Thoracic SMARCA4-deficient undifferentiated tumour

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Thoracic SMARCA4-deficient undifferentiated tumour is poorly differentiated malignancy of the thorax.^[1]

Microscopic

Features:

Poorly differentiated malignancy.
+/-Rhabdoid morphology.

IHC

SMARCA4 loss or strongly reduced (definitional).
AE1/AE3 -ve or focal.
Synaptophysin +ve.
Chromogranin -ve.

See also

SMARCA4.

References

↑ Shinno Y, Ohe Y (March 2024). "Thoracic SMARCA4-deficient undifferentiated tumor: current knowledge and future perspectives". Jpn J Clin Oncol 54 (3): 265–270. doi:10.1093/jjco/hyad175. PMID 38117955.

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Diagnosis