Villitis of unknown etiology - Revision history

Michael at 19:40, 28 January 2014

2014-01-28T19:40:46Z

← Older revision		Revision as of 19:40, 28 January 2014
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	*'''No''' plasma cells - this suggests an infectious etiology.<ref>Sherman, C. 7 February 2011.</ref>		*'''No''' plasma cells - this suggests an infectious etiology.<ref>Sherman, C. 7 February 2011.</ref>
	**Rare plasma cells may be seen in the decidua -- these can be ignored.		**Rare plasma cells may be seen in the decidua -- these can be ignored.

			DDx:
			*[[Acute villitis]].

	===Images===		===Images===

Michael: +SO -- posisible

2014-01-28T19:39:48Z

+SO -- posisible

← Older revision		Revision as of 19:39, 28 January 2014
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	*[http://www.flickr.com/photos/jian-hua_qiao_md/3954022678/in/photostream/ VUE (flickr.com)].<ref name=jian>URL: [http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/ http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/]. Accessed on: 11 January 2011.</ref>		*[http://www.flickr.com/photos/jian-hua_qiao_md/3954022678/in/photostream/ VUE (flickr.com)].<ref name=jian>URL: [http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/ http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/]. Accessed on: 11 January 2011.</ref>

			==Sign out==
			<pre>
			PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CESAREAN SECTION:
			- FETAL MEMBRANES WITH MECONIUM-LADEN MACROPHAGES, NEGATIVE FOR CHORIOAMNIONITIS.
			- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITH:
			-- FOCAL LYMPHOHISTOCYTIC VILLITIS, SEE COMMENT.
			-- LARGE AVASCULAR VILLI.
			-- MINUTE FOCUS OF ACUTE VILLITIS AND SMALL FOCUS OF INTERVILLITIS.
			-- PLACENTAL INFARCTS, MULTIPLE, SMALL.
			-- PERIVILLOUS FIBRIN DEPOSITION, MODERATE.
			-- THROMBUS.
			- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.

			COMMENT:
			The change is suggestive with villitis of unknown etiology.
			</pre>
	==See also==		==See also==
	*[[Acute villitis]].		*[[Acute villitis]].

Michael: /* Microscopic */

2014-01-28T14:09:02Z

Microscopic

← Older revision		Revision as of 14:09, 28 January 2014
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	*Infective villitis is usu. B-cell predominant.		*Infective villitis is usu. B-cell predominant.
	*'''No''' plasma cells - this suggests an infectious etiology.<ref>Sherman, C. 7 February 2011.</ref>		*'''No''' plasma cells - this suggests an infectious etiology.<ref>Sherman, C. 7 February 2011.</ref>
	**~~Plasma~~ cells may be seen in the decidua -- these can be ignored.		**Rare plasma cells may be seen in the decidua -- these can be ignored.

	===Images===		===Images===

Michael at 13:56, 28 January 2014

2014-01-28T13:56:32Z

← Older revision		Revision as of 13:56, 28 January 2014
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	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence = ~~rare~~		\| Prevalence = uncommon
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =

Michael: split-out

2013-09-27T12:13:05Z

split-out

← Older revision		Revision as of 12:13, 27 September 2013
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	~~#redirect~~ [[Placenta~~#Villitis_of_unknown_etiology~~]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Villitis_of_unknown_etiology_-_very_high_mag.jpg
			\| Width =
			\| Caption = Villitis of unknown etiology. [[H&E stain]].
			\| Micro = lymphocytes in the villous stroma, no neutrophils, no significant plasma cells
			\| Subtypes =
			\| LMDDx = [[acute villitis]]
			\| Stains =
			\| IHC = lymphocytes predominantly CD8 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[placenta]]
			\| Assdx = [[IUGR]], recurrent pregnancy loss
			\| Syndromes =
			\| Clinicalhx = +/-previous pregnancy loss
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			}}
			'''Villitis of unknown etiology''', abbreviated '''VUE''', is rare recurrent pathology of the [[placenta]].

			==General==
			Features:<ref name=pmid17889674>{{cite journal \|author=Redline RW \|title=Villitis of unknown etiology: noninfectious chronic villitis in the placenta \|journal=Hum. Pathol. \|volume=38 \|issue=10 \|pages=1439–46 \|year=2007 \|month=October \|pmid=17889674 \|doi=10.1016/j.humpath.2007.05.025 \|url=}}</ref>
			*Usually term placenta.
			*Prevalence: 5% to 15% of all placentas.
			*Associated with:
			**[[Intrauterine growth restriction]] (IUGR).
			**Recurrent reproductive loss/adverse outcomes in subsequent pregnancies -- '''key point'''.
			***Recurrence in up 37% of cases.<ref name=pmid20604650>{{cite journal \|author=Feeley L, Mooney EE \|title=Villitis of unknown aetiology: correlation of recurrence with clinical outcome \|journal=J Obstet Gynaecol \|volume=30 \|issue=5 \|pages=476–9 \|year=2010 \|pmid=20604650 \|doi=10.3109/01443611003802339 \|url=}}</ref>

			Etiology:
			*Unknown - as the name of the entity suggests.
			**Suspected to be immune-mediated.

			==Microscopic==
			Features:<ref name=pmid17889674/>
			*Lymphocytes in villous stroma - '''key feature'''.
			**Usually focal/patchy.
			**Lymphocytes: maternal derivation, T-lymphocytes -- mostly CD8-positive.
			*+/-Intervillositis (lymphocytes between villi).
			*+/-Histiocytes.

			Notes:
			*Lymphocytes are smaller and stain darker than the cells of the villi. (???)
			*Neutrophils are usually absent. A significant number of 'em is suggestive of an infectious villitis.
			*Infective villitis is usu. B-cell predominant.
			*'''No''' plasma cells - this suggests an infectious etiology.<ref>Sherman, C. 7 February 2011.</ref>
			**Plasma cells may be seen in the decidua -- these can be ignored.

			===Images===
			<gallery>
			Image:Villitis_of_unknown_etiology_-_intermed_mag.jpg \| VUE - intermed. mag. (WC)
			Image:Villitis_of_unknown_etiology_-_very_high_mag.jpg \| VUE - very high mag. (WC)
			</gallery>
			www:
			*[http://jcp.bmj.com/content/61/12/1254/F6.large.jpg VUE (bmj.com)].<ref>URL: [http://jcp.bmj.com/content/61/12/1254.abstract http://jcp.bmj.com/content/61/12/1254.abstract]. Accessed on: 11 January 2011.</ref>
			**[http://farm4.static.flickr.com/3501/3954021698_84a3542b43.jpg VUE (flickr.com)].<ref name=jian>URL: [http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/ http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/]. Accessed on: 11 January 2011.</ref>
			*[http://www.flickr.com/photos/jian-hua_qiao_md/3954022678/in/photostream/ VUE (flickr.com)].<ref name=jian>URL: [http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/ http://www.flickr.com/photos/jian-hua_qiao_md/3954021698/]. Accessed on: 11 January 2011.</ref>

			==See also==
			*[[Acute villitis]].
			*[[TORCH infection]].
			*[[Placenta]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Placenta]]

Michael: +cat.

2011-10-18T04:38:02Z

+cat.

← Older revision		Revision as of 04:38, 18 October 2011
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	#redirect [[Placenta#Villitis_of_unknown_etiology]]		#redirect [[Placenta#Villitis_of_unknown_etiology]]

			[[Category:Diagnosis]]

Michael: redirect

2011-08-21T15:53:52Z

redirect

New page

#redirect [[Placenta#Villitis_of_unknown_etiology]]