Urothelial carcinoma-like prostatic carcinoma

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Urothelial carcinoma-like prostatic carcinoma is a prostatic carcinoma that histologically mimics urothelial carcinoma.

It is not a formally recognized type of prostate cancer.

General

  • Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap.
  • Relative proximity of the urinary bladder and prostate results in clinical scenarios where the primary is not readily apparent.

Gross

Classic tumour locations:

  • Bladder neck.
  • Trigone/base of bladder.
  • Prostatic urethra.

Microscopic

Features:

  • Large epithelioid cells with prominent nucleoli.
  • +/-Papillary structures (pseudopapillae).[1]
  • +/-Features suggestive of prostatic carcinoma - cribriforming glands or poorly formed glandular structures.

DDx:

Images

  • Urothelial carcinoma-like prostatic carcinoma -- very low mag.jpg

    UCLPC - very low mag.

  • Urothelial carcinoma-like prostatic carcinoma -- low mag.jpg

    UCLPC - low mag.

  • Urothelial carcinoma-like prostatic carcinoma - alt -- low mag.jpg

    UCLPC - low mag.

  • Urothelial carcinoma-like prostatic carcinoma -- intermed mag.jpg

    UCLPC - intermed. mag.

  • Urothelial carcinoma-like prostatic carcinoma - alt -- intermed mag.jpg

    UCLPC - intermed. mag.

  • Urothelial carcinoma-like prostatic carcinoma -- high mag.jpg

    UCLPC - high mag.

  • Urothelial carcinoma-like prostatic carcinoma - alt -- high mag.jpg

    UCLPC - high mag.

  • Urothelial carcinoma-like prostatic carcinoma -- very high mag.jpg

    UCLPC - very high mag.

  • Urothelial carcinoma-like prostatic carcinoma - alt -- very high mag.jpg

    UCLPC - very high mag.

  • PC - intermed. mag.

  • PC - high mag.

IHC

Features:[1]

  • GATA3 -ve.
  • NKX3.1 +ve.

Images

  • UCLPC - NKX3.1 - intermed. mag.

  • UCLPC - AMACR-CK5/6 - very low mag.

  • UCLPC - AMACR-CK5/6 - intermed. mag.

  • UCLPC - GATA3 - intermed. mag.

  • Urothelium - GATA3 - high mag.

See also

References

  1. ↑ 1.0 1.1 Gordetsky, J.; Epstein, JI. (Jul 2014). "Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall.". Am J Surg Pathol 38 (7): 941-5. doi:10.1097/PAS.0000000000000178. PMID 24503758.
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