Zollinger-Ellison syndrome - Revision history

Michael at 12:33, 14 May 2013

2013-05-14T12:33:47Z

← Older revision		Revision as of 12:33, 14 May 2013
Line 10:		Line 10:
	Laboratory:		Laboratory:
	*Serum gastrin often elevated - though not usually not very high.<ref name=pmid17108778>{{Cite journal \| last1 = Berna \| first1 = MJ. \| last2 = Hoffmann \| first2 = KM. \| last3 = Serrano \| first3 = J. \| last4 = Gibril \| first4 = F. \| last5 = Jensen \| first5 = RT. \| title = Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. \| journal = Medicine (Baltimore) \| volume = 85 \| issue = 6 \| pages = 295-330 \| month = Nov \| year = 2006 \| doi = 10.1097/01.md.0000236956.74128.76 \| PMID = 17108778 }}</ref>		*Serum gastrin often elevated - though not usually not very high.<ref name=pmid17108778>{{Cite journal \| last1 = Berna \| first1 = MJ. \| last2 = Hoffmann \| first2 = KM. \| last3 = Serrano \| first3 = J. \| last4 = Gibril \| first4 = F. \| last5 = Jensen \| first5 = RT. \| title = Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. \| journal = Medicine (Baltimore) \| volume = 85 \| issue = 6 \| pages = 295-330 \| month = Nov \| year = 2006 \| doi = 10.1097/01.md.0000236956.74128.76 \| PMID = 17108778 }}</ref>
			**Gastrin may be elevated due to chronic proton pump inhibitor (PPI) use - 35+/-20 pg/ml (normal) versus 170+/-135 pg/ml (chronic PPI use).<ref name=pmid22460728>{{Cite journal \| last1 = Raines \| first1 = D. \| last2 = Chester \| first2 = M. \| last3 = Diebold \| first3 = AE. \| last4 = Mamikunian \| first4 = P. \| last5 = Anthony \| first5 = CT. \| last6 = Mamikunian \| first6 = G. \| last7 = Woltering \| first7 = EA. \| title = A prospective evaluation of the effect of chronic proton pump inhibitor use on plasma biomarker levels in humans. \| journal = Pancreas \| volume = 41 \| issue = 4 \| pages = 508-11 \| month = May \| year = 2012 \| doi = 10.1097/MPA.0b013e318243a0b6 \| PMID = 22460728 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2013-04-29T22:29:30Z

Microscopic

← Older revision		Revision as of 22:29, 29 April 2013
Line 12:		Line 12:

	==Microscopic==		==Microscopic==
			===Pancreas===
	:See: ''[[Pancreatic neuroendocrine tumour]]''.		:See: ''[[Pancreatic neuroendocrine tumour]]''.

			===Stomach===
			*G-cell hyperplasia.

			DDx:
			*Pseudo-Zollinger-Ellison syndrome.<ref name=pmid10833904>{{Cite journal \| last1 = Tomaszewska \| first1 = R. \| last2 = Kedra \| first2 = B. \| last3 = Stachura \| first3 = J. \| title = Hypertrophic gastritis, primary diffuse G-cell hyperplasia and pancreatic metaplasia of the gastric mucosa (pseudo-Zollinger-Ellison syndrome)--case report. \| journal = Pol J Pathol \| volume = 51 \| issue = 1 \| pages = 51-4 \| month = \| year = 2000 \| doi = \| PMID = 10833904 }}
			</ref>

	==See also==		==See also==

Michael: /* General */

2013-04-29T22:26:39Z

General

← Older revision		Revision as of 22:26, 29 April 2013
Line 7:		Line 7:
	*Abdominal pain.		*Abdominal pain.
	*Diarrhea.		*Diarrhea.

			Laboratory:
			*Serum gastrin often elevated - though not usually not very high.<ref name=pmid17108778>{{Cite journal \| last1 = Berna \| first1 = MJ. \| last2 = Hoffmann \| first2 = KM. \| last3 = Serrano \| first3 = J. \| last4 = Gibril \| first4 = F. \| last5 = Jensen \| first5 = RT. \| title = Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature. \| journal = Medicine (Baltimore) \| volume = 85 \| issue = 6 \| pages = 295-330 \| month = Nov \| year = 2006 \| doi = 10.1097/01.md.0000236956.74128.76 \| PMID = 17108778 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 16:48, 8 January 2012

2012-01-08T16:48:17Z

← Older revision		Revision as of 16:48, 8 January 2012
Line 1:		Line 1:
	'''Zollinger-Ellison syndrome''', abbreviated '''ZES''', is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>		'''Zollinger-Ellison syndrome''', abbreviated '''ZES''', is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>

	~~It may~~ be part of [[MEN 1\|multiple endocrine neoplasia 1]].		==General==
			*May be part of [[MEN 1\|multiple endocrine neoplasia 1]].

			Clinical:
			*Abdominal pain.
			*Diarrhea.

			==Microscopic==
			:See: ''[[Pancreatic neuroendocrine tumour]]''.

	==See also==		==See also==

Michael: create

2012-01-08T16:40:35Z

create

New page

'''Zollinger-Ellison syndrome''', abbreviated '''ZES''', is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.<ref name=pmid13259432>{{cite journal |author=Zollinger RM, Ellison EH |title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas |journal=Ann. Surg. |volume=142 |issue=4 |pages=709–23; discussion, 724–8 |year=1955 |pmid=13259432|doi=10.1097/00000658-195510000-00015 |PMC = 1465210 |URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>

It may be part of [[MEN 1|multiple endocrine neoplasia 1]].

==See also==
*[[Pancreatic neuroendocrine tumour]].
*[[Neuroendocrine tumours]].

==References==
{{Reflist|1}}

[[Category:Syndromes]]
[[Category:Diagnosis]]