Difference between revisions of "Mesonephric adenocarcinoma"
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'''Mesonephric adenocarcinoma''' is a rare malignant tumour of the [[uterine cervix]]. | |||
==General== | |||
*Arises from the [[mesonephric duct remnants]]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*Nuclear atypia - '''key feature'''. | |||
**Nuclear crowding. | |||
*Variable architecture: | |||
**Tubular, papillary, solid, retiform (net-like<ref>URL: [http://www.thefreedictionary.com/retiform http://www.thefreedictionary.com/retiform]. Accessed on: 25 August 2012.</ref>). | |||
DDx: | |||
*[[Mesonephric duct remnants]]. | |||
*[[Cervical adenocarcinoma]]. | |||
**[[Clear cell carcinoma of the uterine cervix]]. | |||
*[[Colorectal adenocarcinoma]]. | |||
*[[Endometrioid endometrial adenocarcinoma]]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*CK7 +ve. | |||
*CD10 +ve. | |||
*AMACR +ve. | |||
*Napsin A +ve.<ref name=pmid31361605>{{cite journal |authors=Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L |title=Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract |journal=Appl Immunohistochem Mol Morphol |volume=28 |issue=8 |pages=593–601 |date=September 2020 |pmid=31361605 |pmc=6987010 |doi=10.1097/PAI.0000000000000801 |url=}}</ref> | |||
*HNF-1beta +ve/-ve. | |||
**Not useful for differentiation from clear cell carcinoma of the gynecologic tract.<ref name=pmid31361605/> | |||
Others:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref> | |||
*[[CK20]] -ve. | |||
*ER -ve. | |||
*PR -ve. | |||
*CEA -ve. | |||
==See also== | |||
*[[Gynecologic pathology]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Gynecologic pathology]] | |||
Latest revision as of 19:17, 17 November 2021
Mesonephric adenocarcinoma is a rare malignant tumour of the uterine cervix.
General
- Arises from the mesonephric duct remnants.
Microscopic
Features:[1]
- Nuclear atypia - key feature.
- Nuclear crowding.
- Variable architecture:
- Tubular, papillary, solid, retiform (net-like[2]).
DDx:
- Mesonephric duct remnants.
- Cervical adenocarcinoma.
- Colorectal adenocarcinoma.
- Endometrioid endometrial adenocarcinoma.
IHC
Features:[1]
- CK7 +ve.
- CD10 +ve.
- AMACR +ve.
- Napsin A +ve.[3]
- HNF-1beta +ve/-ve.
- Not useful for differentiation from clear cell carcinoma of the gynecologic tract.[3]
Others:[1]
- CK20 -ve.
- ER -ve.
- PR -ve.
- CEA -ve.
See also
References
- ↑ 1.0 1.1 1.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 442. ISBN 978-0781765275.
- ↑ URL: http://www.thefreedictionary.com/retiform. Accessed on: 25 August 2012.
- ↑ 3.0 3.1 Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L (September 2020). "Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract". Appl Immunohistochem Mol Morphol 28 (8): 593–601. doi:10.1097/PAI.0000000000000801. PMC 6987010. PMID 31361605. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987010/.