Vascular tumours - Revision history

Michael at 22:03, 29 November 2024

2024-11-29T22:03:27Z

← Older revision		Revision as of 22:03, 29 November 2024
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	*[[Vasculitides]].		*[[Vasculitides]].
	*[[Soft tissue lesions]].		*[[Soft tissue lesions]].
			*[[Cisterna chyli]].

	=References=		=References=

Michael at 17:15, 18 January 2024

2024-01-18T17:15:50Z

← Older revision		Revision as of 17:15, 18 January 2024
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	==Retiform hemangioendothelioma==		==Retiform hemangioendothelioma==
	{{Main\|Retiform hemangioendothelioma}}		{{Main\|Retiform hemangioendothelioma}}

			==Intimal sarcoma==
			{{Main\|Intimal sarcoma}}

	=See also=		=See also=

Michael: /* Retiform haemangioendothelioma */

2020-03-03T21:20:48Z

Retiform haemangioendothelioma

← Older revision		Revision as of 21:20, 3 March 2020
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	{{Main\|Epithelioid hemangioendothelioma}}		{{Main\|Epithelioid hemangioendothelioma}}

	==Retiform ~~haemangioendothelioma~~==		==Retiform hemangioendothelioma==
	{{Main\|Retiform ~~haemangioendothelioma~~}}		{{Main\|Retiform hemangioendothelioma}}

	=See also=		=See also=

Michael: /* Epithelioid hemangioendothelioma */ +retiform h.

2020-03-03T21:18:56Z

Epithelioid hemangioendothelioma: +retiform h.

← Older revision		Revision as of 21:18, 3 March 2020
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	==Epithelioid hemangioendothelioma==		==Epithelioid hemangioendothelioma==
	{{Main\|Epithelioid hemangioendothelioma}}		{{Main\|Epithelioid hemangioendothelioma}}

			==Retiform haemangioendothelioma==
			{{Main\|Retiform haemangioendothelioma}}

	=See also=		=See also=

Michael at 19:22, 8 January 2018

2018-01-08T19:22:53Z

← Older revision		Revision as of 19:22, 8 January 2018
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			[[Image:Capillary_hemangioma_-_very_high_mag.jpg\|thumb\|right\|[[Micrograph]] showing a [[capillary hemangioma]], a common type of vascular tumour. [[H&E stain]].]]
	This article covers [[soft tissue lesions\|soft tissue]] '''vascular tumours'''. Vascular malformations are covered in the ''[[vascular malformations]]'' article.		This article covers [[soft tissue lesions\|soft tissue]] '''vascular tumours'''. Vascular malformations are covered in the ''[[vascular malformations]]'' article.

Michael: /* Hemangioma */

2015-10-19T13:41:45Z

Hemangioma

← Older revision		Revision as of 13:41, 19 October 2015
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	==Hemangioma==		==Hemangioma==
	{{Main\|Hemangioma}}		{{Main\|Hemangioma}}
			{{Main\|Liver hemangioma}}

	==Lymphangioma==		==Lymphangioma==

Michael: /* Masson hemangioma */ split out

2014-06-04T20:59:59Z

Masson hemangioma: split out

← Older revision		Revision as of 20:59, 4 June 2014
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	*[[AKA]] ''intravascular papillary endothelial hyperplasia''.<ref name=pmid15865098>{{cite journal \|author=Korkolis DP, Papaevangelou M, Koulaxouzidis G, Zirganos N, Psichogiou H, Vassilopoulos PP \|title=Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma \|journal=Anticancer Res. \|volume=25 \|issue=2B \|pages=1409–12 \|year=2005 \|pmid=15865098 \|doi= \|url=}}</ref>		*[[AKA]] ''intravascular papillary endothelial hyperplasia''.<ref name=pmid15865098>{{cite journal \|author=Korkolis DP, Papaevangelou M, Koulaxouzidis G, Zirganos N, Psichogiou H, Vassilopoulos PP \|title=Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a soft-tissue sarcoma \|journal=Anticancer Res. \|volume=25 \|issue=2B \|pages=1409–12 \|year=2005 \|pmid=15865098 \|doi= \|url=}}</ref>
	*[[AKA]] ''Masson tumor''.<ref>URL: [http://path.upmc.edu/cases/case544/dx.html http://path.upmc.edu/cases/case544/dx.html]. Accessed on: 25 January 2012.</ref>		*[[AKA]] ''Masson tumor''.<ref>URL: [http://path.upmc.edu/cases/case544/dx.html http://path.upmc.edu/cases/case544/dx.html]. Accessed on: 25 January 2012.</ref>
	~~===General===~~		{{Main\|intravascular papillary endothelial hyperplasia}}
	*Benign non-neoplastic lesion - a vessel that has thrombosed and recanalized.
	*Histomorphologically may be confused with low-grade [[angiosarcoma]] or other soft tissue sarcomas.<ref name=pmid15865098/>
	~~===Microscopic===~~
	~~Features:~~
	*Well-circumscribed - '''key (low power) feature'''.
	*Abundant small vascular channels with benign endothelium.
	*+/-Papillary formation with a fibrotic core covered by benign endothelium.<ref>URL: [http://path.upmc.edu/cases/case544.html http://path.upmc.edu/cases/case544.html]. Accessed on: 25 January 2012.</ref>

	~~Notes:~~
	*Looks like [[Kaposi sarcoma]] at high power.

	~~Images:~~
	*[http://path.upmc.edu/cases/case544.html Masson hemangioma - several images (upmc.edu)].

	==Angiosarcoma==		==Angiosarcoma==

Michael: /* Epithelioid hemangioendothelioma */ split out

2014-04-03T00:16:29Z

Epithelioid hemangioendothelioma: split out

← Older revision		Revision as of 00:16, 3 April 2014
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	==Epithelioid hemangioendothelioma==		==Epithelioid hemangioendothelioma==
	*Should '''not''' be confused with ''[[epithelioid hemangioma]]''.		{{Main\|Epithelioid hemangioendothelioma}}
	~~===General===~~
	*Malignant.<ref name=Ref_WMSP603>{{~~Ref WMSP\|603}}</ref>~~
	*Adults - wide age range.
	*Associated with oral contraceptives, vinyl chloride.<ref name=pmid20165548/>

	~~===Microscopic===~~
	Features:<ref name=pmid20165548>{{Cite journal \| last1 = Gupta \| first1 = R. \| last2 = Mathur \| first2 = SR. \| last3 = Gupta \| first3 = SD. \| last4 = Durgapal \| first4 = P. \| last5 = Iyer \| first5 = VK. \| last6 = Das \| first6 = CJ. \| last7 = Shalimar \| first7 = SK. \| last8 = Acharya \| first8 = . \| title = Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology. \| journal = Cytojournal \| volume = 6 \| issue = \| pages = 25 \| month = \| year = 2010 \| doi = 10.4103/1742-6413.58951 \| PMID = 20165548 \| URL = http://www.biomedsearch.com/nih/Hepatic-epithelioid-hemangioendothelioma-diagnostic-pitfall/20165548.html }}</ref>
	*Large epithelioid perivascular cells with:
	**Abundant pale eosinophilic cytoplasm.
	**Cytoplasmic vacuolation (some cells) - [[AKA]] "blister cells" - '''key feature'''.
	***May form lumen and have RBC within.
	**Vesicular nucleus with prominent nucleolus in some cells.
	*Tuft-like projections into capillaries.
	*Tumour cells may be in well-circumscribed paucicellular nodules ''or'' more cellular poorly formed aggregates.

	~~DDx:~~
	*[[Angiosarcoma]], epithelioid.
	*[[Hemangioma]].

	~~====Images====~~
	~~<gallery>~~
	~~Image:Epithelioid_hemangioendothelioma.jpg~~ \| Epithelioid hemangioendothelioma~~. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.flickr.com/photos/pulmonary_pathology/5600772691/in/photostream/ Epithelioid hemangioendothelioma - low mag. (flickr.com/Rosen)].
	*[http://www.flickr.com/photos/pulmonary_pathology/5601354962/ Epithelioid hemangioendothelioma - high mag. (flickr.com/Rosen)].
	*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170854495 Epithelioid hemangioendothelioma (surgicalpathologyatlas.com)].

	~~===IHC===~~
	Features:<ref name=pmid20165548>{{Cite journal \| last1 = Gupta \| first1 = R. \| last2 = Mathur \| first2 = SR. \| last3 = Gupta \| first3 = SD. \| last4 = Durgapal \| first4 = P. \| last5 = Iyer \| first5 = VK. \| last6 = Das \| first6 = CJ. \| last7 = Shalimar \| first7 = SK. \| last8 = Acharya \| first8 = . \| title = Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology. \| journal = Cytojournal \| volume = 6 \| issue = \| pages = 25 \| month = \| year = 2010 \| doi = 10.4103/1742-6413.58951 \| PMID = 20165548 \| URL = http://www.biomedsearch.com/nih/Hepatic-epithelioid-hemangioendothelioma-diagnostic-pitfall/20165548.html }}~~</ref>~~
	*CD31 +ve.
	*CD34 +ve.
	*Factor VIII +ve.

	=See also=		=See also=

Michael: /* IHC */ fix ref.

2013-11-04T04:06:01Z

IHC: fix ref.

← Older revision		Revision as of 04:06, 4 November 2013
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	===IHC===		===IHC===
	Features:<ref name=pmid19098468>{{Cite journal \| last1 = Kalof \| first1 = AN. \| last2 = Cooper \| first2 = K. \| title = D2-40 immunohistochemistry--so far! \| journal = Adv Anat Pathol \| volume = 16 \| issue = 1 \| pages = 62-4 \| month = Jan \| year = 2009 \| doi = 10.1097/PAP.0b013e3181915e94 \| PMID = 19098468 }}</ref><ref name=pmid11950918/>		Features:<ref name=pmid19098468>{{Cite journal \| last1 = Kalof \| first1 = AN. \| last2 = Cooper \| first2 = K. \| title = D2-40 immunohistochemistry--so far! \| journal = Adv Anat Pathol \| volume = 16 \| issue = 1 \| pages = 62-4 \| month = Jan \| year = 2009 \| doi = 10.1097/PAP.0b013e3181915e94 \| PMID = 19098468 }}</ref><ref name=pmid11950918>{{Cite journal \| last1 = Kahn \| first1 = HJ. \| last2 = Bailey \| first2 = D. \| last3 = Marks \| first3 = A. \| title = Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. \| journal = Mod Pathol \| volume = 15 \| issue = 4 \| pages = 434-40 \| month = Apr \| year = 2002 \| doi = 10.1038/modpathol.3880543 \| PMID = 11950918 }}</ref>
	*D2-40 +ve.		*D2-40 +ve.

Michael: /* Hemangioma */ split-out

2013-10-24T03:30:49Z

Hemangioma: split-out

← Older revision		Revision as of 03:30, 24 October 2013
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	=Distinct entities=		=Distinct entities=
	==Hemangioma==		==Hemangioma==
	{{ ~~Infobox external links~~		{{Main\|Hemangioma}}
	\| ~~Name =~~ Hemangioma
	~~\| EHVSC = 10172~~
	~~\| pathprotocols =~~
	~~\| wikipedia =~~
	~~\| pathoutlines =~~
	}}
	~~===General===~~
	*May be found in the liver.
	**Classically subcapsular.
	***May rupture and be life-threatening.<ref>{{Cite journal \| last1 = Vokaer \| first1 = B. \| last2 = Kothonidis \| first2 = K. \| last3 = Delatte \| first3 = P. \| last4 = De Cooman \| first4 = S. \| last5 = Pector \| first5 = JC. \| last6 = Liberale \| first6 = G. \| title = Should ruptured liver haemangioma be treated by surgery or by conservative means? A case report. \| journal = Acta Chir Belg \| volume = 108 \| issue = 6 \| pages = 761-4 \| month = \| year = \| doi = \| PMID = 19241936 }}</ref>

	~~Hemangiomas to remember - if you're only going remember a few:~~
	*''Glomeruloid'', ''infantile'', ''caverous'', ''capillary'', ''arteriovenous'', ''venous'' and ''intramuscular''.

	~~====Childhood====~~
	Common childhood hemangiomas:<ref name=pmid10410855>{{cite journal \|author=Prieto VG, Shea CR \|title=Selected cutaneous vascular neoplasms. A review \|journal=Dermatol Clin \|volume=17 \|issue=3 \|pages=507–20, viii \|year=1999 \|month=July \|pmid=10410855 \|doi= \|url=}}</ref>
	*Tufted - small clusters of blood vessels.
	*Microvenular hemangioma.
	*Glomeruloid hemangioma - associated with [[POEMS syndrome]], [[Castleman disease]].<ref name=pmid16860182>{{cite journal \|author=Uthup S, Balachandran K, Ammal VA, ''et al.'' \|title=Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma \|journal=Am. J. Kidney Dis. \|volume=48 \|issue=2 \|pages=e17–24 \|year=2006 \|month=August \|pmid=16860182 \|doi=10.1053/j.ajkd.2006.04.089 \|url=}}</ref><ref name=Ref_WMSP618>{{Ref WMSP\|618}}</ref>
	*Epithelioid hemangioma - see ''[[angiolymphoid hyperplasia with eosinophilia‎]]''.
	*Targetoid hemosideric hemangioma.
	*Infantile hemangioma (AKA juvenile hemangioma<ref name=pmid10665907>{{Cite journal \| last1 = North \| first1 = PE. \| last2 = Waner \| first2 = M. \| last3 = Mizeracki \| first3 = A. \| last4 = Mihm \| first4 = MC. \| title = GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. \| journal = Hum Pathol \| volume = 31 \| issue = 1 \| pages = 11-22 \| month = Jan \| year = 2000 \| doi = \| PMID = 10665907 }}</ref>) - these tumours are ''GLUT-1'' +ve. They tumours grow and then spontaneously regress.<ref name=pmid15143338>{{Cite journal \| last1 = Dadras \| first1 = SS. \| last2 = North \| first2 = PE. \| last3 = Bertoncini \| first3 = J. \| last4 = Mihm \| first4 = MC. \| last5 = Detmar \| first5 = M. \| title = Infantile hemangiomas are arrested in an early developmental vascular differentiation state. \| journal = Mod Pathol \| volume = 17 \| issue = 9 \| pages = 1068-79 \| month = Sep \| year = 2004 \| doi = 10.1038/modpathol.3800153 \| PMID = 15143338 }}</ref>

	~~====Soft tissue====~~
	~~Several types are seen in soft tissue:<ref>{{Ref WMSP\|602}}</ref>~~
	*Capillary.
	*Cavernous.
	*Arteriovenous.
	*Venous.
	*Intramuscular.
	*Synovial.

	~~===Microscopic===~~
	~~Features:~~
	*Channels lined by benign endothelium containing [[RBC]]s.

	~~DDx:~~
	*[[Lymphangioma]].
	*[[Angiokeratoma]].
	*[[Lobular capillary hemangioma]] (pyogenic granuloma).

	~~====Images====~~
	~~<gallery>~~
	~~Image:Capillary_hemangioma_-_intermed_mag.jpg \| Capillary hemangioma - intermed. mag. (WC/Nephron)~~
	~~Image:Capillary_hemangioma_-_very_high_mag.jpg \| Capillary hemangioma - very high mag. (WC/Nephron)~~
	~~Image:Cavernous liver hemangioma - intermed mag.jpg \| Cavernous liver hemangioma - intermed. mag. (WC/Nephron)~~
	~~Image:Cavernous_liver_hemangioma_-_high_mag.jpg \| Cavernous liver hemangioma - high mag. (WC/Nephron)~~
	~~Image:Cavernous_hemangioma_histopathology_(1).jpg \| Cavernous hemangioma. (WC/KGH)~~
	~~Image:Cavernous_hemangioma_histopathology_%282%29.jpg \| Cavernous hemangioma. (WC/KGH)~~
	~~</gallery>~~
	~~www:~~
	*[http://path.upmc.edu/cases/case277.html Diffuse hemangioma - several images (upmc.edu)].

	~~===IHC===~~
	*CD31 +ve.
	*D2-40 -ve.<ref name=pmid11950918>{{Cite journal \| last1 = Kahn \| first1 = HJ. \| last2 = Bailey \| first2 = D. \| last3 = Marks \| first3 = A. \| title = Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. \| journal = Mod Pathol \| volume = 15 \| issue = 4 \| pages = 434-40 \| month = Apr \| year = 2002 \| doi = 10.1038/modpathol.3880543 \| PMID = 11950918 \| URL = http://www.nature.com/modpathol/journal/v15/n4/full/3880543a.html }}~~</ref>~~

	~~''Juvenile hemangioma'':<ref name=pmid10665907/>~~
	*GLUT-1 +ve.

	~~===Sign out===~~
	~~<pre>~~
	~~SUBCUTANEOUS NECK LESION, LEFT, EXCISION:~~
	~~- CAVERNOUS HEMANGIOMA.~~
	~~- NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	~~<pre>~~
	~~LESION, LEFT SIDE OF FACE, EXCISION:~~
	~~- CAPILLARY HEMANGIOMA.~~
	~~- NEGATIVE FOR MALIGNANCY.~~
	~~</pre>~~

	~~====Micro====~~
	The sections show hair-bearing skin with abundant small superficial vascular channels containing red blood cells. The endothelial cells of the vascular channels do not have atypia. No mitotic activity is appreciated. The overlying epidermis is unremarkable. Extensive solar elastosis is present. No nevus is identified.

	==Lymphangioma==		==Lymphangioma==