Wilson's disease - Revision history

Mitchell: /* Microscopic */ added a case

2017-01-09T19:17:20Z

Microscopic: added a case

← Older revision		Revision as of 19:17, 9 January 2017
Line 22:		Line 22:
	*[[Steatosis of the liver\|Steatosis]].		*[[Steatosis of the liver\|Steatosis]].
	*Portal fibrosis.		*Portal fibrosis.
	{\|
	[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]		A. [[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]<br>
	[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]		B. [[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]<br>
	<br>		C. [[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]<br>
	[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]		D. [[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]<br>
	[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]		Wilson’s disease, pre-cirrhotic. A. Inflamed & relatively unaffected segments. B. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]. C. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli. D. Trichrome shows periportal & sinusoidal fibrosis.
	\|}
	Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments ~~(UL 40X)~~. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] ~~(UR 200X)~~. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli ~~(LL 400X)~~. Trichrome shows periportal & sinusoidal fibrosis (~~LR 100X~~).		[[File:4 38555059990939 sl 1.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 2.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 3.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 4.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 5.png\|Wilson’s disease with cirrhosis]] <br>
			Wilson’s disease with cirrhosis in a 22 year old woman. A. Nodules show steatosis without definite triads. B. Trichrome shows minute fibrous bound nodules in this case. C. Reticulin shows extensive regeneration (2-3 nuclei thick cords with lack of direction) with nodule formation. D. Bridge with extensive proliferated bile ductules and acute and chronic inflammatory cells. E. Ballooning degeneration with Mallory bodies.

	==Stains==		==Stains==

Mitchell: /* Microscopic */

2016-07-29T16:55:08Z

Microscopic

← Older revision		Revision as of 16:55, 29 July 2016
Line 25:		Line 25:
	[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]		[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]
	[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]		[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
			<br>
	[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]		[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
	[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]		[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]

Mitchell: /* Microscopic */

2016-07-22T20:04:13Z

Microscopic

← Older revision		Revision as of 20:04, 22 July 2016
Line 22:		Line 22:
	*[[Steatosis of the liver\|Steatosis]].		*[[Steatosis of the liver\|Steatosis]].
	*Portal fibrosis.		*Portal fibrosis.
	~~Table show [[WILSON 1]]~~
	{\|
	~~[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]~~
	~~[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]~~
	\|-
	~~[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]~~
	~~[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]~~
	\|}
	Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).

	{\|		{\|
	[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]		[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]

Mitchell: /* Microscopic */ Added a case of pre-cirrhotic Wilson's disease

2016-07-22T20:03:32Z

Microscopic: Added a case of pre-cirrhotic Wilson's disease

← Older revision		Revision as of 20:03, 22 July 2016
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	[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]		[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
	\|-		\|-
			[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
			[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]
			\|}
			Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).

			{\|
			[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]
			[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
	[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]		[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
	[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]		[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]

Mitchell: /* Microscopic */ Added a case of pre-cirrhotic Wilson's disease

2016-07-22T20:02:40Z

Microscopic: Added a case of pre-cirrhotic Wilson's disease

← Older revision		Revision as of 20:02, 22 July 2016
Line 22:		Line 22:
	*[[Steatosis of the liver\|Steatosis]].		*[[Steatosis of the liver\|Steatosis]].
	*Portal fibrosis.		*Portal fibrosis.
			Table show [[WILSON 1]]
			{\|
			[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]
			[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
			\|-
			[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
			[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]
			\|}
			Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).

	==Stains==		==Stains==

Michael: /* Additional testing */

2015-09-25T14:27:15Z

Additional testing

← Older revision		Revision as of 14:27, 25 September 2015
Line 38:		Line 38:
	*Atomic absorption spectroscopy.		*Atomic absorption spectroscopy.
	**>250 microg of copper/g of liver suggest Wilson's disease; below does not exclude it.<ref name=pmid16234011>{{Cite journal \| last1 = Ferenci \| first1 = P. \| last2 = Steindl-Munda \| first2 = P. \| last3 = Vogel \| first3 = W. \| last4 = Jessner \| first4 = W. \| last5 = Gschwantler \| first5 = M. \| last6 = Stauber \| first6 = R. \| last7 = Datz \| first7 = C. \| last8 = Hackl \| first8 = F. \| last9 = Wrba \| first9 = F. \| title = Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease. \| journal = Clin Gastroenterol Hepatol \| volume = 3 \| issue = 8 \| pages = 811-8 \| month = Aug \| year = 2005 \| doi = \| PMID = 16234011 }}</ref>		**>250 microg of copper/g of liver suggest Wilson's disease; below does not exclude it.<ref name=pmid16234011>{{Cite journal \| last1 = Ferenci \| first1 = P. \| last2 = Steindl-Munda \| first2 = P. \| last3 = Vogel \| first3 = W. \| last4 = Jessner \| first4 = W. \| last5 = Gschwantler \| first5 = M. \| last6 = Stauber \| first6 = R. \| last7 = Datz \| first7 = C. \| last8 = Hackl \| first8 = F. \| last9 = Wrba \| first9 = F. \| title = Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease. \| journal = Clin Gastroenterol Hepatol \| volume = 3 \| issue = 8 \| pages = 811-8 \| month = Aug \| year = 2005 \| doi = \| PMID = 16234011 }}</ref>
	**250 microg of copper/g of liver cut-off [[~~sensitivity~~]] ~~80-86% (dependent on sampling).~~<ref>{{Cite journal \| last1 = Liggi \| first1 = M. \| last2 = Mais \| first2 = C. \| last3 = Demurtas \| first3 = M. \| last4 = Sorbello \| first4 = O. \| last5 = Demelia \| first5 = E. \| last6 = Civolani \| first6 = A. \| last7 = Demelia \| first7 = L. \| title = Uneven distribution of hepatic copper concentration and diagnostic value of double-sample biopsy in Wilson's disease. \| journal = Scand J Gastroenterol \| volume = 48 \| issue = 12 \| pages = 1452-8 \| month = Dec \| year = 2013 \| doi = 10.3109/00365521.2013.845904 \| PMID = 24164422 }}</ref>
			[[Sensitivity]]:<ref>{{Cite journal \| last1 = Liggi \| first1 = M. \| last2 = Mais \| first2 = C. \| last3 = Demurtas \| first3 = M. \| last4 = Sorbello \| first4 = O. \| last5 = Demelia \| first5 = E. \| last6 = Civolani \| first6 = A. \| last7 = Demelia \| first7 = L. \| title = Uneven distribution of hepatic copper concentration and diagnostic value of double-sample biopsy in Wilson's disease. \| journal = Scand J Gastroenterol \| volume = 48 \| issue = 12 \| pages = 1452-8 \| month = Dec \| year = 2013 \| doi = 10.3109/00365521.2013.845904 \| PMID = 24164422 }}</ref>
			*250 microg of copper/g of liver - 80-86% (value dependent on sampling).
			*50 microg of copper/g of liver - 97%.

	==See also==		==See also==

Michael: /* Additional testing */

2015-09-25T14:11:17Z

Additional testing

← Older revision		Revision as of 14:11, 25 September 2015
Line 38:		Line 38:
	*Atomic absorption spectroscopy.		*Atomic absorption spectroscopy.
	**>250 microg of copper/g of liver suggest Wilson's disease; below does not exclude it.<ref name=pmid16234011>{{Cite journal \| last1 = Ferenci \| first1 = P. \| last2 = Steindl-Munda \| first2 = P. \| last3 = Vogel \| first3 = W. \| last4 = Jessner \| first4 = W. \| last5 = Gschwantler \| first5 = M. \| last6 = Stauber \| first6 = R. \| last7 = Datz \| first7 = C. \| last8 = Hackl \| first8 = F. \| last9 = Wrba \| first9 = F. \| title = Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease. \| journal = Clin Gastroenterol Hepatol \| volume = 3 \| issue = 8 \| pages = 811-8 \| month = Aug \| year = 2005 \| doi = \| PMID = 16234011 }}</ref>		**>250 microg of copper/g of liver suggest Wilson's disease; below does not exclude it.<ref name=pmid16234011>{{Cite journal \| last1 = Ferenci \| first1 = P. \| last2 = Steindl-Munda \| first2 = P. \| last3 = Vogel \| first3 = W. \| last4 = Jessner \| first4 = W. \| last5 = Gschwantler \| first5 = M. \| last6 = Stauber \| first6 = R. \| last7 = Datz \| first7 = C. \| last8 = Hackl \| first8 = F. \| last9 = Wrba \| first9 = F. \| title = Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease. \| journal = Clin Gastroenterol Hepatol \| volume = 3 \| issue = 8 \| pages = 811-8 \| month = Aug \| year = 2005 \| doi = \| PMID = 16234011 }}</ref>
			**250 microg of copper/g of liver cut-off [[sensitivity]] 80-86% (dependent on sampling).<ref>{{Cite journal \| last1 = Liggi \| first1 = M. \| last2 = Mais \| first2 = C. \| last3 = Demurtas \| first3 = M. \| last4 = Sorbello \| first4 = O. \| last5 = Demelia \| first5 = E. \| last6 = Civolani \| first6 = A. \| last7 = Demelia \| first7 = L. \| title = Uneven distribution of hepatic copper concentration and diagnostic value of double-sample biopsy in Wilson's disease. \| journal = Scand J Gastroenterol \| volume = 48 \| issue = 12 \| pages = 1452-8 \| month = Dec \| year = 2013 \| doi = 10.3109/00365521.2013.845904 \| PMID = 24164422 }}</ref>

	==See also==		==See also==

Michael: /* Additional testing */

2015-09-23T18:05:52Z

Additional testing

← Older revision		Revision as of 18:05, 23 September 2015
Line 34:		Line 34:

	==Additional testing==		==Additional testing==
	*Mass spectrometry - ~~determine portion~~ of copper.		Copper quantification:
			*Mass spectrometry.<ref name=pmid24731025>{{Cite journal \| last1 = Hahn \| first1 = SH. \| title = Population screening for Wilson's disease. \| journal = Ann N Y Acad Sci \| volume = 1315 \| issue = \| pages = 64-9 \| month = May \| year = 2014 \| doi = 10.1111/nyas.12423 \| PMID = 24731025 }}</ref>
			*Atomic absorption spectroscopy.
			**>250 microg of copper/g of liver suggest Wilson's disease; below does not exclude it.<ref name=pmid16234011>{{Cite journal \| last1 = Ferenci \| first1 = P. \| last2 = Steindl-Munda \| first2 = P. \| last3 = Vogel \| first3 = W. \| last4 = Jessner \| first4 = W. \| last5 = Gschwantler \| first5 = M. \| last6 = Stauber \| first6 = R. \| last7 = Datz \| first7 = C. \| last8 = Hackl \| first8 = F. \| last9 = Wrba \| first9 = F. \| title = Diagnostic value of quantitative hepatic copper determination in patients with Wilson's Disease. \| journal = Clin Gastroenterol Hepatol \| volume = 3 \| issue = 8 \| pages = 811-8 \| month = Aug \| year = 2005 \| doi = \| PMID = 16234011 }}</ref>

	==See also==		==See also==

Michael: /* General */

2015-09-14T16:13:15Z

General

← Older revision		Revision as of 16:13, 14 September 2015
Line 11:		Line 11:
	*Kayser-Fleischer rings --> on slit-lamp examination (green eyes).		*Kayser-Fleischer rings --> on slit-lamp examination (green eyes).
	*May present to psychiatry or appear to be abusing EtOH.		*May present to psychiatry or appear to be abusing EtOH.
	*Serum ceruloplasmin - lower than normal.		*Serum ceruloplasmin - lower than normal; typical value for Wilson's ~ 0.12 g/L.
			**<0.20 g/L is a criteria for Wilson's disease.<ref name=pmid18556333>Diagnostic accuracy of serum ceruloplasmin in Wilson disease: determination of sensitivity and specificity by ROC curve analysis among ATP7B-genotyped subjects. Mak CM, Lam CW, Tam S. Clin Chem. 2008 Aug;54(8):1356-62. Epub 2008 Jun 12. PMID 18556333. URL: [http://www.clinchem.org/cgi/reprint/54/8/1356.pdf http://www.clinchem.org/cgi/reprint/54/8/1356.pdf]. Accessed on: 28 September 2009.</ref>

	Etiology:		Etiology:

Michael at 12:15, 14 September 2015

2015-09-14T12:15:54Z

← Older revision		Revision as of 12:15, 14 September 2015
Line 45:		Line 45:

	[[Category:Medical liver disease]]		[[Category:Medical liver disease]]
			[[Category:Diagnosis]]

← Older revision		Revision as of 19:17, 9 January 2017
Line 22:		Line 22:
	*[[Steatosis of the liver\|Steatosis]].		*[[Steatosis of the liver\|Steatosis]].
	*Portal fibrosis.		*Portal fibrosis.
	{\|
	[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]		A. [[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]<br>
	[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]		B. [[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]<br>
	<br>		C. [[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]<br>
	[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]		D. [[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]<br>
	[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]		Wilson’s disease, pre-cirrhotic. A. Inflamed & relatively unaffected segments. B. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]. C. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli. D. Trichrome shows periportal & sinusoidal fibrosis.
	\|}
	Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments ~~(UL 40X)~~. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] ~~(UR 200X)~~. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli ~~(LL 400X)~~. Trichrome shows periportal & sinusoidal fibrosis (~~LR 100X~~).		[[File:4 38555059990939 sl 1.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 2.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 3.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 4.png\|Wilson’s disease with cirrhosis]]
			[[File:4 38555059990939 sl 5.png\|Wilson’s disease with cirrhosis]] <br>
			Wilson’s disease with cirrhosis in a 22 year old woman. A. Nodules show steatosis without definite triads. B. Trichrome shows minute fibrous bound nodules in this case. C. Reticulin shows extensive regeneration (2-3 nuclei thick cords with lack of direction) with nodule formation. D. Bridge with extensive proliferated bile ductules and acute and chronic inflammatory cells. E. Ballooning degeneration with Mallory bodies.

	==Stains==		==Stains==

← Older revision		Revision as of 16:55, 29 July 2016
Line 25:		Line 25:
	[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]		[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]
	[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]		[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
			<br>
	[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]		[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
	[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]		[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]

← Older revision		Revision as of 20:04, 22 July 2016
Line 22:		Line 22:
	*[[Steatosis of the liver\|Steatosis]].		*[[Steatosis of the liver\|Steatosis]].
	*Portal fibrosis.		*Portal fibrosis.
	~~Table show [[WILSON 1]]~~
	{\|
	~~[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]~~
	~~[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]~~
	\|-
	~~[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]~~
	~~[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]~~
	\|}
	Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).

	{\|		{\|
	[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]		[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]

← Older revision		Revision as of 20:03, 22 July 2016
Line 27:		Line 27:
	[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]		[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
	\|-		\|-
			[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
			[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]
			\|}
			Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).

			{\|
			[[File:1 Wilson 1 680x512px.tif\|Inflamed & relatively unaffected segments (40X).]]
			[[File:2 Wilson 1 680x512px.tif\|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]
	[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]		[[File:3 Wilson 1 680x512px.tif\|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
	[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]		[[File:4 Wilson 1 680x512px.tif\|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]