OCT3/4
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OCT3/4 is a common immunostain used in the work-up of germ cell tumours.
Positive
Non-germ cell tumours:
- Renal medullary carcinoma.[1]
- Prostatic adenocarcinoma.
- Mucoepidermoid carcinoma.
- Non-small cell lung carcinoma.
- Diffuse large B-cell lymphoma.[2] - described pitfall.
Oct3/4 in a germinoma
Negative
See also
References
- ↑ Rao P, Tannir NM, Tamboli P (April 2012). "Expression of OCT3/4 in renal medullary carcinoma represents a potential diagnostic pitfall". Am J Surg Pathol 36 (4): 583–8. doi:10.1097/PAS.0b013e3182417d78. PMID 22301499.
- ↑ Williams AS, Shawwa A, Merrimen J, Dakin Haché K (July 2016). "Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma: An Analysis of 145 Consecutive Cases and Testicular Lymphomas". Am J Surg Pathol 40 (7): 950–7. doi:10.1097/PAS.0000000000000648. PMID 27035612.