Hyperplastic polyp with perineuromatous stroma

From Libre Pathology
Revision as of 21:03, 20 April 2021 by Michael (talk | contribs)
Jump to navigation Jump to search
Hyperplastic polyp with perineuromatous stroma
Diagnosis in short
Template:Px
Hyperplastic polyp with perineuromatous stroma. H&E stain.
Synonyms benign serrated colorectal fibroblastic polyps/intramucosal perineurioma, hybrid hyperplastic polyp/mucosal perineurioma
LM serrated epithelial cells (at the surface), perineuromatous stroma
LM DDx colonic ganglioneuroma, hyperplastic polyp
Site colon and rectum
Prevalence rare
Endoscopy polyp
Prognosis benign
Clin. DDx other types of colorectal polyps

Hyperplastic polyp with perineuromatous stroma, also known as benign serrated colorectal fibroblastic polyps/intramucosal perineurioma and hybrid hyperplastic polyp/mucosal perineurioma, is a benign colorectal polyp.

It may be referred to as perineurioma and fibroblastic polyp.[1]

General

  • Rare.
  • Benign.[2]

Microscopic

Features:

  • Serrated epithelial cells (at the surface of the gland) - key feature.
    • Serrated appearance = saw-tooth appearance, epithelium has jagged edge.
  • Perineuromatous stroma.

DDx:

Images

  • Hyperplastic polyp with perineuromatous stroma -- very low mag.jpg

    HP with PNS - very low mag.

  • Hyperplastic polyp with perineuromatous stroma -- low mag.jpg

    HP with PNS - low mag.

  • HP with PNS - intermed. mag.

  • Hyperplastic polyp with perineuromatous stroma - alt -- intermed mag.jpg

    HP with PNS - intermed. mag.

  • Hyperplastic polyp with perineuromatous stroma -- high mag.jpg

    HP with PNS - high mag.

  • Hyperplastic polyp with perineuromatous stroma - alt -- high mag.jpg

    HP with PNS - high mag.

  • Hyperplastic polyp with perineuromatous stroma -- very high mag.jpg

    HP with PNS - very high mag.

See also

References

  1. ↑ "Fibroblastic polyp of the colon and colonic perineurioma: 2 names for a single entity?". Am J Surg Pathol 32 (7): 1088–94. July 2008. doi:10.1097/PAS.0b013e318160df3f. PMID 18520438.
  2. ↑ Agaimy, A.; Stoehr, R.; Vieth, M.; Hartmann, A. (Nov 2010). "Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.". Am J Surg Pathol 34 (11): 1663-71. doi:10.1097/PAS.0b013e3181f4a458. PMID 20962618.
Retrieved from "https://librepathology.org/w/index.php?title=Hyperplastic_polyp_with_perineuromatous_stroma&oldid=51290"