Sarcomatoid urothelial carcinoma

Sarcomatoid urothelial carcinoma (abbreviated sarcomatoid UC), also sarcomatoid urothelial cell carcinoma (abbreviated sarcomatoid UCC), is a rare variant of urothelial carcinoma.

General

• Rare.
• Aggressive >55% dead within one year of presentation.

Microscopic

Features:

1. Urothelial carcinoma (classic or recognizable variant).
2. Sarcomatoid differentiation - typically (undifferentiated) spindle cells.
   • Approximately have 10% of heterologous elements, e.g. chondrosarcomatous differentiation, osteosarcomatous differentiation.

DDx:

• Sarcoma - esp. those arising from the retroperitoneum.

Images

• 
  Sarcomatoid UCC - low mag.
• 
  Sarcomatoid UCC - intermed. mag.
• 
  Sarcomatoid UCC - high mag.

See also

• Urothelial carcinoma.
• Carcinosarcoma.