reaction and chronic inflammation.

			Comment:
			The urothelium has weak-to-moderate CK20 staining that extends to the basement membrane. A p53 stain is NEGATIVE (<10% staining). A Ki-67 stain shows increased staining (marks 20% of urothelium). A p63 stain shows weak/negative surface staining.
			</pre>
			===Block letters===
			<pre>
			RIGHT URETER (MARGIN), EXCISION:
	- UROTHELIAL DYSPLASIA, SEE COMMENT.		- UROTHELIAL DYSPLASIA, SEE COMMENT.
	- NEGATIVE FOR UROTHELIAL CARCINOMA.		- NEGATIVE FOR UROTHELIAL CARCINOMA.

Michael: /* IHC */

2016-05-18T12:21:15Z

IHC

← Older revision		Revision as of 12:21, 18 May 2016
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	\| -ve <=10% of cells (+/-rare basal cells)		\| -ve <=10% of cells (+/-rare basal cells)
	\| -ve <20% of cells (+/-weak staining)		\| -ve <20% of cells (+/-weak staining)
	\| -ve		\| -ve surface cells
	\|-		\|-
	\| Urothelial dysplasia		\| Urothelial dysplasia
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	\| +ve >10% of cells (~40% of cases)		\| +ve >10% of cells (~40% of cases)
	\| +ve >=20% of cells (~70% of cases)		\| +ve >=20% of cells (~70% of cases)
	\| -ve <ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref name=OJP>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>		\| -ve surface cells<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref name=OJP>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>
	\|-		\|-
	\| [[Urothelial carcinoma in situ\|Urothelial carcinoma in situ]] (UCIS)		\| [[Urothelial carcinoma in situ\|Urothelial carcinoma in situ]] (UCIS)
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	\| +ve >10% of cells (~95% of cases)		\| +ve >10% of cells (~95% of cases)
	\| +ve >=20% of cells (~80% of cases)		\| +ve >=20% of cells (~80% of cases)
	\| +ve <ref name=pmid19690775/><ref name=OJP/>		\| +ve surface cells<ref name=pmid19690775/><ref name=OJP/>
	\|}		\|}

Michael: /* IHC */

2016-05-18T12:19:55Z

IHC

← Older revision		Revision as of 12:19, 18 May 2016
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	! Ki-67		! Ki-67
	! p53		! p53
			! p63 ‡
	\|-		\|-
	\| Benign (reactive)		\| Benign (reactive)
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	\| -ve <=10% of cells (+/-rare basal cells)		\| -ve <=10% of cells (+/-rare basal cells)
	\| -ve <20% of cells (+/-weak staining)		\| -ve <20% of cells (+/-weak staining)
			\| -ve
	\|-		\|-
	\| Urothelial dysplasia		\| Urothelial dysplasia
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	\| +ve >10% of cells (~40% of cases)		\| +ve >10% of cells (~40% of cases)
	\| +ve >=20% of cells (~70% of cases)		\| +ve >=20% of cells (~70% of cases)
			\| -ve <ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref name=OJP>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>
	\|-		\|-
	\| [[Urothelial carcinoma in situ\|Urothelial carcinoma in situ]] (UCIS)		\| [[Urothelial carcinoma in situ\|Urothelial carcinoma in situ]] (UCIS)
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	\| +ve >10% of cells (~95% of cases)		\| +ve >10% of cells (~95% of cases)
	\| +ve >=20% of cells (~80% of cases)		\| +ve >=20% of cells (~80% of cases)
			\| +ve <ref name=pmid19690775/><ref name=OJP/>
	\|}		\|}

	Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on ~~IHC~~ for dysplasia versus UCIS that is published in lesser known journals and suggests:<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>		Note:
	*p63 -ve at surface in dysplasia.		*‡ Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on [[p63]] for dysplasia versus UCIS that is published in lesser known journals.
	**p63 +ve at surface in UCIS

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Michael: /* IHC */

2016-05-18T12:15:48Z

IHC

← Older revision		Revision as of 12:15, 18 May 2016
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	\| +ve >=20% of cells (~70% of cases)		\| +ve >=20% of cells (~70% of cases)
	\|-		\|-
	\| [[Urothelial carcinoma in situ\|Urothelial carcinoma in situ]] (UCIS		\| [[Urothelial carcinoma in situ\|Urothelial carcinoma in situ]] (UCIS)
	\| +ve non-umbrella cells (~70% of cases)		\| +ve non-umbrella cells (~70% of cases)
	\| +ve >10% of cells (~95% of cases)		\| +ve >10% of cells (~95% of cases)

Michael: /* IHC */

2016-05-18T12:15:11Z

IHC

← Older revision		Revision as of 12:15, 18 May 2016
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	\|}		\|}

			Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on IHC for dysplasia versus UCIS that is published in lesser known journals and suggests:<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>
	*Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on IHC for dysplasia versus UCIS that is published in lesser known journals and suggests:<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>
	*p63 -ve at surface in dysplasia.		*p63 -ve at surface in dysplasia.
	**p63 +ve at surface in UCIS		**p63 +ve at surface in UCIS

Michael: /* IHC */

2016-05-18T12:14:58Z

IHC

← Older revision		Revision as of 12:14, 18 May 2016
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	*Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on IHC for dysplasia versus UCIS.<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref> ~~It is published in lesser known journals but suggests:~~		*Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on IHC for dysplasia versus UCIS that is published in lesser known journals and suggests:<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref>
	*p63 -ve at surface in dysplasia.		*p63 -ve at surface in dysplasia.
	**p63 +ve at surface in UCIS		**p63 +ve at surface in UCIS

Michael: /* IHC */

2016-05-18T12:14:00Z

IHC

← Older revision		Revision as of 12:14, 18 May 2016
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	==IHC==		==IHC==
	There is a small literature on IHC for dysplasia versus UCIS.<ref>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref> It is published in lesser known journals but suggests:
	*p63 -ve at surface in dysplasia.
	**p63 +ve at surface in UCIS

	A comparison between benign, dysplasia and [[UCIS]]:<ref name=pmid12640096>{{Cite journal \| last1 = Mallofré \| first1 = C. \| last2 = Castillo \| first2 = M. \| last3 = Morente \| first3 = V. \| last4 = Solé \| first4 = M. \| title = Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. \| journal = Mod Pathol \| volume = 16 \| issue = 3 \| pages = 187-91 \| month = Mar \| year = 2003 \| doi = 10.1097/01.MP.0000056628.38714.5D \| PMID = 12640096 }}</ref>		A comparison between benign, dysplasia and [[UCIS]]:<ref name=pmid12640096>{{Cite journal \| last1 = Mallofré \| first1 = C. \| last2 = Castillo \| first2 = M. \| last3 = Morente \| first3 = V. \| last4 = Solé \| first4 = M. \| title = Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. \| journal = Mod Pathol \| volume = 16 \| issue = 3 \| pages = 187-91 \| month = Mar \| year = 2003 \| doi = 10.1097/01.MP.0000056628.38714.5D \| PMID = 12640096 }}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
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	\|}		\|}

	~~Note:~~
	*Morphology is considered the gold standard for UCIS versus urothelial dysplasia.{{~~fact~~}}		*Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on IHC for dysplasia versus UCIS.<ref name=pmid19690775>{{Cite journal \| last1 = Stepan \| first1 = A. \| last2 = Mărgăritescu \| first2 = C. \| last3 = Simionescu \| first3 = C. \| last4 = Ciurea \| first4 = R. \| title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. \| journal = Rom J Morphol Embryol \| volume = 50 \| issue = 3 \| pages = 461-5 \| month = \| year = 2009 \| doi = \| PMID = 19690775 }}</ref><ref>{{Cite journal \| last1 = Raheem\| first1 = Sayad A.\| last2 = Saied \| first2 = Abdel N. \| last3 = Al Shaer \| first3 = Rabee \| last4 = Mustafa \| first4 = Osama \| last5 = Ali \| first5 = Ali H. \| title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study \| journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] \| volume = \| issue = 4\| pages = 181-193 \| month = \| year = 2014 \| doi = 10.4236/ojpathology.2014.44024 \| PMID = \| PMC = \| url = }}</ref> It is published in lesser known journals but suggests:
			*p63 -ve at surface in dysplasia.
			**p63 +ve at surface in UCIS

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