Atypical lobular hyperplasia
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| Atypical lobular hyperplasia | |
|---|---|
| Diagnosis in short | |
|
Template:Px Atypical lobular hyperplasia. H&E stain. (WC/Nephron) | |
| LM DDx | lobular carcinoma in situ, lobular carcinoma |
| IHC | E-cadherin -ve |
| Site | breast |
|
| |
| Prognosis | benign |
Atypical lobular hyperplasia, abbreviated ALH, a pre-malignant change in the breast characterized by cellular proliferation and cellular dyscohesion.
It can be seen as the precursor to lobular carcinoma in situ, the precursor of lobular carcinoma.
General
- May occur with ductal involvement by cells of atypical lobular hyperplasia (abbreviated DIALH).[1]
- ALH with DIALH has a risk of developing breast cancer that is similar to LCIS.
Microscopic
Features:
- Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved.
- See lobular carcinoma in situ for details.
DDx:
Images
- Atypical lobular hyperplasia -- low mag.jpg
ALH - low mag. (WC)
- Atypical lobular hyperplasia -- intermed mag.jpg
ALH - intermed. mag. (WC)
- Atypical lobular hyperplasia -- high mag.jpg
ALH - high mag. (WC)
- Atypical lobular hyperplasia - E-cadherin -- intermed mag.jpg
ALH - E-cadherin - intermed. mag. (WC)
- Atypical lobular hyperplasia - E-cadherin -- high mag.jpg
ALH - E-cadherin - high mag. (WC)
- Benign breast - E-cadherin -- intermed mag.jpg
Benign breast - E-cadherin - intermed. mag. (WC)
- Benign breast - E-cadherin -- high mag.jpg
Benign breast - E-cadherin - high mag. (WC)
- Benign breast - E-cadherin - alt -- high mag.jpg
Benign breast - E-cadherin - high mag. (WC)
IHC
- E-cadherin -ve or incomplete membrane staining.