Hyperplastic polyp with perineuromatous stroma

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Hyperplastic polyp with perineuromatous stroma, also known as benign serrated colorectal fibroblastic polyps/intramucosal perineurioma and hybrid hyperplastic polyp/mucosal perineurioma, is a benign colorectal polyp.

General

  • Rare.
  • Benign.[1]

Microscopic

Features:

  • Serrated epithelial cells (at the surface of the gland) - key feature.
    • Serrated appearance = saw-tooth appearance, epithelium has jagged edge.
  • Perineuromatous stroma.

DDx:

Images

  • Hyperplastic polyp with perineuromatous stroma -- very low mag.jpg

    HP with PNS - very low mag.

  • Hyperplastic polyp with perineuromatous stroma -- low mag.jpg

    HP with PNS - low mag.

  • Hyperplastic polyp with perineuromatous stroma -- intermed mag.jpg

    HP with PNS - intermed. low mag.

  • Hyperplastic polyp with perineuromatous stroma - alt -- intermed mag.jpg

    HP with PNS - intermed. low mag.

  • Hyperplastic polyp with perineuromatous stroma -- high mag.jpg

    HP with PNS - high mag.

  • Hyperplastic polyp with perineuromatous stroma - alt -- high mag.jpg

    HP with PNS - high mag.

  • Hyperplastic polyp with perineuromatous stroma -- very high mag.jpg

    HP with PNS - very high mag.

See also

References

  1. ↑ Agaimy, A.; Stoehr, R.; Vieth, M.; Hartmann, A. (Nov 2010). "Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.". Am J Surg Pathol 34 (11): 1663-71. doi:10.1097/PAS.0b013e3181f4a458. PMID 20962618.
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