Zoon vulvitis - Revision history

Michael at 03:43, 14 November 2014

2014-11-14T03:43:09Z

← Older revision		Revision as of 03:43, 14 November 2014
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	DDx:		DDx:
	*[[Syphilis]] - Spirochete immunostain (in red) is helpful.		*[[Syphilis]] - Spirochete immunostain (in red) is helpful.
	*Spongiotic vulvitis		*Spongiotic vulvitis.
	**Might look very similar		**Might look very similar.
	**Usually wont show iron deposition		**Usually wont show iron deposition.
	**Clinical correlation important		**Clinical correlation important.
	*Superficial fungal vulvitis (usually Candida)		*Superficial fungal vulvitis (usually Candida).
	*Lichenoid vulvitis (lichen planus/lichenoid drug reaction).		*Lichenoid vulvitis (lichen planus/lichenoid drug reaction).
	**Both can be very plasmocellular on mucosal surfaces.		**Both can be very plasmocellular on mucosal surfaces.

2014-10-30T07:25:42Z

Microscopic

← Older revision		Revision as of 07:25, 30 October 2014
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	**Usually wont show iron deposition		**Usually wont show iron deposition
	**Clinical correlation important		**Clinical correlation important
			*Superficial fungal vulvitis (usually Candida)
	*Lichenoid vulvitis (lichen planus/lichenoid drug reaction).		*Lichenoid vulvitis (lichen planus/lichenoid drug reaction).
	**Both can be very plasmocellular on mucosal surfaces.		**Both can be very plasmocellular on mucosal surfaces.

2014-10-30T07:24:42Z

Microscopic

← Older revision		Revision as of 07:24, 30 October 2014
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	**"Lozenge"-shaped (diamond-like shape).		**"Lozenge"-shaped (diamond-like shape).
	*Abundant plasma cells - esp. superficial dermis.		*Abundant plasma cells - esp. superficial dermis.
			**Keep in mind that plasma cells are a common component of mucosal infiltrates, much more so than for skin.
			**A plasma cell component has to be relatively prominent to be relevant in this location (the same can be said for eosinophils).
	*Hemosiderin deposits.<ref name=pmid6833541>{{Cite journal \| last1 = Davis \| first1 = J. \| last2 = Shapiro \| first2 = L. \| last3 = Baral \| first3 = J. \| title = Vulvitis circumscripta plasmacellularis. \| journal = J Am Acad Dermatol \| volume = 8 \| issue = 3 \| pages = 413-6 \| month = Mar \| year = 1983 \| doi = \| PMID = 6833541 }}</ref>		*Hemosiderin deposits.<ref name=pmid6833541>{{Cite journal \| last1 = Davis \| first1 = J. \| last2 = Shapiro \| first2 = L. \| last3 = Baral \| first3 = J. \| title = Vulvitis circumscripta plasmacellularis. \| journal = J Am Acad Dermatol \| volume = 8 \| issue = 3 \| pages = 413-6 \| month = Mar \| year = 1983 \| doi = \| PMID = 6833541 }}</ref>

2014-10-30T05:55:31Z

Microscopic

← Older revision		Revision as of 05:55, 30 October 2014
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	DDx:		DDx:
	*[[Syphilis]] - Spirochete immunostain (in red) is helpful.		*[[Syphilis]] - Spirochete immunostain (in red) is helpful.
	*Spongiotic vulvitis ~~- Can~~ look very similar ~~- may contain more eosinophils~~		*Spongiotic vulvitis
	*~~Mucosal~~ lichen planus/~~Lichenoid~~ drug reaction.		**Might look very similar
			**Usually wont show iron deposition
			**Clinical correlation important
			*Lichenoid vulvitis (lichen planus/lichenoid drug reaction).
	**Both can be very plasmocellular on mucosal surfaces.		**Both can be very plasmocellular on mucosal surfaces.
	**Zoon vulvitis won't show prominent lichenoid destruction of the epithelium.		**Zoon vulvitis won't show prominent lichenoid destruction of the epithelium.

2014-10-30T05:44:54Z

Microscopic

← Older revision		Revision as of 05:44, 30 October 2014
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	DDx:		DDx:
	*[[Syphilis]] - Spirochete immunostain (in red) is helpful.		*[[Syphilis]] - Spirochete immunostain (in red) is helpful.
	*Spongiotic vulvitis - Can look very similar - may be more ~~eosinophilic~~		*Spongiotic vulvitis - Can look very similar - may contain more eosinophils
	*Mucosal lichen planus/Lichenoid drug reaction.		*Mucosal lichen planus/Lichenoid drug reaction.
	**Both can be very plasmocellular on mucosal surfaces.		**Both can be very plasmocellular on mucosal surfaces.

2014-10-30T05:44:26Z

Microscopic

← Older revision		Revision as of 05:44, 30 October 2014
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	DDx:		DDx:
	*[[Syphilis]].		*[[Syphilis]] - Spirochete immunostain (in red) is helpful.
	*Lichenoid drug reaction.		*Spongiotic vulvitis - Can look very similar - may be more eosinophilic
	*~~Spongiotic vulvitis~~.		*Mucosal lichen planus/Lichenoid drug reaction.
	*~~Mucosal lichen planus~~.		**Both can be very plasmocellular on mucosal surfaces.
			**Zoon vulvitis won't show prominent lichenoid destruction of the epithelium.

	====Images====		====Images====

2014-10-30T05:40:05Z

Microscopic

2014-10-30T05:39:38Z

Microscopic

2014-10-30T05:39:07Z

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← Older revision		Revision as of 05:39, 30 October 2014
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	A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain		A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain
	is negative. Ki-67 positive cells are basal. No microorganisms are apparent		is negative. Ki-67 positive cells are basal. No microorganisms are apparent
	with a PASF stain. A Perls positive iron is admixed with the inflammatory infiltrate.		with a PASF stain. Perls stain positive iron is admixed with the inflammatory infiltrate.
	</pre>		</pre>

2014-10-30T05:38:46Z

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← Older revision		Revision as of 05:38, 30 October 2014
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	A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain		A CD138 immunostain demonstrates clusters of plasma cells. A p16 immunostain
	is negative. Ki-67 positive cells are basal. No microorganisms are apparent		is negative. Ki-67 positive cells are basal. No microorganisms are apparent
	with a PASF stain.		with a PASF stain. A Perls positive iron is admixed with the inflammatory infiltrate.
	</pre>		</pre>