Zenker's diverticulum - Revision history

Michael: +infobox

2016-01-21T15:25:56Z

+infobox

← Older revision		Revision as of 15:25, 21 January 2016
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Pharyngoesophageal diverticulum -- low mag.jpg
			\| Width =
			\| Caption = Consistent with Zenker's diverticulum (squamous mucosa). [[H&E stain]].
			\| Synonyms = cricopharyngeal diverticulum, pharyngoesophageal diverticulum and hypopharyngeal diverticulum
			\| Micro = squamous mucosa without [[nuclear atypia]] +/- parakeratosis
			\| Subtypes =
			\| LMDDx = [[squamous dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]], [[squamous cell carcinoma of the head and neck]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[esophagus]]/pharynx
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = elderly
			\| Signs =
			\| Symptoms = dysphagia
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx = excision
			}}
	'''Zenker's diverticulum''' is an outpouching of the mucosa and submucosa at the junction of the pharynx and [[esophagus]].		'''Zenker's diverticulum''' is an outpouching of the mucosa and submucosa at the junction of the pharynx and [[esophagus]].

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	Clinical:<ref name=pmid24055983>{{Cite journal \| last1 = Law \| first1 = R. \| last2 = Katzka \| first2 = DA. \| last3 = Baron \| first3 = TH. \| title = Zenker's Diverticulum. \| journal = Clin Gastroenterol Hepatol \| volume = 12 \| issue = 11 \| pages = 1773-82; quiz e111-2 \| month = Nov \| year = 2014 \| doi = 10.1016/j.cgh.2013.09.016 \| PMID = 24055983 }}</ref>		Clinical:<ref name=pmid24055983>{{Cite journal \| last1 = Law \| first1 = R. \| last2 = Katzka \| first2 = DA. \| last3 = Baron \| first3 = TH. \| title = Zenker's Diverticulum. \| journal = Clin Gastroenterol Hepatol \| volume = 12 \| issue = 11 \| pages = 1773-82; quiz e111-2 \| month = Nov \| year = 2014 \| doi = 10.1016/j.cgh.2013.09.016 \| PMID = 24055983 }}</ref>
	*Eldery.		*Eldery.
	*Dysphagia.		*Dysphagia - difficultly swallowing.
	*May mimic a [[thyroid gland\|thyroid]] nodule.<ref name=pmid20665743>{{Cite journal \| last1 = Singaporewalla \| first1 = RM. \| last2 = Mukherjee \| first2 = JJ. \| last3 = Thamboo \| first3 = TP. \| last4 = Cheah \| first4 = WK. \| title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. \| journal = Head Neck \| volume = 33 \| issue = 12 \| pages = 1800-3 \| month = Dec \| year = 2011 \| doi = 10.1002/hed.21474 \| PMID = 20665743 }}</ref>		*May mimic a [[thyroid gland\|thyroid]] nodule.<ref name=pmid20665743>{{Cite journal \| last1 = Singaporewalla \| first1 = RM. \| last2 = Mukherjee \| first2 = JJ. \| last3 = Thamboo \| first3 = TP. \| last4 = Cheah \| first4 = WK. \| title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. \| journal = Head Neck \| volume = 33 \| issue = 12 \| pages = 1800-3 \| month = Dec \| year = 2011 \| doi = 10.1002/hed.21474 \| PMID = 20665743 }}</ref>
	*+/-Aspiration of food.		*+/-Aspiration of food.
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	*[[Squamous dysplasia of the esophagus]].		*[[Squamous dysplasia of the esophagus]].
	*[[Squamous cell carcinoma of the esophagus]].		*[[Squamous cell carcinoma of the esophagus]].
			*[[Squamous cell carcinoma of the head and neck]].

	===Images===		===Images===

Michael: /* Microscopic */

2015-12-12T02:30:28Z

Microscopic

← Older revision		Revision as of 02:30, 12 December 2015
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	*[[Squamous dysplasia of the esophagus]].		*[[Squamous dysplasia of the esophagus]].
	*[[Squamous cell carcinoma of the esophagus]].		*[[Squamous cell carcinoma of the esophagus]].

			===Images===
			<gallery>
			Image: Pharyngoesophageal diverticulum -- very low mag.jpg \| ZD - very low mag. (WC)
			Image: Pharyngoesophageal diverticulum - alt -- very low mag.jpg \| ZD - very low mag. (WC)
			Image: Pharyngoesophageal diverticulum -- low mag.jpg \| ZD - low mag. (WC)
			Image: Pharyngoesophageal diverticulum -- intermed mag.jpg \| ZD - intermed. mag. (WC)
			</gallery>

	==Sign out==		==Sign out==

Michael: /* General */

2015-11-09T15:55:47Z

General

← Older revision		Revision as of 15:55, 9 November 2015
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	*Benign.		*Benign.
	**A malignancy ([[squamous cell carcinoma]]) may arise from it;<ref name=pmid26415863>{{Cite journal \| last1 = Acar \| first1 = T. \| last2 = Savaş \| first2 = R. \| last3 = Kocaçelebi \| first3 = K. \| last4 = Ersöz \| first4 = G. \| title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. \| journal = Dis Esophagus \| volume = \| issue = \| pages = \| month = Sep \| year = 2015 \| doi = 10.1111/dote.12406 \| PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal \| last1 = Wakita \| first1 = A. \| last2 = Motoyama \| first2 = S. \| last3 = Sato \| first3 = Y. \| last4 = Yoshino \| first4 = K. \| last5 = Sasaki \| first5 = T. \| last6 = Saito \| first6 = H. \| last7 = Minamiya \| first7 = Y. \| last8 = Ogawa \| first8 = J. \| title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. \| journal = Int J Surg Case Rep \| volume = 3 \| issue = 11 \| pages = 574-6 \| month = \| year = 2012 \| doi = 10.1016/j.ijscr.2012.07.010 \| PMID = 22940699 }}</ref> seen in ~0.3% of cases.<ref>{{Ref GLP\|7}}</ref>		**A malignancy ([[squamous cell carcinoma]]) may arise from it;<ref name=pmid26415863>{{Cite journal \| last1 = Acar \| first1 = T. \| last2 = Savaş \| first2 = R. \| last3 = Kocaçelebi \| first3 = K. \| last4 = Ersöz \| first4 = G. \| title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. \| journal = Dis Esophagus \| volume = \| issue = \| pages = \| month = Sep \| year = 2015 \| doi = 10.1111/dote.12406 \| PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal \| last1 = Wakita \| first1 = A. \| last2 = Motoyama \| first2 = S. \| last3 = Sato \| first3 = Y. \| last4 = Yoshino \| first4 = K. \| last5 = Sasaki \| first5 = T. \| last6 = Saito \| first6 = H. \| last7 = Minamiya \| first7 = Y. \| last8 = Ogawa \| first8 = J. \| title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. \| journal = Int J Surg Case Rep \| volume = 3 \| issue = 11 \| pages = 574-6 \| month = \| year = 2012 \| doi = 10.1016/j.ijscr.2012.07.010 \| PMID = 22940699 }}</ref> seen in ~0.3% of cases.<ref>{{Ref GLP\|7}}</ref>
	*~~Uncommon.~~<ref name=pmid24055983/>		*Relatively uncommon<ref name=pmid24055983/> - but most common among esophageal diverticula.<ref>{{Ref GLP\|6}}</ref>

	Clinical:<ref name=pmid24055983>{{Cite journal \| last1 = Law \| first1 = R. \| last2 = Katzka \| first2 = DA. \| last3 = Baron \| first3 = TH. \| title = Zenker's Diverticulum. \| journal = Clin Gastroenterol Hepatol \| volume = 12 \| issue = 11 \| pages = 1773-82; quiz e111-2 \| month = Nov \| year = 2014 \| doi = 10.1016/j.cgh.2013.09.016 \| PMID = 24055983 }}</ref>		Clinical:<ref name=pmid24055983>{{Cite journal \| last1 = Law \| first1 = R. \| last2 = Katzka \| first2 = DA. \| last3 = Baron \| first3 = TH. \| title = Zenker's Diverticulum. \| journal = Clin Gastroenterol Hepatol \| volume = 12 \| issue = 11 \| pages = 1773-82; quiz e111-2 \| month = Nov \| year = 2014 \| doi = 10.1016/j.cgh.2013.09.016 \| PMID = 24055983 }}</ref>

Michael: /* General */

2015-11-09T15:54:40Z

General

← Older revision		Revision as of 15:54, 9 November 2015
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	*[[Clinical diagnosis]].		*[[Clinical diagnosis]].
	*Benign.		*Benign.
	**[[~~Squamous~~ cell carcinoma]] may arise from it.<ref name=pmid26415863>{{Cite journal \| last1 = Acar \| first1 = T. \| last2 = Savaş \| first2 = R. \| last3 = Kocaçelebi \| first3 = K. \| last4 = Ersöz \| first4 = G. \| title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. \| journal = Dis Esophagus \| volume = \| issue = \| pages = \| month = Sep \| year = 2015 \| doi = 10.1111/dote.12406 \| PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal \| last1 = Wakita \| first1 = A. \| last2 = Motoyama \| first2 = S. \| last3 = Sato \| first3 = Y. \| last4 = Yoshino \| first4 = K. \| last5 = Sasaki \| first5 = T. \| last6 = Saito \| first6 = H. \| last7 = Minamiya \| first7 = Y. \| last8 = Ogawa \| first8 = J. \| title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. \| journal = Int J Surg Case Rep \| volume = 3 \| issue = 11 \| pages = 574-6 \| month = \| year = 2012 \| doi = 10.1016/j.ijscr.2012.07.010 \| PMID = 22940699 }}</ref>		**A malignancy ([[squamous cell carcinoma]]) may arise from it;<ref name=pmid26415863>{{Cite journal \| last1 = Acar \| first1 = T. \| last2 = Savaş \| first2 = R. \| last3 = Kocaçelebi \| first3 = K. \| last4 = Ersöz \| first4 = G. \| title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. \| journal = Dis Esophagus \| volume = \| issue = \| pages = \| month = Sep \| year = 2015 \| doi = 10.1111/dote.12406 \| PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal \| last1 = Wakita \| first1 = A. \| last2 = Motoyama \| first2 = S. \| last3 = Sato \| first3 = Y. \| last4 = Yoshino \| first4 = K. \| last5 = Sasaki \| first5 = T. \| last6 = Saito \| first6 = H. \| last7 = Minamiya \| first7 = Y. \| last8 = Ogawa \| first8 = J. \| title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. \| journal = Int J Surg Case Rep \| volume = 3 \| issue = 11 \| pages = 574-6 \| month = \| year = 2012 \| doi = 10.1016/j.ijscr.2012.07.010 \| PMID = 22940699 }}</ref> seen in ~0.3% of cases.<ref>{{Ref GLP\|7}}</ref>
	*Uncommon.<ref name=pmid24055983/>		*Uncommon.<ref name=pmid24055983/>

Michael: /* Alternate */

2015-11-09T15:41:12Z

Alternate

← Older revision		Revision as of 15:41, 9 November 2015
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	<pre>		<pre>
	Submitted as "Zenker's Diverticulum", Excision:		Submitted as "Zenker's Diverticulum", Excision:
	- Squamous mucosa with ~~epithelial hyperplasia,~~ mild chronic inflammation		- Squamous mucosa with mild chronic inflammation and reactive
	~~and reactive~~ changes; compatible with Zenker's diverticulum.		changes; compatible with Zenker's diverticulum.
	- Benign skeletal muscle.		- Benign skeletal muscle.
	- NEGATIVE for dysplasia and NEGATIVE for malignancy.		- NEGATIVE for dysplasia and NEGATIVE for malignancy.

Michael: /* Sign out */

2015-11-09T15:39:05Z

Sign out

← Older revision		Revision as of 15:39, 9 November 2015
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	- Squamous mucosa with parakeratosis, mild chronic inflammation		- Squamous mucosa with parakeratosis, mild chronic inflammation
	and fibrosis; compatible with Zenker's diverticulum.		and fibrosis; compatible with Zenker's diverticulum.
			- NEGATIVE for dysplasia and NEGATIVE for malignancy.
			</pre>

			===Alternate===
			<pre>
			Submitted as "Zenker's Diverticulum", Excision:
			- Squamous mucosa with epithelial hyperplasia, mild chronic inflammation
			and reactive changes; compatible with Zenker's diverticulum.
			- Benign skeletal muscle.
	- NEGATIVE for dysplasia and NEGATIVE for malignancy.		- NEGATIVE for dysplasia and NEGATIVE for malignancy.
	</pre>		</pre>

Michael: /* Sign out */

2015-11-03T17:18:35Z

Sign out

← Older revision		Revision as of 17:18, 3 November 2015
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	- Squamous mucosa with parakeratosis, mild chronic inflammation		- Squamous mucosa with parakeratosis, mild chronic inflammation
	and fibrosis; compatible with Zenker's diverticulum.		and fibrosis; compatible with Zenker's diverticulum.
	- NEGATIVE for dysplasia and NEGATIVE malignancy.		- NEGATIVE for dysplasia and NEGATIVE for malignancy.
	</pre>		</pre>

Michael: /* Microscopic */

2015-11-03T17:18:23Z

Microscopic

← Older revision		Revision as of 17:18, 3 November 2015
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid20665743>{{Cite journal \| last1 = Singaporewalla \| first1 = RM. \| last2 = Mukherjee \| first2 = JJ. \| last3 = Thamboo \| first3 = TP. \| last4 = Cheah \| first4 = WK. \| title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. \| journal = Head Neck \| volume = 33 \| issue = 12 \| pages = 1800-3 \| month = Dec \| year = 2011 \| doi = 10.1002/hed.21474 \| PMID = 20665743 }}</ref>		Features:<ref name=pmid20665743>{{Cite journal \| last1 = Singaporewalla \| first1 = RM. \| last2 = Mukherjee \| first2 = JJ. \| last3 = Thamboo \| first3 = TP. \| last4 = Cheah \| first4 = WK. \| title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. \| journal = Head Neck \| volume = 33 \| issue = 12 \| pages = 1800-3 \| month = Dec \| year = 2011 \| doi = 10.1002/hed.21474 \| PMID = 20665743 }}</ref>
	*Squamous mucosa.		*Squamous mucosa without [[nuclear atypia]] +/- parakeratosis.

	DDx:		DDx:
			*[[Squamous dysplasia of the esophagus]].
	*[[Squamous cell carcinoma of the esophagus]].		*[[Squamous cell carcinoma of the esophagus]].

			==Sign out==
			<pre>
			Submitted as "Zenker's Diverticulum", Excision:
			- Squamous mucosa with parakeratosis, mild chronic inflammation
			and fibrosis; compatible with Zenker's diverticulum.
			- NEGATIVE for dysplasia and NEGATIVE malignancy.
			</pre>

	==See also==		==See also==

Michael: /* Microscopic */

2015-10-30T02:44:47Z

Microscopic

← Older revision		Revision as of 02:44, 30 October 2015
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	</gallery>		</gallery>
	==Microscopic==		==Microscopic==
	Features:		Features:<ref name=pmid20665743>{{Cite journal \| last1 = Singaporewalla \| first1 = RM. \| last2 = Mukherjee \| first2 = JJ. \| last3 = Thamboo \| first3 = TP. \| last4 = Cheah \| first4 = WK. \| title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. \| journal = Head Neck \| volume = 33 \| issue = 12 \| pages = 1800-3 \| month = Dec \| year = 2011 \| doi = 10.1002/hed.21474 \| PMID = 20665743 }}</ref>
	*Squamous mucosa.		*Squamous mucosa.

			DDx:
			*[[Squamous cell carcinoma of the esophagus]].

	==See also==		==See also==

Michael: /* General */

2015-10-30T02:43:57Z

General

← Older revision		Revision as of 02:43, 30 October 2015
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	*Eldery.		*Eldery.
	*Dysphagia.		*Dysphagia.
			*May mimic a [[thyroid gland\|thyroid]] nodule.<ref name=pmid20665743>{{Cite journal \| last1 = Singaporewalla \| first1 = RM. \| last2 = Mukherjee \| first2 = JJ. \| last3 = Thamboo \| first3 = TP. \| last4 = Cheah \| first4 = WK. \| title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. \| journal = Head Neck \| volume = 33 \| issue = 12 \| pages = 1800-3 \| month = Dec \| year = 2011 \| doi = 10.1002/hed.21474 \| PMID = 20665743 }}</ref>
	*+/-Aspiration of food.		*+/-Aspiration of food.