Difference between revisions of "Foamy gland carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Intraluminal eosinophilic crystalloid of prostate gland - high mag.jpg | |||
| Width = | |||
| Caption = Foamy gland carcinoma. [[H&E stain]]. | |||
| Synonyms = foamy gland adenocarcinoma | |||
| Micro = | |||
| Subtypes = (subtype of [[prostate carcinoma]]) | |||
| LMDDx = [[adenosis of the prostate]], [[bulbourethral gland]], [[pseudohyperplastic adenocarcinoma]] | |||
| Stains = | |||
| IHC = AMACR +ve, CK5/6 -ve, p63 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = see ''[[prostate carcinoma]]'' | |||
| Grossing = see ''[[prostate carcinoma]]'' | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] - see ''[[prostate carcinoma]]'' | |||
| Assdx = | |||
| Syndromes = see ''[[prostate carcinoma]]'' | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = often good, dependent on [[prostate cancer grading|grade]] & stage | |||
| Other = | |||
| ClinDDx = see ''[[prostate carcinoma]]'' | |||
| Tx = see ''[[prostate carcinoma]]'' | |||
}} | |||
'''Foamy gland carcinoma''', also '''foamy gland adenocarcinoma''',<ref name=pmid19033862/> is an uncommon variant of [[prostate carcinoma]] that has a bland appearance and may be confused with benign glands. | '''Foamy gland carcinoma''', also '''foamy gland adenocarcinoma''',<ref name=pmid19033862/> is an uncommon variant of [[prostate carcinoma]] that has a bland appearance and may be confused with benign glands. | ||
==General== | ==General== | ||
{{Main|Prostate_carcinoma#General| l1 = Prostate carcinoma}} | |||
*Rare. | *Rare. | ||
*Usually low grade, i.e. Gleason score 6/10.<ref name=pmid19033862>{{Cite journal | last1 = Zhao | first1 = J. | last2 = Epstein | first2 = JI. | title = High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 583-90 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818a5c6c | PMID = 19033862 }}</ref> | *Usually low grade, i.e. [[Gleason score]] 6/10.<ref name=pmid19033862>{{Cite journal | last1 = Zhao | first1 = J. | last2 = Epstein | first2 = JI. | title = High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 583-90 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818a5c6c | PMID = 19033862 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Latest revision as of 03:39, 9 February 2016
| Foamy gland carcinoma | |
|---|---|
| Diagnosis in short | |
 Foamy gland carcinoma. H&E stain. | |
|
| |
| Synonyms | foamy gland adenocarcinoma |
| Subtypes | (subtype of prostate carcinoma) |
| LM DDx | adenosis of the prostate, bulbourethral gland, pseudohyperplastic adenocarcinoma |
| IHC | AMACR +ve, CK5/6 -ve, p63 -ve |
| Gross | see prostate carcinoma |
| Grossing notes | see prostate carcinoma |
| Staging | prostate cancer staging |
| Site | prostate gland - see prostate carcinoma |
|
| |
| Syndromes | see prostate carcinoma |
|
| |
| Prevalence | uncommon |
| Prognosis | often good, dependent on grade & stage |
| Clin. DDx | see prostate carcinoma |
| Treatment | see prostate carcinoma |
Foamy gland carcinoma, also foamy gland adenocarcinoma,[1] is an uncommon variant of prostate carcinoma that has a bland appearance and may be confused with benign glands.
General
Main article: Prostate carcinoma
- Rare.
- Usually low grade, i.e. Gleason score 6/10.[1]
Microscopic
Features:
- Increased glandular density - key feature.
- Eosinophilic intraluminal amorphous secretions - key feature.
- Abundant foamy cytoplasm.
- Tufted glandular border.
- Gland size larger than "typical" prostate cancer.
Note:
- Prominent nucleoli usually infrequent or absent![1]
- Can be thought of as pseudohyperplastic adenocarcinoma without the nucleoli.
DDx:
Images
Intraluminal eosinophilic crystalloid in foamy glands. (WC)
www: