Uterine cervix - Revision history

Michael: /* Mesonephric adenocarcinoma */

2021-11-17T18:31:12Z

Mesonephric adenocarcinoma

← Older revision		Revision as of 18:31, 17 November 2021
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	==Mesonephric adenocarcinoma==		==Mesonephric adenocarcinoma==
	~~===General===~~		{{Main\|Mesonephric adenocarcinoma}}
	*Arises from the [[mesonephric duct remnants]].

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP442>~~{{~~Ref WMSP~~\|~~442}}</ref>~~
	*Nuclear atypia - '''key feature'''.
	**Nuclear crowding.
	*Variable architecture:
	**Tubular, papillary, solid, retiform (net-like<ref>URL: [http://www.thefreedictionary.com/retiform http://www.thefreedictionary.com/retiform]. Accessed on: 25 August 2012.</ref>).

	~~DDx:~~
	*[[Mesonephric ~~duct remnants]].~~
	*[[Cervical adenocarcinoma]].
	*[[Colorectal adenocarcinoma~~]].~~
	*Endometrioid adenocarcinoma.

	~~===IHC===~~
	~~Features:<ref name=Ref_WMSP442>{{Ref WMSP\|442}}</ref>~~
	*CK7 +ve.
	*CD10 +ve.
	*AMACR +ve.
	*Napsin A +ve.<ref name=pmid31361605>{{cite journal \|authors=Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L \|title=Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract \|journal=Appl Immunohistochem Mol Morphol \|volume=28 \|issue=8 \|pages=593–601 \|date=September 2020 \|pmid=31361605 \|pmc=6987010 \|doi=10.1097/PAI.0000000000000801 \|url=}}</ref>
	*HNF-1beta +ve/-ve.
	**Not useful for differentiation from clear cell carcinoma of the gynecologic tract.<ref name=pmid31361605/>

	~~Others:<ref name=Ref_WMSP442>{{Ref WMSP\|442~~}}~~</ref>~~
	*[[CK20]] -ve.
	*ER -ve.
	*PR -ve.
	*CEA -ve.

	==Minimal deviation adenocarcinoma of the uterine cervix==		==Minimal deviation adenocarcinoma of the uterine cervix==

Michael: /* Mesonephric adenocarcinoma */

2021-11-17T18:28:47Z

Mesonephric adenocarcinoma

← Older revision		Revision as of 18:28, 17 November 2021
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	*CK7 +ve.		*CK7 +ve.
	*CD10 +ve.		*CD10 +ve.
			*AMACR +ve.
			*Napsin A +ve.<ref name=pmid31361605>{{cite journal \|authors=Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L \|title=Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract \|journal=Appl Immunohistochem Mol Morphol \|volume=28 \|issue=8 \|pages=593–601 \|date=September 2020 \|pmid=31361605 \|pmc=6987010 \|doi=10.1097/PAI.0000000000000801 \|url=}}</ref>
			*HNF-1beta +ve/-ve.
			**Not useful for differentiation from clear cell carcinoma of the gynecologic tract.<ref name=pmid31361605/>

	Others:<ref name=Ref_WMSP442>{{Ref WMSP\|442}}</ref>		Others:<ref name=Ref_WMSP442>{{Ref WMSP\|442}}</ref>

Michael at 23:23, 1 August 2016

2016-08-01T23:23:04Z

← Older revision		Revision as of 23:23, 1 August 2016
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	===IHC===		===IHC===
	Features:<ref name=pmid8803599>{{Cite journal \| last1 = Marques \| first1 = T. \| last2 = Andrade \| first2 = LA. \| last3 = Vassallo \| first3 = J. \| title = Endocervical tubal metaplasia and adenocarcinoma in situ: role of immunohistochemistry for carcinoembryonic antigen and vimentin in differential diagnosis. \| journal = Histopathology \| volume = 28 \| issue = 6 \| pages = 549-50 \| month = Jun \| year = 1996 \| doi = \| PMID = 8803599 }}</ref>		Features:<ref name=pmid8803599>{{Cite journal \| last1 = Marques \| first1 = T. \| last2 = Andrade \| first2 = LA. \| last3 = Vassallo \| first3 = J. \| title = Endocervical tubal metaplasia and adenocarcinoma in situ: role of immunohistochemistry for carcinoembryonic antigen and vimentin in differential diagnosis. \| journal = Histopathology \| volume = 28 \| issue = 6 \| pages = 549-50 \| month = Jun \| year = 1996 \| doi = \| PMID = 8803599 }}</ref>
	*Vimentin +ve.		*[[Vimentin]] +ve.
	*CEA -ve/+ve.		*CEA -ve/+ve.
	*p16 -ve.{{fact}}		*p16 -ve.{{fact}}

Michael: /* Stratified mucin-producing intraepithelial lesions of the cervix */

2016-06-16T13:19:27Z

Stratified mucin-producing intraepithelial lesions of the cervix

← Older revision		Revision as of 13:19, 16 June 2016
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	==Stratified mucin-producing intraepithelial lesions of the cervix==		==Stratified mucin-producing intraepithelial lesions of the cervix==
	*Abbreviated ''SMILE'' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion).		*Abbreviated ''SMILE'' ('''S'''tratified '''M'''ucin-producing '''I'''ntraepithelial '''LE'''sion).
	~~===General===~~		{{Main\|Stratified mucin-producing intraepithelial lesion of the cervix}}
	*Rare.
	*Often accompanied by [[cervical intraepithelial neoplasia]] and [[adenocarcinoma in situ]].<ref name=pmid11023104/>

	~~===Microscopic===~~
	~~Features:<ref name=pmid11023104>~~{{~~Cite journal \| last1 = Park \| first1 = JJ. \| last2 = Sun \| first2 = D. \| last3 = Quade \| first3 = BJ. \| last4 = Flynn \| first4 = C. \| last5 = Sheets~~ \| ~~first5 = EE. \| last6 = Yang \| first6 = A. \| last7 = McKeon \| first7 = F. \| last8 = Crum \| first8 = CP. \| title =~~ Stratified mucin-producing intraepithelial ~~lesions~~ of the cervix~~: adenosquamous or columnar cell neoplasia? \| journal = Am J Surg Pathol \| volume = 24 \| issue = 10 \| pages = 1414-9 \| month = Oct \| year = 2000 \| doi = \| PMID = 11023104~~ }}~~</ref>~~
	*Stratified epithelium with:
	**Nuclear atypia.
	**Cytoplasmic clearing or vacuoles in lesions - through-out.

	~~DDx:~~
	*[[HSIL]].
	**Mucin may be present superficially.<ref name=pmid11023104/>

	~~Images:~~
	*[http://sunnybrook.ca/uploads/cx_SMILE_S10-1021_vd_1.jpg SMILE (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_mal_ais_smile]. Accessed on: 30 March 2012.</ref>
	*[http://sunnybrook.ca/uploads/cx_SMILE_S10-1021_vd_2.jpg SMILE (sunnybrook.ca)].

	~~===IHC===~~
	~~Features:~~
	*Ki-67 high.
	*Keratin 14 -ve.
	*p63 +ve/-ve -- only basal if positive.

	=Uncommon types of cervical cancer=		=Uncommon types of cervical cancer=

Michael: /* Minimal deviation adenocarcinoma of the uterine cervix */ split out

2016-03-13T21:56:20Z

Minimal deviation adenocarcinoma of the uterine cervix: split out

← Older revision		Revision as of 21:56, 13 March 2016
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	*[[AKA]] ''adenoma malignum''.		*[[AKA]] ''adenoma malignum''.
	*[[AKA]] ''minimal deviation adenocarcinoma'', abbreviated ''MDA''.		*[[AKA]] ''minimal deviation adenocarcinoma'', abbreviated ''MDA''.
	~~===General===~~		{{Main\|Minimal deviation adenocarcinoma of the uterine cervix}}
	*Rare and difficult diagnosis.<ref name=pmid12828609>{{~~Cite journal~~ \| last1 = Tsuda \| first1 = H. \| last2 = Mikami \| first2 = Y. \| last3 = Kaku \| first3 = T. \| last4 = Akiyama \| first4 = F. \| last5 = Hasegawa \| first5 = T. \| last6 = Okada \| first6 = S. \| last7 = Hayashi \| first7 = I. \| last8 = Kasamatsu \| first8 = T. \| title = Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. \| journal = Pathol Int \| volume = 53 \| issue = 7 \| pages = 440-9 \| month = Jul \| year = 2003 \| doi = \| PMID = 12828609 }}</ref>
	**Requires a deep sampling;<ref name=pmid22385609>{{Cite journal \| last1 = Lim \| first1 = KT. \| last2 = Lee \| first2 = IH. \| last3 = Kim \| first3 = TJ. \| last4 = Kwon \| first4 = YS. \| last5 = Jeong \| first5 = JG. \| last6 = Shin \| first6 = SJ. \| title = Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases. \| journal = Kaohsiung J Med Sci \| volume = 28 \| issue = 3 \| pages = 161-4 \| month = Mar \| year = 2012 \| doi = 10.1016/j.kjms.2011.10.009 \| PMID = 22385609 }}</ref> thus, usually diagnosed on cone biopsy or hysterectomy.
	*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal \| last1 = Riegert-Johnson \| first1 = D. \| last2 = Roberts \| first2 = M. \| last3 = Gleeson \| first3 = FC. \| last4 = Krishna \| first4 = M. \| last5 = Boardman \| first5 = L. \| title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. \| journal = Fam Cancer \| volume = 10 \| issue = 3 \| pages = 463-8 \| month = Sep \| year = 2011 \| doi = 10.1007/s10689-011-9438-x \| PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal \| last1 = Ito \| first1 = M. \| last2 = Minamiguchi \| first2 = S. \| last3 = Mikami \| first3 = Y. \| last4 = Ueda \| first4 = Y. \| last5 = Sekiyama \| first5 = K. \| last6 = Yamamoto \| first6 = T. \| last7 = Takakura \| first7 = K. \| title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. \| journal = Pathol Res Pract \| volume = \| issue = \| pages = \| month = Aug \| year = 2012 \| doi = 10.1016/j.prp.2012.06.008 \| PMID = 22878090 }}</ref>
	*Poor prognosis.<ref name=pmid2764221>{{Cite journal \| last1 = Gilks \| first1 = CB. \| last2 = Young \| first2 = RH. \| last3 = Aguirre \| first3 = P. \| last4 = DeLellis \| first4 = RA. \| last5 = Scully \| first5 = RE. \| title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 9 \| pages = 717-29 \| month = Sep \| year = 1989 \| doi = \| PMID = 2764221 }}</ref>

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP441-2>{{Ref WMSP\|441-2}}</ref>~~
	*Deep infiltrating glands - '''key feature'''.
	**Desmoplastic stroma - may be subtle.
	**Perivascular and/or perineural location.
	*Minimal nuclear atypia.
	*Abnormal gland morphology<ref name=pmid2764221/> / loss of lobular (gland) architecture. †

	~~Note:~~
	*† '''Not''' a criterion required by all pathologists.<ref name=pmid12828609/>

	~~DDx:<ref name=pmid12828609/>~~
	*[[Adenocarcinoma of the uterine cervix]] - has "obvious" nuclear atypia.
	*[[Tunnel cluster]].

	~~===IHC===~~
	~~Features:~~
	*CEA +ve.<ref name=pmid2764221/>
	*p16 -ve.<ref name=pmid21497449>{{Cite journal \| last1 = He \| first1 = Y. \| last2 = Li \| first2 = L. \| last3 = Jiang \| first3 = W. \| last4 = Wang \| first4 = DQ. \| last5 = Xu \| first5 = L. \| last6 = Huang \| first6 = Q. \| last7 = Zhang \| first7 = Y. \| last8 = Yang \| first8 = KX. \| title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. \| journal = Pathol Res Pract \| volume = 207 \| issue = 5 \| pages = 295-9 \| month = May \| year = 2011 \| doi = 10.1016/j.prp.2011.02.011 \| PMID = 21497449 }}~~</ref>~~

	=See also=		=See also=

Michael: /* Minimal deviation adenocarcinoma of the uterine cervix */

2015-02-18T20:08:19Z

Minimal deviation adenocarcinoma of the uterine cervix

← Older revision		Revision as of 20:08, 18 February 2015
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	Features:		Features:
	*CEA +ve.<ref name=pmid2764221/>		*CEA +ve.<ref name=pmid2764221/>
	*p16 -ve.{{~~fact~~}}		*p16 -ve.<ref name=pmid21497449>{{Cite journal \| last1 = He \| first1 = Y. \| last2 = Li \| first2 = L. \| last3 = Jiang \| first3 = W. \| last4 = Wang \| first4 = DQ. \| last5 = Xu \| first5 = L. \| last6 = Huang \| first6 = Q. \| last7 = Zhang \| first7 = Y. \| last8 = Yang \| first8 = KX. \| title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. \| journal = Pathol Res Pract \| volume = 207 \| issue = 5 \| pages = 295-9 \| month = May \| year = 2011 \| doi = 10.1016/j.prp.2011.02.011 \| PMID = 21497449 }}</ref>

	=See also=		=See also=

Michael at 04:41, 21 October 2014

2014-10-21T04:41:35Z

← Older revision		Revision as of 04:41, 21 October 2014
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	#Identify possible squamous lesions.		#Identify possible squamous lesions.
	#Identify possible endocervical lesions.		#Identify possible endocervical lesions.

			==Benign entities of the cervix==
			The cervix is ''MANTLED'':
			* Mullerian papilloma/Mesonephric hyperplasia/[[Microglandular hyperplasia]].
			* [[Arias Stella reaction]].
			* [[Nabothian cyst]].
			* [[Tunnel cluster]]/Tuboendometrioid metaplasia.
			* Lobular endocervical glandular hyperplasia.
			* [[Endocervical polyp]]/Endocervicosis/[[Endometriosis]]/Ectopic prostatic tissue.
			* Diffuse laminar endocervical hyperplasia.

	=Benign=		=Benign=

Michael: /* Squamous metaplasia of the uterine cervix */ split out

2014-05-06T01:58:51Z

Squamous metaplasia of the uterine cervix: split out

← Older revision		Revision as of 01:58, 6 May 2014
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	==Squamous metaplasia of the uterine cervix==		==Squamous metaplasia of the uterine cervix==
	*Abbreviated ''SMC''.		*Abbreviated ''SMC''.
	~~===General===~~		{{Main\|Squamous metaplasia of the uterine cervix}}
	*Benign process: columnar cells -> squamoid cells.
	**Biologic response to irritation and/or inflammation.

	~~===Gross===~~
	*[[Acetowhite epithelium\|Acetowhite lesion]].<ref name=pmid19256708>{{~~Cite journal~~ \| last1 = Li \| first1 = W. \| last2 = Venkataraman \| first2 = S. \| last3 = Gustafsson \| first3 = U. \| last4 = Oyama \| first4 = JC. \| last5 = Ferris \| first5 = DG. \| last6 = Lieberman \| first6 = RW. \| title = Using acetowhite opacity index for detecting cervical intraepithelial neoplasia. \| journal = J Biomed Opt \| volume = 14 \| issue = 1 \| pages = 014020 \| month = \| year = \| doi = 10.1117/1.3079810 \| PMID = 19256708 }}</ref>

	~~===Microscopic===~~
	~~Features:~~
	* Uniform cell spacing - no crowding - '''key feature'''.
	* Nuclei are uniform size and round.
	** [[Nucleoli]] present.
	*Distinct cell borders
	* +/-Intercellular bridges (due to edema) - common.
	* Adjacent/closely associated with columnar epithelium.
	** Columnar epithelium superficial in immature metaplasia.

	~~Negatives:~~
	* No mitoses (think cancer/CIN if you see 'em).
	* Usually no hyperchromatism (think cancer/CIN if you see it).

	~~Notes:~~
	*NC ratio high - possible to confuse with CIN III.
	*May have goblet cells - uncommon.<ref name=pmid21077478>{{Cite journal \| last1 = Sivridis \| first1 = E. \| last2 = Karpathiou \| first2 = G. \| last3 = Malamou-Mitsi \| first3 = V. \| last4 = Giatromanolaki \| first4 = A. \| title = Intestinal-type metaplasia in the original squamous epithelium of the cervix~~. \| journal = Eur J Gynaecol Oncol \| volume = 31 \| issue = 3 \| pages = 319-22 \| month = \| year = 2010 \| doi = \| PMID = 21077478~~ }}~~</ref>~~

	~~DDx:~~
	*[[CIN II]] - esp. for immature squamous metaplasia.
	*[[CIN III]].
	*[[Squamous cell carcinoma of the uterine cervix]].

	~~Images:~~
	*[http://www.sciencephoto.com/media/294722/view Squamous metaplasia - cervix (sciencephoto.com)].
	*[http://commons.wikimedia.org/wiki/File:Bronchial_squamous_metaplasia.jpg Squamous metaplasia - bronchus (WC)].
	*[http://nih.techriver.net/patientImages%5C6676.jpg Squamous metaplasia - cytology (techriver.net)].
	*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod1img4b.html Immature squamous metaplasia (eurocytology.eu)].<ref>URL: [http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html http://www.eurocytology.eu/static/eurocytology/eng/cervical/LP1ContentAcontD.html]. Accessed on: 9 October 2013.</ref>

	~~===IHC===~~
	*p16 weak-to-moderate patchy +ve -- checkerboard-like; not full thickness.
	**Strong diffuse full thickness positivity in HSIL and SCC.
	*Ki-67 - low proliferative rate.

	~~===Sign out===~~
	~~====ECC====~~
	~~<pre>~~
	~~UTERINE ENDOCERVIX, CURETTAGE:~~
	~~- SQUAMOUS METAPLASTIC EPITHELIUM.~~
	~~- VERY SCANT STRIPPED ENDOCERVICAL EPITHELIUM.~~
	~~</pre>~~

	~~====Cervical biopsy====~~
	~~<pre>~~
	~~UTERINE CERVIX, BIOPSY:~~
	~~- SQUAMOUS METAPLASTIC EPITHELIUM.~~
	~~- SCANT BENIGN ENDOCERVICAL GLANDS.~~
	~~</pre>~~

	~~<pre>~~
	~~UTERINE CERVIX, BIOPSY:~~
	~~- SQUAMOUS METAPLASTIC EPITHELIUM.~~
	~~- SCANT BENIGN ENDOCERVICAL GLANDS.~~
	~~- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	~~====Micro====~~
	~~The sections show stratified squamous epithelium. The cells are equally spaced and spaces are seen between the cells (edema).~~

	The nuclei are not significantly enlarged (<3x resting lymphocyte diameter). No nuclear halos are apparent. The nuclear membranes are regular. Mild inflammation is present. Nucleoli are present focally.

	~~No endocervical cells are identified.~~

	==Reactive squamous epithelium of the uterine cervix==		==Reactive squamous epithelium of the uterine cervix==

Michael: /* Adenosquamous carcinoma */ split out

2014-04-25T02:39:01Z

Adenosquamous carcinoma: split out

← Older revision		Revision as of 02:39, 25 April 2014
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	*Like other [[serous carcinoma]]s.		*Like other [[serous carcinoma]]s.

	==Adenosquamous carcinoma==		==Adenosquamous carcinoma of the uterine cervix==
	~~===General===~~		{{Main\|Adenosquamous carcinoma of the uterine cervix}}
	*Uncomon.

	~~Note:~~
	*[[Glassy cell carcinoma]] is considered to be a subtype of adenosquamous carcinoma.<ref>{{~~Cite journal~~ \| last1 = Kosińiska-Kaczyńska \| first1 = K. \| last2 = Mazanowska \| first2 = N. \| last3 = Bomba-Opoń \| first3 = D. \| last4 = Horosz \| first4 = E. \| last5 = Marczewska \| first5 = M. \| last6 = Wielgoś \| first6 = M. \| title = Glassy cell carcinoma of the cervix~~--a case report with review of the literature. \| journal = Ginekol Pol \| volume = 82 \| issue = 12 \| pages = 936-9 \| month = Dec \| year = 2011 \| doi = \| PMID = 22384631~~ }}~~</ref>~~

	~~===Microscopic===~~
	~~Features:~~
	*Morphologic features of both squamous carcinoma and adenocarcinoma:
	**Adenocarcinoma: gland forming ''or'' mucin vacuoles.
	**[[Squamous carcinoma]]: abundant eosinophilic cytoplasm, central nucleus.

	~~====Images====~~
	~~<gallery>~~
	~~Image:Adenosquamous_carcinoma_intermed_mag.jpg \| Adenosquamous carcinoma - intermed. mag. (WC)~~
	~~Image:Adenosquamous_carcinoma_high_mag.jpg \| Adenosquamous carcinoma - high mag. (WC)~~
	~~</gallery>~~

	==Clear cell carcinoma of the uterine cervix==		==Clear cell carcinoma of the uterine cervix==

Michael: /* Glassy cell carcinoma */

2014-04-25T02:24:46Z

Glassy cell carcinoma

← Older revision		Revision as of 02:24, 25 April 2014
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	==Glassy cell carcinoma==		==Glassy cell carcinoma==
	~~===General===~~		{{Main\|Glassy cell carcinoma}}
	*Rare.
	*Rapid growth, poor prognosis.<ref name=pmid19527406>{{~~Cite journal~~ \| last1 = Nasu \| first1 = K. \| last2 = Takai \| first2 = N. \| last3 = Narahara \| first3 = H. \| title = Multimodal treatment for glassy cell carcinoma of the uterine cervix. \| journal = J Obstet Gynaecol Res \| volume = 35 \| issue = 3 \| pages = 584-7 \| month = Jun \| year = 2009 \| doi = 10.1111/j.1447-0756.2008.00968.x \| PMID = 19527406 }}</ref>
	*Considered a subtype of [[adenosquamous carcinoma]].<ref name=pmid22384631>{{Cite journal \| last1 = Kosińiska-Kaczyńska \| first1 = K. \| last2 = Mazanowska \| first2 = N. \| last3 = Bomba-Opoń \| first3 = D. \| last4 = Horosz \| first4 = E. \| last5 = Marczewska \| first5 = M. \| last6 = Wielgoś \| first6 = M. \| title = Glassy cell carcinoma of the cervix--a case report with review of the literature. \| journal = Ginekol Pol \| volume = 82 \| issue = 12 \| pages = 936-9 \| month = Dec \| year = 2011 \| doi = \| PMID = 22384631 }}</ref>

	~~===Microscopic===~~
	Features:<ref name=pmid11393075>{{Cite journal \| last1 = Reis-Filho \| first1 = JS. \| last2 = Fillus Neto \| first2 = J. \| last3 = Schonemann \| first3 = E. \| last4 = Sanderson \| first4 = A. \| last5 = Schmitt \| first5 = FC. \| title = Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. \| journal = Acta Cytol \| volume = 45 \| issue = 3 \| pages = 407-10 \| month = \| year = \| doi = \| PMID = 11393075 }}</ref>
	*Epithelioid cells in sheets or cords.
	*Round/oval nucleus.
	*One or more prominent nucleoli.
	*Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
	*Distinct cell borders.
	*Inflammation - esp. eosinophils.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=561 http://www.webpathology.com/image.asp?n=2&Case=561]. Accessed on: 4 September 2011.</ref>

	~~DDx:~~
	*[[Adenosquamous carcinoma of the uterine cervix]].
	*[[Squamous carcinoma of the uterine cervix]].

	~~====Images====~~
	~~<gallery>~~
	~~Image:Glassy_cell_carcinoma_-_low_mag.jpg \| GCC - low mag. (WC)~~
	~~Image:Glassy_cell_carcinoma_-_intermed_mag.jpg \| GCC - intermed. mag. (WC)~~
	~~Image:Glassy_cell_carcinoma_-_high_mag.jpg \| GCC - high mag. (WC)~~
	~~Image:Glassy_cell_carcinoma_-_very_high_mag.jpg \| GCC - very high mag. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.webpathology.com/image.asp?n=1&Case=561 GCC - low mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=2&Case=561 GCC - high mag. (webpathology.com)].
	*[http://path.upmc.edu/cases/case100/dx.html GCC - several images (upmc.edu)].

	~~===Stains===~~
	*[[PAS stain]] - marks plasma membrane.<ref name=pmid15318016>{{Cite journal \| last1 = Deshpande \| first1 = AH. \| last2 = Kotwal \| first2 = MN. \| last3 = Bobhate \| first3 = SK. \| title = Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. \| journal = Indian J Cancer \| volume = 41 \| issue = 2 \| pages = 92-5 \| month = \| year = \| doi = \| PMID = 15318016 \| URL = http://www.indianjcancer.com/text.asp?2004/41/2/92/12353}}~~</ref>~~

	==Villoglandular adenocarcinoma of the cervix==		==Villoglandular adenocarcinoma of the cervix==