Mantle cell lymphoma

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Mantle cell lymphoma, abbreviated MCL, is less common small cell lymphoma that is relatively aggressive when compared to other small cell lymphomas.

General

  • Relatively aggressive - guarded prognosis.[1]

Microscopic

Features:[2]

  • Small monomorphic (uniform size, shape and staining) lymphoid population.
  • Abundant mitoses.
  • Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
  • Sclerosed blood vessels.

DDx:

Images

  • Mantle cell lymphoma - low mag.jpg

    MCL - low mag. (WC)

  • Mantle cell lymphoma - intermed mag.jpg

    MCL - intermed. mag. (WC)

  • Mantle cell lymphoma - low mag - cyclin D1.jpg

    MCL - low mag. - cyclin D1. (WC)

  • Mantle cell lymphoma - intermed mag - cyclin D1.jpg

    MCL - intermed. mag. - cyclin D1. (WC)

www:

IHC

  • CD5 +ve.
    • Negative in case reports.[3]
  • CD43 +ve.
  • Cyclin D1 +ve.

Others:

  • CD23 -ve.
    • Positive in CLL.

Molecular

  • t(11;14)(q13;q32) / IGH-CCND1.[5]

See also

References

  1. ↑ Hankin, RC.; Hunter, SV. (Dec 1999). "Mantle cell lymphoma.". Arch Pathol Lab Med 123 (12): 1182-8. doi:10.1043/0003-9985(1999)1231182:MCL2.0.CO;2. PMID 10583923.
  2. ↑ Good, D. 17 August 2010.
  3. ↑ URL: http://path.upmc.edu/cases/case308/dx.html. Accessed on: 14 January 2012.
  4. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
  5. ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.
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