Difference between revisions of "Pulmonary carcinoid tumourlet"
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'''Pulmonary carcinoid tumourlet''', also '''carcinoid tumourlet''', is a small benign proliferation of Kulchitsky cells. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
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| Synonyms = carcinoid tumourlet | |||
| Micro = cells with salt and pepper chromatin, usually nested architecture, no necrosis, minimal mitotic activity (see below) | |||
| Subtypes = | |||
| LMDDx = [[typical carcinoid lung tumour]], [[atypical lung carcinoid tumour]] | |||
| Stains = | |||
| IHC = Ki-67 ~2% (0-7%) | |||
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| Molecular = | |||
| IF = | |||
| Gross = <5 mm by definition | |||
| Grossing = | |||
| Site = [[lung]] - see ''[[lung tumours]]'' | |||
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| Syndromes = | |||
| Clinicalhx = often an incidental finding | |||
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| Prevalence = not common | |||
| Bloodwork = | |||
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| Prognosis = benign | |||
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}} | |||
'''Pulmonary carcinoid tumourlet''', also '''carcinoid tumourlet''', is a small benign proliferation of Kulchitsky cells. | |||
The entity is separated from the ''[[typical lung carcinoid tumour]]'' by size. Carcinoid tumourlets are < 5 mm, typical lung carcinoid tumours are >=5 mm. | |||
==General== | ==General== | ||
Revision as of 03:41, 28 August 2015
| Pulmonary carcinoid tumourlet | |
|---|---|
| Diagnosis in short | |
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| Synonyms | carcinoid tumourlet |
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| |
| LM | cells with salt and pepper chromatin, usually nested architecture, no necrosis, minimal mitotic activity (see below) |
| LM DDx | typical carcinoid lung tumour, atypical lung carcinoid tumour |
| IHC | Ki-67 ~2% (0-7%) |
| Gross | <5 mm by definition |
| Site | lung - see lung tumours |
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| |
| Clinical history | often an incidental finding |
| Prevalence | not common |
| Prognosis | benign |
Pulmonary carcinoid tumourlet, also carcinoid tumourlet, is a small benign proliferation of Kulchitsky cells.
The entity is separated from the typical lung carcinoid tumour by size. Carcinoid tumourlets are < 5 mm, typical lung carcinoid tumours are >=5 mm.
General
- Neuroendocrine cell proliferation.[1]
- Essentially a small typical carcinoid.
- Arise from Kulchitsky cells of the bronchial epithelium.[2]
Microscopic
Features:
- Nests of cells - classic pattern.
- Salt and pepper chromatin - key feature.
- Size criterion: <5 mm.[3][4]
DDx:
Images
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A. Lymph Node, Station 4R, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. B. Lymph Node, Station 11R, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. C. Lung, Right Middle Lobe, Lobectomy: - Typical carcinoid tumour (13 mm maximal dimension). - Carcinoid tumourlet (3 mm maximal dimension). - Margins clear of tumour. - Please see tumour summary.
See also
References
- ↑ Bennett, GL.; Chew, FS. (Mar 1994). "Pulmonary carcinoid tumorlets.". AJR Am J Roentgenol 162 (3): 568. PMID 8109497.
- ↑ Ramón Capilla, M.; Arnau Obrer, A.; Navarro Ibáñez, R.; Galbis Caravajal, J.; Traves Zapata, V.; Cantó Armengod, A. (Nov 1996). "[Pulmonary tumorlet. Report of 5 cases].". Arch Bronconeumol 32 (9): 489-91. PMID 9064089.
- ↑ URL: http://pathhsw5m54.ucsf.edu/case7/image75.html. Accessed on: 23 January 2012.
- ↑ He, P.; Gu, X.; Wu, Q.; Lin, Y.; Gu, Y.; He, J. (Dec 2012). "Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis.". J Thorac Dis 4 (6): 655-8. doi:10.3978/j.issn.2072-1439.2012.06.11. PMID 23205296.